Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat
Abstract
Social defeat is an ethologically relevant stress inducing neuroadaptive changes in the mesocorticolimbic dopaminergic system. Three weeks after 10 days of daily defeat salient behaviors and in vivo dopamine (DA) neuron firing were evaluated in mice. Prior defeat induced social avoidance and hyperphagia and increased ventral tegmental area (VTA) DA neuron bursting activity. These data extend previous studies and suggest that increased phasic DA neuron firing in the VTA could be considered amongst the features defining the lasting imprint of social defeat stress.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Following chronic social defeat stress, stress-susceptible animals have increased ventral tegmental area dopamine neuron firing that persists for several weeks after stress termination.
“Following CSDS, stress-susceptible animals have increased VTA dopamine neuron firing [13, 23–29] that persists for several weeks after stress termination [28].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [28]
Chronic physical or psychosocial stressors increase ventral tegmental area dopamine neuron activity to elicit depression-like behavior.
“Chronic physical or psychosocial stressors increase VTA dopamine neuron activity to elicit depression-like behavior.”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [28]
Cites
Coping styles in animals: current status in behavior and stress-physiology
Koolhaas, J. M., Korte, S. M., De Boer, S. F., Van Der Vegt, B. J., Van Reenen, C. G., Hopster, H., De Jong, I. C., Ruis, M. A. W., & Blokhuis, H. J. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00026-3 · Cited by 2,875 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Implications of resilience concepts for scientific understanding
RUTTER, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.002 · Cited by 1,648 · see citing works
Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons
Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937 · see citing works
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works
Role of stress in the pathogenesis of the metabolic syndrome
Rosmond, R. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.05.007 · Cited by 516 · see citing works
Tidey, J. W., & Miczek, K. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00159-x · Cited by 496 · see citing works
Figlewicz, D. P., Evans, S. B., Murphy, J., Hoen, M., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04087-8 · Cited by 482 · see citing works
Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli
Jensen, J., McIntosh, A. R., Crawley, A. P., Mikulis, D. J., Remington, G., & Kapur, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00724-4 · Cited by 455 · see citing works
Fitzgerald, L., Ortiz, J., Hamedani, A., & Nestler, E. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00274.1996 · Cited by 450 · see citing works
Role of brain dopamine in food reward and reinforcement
Wise, R. A. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1854 · Cited by 436 · see citing works
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
Holmes, A., Heilig, M. A., Rupniak, N. M. J., Steckler, T., & Griebel, G. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.09.011 · Cited by 401 · see citing works
Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake
MICZEK, K., YAP, J., & COVINGTONIII, H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.07.006 · Cited by 338 · see citing works
Kuczenski, R. T., Segal, D., & Aizenstein, M. L. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02703.1991 · Cited by 285 · see citing works
Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats
Anstrom, K. K., Miczek, K. A., & Budygin, E. A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.023 · Cited by 246 · see citing works
HOEBEL, B. G., HERNANDEZ, L., SCHWARTZ, D. H., MARK, G. P., & HUNTER, G. A. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb53242.x · Cited by 220 · see citing works
Neurotrophic Mechanisms in Drug Addiction
Bolaños, C. A., & Nestler, E. J. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:069 · Cited by 195 · see citing works
Krishnan, V., Han, M.-H., Mazei-Robison, M., Iñiguez, S. D., Ables, J. L., Vialou, V., Berton, O., Ghose, S., Covington, H. E., Wiley, M. D., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.003 · Cited by 176 · see citing works
Hypocretin/orexin in arousal and stress
Berridge, C. W., España, R. A., & Vittoz, N. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.019 · Cited by 172 · see citing works
Biochemical Adaptations in the Mesolimbic Dopamine System in Response to Repeated Stress
Ortiz, J. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00152-4 · Cited by 170 · see citing works
Bartolomucci, A., Cabassi, A., Govoni, P., Ceresini, G., Cero, C., Berra, D., Dadomo, H., Franceschini, P., Dell’Omo, G., Parmigiani, S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004331 · Cited by 165 · see citing works
Different susceptibility to social defeat stress of BalbC and C57BL6/J mice
Razzoli, M., Carboni, L., Andreoli, M., Ballottari, A., & Arban, R. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.014 · Cited by 147 · see citing works
Self-citationGalanin: A Significant Role in Depression?
Weiss, J. M., Bonsall, R. W., Demetrikopoulos, M. K., Emery, M., & West, C. H. K. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10707.x · Cited by 140 · see citing works
Quarta, D., Francesco, C. D., Melotto, S., Mangiarini, L., Heidbreder, C., & Hédou, G. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.006 · Cited by 136 · see citing works
Self-citationSynaptic plasticity in the mesolimbic system
Chen, B. T., Hopf, F. W., & Bonci, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05154.x · Cited by 128 · see citing works
Chronic social defeat stress disrupts regulation of lipid synthesis
Chuang, J.-C., Cui, H., Mason, B. L., Mahgoub, M., Bookout, A. L., Yu, H. G., Perello, M., Elmquist, J. K., Repa, J. J., Zigman, J. M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002196 · Cited by 126 · see citing works
Chuang, J.-C., Krishnan, V., Yu, H. G., Mason, B., Cui, H., Wilkinson, M. B., Zigman, J. M., Elmquist, J. K., Nestler, E. J., & Lutter, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.003 · Cited by 114 · see citing works
The Role of Neurotrophic Factors in Psychostimulant-induced Behavioral and Neuronal Plasticity
Pierce, R. C., & Bari, A. (2001) · Reviews in the Neurosciences · doi:10.1515/revneuro.2001.12.2.95 · Cited by 111 · see citing works
Iñiguez, S. D., Vialou, V., Warren, B. L., Cao, J.-L., Alcantara, L. F., Davis, L. C., Manojlovic, Z., Neve, R. L., Russo, S. J., Han, M.-H., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0951-10.2010 · Cited by 103 · see citing works
Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression
Simon, N. G., Cologer–Clifford, A., Lu, S., McKenna, S., & Hu, S. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00034-7 · Cited by 101 · see citing works
Budygin, E. A., Kilpatrick, M., Gainetdinov, R. R., & Wightman, R. M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00813-2 · Cited by 96 · see citing works
Wommack, J. C., & Delville, Y. (2003) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.08.002 · Cited by 89 · see citing works
Nikulina, E. M., Arrillaga‐Romany, I., Miczek, K. A., & Hammer, R. P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06176.x · Cited by 81 · see citing works
Sabeti, J., Gerhardt, G. A., & Zahniser, N. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035816 · Cited by 71 · see citing works
In Vivo and in Vitro Intracellular Recordings from Rat Midbrain Dopamine Neuronsa
Grace, A. A. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42096.x · Cited by 67 · see citing works
Defense changes in stress nonresponsive subordinate males in a visible burrow system
Blanchard, R. J., Yudko, E. B., Dulloog, L., & Blanchard, D. C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00449-2 · Cited by 62 · see citing works
A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression
Hines, L. M., Hoffman, P. L., Bhave, S. V., Saba, L. M., Kaiser, A., Snell, L. D., Goncharov, I., Legault, L., Dongier, M., Grant, B. F., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1040-06.2006 · Cited by 48 · see citing works
Wommack, J. C., & Delville, Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02311-9 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works
Neural Substrates of Depression and Resilience
Han, M., & Nestler, E. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0527-x · Cited by 178 · see citing works
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Friedman, A. K., Juarez, B., Ku, S. M., Zhang, H., Calizo, R. C., Walsh, J. J., Chaudhury, D., Zhang, S., Hawkins, A., Dietz, D. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms11671 · Cited by 172 · see citing works
Liu, H., Zhang, C., Ji, Y., & Yang, L. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00326 · Cited by 149 · see citing works
Neuronal correlates of depression
Chaudhury, D., Liu, H., & Han, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 142 · see citing works
Stress responses and the mesolimbic dopamine system: Social contexts and sex differences
Trainor, B. C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.013 · Cited by 138 · see citing works
Heterogeneity of dopamine neuron activity across traits and states
Marinelli, M., & McCutcheon, J. E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.034 · Cited by 141 · see citing works
Stress and VTA synapses: implications for addiction and depression
Polter, A. M., & Kauer, J. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12490 · Cited by 141 · see citing works
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Iñiguez, S. D., Aubry, A., Riggs, L. M., Alipio, J. B., Zanca, R. M., Flores-Ramirez, F. J., Hernandez, M. A., Nieto, S. J., Musheyev, D., & Serrano, P. A. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.07.001 · Cited by 105 · see citing works
The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context
Walsh, J. J., & Han, M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.006 · Cited by 106 · see citing works
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Targeting opioid dysregulation in depression for the development of novel therapeutics
Browne, C. A., & Lucki, I. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.009 · Cited by 97 · see citing works
Long-term effects of chronic stress models in adult mice
Tran, I., & Gellner, A. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02598-6 · Cited by 90 · see citing works
Circuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond
Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 85 · see citing works
Richey, J. A., Brewer, J. A., Sullivan-Toole, H., Strege, M. V., Kim-Spoon, J., White, S. W., & Ollendick, T. H. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2019.101756 · Cited by 79 · see citing works
Henriques-Alves, A. M., & Queiroz, C. M. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00364 · Cited by 77 · see citing works
Social defeat in adolescent mice increases vulnerability to alcohol consumption
Rodríguez‐Arias, M., Navarrete, F., Blanco-Gandía, M. C., Arenas, M. C., Bartoll-Andrés, A., Aguilar, M. A., Rubio, G., Miñarro, J., & Manzanares, J. (2014) · Addiction Biology · doi:10.1111/adb.12184 · Cited by 74 · see citing works
Liu, Y., Harding, M., Pittman, N., Doré, J. J. E., Striessnig, J., Rajadhyaksha, A. M., & Chen, X. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00757.2013 · Cited by 72 · see citing works
Leptin/LepRb in the Ventral Tegmental Area Mediates Anxiety-Related Behaviors
Liu, J., Guo, M., & Lu, X. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv115 · Cited by 65 · see citing works
Tsai, S., Hsu, P., Chen, Y., Hossain, M. S., Chen, P., Tzeng, S., Chen, P. S., & Kuo, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01787-1 · Cited by 63 · see citing works
The effects of social defeat on behavior and dopaminergic markers in mice
Jin, H.-M., Muna, S. S., Bagalkot, T. R., Cui, Y., Yadav, B. K., & Chung, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.043 · Cited by 59 · see citing works
Sex differences in effects of dopamine D1 receptors on social withdrawal
Campi, K. L., Greenberg, G. D., Kapoor, A., Ziegler, T. E., & Trainor, B. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.026 · Cited by 55 · see citing works
Yap, J. J., Chartoff, E. H., Holly, E. N., Potter, D. N., Carlezon, W. A., & Miczek, K. A. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3796-7 · Cited by 55 · see citing works
Steinman, M. Q., & Trainor, B. C. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.021 · Cited by 54 · see citing works
Effect of chronic social defeat stress on behaviors and dopamine receptor in adult mice
Huang, G., Zhao, T., Gao, X., Zhang, H., Xu, Y., Li, H., & Lv, L. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.12.002 · Cited by 49 · see citing works
Greenberg, G. D., Steinman, M. Q., Doig, I. E., Hao, R., & Trainor, B. C. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13099 · Cited by 49 · see citing works
Taylor, S. L., Stanek, L. M., Ressler, K. J., & Huhman, K. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026172 · Cited by 49 · see citing works
Montagud‐Romero, S., Núñez, C., Blanco-Gandía, M. C., Laorden, E. M., Aguilar, M. A., Navarro‐Zaragoza, J., Almela, P., Milanés, M. V., Laorden, M. L., Miñarro, J., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4612-y · Cited by 48 · see citing works
Molecular and neurocircuitry mechanisms of social avoidance
Gellner, A., Voelter, J., Schmidt, U., Beins, E. C., Stein, V., Philipsen, A., & Hurlemann, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03649-x · Cited by 51 · see citing works
Gray, C. L., Norvelle, A., Larkin, T. E., & Huhman, K. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.030 · Cited by 44 · see citing works
Karkhanis, A. N., Leach, A. C., Yorgason, J. T., Uneri, A., Barth, S. H., Niere, F., Alexander, N. J., Weiner, J. L., McCool, B. A., Raab‐Graham, K. F., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00360 · Cited by 46 · see citing works
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test
Addy, N. A., Nunes, E. J., & Wickham, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.002 · Cited by 42 · see citing works
Lee, E. H., & Han, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.014 · Cited by 40 · see citing works
Social withdrawal and gender differences: Clinical phenotypes and biological bases
Masi, G., Berloffa, S., Milone, A., & Brovedani, P. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24802 · Cited by 42 · see citing works
Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine
Cardona-Acosta, A. M., & Bolaños‐Guzmán, C. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109374 · Cited by 36 · see citing works
Huang, S.-H., Liu, W.-Z., Qin, X., Guo, C.-Y., Xiong, Q.-C., Wang, Y., Hu, P., Pan, B., & Zhang, W.-H. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00762-0 · Cited by 32 · see citing works
Montagud-Romero, S., Reguilon, M. D., Roger-Sanchez, C., Pascual, M., Aguilar, M. A., Guerri, C., Miñarro, J., & Rodríguez-Arias, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.008 · Cited by 31 · see citing works
Panin, F., Cathala, A., Piazza, P. V., & Spampinato, U. (2012) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2012.01.003 · Cited by 26 · see citing works
Oxytocin reverses ethanol consumption and neuroinflammation induced by social defeat in male mice
Reguilón, M. D., Perez, C. F., Miñarro, J., & Rodríguez‐Arias, M. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104875 · Cited by 26 · see citing works
Zhang, J., He, Z., Wang, L., Yuan, W., Li, L., Hou, W., Yang, Y., Guo, Q., Zhang, X., Cai, W., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00256 · Cited by 25 · see citing works
Pinto, S. R., & Uchida, N. (2025) · Nature Communications · doi:10.1038/s41467-025-62280-1 · Cited by 22 · see citing works
Of Mice, Men, and Microbial Opsins: How Optogenetics Can Help Hone Mouse Models of Mental Illness
Marton, T. F., & Sohal, V. S. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.012 · Cited by 21 · see citing works
Wohlschläger, A. M., Karne, H. S., Jordan, D., Lowe, M. J., Jones, S. E., & Anand, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00163 · Cited by 20 · see citing works
Zhang, M., Li, R., Wang, Y., & Huang, Z. (2017) · Neural Plasticity · doi:10.1155/2017/5870735 · Cited by 19 · see citing works
Prabhu, V. V., Nguyen, T. B., Cui, Y., Oh, Y.-E., Lee, K., Bagalkot, T. R., & Chung, Y. (2018) · Behavioral and Brain Functions · doi:10.1186/s12993-018-0148-5 · Cited by 18 · see citing works
Metabolite signature associated with stress susceptibility in socially defeated mice
Prabhu, V. V., Nguyen, T. B., Cui, Y., Oh, Y.-E., Piao, Y. H., Baek, H., Kim, J.-Y., Shin, K., Kim, J. H., Lee, K., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.020 · Cited by 16 · see citing works
Sex Differences in the Social Behavior Network and Mesolimbic Dopamine System
Greenberg, G. D., & Trainor, B. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00004-4 · Cited by 15 · see citing works
Brown, R. W., Noel, D. M., Smith, J. J., Smith, M. L., Huggins, K. N., Szebeni, K., Szebeni, A., Duffourc, M. M., Chandley, M., & Ordway, G. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.013 · Cited by 14 · see citing works
Tong, Y., Pfeiffer, L., Serchov, T., Coenen, V. A., & Döbrössy, M. D. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25014 · Cited by 14 · see citing works
Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
Han, M., Russo, S. J., & Nestler, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00012-3 · Cited by 13 · see citing works
Rami, F. Z., Nguyen, T. B., Oh, Y.-E., Karamikheirabad, M., Le, T.-H., & Chung, Y. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.2.373 · Cited by 12 · see citing works
Zhao, T., Gao, X., & Huang, G. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.731373 · Cited by 10 · see citing works
Mansari, M. E., Hamoudeh, R. A., Daniels, S., & Blier, P. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231209235 · Cited by 7 · see citing works
Pohorecky, L. A., Sweeny, A., & Buckendahl, P. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2339-8 · Cited by 6 · see citing works
Untangling the multifaceted VTA responses to stress
Skupio, U., Harris, A. Z., & Polter, A. M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.06.004 · Cited by 5 · see citing works
The neural mechanism underlying resilience
Liu, H., Zhang, C., & Yang, L. (2019) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2019.00312 · Cited by 5 · see citing works
Pan, Y., Mou, Q., Huang, Z., Chen, S., Shi, Y., Ye, M., Shao, M., & Wang, Z. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114456 · Cited by 3 · see citing works
Patterns of phosphorylated tyrosine hydroxylase vary with song production in female starlings
Ellis, J. M. S., & Riters, L. V. (2012) · Brain Research · doi:10.1016/j.brainres.2012.12.020 · Cited by 4 · see citing works
Amphetamine modifies ethanol intake of psychosocially stressed male rats
Pohorecky, L. A., & Sweeny, A. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.01.010 · Cited by 3 · see citing works
Walsh, J. J., Walsh, J. J., Chaudhury, D., Friedman, A. K., Juarez, B., Ku, S. M., Lobo, M. K., & Han, M. (2012) · Protocol Exchange · doi:10.1038/protex.2012.049 · Cited by 3 · see citing works
Regulation and Modulation of Depression-Related Behaviours: Role of Dopaminergic Neurons
Radwan, B., Liu, H., & Chaudhury, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-46437-4_8 · Cited by 2 · see citing works
Brain Mechanisms Related to Social and Reproductive Behavior
Freed, W. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-10477-0_16 · Cited by 2 · see citing works
Understanding Mood Disorders Using Electrophysiology and Circuit Breaking
Liu, H., & Chaudhury, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-57363-2_14
Vasconcelos, P. E. N. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2018.tde-21022018-143912
Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders
Morris, L. S., Beltran, J., Murrough, J. W., & Morel, C. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.008
Ventral Tegmental Area Amylin Receptors Mediate Maladaptive Responses to Social StressPreprint
Fox, M., Ostman, A. E., Murdaugh, L., Sohail, H., Montemarano, A., & Briones, A. (2026) · Research Square · doi:10.21203/rs.3.rs-9889675/v1
Circuit-specific remodeling of synaptic co-transmission in stress-responsive networks
Park, H., Kim, H., Sim, M., Ham, D., & Chung, C. (2026) · Animal Cells and Systems · doi:10.1080/19768354.2026.2730204
- Authors
- Razzoli, M., Andreoli, M., Michielin, F., Quarta, D., & Sokal, D. M.
- Affiliations
- GlaxoSmithKline (Italy) (IT)
- Corresponding author
- Razzoli, Maria
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 218
- Issue
- 1
- Pages
- 253-257
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2059326607
- Cited by
- 76
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- social defeat, ventral tegmental area, dopaminergic neurons, neuronal bursting, phasic firing, repeated stress, social avoidance, hyperphagia, neural adaptation
- MeSH terms
- Action Potentials, Animals, Dominance-Subordination, Dopamine, Electrophysiology, Hyperphagia, Neurons, Ventral Tegmental Area, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review