Behavioral effects of PNU-282987, an alpha7 nicotinic receptor agonist, in mice
Abstract
The cholinergic system is closely related to learning and memory processes, and its neurodegeneration seems to be involved in neurodegenerative and neuropsychiatric cognitive disorders in the elderly. Alpha7 nicotinic acetylcholine receptors (nAChRs) have recently been shown to mediate neuroprotection and enhance cognitive performance in a variety of tasks, suggesting that there may be a new target for the pharmacotherapy of cognitive deficiencies. In this study, we investigated the behavioral effects of the acute and sub-chronic administration of 0, 1, 3, and 5 mg/kg of PNU-282987 (PNU) on motor activity, anxiety and learning in open-field and Morris water maze tasks in mice. Our results showed that the highest dose of PNU (5 mg/kg) diminished motor activity in the open-field following 5 and 12 days of administration (acute and sub-chronic, respectively). No effects on the acquisition of the Morris water maze were observed. However, only 1 mg/kg of PNU administered just before training trials over a period of 5 days showed beneficial effects on the retention of the water maze when evaluated 4 h after water maze acquisition. Further studies are needed to clarify the effects on the cognitive performance and potential neuroprotection of these agents in an elderly population with slight or severe deficiency in learning and memory processes, and/or in animal models vulnerable to neurodegenerative disorders.
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a7 nAChRs have not been implicated directly in anxiety.
“Furthermore, although a7 nAChRs have not been implicated directly in anxiety (Paylor et al., 1998;Vicens et al., 2011) they are necessary in the ventral tegmental area for the expression of withdrawal from nicotine, suggesting that targeting of the a7 subtype may also relieve nicotine withdrawal symptoms (Nomikos et al., 1999).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Vicens et al., 2011
To date, a7 nAChRs have not been implicated in anxiety during nicotine withdrawal.
“To date, a7 nAChRs have not been implicated in anxiety during nicotine withdrawal (Vicens et al., 2011), and they do not appear to be necessary for somatic signs of withdrawal (Markou and Paterson, 2001).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Vicens et al., 2011
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- Authors
- Vicens, P., Ribes, D., Torrente, M., & Domingo, J. L.
- Affiliations
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Corresponding author
- Vicens, Paloma
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 216
- Issue
- 1
- Pages
- 341-348
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2013722058
- Cited by
- 39
- References
- 50
- Citations by year
- 2026: 2 · 2024: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- PNU-282987, α7 nicotinic acetylcholine receptor agonist, cognitive enhancement, learning and memory, Morris water maze, motor activity, anxiety, neuroprotection, cholinergic system, neurodegenerative diseases, cognitive impairment in older adults
- MeSH terms
- Analysis of Variance, Animals, Anxiety, Benzamides, Bridged Bicyclo Compounds, Cognition, Dose-Response Relationship, Drug, Female, Motor Activity, Random Allocation, Receptors, Nicotinic, Retention, Psychology, Spatial Behavior, Nicotinic Agonists, Maze Learning, Mice, alpha7 Nicotinic Acetylcholine Receptor
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