Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

Young, Jared W.; Crawford, Nicola; Kelly, John S.; Kerr, Lorraine E.; Marston, Hugh M.; Spratt, Christopher; Finlayson, Keith; Sharkey, John

doi:10.1016/j.euroneuro.2006.03.008

Cited by 233Nicotinic Acetylcholine Receptors StudySchizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

Young, Jared W., Crawford, Nicola, Kelly, John S., Kerr, Lorraine E., Marston, Hugh M., Spratt, Christopher, Finlayson, Keith, Sharkey, John·2007·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2006.03.008

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Abstract

alpha7-Nicotinic acetylcholine receptors (alpha7-nAChR) have been implicated in a range of cognitive deficits in schizophrenia. Therefore we examined alpha7-nAChR knockout (KO), heterozygote (HT) and wildtype (WT) littermate mice in the 5-CSR (a rodent model of sustained attention) and odour span (a novel mouse working memory paradigm) tasks, and related performance to nAChR density. Whilst there was no difference between groups in baseline 5-CSR task performance, alpha7-nAChR KO's exhibited significantly higher omission levels compared to WT mice on increasing the attentional load, with HT mice performing at an intermediate level. Furthermore, alpha7-nAChR KO mice were significantly impaired in the odour span task when compared to WT mice, in a pattern consistent with impaired attention. These behavioural deficits were associated with the loss of alpha7-nAChRs, as alpha4beta2-nAChR density was unaltered in these mice. Thus these studies intimate that the attentional impairment in alpha7-nAChR transgenic mice maybe core to other deficits in cognition.

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Attentional impairments are seen in mice lacking the α7 nAChR.
“In contrast, attentional impairments were seen in mice lacking the α7 nAChR (Hoyle et al, 2006; Young et al, 2007).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Young et al, 2007

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Authors: Young, J. W., Crawford, N., Kelly, J. S., Kerr, L. E., Marston, H. M., Spratt, C., Finlayson, K., & Sharkey, J.
Affiliations: University of Edinburgh (GB)
Corresponding author: Finlayson, Keith
ORCID: Young, Jared W.
Kelly, John S.
Marston, Hugh M.
Finlayson, Keith
Sharkey, John
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2007-01
Volume: 17
Issue: 2
Pages: 145-155
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2006.03.008
OpenAlex: W2074915076
Cited by: 233
References: 74
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 17 · 2015: 19 · 2014: 18 · 2013: 27 · 2012: 20
FWCI: 5.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Astellas Foundation for Research on Metabolic Disorders
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: alpha7 nicotinic acetylcholine receptor, knockout mice, sustained attention, working memory, attentional load, omission errors, α4β2 nicotinic acetylcholine receptor, receptor density
MeSH terms: Quinolizidine Alkaloids, Aconitine, Alkaloids, Animals, Animals, Newborn, Attention Deficit Disorder with Hyperactivity, Azocines, Behavior, Animal, Choice Behavior, Cognition Disorders, Dose-Response Relationship, Drug, Protein Binding, Quinolizines, Reaction Time, Receptors, Nicotinic, Tritium, Mice, Knockout, Nicotinic Antagonists, Mice, alpha7 Nicotinic Acetylcholine Receptor

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Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

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