Cited by 11Prion Diseases and Protein MisfoldingNeuroendocrine regulation and behaviorPrimate Behavior and Ecology

Deletion of the prion gene Prnp affects offensive aggression in mice

Büdefeld, Tomaz, Majer, Aljaz, Jerin, Ales, Majdic, Gregor·2014·Behavioural Brain Research

Abstract

Prion protein (Prp(c)) is involved in the etiology of prion neurodegenerative diseases in mammals. The biological functions of Prp(c) are still largely unknown despite many studies in recent years. Different studies have shown impairment in locomotion, emotional/social behaviors, sleep disorders and memory impairment in mice lacking the prion gene Prnp (Prnp(-/-)) but its exact functions in the brain are still unclear. In the present study, Zurich I Prnp(-/-) and their littermate wild type (WT) control male mice were behaviorally characterized for offensive aggressive behavior in a resident-intruder paradigm with the aim to establish the possible function of Prp(c) in the regulation of offensive aggressive behavior. Prnp(-/-) mice showed reduced latencies to the first attack and bite, higher percentage of mice biting and higher frequencies of attacks of stimulus males. These results show that Prnp(-/-) mice exhibit altered aggressive behavior in comparison to their WT controls and therefore suggest that lack of the Prnp either directly or indirectly affects brain circuitry responsible for the regulation of offensive aggressive behavior.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2014.03.006

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Büdefeld, T., Majer, A., Jerin, A., & Majdic, G.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2014-06
Volume
266
Pages
216-221
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2037777456
Cited by
11
References
71
Citations by year
2023: 1 · 2018: 3 · 2017: 2 · 2015: 2 · 2014: 3
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
ARRS
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Keywords
prion protein, Prnp knockout mice, offensive aggression, resident-intruder paradigm, aggression, social behavior
MeSH terms
Prion Proteins, Aggression, Animals, Genotype, Male, Mice, Inbred C57BL, Mice, Transgenic, Prions, Radioimmunoassay, Reaction Time, Testosterone, Statistics, Nonparametric, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review