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Molecular biology of 5-HT receptors

Hannon, Jason, Hoyer, Daniel·2008·Behavioural Brain Research

DOI 10.1016/j.bbr.2008.03.020

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Abstract

Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family which includes the monoamine receptors and a combination of ligand-gated ion channels (5-HT3) of the Cys loop family which constitutes heteropentamers. 5-HT receptors are currently divided into seven classes (5-HT1 to 5-HT7), based on structural, transductional and operational features. While this degree of physical diversity clearly underscores the physiological importance of serotonin, evidence for an even greater degree of operational diversity is supported by the existence of a great number of splice and editing variants for several 5-HT receptors, their possible modulation by accessory proteins and chaperones, as well as their potential to form homo or heteromers both at the GPCR and at the ligand-gated channel level.

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Authors: Hannon, J., & Hoyer, D.
Affiliations: Novartis (Switzerland) (CH)
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2008-12
Volume: 195
Issue: 1
Pages: 198-213
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2008.03.020
OpenAlex: W2010391271
Cited by: 815
References: 243
Citations by year: 2026: 20 · 2025: 41 · 2024: 39 · 2023: 47 · 2022: 39 · 2021: 54 · 2020: 46 · 2019: 52 · 2018: 52 · 2017: 44 · 2016: 53 · 2015: 45 · 2014: 53 · 2013: 59 · 2012: 54
FWCI: 15.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin receptors, G protein-coupled receptors, 5-HT3 receptor, ligand-gated ion channels, Cys-loop receptors, receptor splice variants, alternative splicing, receptor editing, accessory proteins, molecular chaperones, receptor heteromers
MeSH terms: Animals, Humans, Ligands, Protein Binding, Receptors, Serotonin, Serotonin, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins

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