Sex-dependent cognitive phenotype of mice lacking mGluR8
Open accessAbstract
Metabotropic glutamate receptors (mGluRs) modulate glutamatergic and GABAergic neurotransmission. mGluR8 is generally located presynaptically where it regulates neurotransmitter release. Previously we reported that 6-month-old mGluR8(-/-) male mice show higher measures of anxiety in anxiety tests involving avoidable anxiety-provoking stimuli than age-matched wild-type male mice. In wild-type mice, middle-aged females and males show higher measures of anxiety in such tests and reduced spatial learning than young adults. In this study we evaluated in middle-aged mice the effects of mGluR8 deficiency on measures of anxiety involving avoidable and unavoidable anxiety-provoking stimuli and on cognitive performance and whether these effects are sex-dependent. Female and male mGluR8(-/-) mice showed increased measures of anxiety in the open field. In contrast, male mGluR8(-/-) mice showed increased but female mGluR8(-/-) mice decreased measures of anxiety in the elevated plus maze and the acoustic startle response. mGluR8 deficiency impaired novel location recognition and spatial memory retention in the water maze. The impairment in spatial memory retention in the water maze, but not in novel location recognition, was more pronounced in female than male mice. Thus, potential sex differences in the therapeutic effects of mGluR8 modulation to reduce measures of anxiety and improve cognitive performance should be carefully considered.
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Mice lacking the Group III receptor subunit GRM8 display increased age- and sex-dependent anxiety-like behaviors and startle response.
“Mice lacking the Group III receptor subunit GRM8 (mGluR8) display increased age-and sex-dependent anxiety-like behaviors and startle response (Duvoisin et al., 2005(Duvoisin et al., , 2010)).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Duvoisin et al., 2010
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- Authors
- Duvoisin, R. M., Villasana, L., Pfankuch, T., & Raber, J.
- Affiliations
- Oregon Health & Science University (US)
- Oregon National Primate Research Center (US)
- Corresponding author
- Raber, Jacob
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 209
- Issue
- 1
- Pages
- 21-26
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC2832071
- OpenAlex
- W1976206947
- Cited by
- 33
- References
- 32
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 2 · 2022: 6 · 2020: 1 · 2019: 3 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH77647, R01MH077647)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- mGluR8, sex differences, anxiety, spatial memory, water maze, open field, elevated plus maze, acoustic startle response, cognitive phenotypes, middle-aged mice
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Anxiety, Cognition, Exploratory Behavior, Female, Male, Memory Disorders, Mice, Inbred C57BL, Motor Activity, Phenotype, Sex Characteristics, Reflex, Startle, Receptors, Metabotropic Glutamate, Mice, Knockout, Maze Learning, Recognition, Psychology, Mice
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