Estrogens and age-related memory decline in rodents: What have we learned and where do we go from here?

Frick, Karyn M.

doi:10.1016/j.yhbeh.2008.08.015

Cited by 205Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsMemory and Neural Mechanisms

Estrogens and age-related memory decline in rodents: What have we learned and where do we go from here?

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Frick, Karyn M.·2009·Hormones and Behavior

DOI 10.1016/j.yhbeh.2008.08.015PMC PMC2664384

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Abstract

The question of whether ovarian hormone therapy can prevent or reduce age-related memory decline in menopausal women has been the subject of much recent debate. Although numerous studies have demonstrated a beneficial effect of estrogen and/or progestin therapy for certain types of memory in menopausal women, recent clinical trials suggest that such therapy actually increases the risk of cognitive decline and dementia. Because rodent models have been frequently used to examine the effects of age and/or ovarian hormone deficiency on mnemonic function, rodent models of age-related hormone and memory decline may be useful in helping to resolve this issue. This review will focus on evidence suggesting that estradiol modulates memory, particularly hippocampal-dependent memory, in young and aging female rats and mice. Various factors affecting the mnemonic response to estradiol in aging females will be highlighted to illustrate the complications inherent to studies of estrogen therapy in aging females. Avenues for future development of estradiol-based therapies will also be discussed, and it is argued that an approach to drug development based on identifying the molecular mechanisms underlying estrogenic modulation of memory may lead to promising future treatments for reducing age-related mnemonic decline.

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Authors: Frick, K. M.
Affiliations: Yale University (US)
Corresponding author: Frick, Karyn M.
ORCID: Frick, Karyn M.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2009-01
Volume: 55
Issue: 1
Pages: 2-23
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2008.08.015
PMC: PMC2664384
OpenAlex: W2136011008
Cited by: 205
References: 301
Citations by year: 2026: 2 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 3 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 17 · 2012: 24
FWCI: 2.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG022525, AG022525)
National Institute of Mental Health (MH 065460, R03MH065460)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: estradiol, age-related memory decline, ovarian hormone deficiency, menopause, estrogen therapy, hippocampal-dependent memory, dementia risk
MeSH terms: Aging, Animals, Brain, Environment, Estradiol, Estrogens, Female, Memory, Memory Disorders, Progestins, Spatial Behavior, Signal Transduction, Maze Learning, Hormone Replacement Therapy, Selective Estrogen Receptor Modulators, Mice, Rats

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Estrogens and age-related memory decline in rodents: What have we learned and where do we go from here?

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