Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning
Abstract
Neurosteroids (NS) are substances synthesised de novo in the brain that have rapid modulatory effects on ionotropic receptors. Specifically, NS can act as positive allosteric modulators of GABAA receptors as pregnanolone or allopregnanolone (Allop), or GABAA negative modulators and NMDA positive modulators as pregnenolone (PREG) or dehydroepiandrosterone (DHEA) and their sulphate esters (PREGS and DHEAS). Given this, their role in anxiety and emotional disturbances has been suggested. In addition, NS such as PREGS or DHEAS have demonstrated a promnesic role in several learning tests. The aim of the present work is to highlight the role that the dorsal (CA1) hippocampus plays in the behavioural profile of NS such as Allop and PREGS in tests assessing exploration, anxiety and aversive learning in rats. For this purpose, animals were administered intrahippocampally with Allop (0.2μg/0.5μl), PREGS (5ng/0.5μl) or vehicle in each hippocampus, and tested in the Boissier and elevated plus maze (EPM) tests. For learning test we have chosen the passive avoidance paradigm. Results indicate that intrahippocampal administration of Allop enhances exploration, reflected in an increase in the total and the inner number of head-dips. Allop-injected animals also showed an increase in the percentage of entries into the open arms of the EPM, suggesting an anxiolytic-like profile. In addition, post-acquisition PREGS administration enhanced passive avoidance retention, while post-acquisition Allop administration had no effects on aversive learning retention. These results point out the important role of the dorsal (CA1) hippocampus in several NS behavioural effects, such as exploration, anxiety, learning and memory.
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CA1 α1GABAARs play a role in memory consolidation.
“Thus, these findings may suggest a role for CA1 α1 GABAARs in memory consolidation, providing temporal and anatomical specificity to early reports that the amnestic effects of diazepam were abolished in α1 (H101R) mice, in which diazepam does not bind to α1GABAARs [63].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [44]
Administration of pregnenolone sulfate into the dorsal CA1 area following memory acquisition improves memory in a passive avoidance task.
“Administration of pregnenolone sulfate into the dorsal CA1 area following memory acquisition improves memory in a passive avoidance task [44].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [44]
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- Authors
- Mòdol, L., Darbra, S., & Pallarès, M.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 222
- Issue
- 1
- Pages
- 223-229
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1976651476
- Cited by
- 46
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación (PSI2009-13759)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neurosteroids, allopregnanolone, hippocampal CA1, exploratory behavior, anxiety-like behavior, aversive learning, passive avoidance, elevated plus maze, anxiolytic effects, memory
- MeSH terms
- Animals, Anxiety, Avoidance Learning, Body Weight, Disease Models, Animal, Exploratory Behavior, Male, Pregnanolone, Pregnenolone, Rats, Wistar, Statistics, Nonparametric, Maze Learning, Rats, CA1 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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