Genetics of aggressive behavior: An overview
Abstract
The Research Domain Criteria (RDoC) address three types of aggression: frustrative non‐reward, defensive aggression and offensive/proactive aggression. This review sought to present the evidence for genetic underpinnings of aggression and to determine to what degree prior studies have examined phenotypes that fit into the RDoC framework. Although the constructs of defensive and offensive aggression have been widely used in the animal genetics literature, the human literature is mostly agnostic with regard to all the RDoC constructs. We know from twin studies that about half the variance in behavior may be explained by genetic risk factors. This is true for both dimensional, trait‐like, measures of aggression and categorical definitions of psychopathology. The non‐shared environment seems to have a moderate influence with the effects of shared environment being unclear. Human molecular genetic studies of aggression are in an early stage. The most promising candidates are in the dopaminergic and serotonergic systems along with hormonal regulators. Genome‐wide association studies have not yet achieved genome‐wide significance, but current samples are too small to detect variants having the small effects one would expect for a complex disorder. The strongest molecular evidence for a genetic basis for aggression comes from animal models comparing aggressive and non‐aggressive strains or documenting the effects of gene knockouts. Although we have learned much from these prior studies, future studies should improve the measurement of aggression by using a systematic method of measurement such as that proposed by the RDoC initiative. © 2015 Wiley Periodicals, Inc.
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Studies of rare human genetic conditions and gene knockouts in mice show that many genetic determinants play critical roles in shaping the emotional circuitry of the brain and modulating aggressive behavior.
“Studies of rare human genetic conditions [14] and gene knockouts (KOs) in mice [15, 16] show that many genetic determinants play critical roles in shaping the emotional circuitry of the brain and modulating aggressive behavior [17, 18].”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [15]
Several recent reviews in human and animals have consistently identified these pathways.
“Indeed, several recent reviews in human and animals have consistently identified these pathways [11, 15, 51].”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [15]
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- Authors
- Veroude, K., Zhang‐James, Y., Fernàndez‐Castillo, N., Bakker, M. J., Cormand, B., & Faraone, S. V.
- Affiliations
- Radboud University Nijmegen (NL)
- SUNY Upstate Medical University (US)
- Departament de Genètica, Facultat de Biologia Universitat de Barcelona Catalonia Spain
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Corresponding author
- Faraone, Stephen V.
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2015-09-08
- Volume
- 171
- Issue
- 1
- Pages
- 3-43
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W1939711497
- Cited by
- 147
- References
- 382
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 8 · 2023: 15 · 2022: 17 · 2021: 19 · 2020: 22 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 8 · 2015: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH094469)
- Ministerio de Economía y Competitividad (SAF2012‐33484)
- Agència de Gestió d'Ajuts Universitaris i de Recerca (2014SGR932)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Keywords
- aggression, Research Domain Criteria, defensive aggression, offensive aggression, twin studies, heritability, nonshared environment, dopaminergic system, serotonergic system, hormonal regulation, genome-wide association study, animal models of aggression, knockout mice, aggression measurement
- MeSH terms
- Aggression, Animals, Behavior, Environment, Humans, Phenotype, Serotonin, Genome-Wide Association Study
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