Cited by 101Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and ApplicationsMental Health and Psychiatry

The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.

Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: A diffusion tensor study using TBSS

Liu, Xiaoyi, Lai, Yunyao, Wang, Xijin, Hao, Chuanxi, Chen, Lei, Zhou, Zhenyu, Yu, Xin, Hong, Nan·2013·Behavioural Brain Research

DOI 10.1016/j.bbr.2013.05.061

Open this paper in CoChat — free account

Abstract

Background Disrupted white matter (WM) integrity is the pathological hallmark of schizophrenia. Previous studies have reported the cognitive deficits that are associated with WM disruption in schizophrenia with anti-psychiatric treatment. However, no study has yet revealed the correlation between cognition and WM abnormalities in never-medicated chronic schizophrenia.Methods We used the diffusion tensor imaging (DTI) with tract-based spatial statistics (TBSS) approach to investigate the whole-brain difference in the WM fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values between 17 schizophrenia patients and 17 healthy controls matched in age, gender and education level. Patients' cognition was assessed through the MATRICS Consensus Cognitive Battery (MCCB). We explored the association between WM reduction and cognitive, clinical characteristics (severity of clinical symptoms, age, age of onset, illness duration).Results Voxel-wise statistics revealed that schizophrenia patients showed significant FA reduction in left inferior longitudinal fasciculus (ILF) and left inferior fronto-occipital fasciculus (IFOF), and no difference in MD, AD or RD as compared to healthy subjects. Furthermore, in the patients group, lower FA value of the left ILF and left IFOF significantly correlated with worse processing speed, as well as verbal learning and visual learning abilities. There was no correlation between the FA value and the severity of clinical symptoms, age, and age of onset or illness duration.Conclusion Our results provide evidence to support that the disconnection of WM pathways may contribute to the pathophysiology of schizophrenia and suggest that the disturbance of left ILF and left IFOF integrity may contribute to cognitive deficits in schizophrenia, independent of effects of antipsychotic medication.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2013.05.061

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen‐Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,598
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658
A diffusion tensor imaging tractography atlas for virtual in vivo dissections.
CATANI, M., & THIEBAUTDESCHOTTEN, M. (2008) · Cortex · doi:10.1016/j.cortex.2008.05.004 · Cited by 1,642

Show all 89 references

Research works printed but not linked: 1

Nakamura, 2012, Reduced white matter fractional anisotropy and clinical symptoms in schizophrenia: a voxel-based diffusion tensor imaging study, Psychiatry Research, 202, 233, 10.1016/j.pscychresns.2011.09.006 · DOI

Sorted by citations

A review of structural neuroimaging in schizophrenia: from connectivity to connectomics
Wheeler, A. L., & Voineskos, A. N. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00653 · Cited by 266
Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia
Maas, D. A., Vallès, A., & Martens, G. J. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.138 · Cited by 183
Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia
Zhou, Y., Fan, L., Qiu, C., & Jiang, T. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-014-1502-8 · Cited by 187
A selective review of structural connectivity abnormalities of schizophrenic patients at different stages of the disease
Canu, E., Agosta, F., & Filippi, M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.020 · Cited by 171
Two Patterns of White Matter Abnormalities in Medication-Naive Patients With First-Episode Schizophrenia Revealed by Diffusion Tensor Imaging and Cluster Analysis
Sun, H., Lui, S., Li, Y., Deng, W., Xiao, Y., Zhang, W., Huang, X., Hu, J., Bi, F., Li, T., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0505 · Cited by 161
Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls.
Svatkova, A., Mandl, R. C. W., Scheewe, T. W., Cahn, W., Kahn, R. S., & Hulshoff Pol, H. E. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv033 · Cited by 120
White Matter Abnormalities and Cognitive Impairment in Early-Onset Schizophrenia-Spectrum Disorders
Epstein, K. A., Cullen, K. R., Mueller, B. A., Robinson, P., Lee, S. S., & Kumra, S. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.12.007 · Cited by 90
Abnormal white matter microstructure in drug-naive first episode schizophrenia patients before and after eight weeks of antipsychotic treatment
Zeng, B., Ardekani, B. A., Tang, Y., Zhang, T., Zhao, S., Cui, H., Fan, X., Zhuo, K., Li, C., Xu, Y., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.051 · Cited by 89
Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study
Squarcina, L., Bellani, M., Rossetti, M. G., Perlini, C., Delvecchio, G., Dusi, N., Barillari, M., Ruggeri, M., Altamura, C. A., Bertoldo, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178089 · Cited by 80
Transport for language south of the Sylvian fissure: The routes and history of the main tracts and stations in the ventral language network
Bajada, C. J., Ralph, M. A. L., & Cloutman, L. L. (2015) · Cortex · doi:10.1016/j.cortex.2015.05.011 · Cited by 82
Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study
Wang, C., Ji, F., Hong, Z., Poh, J. S., Krishnan, R., Lee, J., Rekhi, G., Keefe, R. S. E., Adcock, R. A., Wood, S. J., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716001410 · Cited by 77
Differential susceptibility of white matter tracts to inflammatory mediators in schizophrenia: An integrated DTI study
Prasad, K. M. R., Upton, C. H., Nimgaonkar, V. L., & Keshavan, M. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.043 · Cited by 75
Effect of clozapine on white matter integrity in patients with schizophrenia: A diffusion tensor imaging study
Eroğlu, E. Ö., Ertuğrul, A., Oğuz, K. K., Has, A. C., Karahan, S., & Yazici, M. K. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.06.001 · Cited by 69
White Matter Abnormalities in Never-Treated Patients With Long-Term Schizophrenia
Xiao, Y., Sun, H., Shi, S., Jiang, D., Bo, T., Zhao, Y., Zhang, W., Gong, Q., Sweeney, J. A., & Lui, S. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17121402 · Cited by 69
Diffusion Imaging of White Matter in Schizophrenia: Progress and Future Directions
Karlsgodt, K. H. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.12.001 · Cited by 71
Diffusion Tensor Imaging findings and their implications in schizophrenia
Kubicki, M. R., & Shenton, M. E. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000053 · Cited by 65
Altered white matter microstructure is associated with social cognition and psychotic symptoms in 22q11.2 microdeletion syndrome
Jalbrzikowski, M., Villalón‐Reina, J. E., Karlsgodt, K. H., Şentürk, D., Chow, C. C., Thompson, P. M., & Bearden, C. E. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00393 · Cited by 65
Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia
Zhang, X., Yang, M., Du, X., Liao, W., Chen, D., Fan, F., Xiu, M., Jia, Q., Ning, Y., Huang, X., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0478-1 · Cited by 59
Decomposition of brain diffusion imaging data uncovers latent schizophrenias with distinct patterns of white matter anisotropy
Arnedo, J., Mamah, D. T., Baranger, D. A. A., Harms, M. P., Barch, D. M., Švrakić, D. M., de Erausquin, G. A., Cloninger, C. R., & Zwir, I. J. S. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.083 · Cited by 55
White matter microstructure in schizophrenia: Associations to neurocognition and clinical symptomatology
Roalf, D. R., Gur, R. E., Verma, R., Parker, W. A., Quarmley, M., Ruparel, K., & Gur, R. C. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.026 · Cited by 50
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy
Giampiccolo, D., Herbet, G., & Duffau, H. (2025) · Brain · doi:10.1093/brain/awaf055 · Cited by 60
Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
Wigand, M. C. C., Kubicki, M. R., von Hohenberg, C. C., Leicht, G., Karch, S., Eckbo, R., Pelavin, P. E., Hawley, K. J., Rujescu, D., Sylvain Bouix, A., et al. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.948063 · Cited by 48
White matter connectivity disruptions in early and chronic schizophrenia
Biase, M. A. D., Cropley, V., Baune, B. T., Olver, J. S., Amminger, G. P., Phassouliotis, C., Bousman, C., McGorry, P. D., Everall, I., Pantelis, C., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717001313 · Cited by 49
Adverse childhood experiences influence white matter microstructure in patients with schizophrenia
Poletti, S., Mazza, E. B., Bollettini, I., Locatelli, C., Cavallaro, R., Smeraldi, E., & Benedetti, F. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.08.003 · Cited by 47
Minimal evidence that untreated psychosis damages brain structures: A systematic review
Anderson, K. K., Rodrigues, M., Mann, K., Voineskos, A. N., Mulsant, B. H., George, T. P., & McKenzie, K. J. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.021 · Cited by 47
Widespread white-matter microstructure integrity reduction in first-episode schizophrenia patients after acute antipsychotic treatment
Meng, L., Li, K., Li, W., Xiao, Y., Lui, S., Sweeney, J. A., & Gong, Q. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.08.021 · Cited by 44
Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia
Lang, X., Zhu, D., Zhang, G., Du, X., Jia, Q., Yin, G., Chen, D., Xiu, M., Cao, B., Wang, L., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0346-9 · Cited by 45
White matter brain aging in relationship to schizophrenia and its cognitive deficit
Wang, J., Kochunov, P., Sampath, H., Hatch, K. S., Ryan, M. C., Xue, F., Jahanshad, N., Thompson, P. M., Hahn, B., Gold, J. M., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.02.003 · Cited by 40
White matter tractography in early psychosis: clinical and neurocognitive associations
Hatton, S. N., Lagopoulos, J., Hermens, D. F., Hickie, I. B., Scott, E. M., & Bennett, M. R. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130280 · Cited by 41
Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions
Viher, P. V., Stegmayer, K., Giezendanner, S., Federspiel, A., Bohlhalter, S., Vanbellingen, T., Wiest, R., Strik, W. K., & Walther, S. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.06.013 · Cited by 38
Schizophrenia symptomatic associations with diffusion tensor imaging measured fractional anisotropy of brain: a meta-analysis
Xu, Y., Cao, D., Liang, X., & Zhao, J. (2017) · Neuroradiology · doi:10.1007/s00234-017-1844-9 · Cited by 39
Comparing free water imaging and magnetization transfer measurements in schizophrenia
Mandl, R. C. W., Pasternak, O., Cahn, W., Kubicki, M. R., Kahn, R. S., Shenton, M. E., & Pol, H. E. H. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.046 · Cited by 38
Abnormal frontostriatal connectivity in adolescent-onset schizophrenia and its relationship to cognitive functioning
James, A. C., Joyce, E. M., Lunn, D., Hough, M., Kenny, L., Ghataorhe, P., Fernandez, H., Matthews, P. M., & Zarei, M. (2016) · European Psychiatry · doi:10.1016/j.eurpsy.2016.01.2426 · Cited by 37
Abnormal white matter integrity in antipsychotic-naïve first-episode psychosis patients assessed by a DTI principal component analysis
Alvarado-Alanis, P., León-Ortíz, P., Reyes-Madrigal, F., Favila, R., Rodríguez-Mayoral, O., Nicolini, H., Azcárraga, M., Graff‐Guerrero, A., Rowland, L. M., & de la Fuente‐Sandoval, C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.019 · Cited by 38
Altered diffusion in motor white matter tracts in psychosis patients with catatonia
Viher, P. V., Stegmayer, K., Federspiel, A., Bohlhalter, S., Wiest, R., & Walther, S. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.03.017 · Cited by 38
Myelination-related genes are associated with decreased white matter integrity in schizophrenia
Chavarría‐Siles, I., White, T. J. H., de Leeuw, C., Goudriaan, A., Lips, E. H., Ehrlich, S., Turner, J. A., Calhoun, V. D., Gollub, R. L., Magnotta, V. A., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.120 · Cited by 33
Decreased integrity of the fronto-temporal fibers of the left inferior occipito-frontal fasciculus associated with auditory verbal hallucinations in schizophrenia
Oestreich, L., McCarthy‐Jones, S., & Whitford, T. J. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9421-5 · Cited by 35
Alterations in prefrontal connectivity in schizophrenia assessed using diffusion magnetic resonance imaging
Molina, V., Lubeiro, A., Soto-Angona, Ó., Rodríguez, M., Alvarez, A., Hernández, R., & de Luis-Garcı́a, R. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.001 · Cited by 31
Evidence for progressive brain abnormalities in early schizophrenia: A cross-sectional structural and functional connectivity study
Zhang, F., Qiu, L., Yuan, L., Ma, H., Ye, R., Yu, F., Hu, P., Dong, Y., & Wang, K. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.050 · Cited by 33
Associations between DNA methylation and schizophrenia-related intermediate phenotypes — A gene set enrichment analysis
Haß, J., Walton, E., Wright, C., Beyer, A., Scholz, M. R., Turner, J. A., Liu, J., Smolka, M. N., Roessner, V., Sponheim, S. R., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.006 · Cited by 30
Detection of advanced brain aging in schizophrenia and its structural underpinning by using normative brain age metrics
Chen, C., Hwang, T., Tung, Y.-H., Yang, L., Hsu, Y., Liu, C., Lin, Y.-T., Hsieh, M. H., Liu, C., Chien, Y., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103003 · Cited by 29
Neuropsychology, autobiographical memory, and hippocampal volume in “younger” and “older” patients with chronic schizophrenia
Herold, C. J. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00053 · Cited by 28
Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract‐specific analysis study
Ohoshi, Y., Takahashi, S., Yamada, S., Ishida, T., Tsuda, K., Tsuji, T., Terada, M., Shinosaki, K., & Ukai, S. (2019) · Brain and Behavior · doi:10.1002/brb3.1357 · Cited by 27
Anatomic abnormalities of hippocampal subfields in never-treated and antipsychotic-treated patients with long-term schizophrenia
Hu, N., Sun, H., Fu, G. C., Zhang, W., Xiao, Y., Zhang, L., Li, W., Li, Z., Huang, G., Tan, Y., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.03.020 · Cited by 27
Transdiagnostic role of glutamate and white matter damage in neuropsychiatric disorders: A Systematic Review
Luttenbacher, I., Phillips, A., Kazemi, R., Hadipour, A. L., Sanghvi, I., Martínez-Agosto, J. A., & Adamson, M. M. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.12.042 · Cited by 27
The neurobiology of duration of untreated psychosis: a comprehensive review
Zoghbi, A. W., Lieberman, J. A., & Girgis, R. R. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01718-0 · Cited by 27
Abnormalities of fronto-subcortical pathways in schizophrenia and the differential impacts of antipsychotic treatment: a DTI-based tractography study
Leroux, E., Vandevelde, A., Tréhout, M., & Dollfus, S. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.08.008 · Cited by 25
Race, Socioeconomic Status, and Cerebellum Cortex Fractional Anisotropy in Pre-Adolescents
Assari, S., & Boyce, S. (2021) · Adolescents · doi:10.3390/adolescents1020007 · Cited by 23
Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study
Seitz‐Holland, J., Wojcik, J., Karayumak, S. C., Lyall, A. E., Pasternak, O., Yogesh Rathi, A., Vangel, M. G., Pearlson, G. D., Tamminga, C. A., Sweeney, J. A., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01731-3 · Cited by 25
Abnormal white matter connections between medial frontal regions predict symptoms in patients with first episode schizophrenia
Ohtani, T., Sylvain Bouix, A., Lyall, A. E., Hosokawa, T., Saito, Y., Melonakos, E. D., Westin, C., Seidman, L. J., Goldstein, J. M., Mesholam‐Gately, R. I., et al. (2015) · Cortex · doi:10.1016/j.cortex.2015.05.028 · Cited by 26
Information processing speed mediates the relationship between white matter and general intelligence in schizophrenia
Alloza, C., Cox, S. R., Duff, B. J., Semple, S. I. K., Bastin, M. E., Whalley, H. C., & Lawrie, S. M. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.05.008 · Cited by 24
Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia
Yang, M., Gao, S., & Zhang, X. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01049-0 · Cited by 21
Electroencephalographic theta activity and cognition in schizophrenia: Preliminary results
Wichniak, A., Okruszek, Ł., Linke, M., Jarkiewicz, M., Jędrasik-Styła, M., Ciołkiewicz, A., Wierzbicka, A., Jernajczyk, W., & Jarema, M. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.966145 · Cited by 21
Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness
Bergé, D., Mané, A., Lesh, T. A., Bioque, M., Barcones, F., González-Pinto, A. M., Parellada, M., Vieta, E., Castro‐Fornieles, J., Rodríguez–Jiménez, R., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz132 · Cited by 20
Cognitive decline and white matter changes in mesial temporal lobe epilepsy
Xu, S., Xi, J.-H., Lin, C., Wang, X., Fu, L., Kralik, S. F., & Chen, Z. (2018) · Medicine · doi:10.1097/md.0000000000011803 · Cited by 19
Self-citation
Functional cognitive and cortical abnormalities in chronic and first-admission schizophrenia
Carolus, A. M., Schubring, D., Popov, T. G., Popova, P., Miller, G. A., & Rockstroh, B. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.012 · Cited by 18
Structural organization of the praxis network predicts gesture production: Evidence from healthy subjects and patients with schizophrenia
Viher, P. V., Abdulkadir, A., Savadijev, P., Stegmayer, K., Kubicki, M. R., Makris, N., Karmacharya, S., Federspiel, A., Bohlhalter, S., Vanbellingen, T., et al. (2020) · Cortex · doi:10.1016/j.cortex.2020.05.023 · Cited by 18
Association between the scores of the Japanese version of the Brief Assessment of Cognition in Schizophrenia and whole‐brain structure in patients with chronic schizophrenia: A voxel‐based morphometry and diffusion tensor imaging study
Hidese, S., Ota, M., Matsuo, J., Ishida, I., Hiraishi, M., Teraishi, T., Hattori, K., & Kunugi, H. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12560 · Cited by 17
Reduced white matter integrity associated with cognitive deficits in patients with drug-naive first-episode schizophrenia revealed by diffusion tensor imaging.
Peng, X., Zhang, R., Yan, W., Zhou, M., Lu, S., & Xie, S. (2020) · PubMed Central · Cited by 17
Cognitive and functional deficits are associated with white matter abnormalities in two independent cohorts of patients with schizophrenia
Yamada, S., Takahashi, S., Malchow, B., Papazova, I., Stoecklein, S., Ertl-Wagner, B. B., Papazov, B., Kumpf, U., Wobrock, T., Keller-Varady, K., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01363-8 · Cited by 17
Use of the Chinese version of the MATRICS Consensus Cognitive Battery to assess cognitive functioning in individuals with high risk for psychosis, first-episode schizophrenia and chronic schizophrenia: a systematic review and meta-analysis
Cai, B., Zhu, Y., Liu, D., Li, Y., Bueber, M. A., Yang, X., Luo, G., Su, Y., Grivel, M. M., Yang, L. H., et al. (2024) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2024.101016 · Cited by 15
Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade
Du, Y., Ju, N., Xing, Y., Li, B., & Calhoun, V. D. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae110 · Cited by 16
Biological and cognitive correlates of cortical curvature in schizophrenia
Lubeiro, A., de Luis-Garcı́a, R., Rodríguez, M., Alvarez, A., de la Red, H., & Molina, V. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.10.011 · Cited by 14
Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes
Sefcikova, V., Sporrer, J. K., Juvekar, P., Golby, A. J., & Samandouras, G. (2022) · Brain Structure and Function · doi:10.1007/s00429-021-02438-x · Cited by 14
Anatomical connectivity changes in bipolar disorder and schizophrenia investigated using whole-brain tract-based spatial statistics and machine learning approaches
Sütçübaşı, B., Metin, S. Z., Erguzel, T. T., Metin, B., Taş, C., Arıkan, M. K., & Tarhan, N. (2019) · Neural Computing and Applications · doi:10.1007/s00521-018-03992-y · Cited by 14
Anatomo-functional profile of white matter tracts in relevance to language: A systematic review
Kargar, Y., & Jalilian, M. (2023) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2023.101175 · Cited by 13
Reduced white matter integrity and facial emotion perception in never-medicated patients with first-episode schizophrenia: A diffusion tensor imaging study
Zhao, X., Sui, Y., Yao, J., Lv, Y., Zhang, X., Jin, Z., Chen, L., & Zhang, X. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.025 · Cited by 13
Self-citation
White matter structural integrity differs between people with schizophrenia and healthy groups as a function of cognitive control
Schaeffer, D. J., Rodrigue, A., Burton, C. R., Pierce, J. E., Nash Unsworth, A., Clementz, B. A., & McDowell, J. E. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.11.001 · Cited by 13
White matter alterations in individuals experiencing attenuated positive psychotic symptoms
Cooper, S., Alm, K. H., Olson, I. R., & Ellman, L. M. (2016) · Early Intervention in Psychiatry · doi:10.1111/eip.12306 · Cited by 13
White matter correlates of episodic memory encoding and retrieval in schizophrenia
Green, A. E., Croft, R. J., Maller, J. J., & Fitzgerald, P. B. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.07.002 · Cited by 15
Corpus Callosum Microstructural Tract Integrity Relates to Longer Emotion Recognition Reaction Time in People with Schizophrenia
Burke, T., Gleeson, C., Holleran, L., Mothersill, D., Holland, J. F., Costello, L., Kane, R., McKernan, D. P., Morris, D. W., Kelly, J. P., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12091208 · Cited by 12
Neurobiologie der Schizophrenie
Schmitt, A., Malchow, B., Keeser, D., Falkai, P., & Hasan, A. (2014) · Der Nervenarzt · doi:10.1007/s00115-014-4115-6 · Cited by 15
Structural connectivity between the hippocampus and cortical/subcortical area relates to cognitive impairment in schizophrenia but not in mood disorders
Ikeda, N., Yamada, S., Yasuda, K., Uenishi, S., Tamaki, A., Ishida, T., Tabata, M., Tsuji, T., Kimoto, S., & Takahashi, S. (2022) · Journal of Neuropsychology · doi:10.1111/jnp.12298 · Cited by 11
Neurostructural, Neurofunctional, and Clinical Features of Chronic, Untreated Schizophrenia: A Narrative Review
Tang, B., Li, Y., Strawn, J. R., Zhang, W., & Lui, S. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae152 · Cited by 12
Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness
Wannan, C., Bartholomeusz, C. F., Pantelis, C., Biase, M. A. D., Syeda, W. T., Chakravarty, M. M., Bousman, C., Everall, I., McGorry, P. D., Zalesky, A., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01333-0 · Cited by 10
White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia
Klauser, P., Cropley, V., Baumann, P. S., Lv, J., Steullet, P., Dwir, D., Alemán‐Gómez, Y., Cuadra, M. B., Cuénod, M., Kim, Q., et al. (2021) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgab033 · Cited by 10
The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia
Poletti, S., Mazza, E. B., Bollettini, I., Falini, A., Smeraldi, E., Cavallaro, R., & Benedetti, F. (2016) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000130 · Cited by 12
Multimodal assessment of white matter microstructure in antipsychotic-naïve schizophrenia patients and confounding effects of recreational drug use
Raghava, J. M., Mandl, R. C. W., Nielsen, M. Ø., Fagerlund, B., Glenthoj, B. Y., Rostrup, E., & Ebdrup, B. H. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00230-4 · Cited by 9
Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive Function and White Matter Microstructure in a Case-Control Study for Schizophrenia
Andrews, J. L., Zalesky, A., Nair, S. S., Sullivan, R. P., Green, M. J., Pantelis, C., Newell, K. A., & Fernandez, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115624 · Cited by 8
Sex‐differential associations between cognitive impairments and white matter abnormalities in first episode and drug‐naïve schizophrenia
Yang, M., Gao, S., Xiong, W., & Zhang, X. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.13059 · Cited by 8
Associations between cognition and white matter microstructure in first-episode antipsychotic-naïve patients with schizophrenia and healthy controls: A multivariate pattern analysis
Thomas, M. B., Raghava, J. M., Pantelis, C., Rostrup, E., Nielsen, M. Ø., Jensen, M. H., Glenthoj, B. Y., Mandl, R. C. W., Ebdrup, B. H., & Fagerlund, B. (2021) · Cortex · doi:10.1016/j.cortex.2021.03.003 · Cited by 9
Exploring quantitative group-wise differentiation of Alzheimer’s disease and behavioural variant frontotemporal dementia using tract-specific microstructural white matter and functional connectivity measures at multiple time points
Meijboom, R., Steketee, R. M. E., Ham, L. S., Mantini, D., Bron, E. E., van der Lugt, A., Swieten, J. C. V., & Smits, M. (2019) · European Radiology · doi:10.1007/s00330-019-06061-7 · Cited by 6
Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male, A. G., Goudzwaard, E., Nakahara, S., Turner, J. A., Calhoun, V. D., Mueller, B. A., Lim, K. O., Bustillo, J., Belger, A., Voyvodic, J. T., et al. (2024) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2024.111843 · Cited by 5
Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia
Rajasekaran, A., Shivakumar, V., Kalmady, S. V., Parlikar, R. U., Chhabra, H., Prabhu, A., Subbanna, M., Venugopal, D., Amaresha, A. C., Agarwal, S. M., et al. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102363 · Cited by 5
Abnormal Brain Structure and Function in First-Episode Childhood- and Adolescence-Onset Schizophrenia: Association with Clinical Symptoms
Xia, Y., Lv, D., Liang, Y., Zhang, H., Pei, K., Shao, R., Li, Y., Zhang, Y., Li, Y., Guo, J.-H., et al. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00359-8 · Cited by 4
Fully Automated Detection of Corticospinal Tract Damage in Chronic Stroke Patients
Yang, M., Yang, Y., Li, H., Lu, X., Shi, Y., Liu, B., Chen, H., & Teng, G. (2014) · Computational and Mathematical Methods in Medicine · doi:10.1155/2014/370849 · Cited by 4
Social cognition correlation to white matter integrity alteration in mirror neurons of schizophrenic patients: DTI study
ElShahawi, H. H., Sakr, H. M., Hashim, M. A., Mohamed, H., & Abdeen, M. S. (2020) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2020.10.004 · Cited by 3
Gender differences in cognitive improvements after two months of atypical antipsychotic treatment in first episode schizophrenia
Li, W., Cao, X., Liang, Q., Li, Y., Zhou, C., Du, J., & Xie, S. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1369532 · Cited by 2
Distinct white matter abnormalities and cognitive impairments in deficit schizophrenia: A cross-sectional diffusion tensor imaging study
Gao, J., Yu, D., Yin, M., Li, J., Zhang, X., Tang, X., & Zhang, X. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.11.054 · Cited by 2
The Neuropathology of White Matter in Schizophrenia
Uranova, N. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-68308-5_11 · Cited by 2
Fast density-peaks clustering for registration-free pediatric white matter tract analysis
Fan, X., Duan, Y., Cheng, S., Zhang, Y., & Cheng, H. (2019) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2019.03.002 · Cited by 2
Role of diffusion tensor imaging to evaluate amygdala–hippocampal complex and superior temporal gyrus in treatment-resistant schizophrenia and non-treatment-resistant schizophrenia patients
Nasir, Z. A. M., Sapiai, N. A., Fadzil, N. A., Idris, Z., & Suliman, M. A. (2025) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1186/s43055-025-01442-z · Cited by 1
From adaptive to maladaptive myelination: White matter dynamics in cognition and neurologic disorders
Adebiyi, O. E., Unaran, E., Machado, M. M. F., Saksida, L. M., Menon, R., Káradóttir, R. T., & Bussey, T. J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106779 · Cited by 1
Working Memory Function in Recent-Onset Schizophrenia Patients Associated with White Matter Microstructure: Connectometry Approach
Dolatshahi, M., Rahmani, F., Shadmehr, M. H., Peoppl, T., Shojaie, A., Noorizadeh, F., Aarabi, M. H., & Jooyandeh, S. M. (2017) · Mathematics and visualization · doi:10.1007/978-3-319-54130-3_17 · Cited by 1
Schizophrenia
Fatemi, S. H., & Folsom, T. D. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_6 · Cited by 1
Clinical Correlates and Neural Substrates of P50 Suppression Deficits in Schizophrenia
Hamilton, H. (2015) · eScholarship (California Digital Library)
Biologically relevant subgroups within the schizophrenia syndrome
Lubeiro, A. (2019) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/39211
Causal analysis of education attainment and brain structure in chronic obstructive pulmonary disease: a Mendelian randomization study
Zheng, S., Liu, X., Kong, J., & Luo, J. (2025) · Egyptian Journal of Bronchology · doi:10.1186/s43168-025-00424-z
Self-citation
Myelin Matters in Schizophrenia : Neurobiological Insights from Rat Model and Human Studies
Maas, D. A. (2019) · theses.fr (ABES) · doi:10.70675/4ea9aa0azc70cz4bb4zada7z4f82cac02e1c
Suicide attempts, white matter microstructure, and cognitive function in schizophrenia
Yin, Y., Xie, T., Tong, J., Huang, J., Gou, M., Chen, S., Tan, S., Wang, Z., Tong, Y., Zhou, Y., et al. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02345-4

Authors: Liu, X., Lai, Y., Wang, X., Hao, C., Chen, L., Zhou, Z., Yu, X., & Hong, N.
Affiliations: Peking University (CN)
Corresponding author: Yu, Xin
Hong, Nan
ORCID: Liu, Xiaoyi
Wang, Xijin
Chen, Lei
Zhou, Zhenyu
Yu, Xin
Hong, Nan
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2013-09
Volume: 252
Pages: 157-163
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2013.05.061
OpenAlex: W1992691505
Cited by: 101
References: 89
Citations by year: 2026: 3 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 16 · 2014: 15 · 2013: 1
FWCI: 9.68
Type: journal article
Language: en
Open access: closed
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: chronic schizophrenia, white matter integrity, cognitive impairment, fractional anisotropy, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, processing speed, verbal learning, visual learning, white matter disconnection, diffusion tensor imaging
MeSH terms: Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Photic Stimulation, Schizophrenia, Verbal Learning, Case-Control Studies, Anisotropy, Diffusion Tensor Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: A diffusion tensor study using TBSS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks