Different susceptibility to social defeat stress of BalbC and C57BL6/J mice
Abstract
Social stress may precipitate psychopathological disorders in susceptible individuals. The present experiments were focused on the biology beyond the differential susceptibility to social stress. Social defeat, an ethologically relevant stressor known to elicit different coping strategies, was used in two mouse strains differing for baseline emotionality, such as C57BL6/J and BalbC. In separate experiments, in both strains a single social defeat decreased home-cage activity without altering social aversion; it diminished body weight only in defeated BalbC mice. In longitudinal experiments, mice experienced repeated social defeats that induced multiple long-term consequences. Defeated C57BL6/J increased their body weight and food intake; defeated BalbC mice diminished their metabolic efficiency. Only defeated BalbC subjects exhibited increased social avoidance levels; no differences from controls were seen on forced swim test response in defeated mice of either strain. No long-term effects of social defeat were detected in peripheral biomarkers of stress, metabolic, and immune responses, although the analysis of selected internal organs revealed decreases in abdominal fat and gonadal organs in all defeated subjects. These results demonstrated a strain-distinctive profile in the susceptibility to social defeat stress, either acutely or chronically, with metabolic consequences more consistently found in C57BL6/J while social aversion induced predominantly in BalbC subjects.
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The C57BL/6J line appears to be less susceptible to stress when compared with other strains.
“Of note, a series of recent papers suggests that the C57BL/6J line appears to be less susceptible to stress when compared with other strains39–41.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [41]
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A standardized protocol for repeated social defeat stress in mice
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- Authors
- Razzoli, M., Carboni, L., Andreoli, M., Ballottari, A., & Arban, R.
- Affiliations
- GlaxoSmithKline (Italy) (IT)
- Corresponding author
- Razzoli, Maria
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 216
- Issue
- 1
- Pages
- 100-108
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2128898116
- Cited by
- 147
- References
- 6
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 17 · 2019: 13 · 2018: 12 · 2017: 8 · 2016: 5 · 2015: 16 · 2014: 9 · 2013: 8 · 2012: 3
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- social defeat stress, mouse strain differences, C57BL/6J mice, BALB/c mice, social avoidance, home cage activity, body weight, dietary intake, metabolic effects, abdominal fat, gonadal fat, immune response, stress biomarkers, coping strategies
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Inflammation, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Social Behavior, Species Specificity, Stress, Psychological, Biomarkers, Cytokines, Mice
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