Cited by 76Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat

Razzoli, Maria, Andreoli, Michela, Michielin, Francesca, Quarta, Davide, Sokal, David M.·2011·Behavioural Brain Research

Abstract

Social defeat is an ethologically relevant stress inducing neuroadaptive changes in the mesocorticolimbic dopaminergic system. Three weeks after 10 days of daily defeat salient behaviors and in vivo dopamine (DA) neuron firing were evaluated in mice. Prior defeat induced social avoidance and hyperphagia and increased ventral tegmental area (VTA) DA neuron bursting activity. These data extend previous studies and suggest that increased phasic DA neuron firing in the VTA could be considered amongst the features defining the lasting imprint of social defeat stress.

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Crossref · 10.1016/j.bbr.2010.11.050

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  • Following chronic social defeat stress, stress-susceptible animals have increased ventral tegmental area dopamine neuron firing that persists for several weeks after stress termination.

    “Following CSDS, stress-susceptible animals have increased VTA dopamine neuron firing [13, 23–29] that persists for several weeks after stress termination [28].”
  • Chronic physical or psychosocial stressors increase ventral tegmental area dopamine neuron activity to elicit depression-like behavior.

    “Chronic physical or psychosocial stressors increase VTA dopamine neuron activity to elicit depression-like behavior.”

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Authors
Razzoli, M., Andreoli, M., Michielin, F., Quarta, D., & Sokal, D. M.
Affiliations
GlaxoSmithKline (Italy) (IT)
Corresponding author
Razzoli, Maria
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2011-03
Volume
218
Issue
1
Pages
253-257
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2059326607
Cited by
76
References
47
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
social defeat, ventral tegmental area, dopaminergic neurons, neuronal bursting, phasic firing, repeated stress, social avoidance, hyperphagia, neural adaptation
MeSH terms
Action Potentials, Animals, Dominance-Subordination, Dopamine, Electrophysiology, Hyperphagia, Neurons, Ventral Tegmental Area, Mice

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