Dysregulation of select ATP-dependent chromatin remodeling factors in high trait anxiety
Open accessAbstract
Enhanced anxiety is a salient feature of a number of psychiatric disorders including anxiety disorders, trauma-related disorders and depression. Although aberrant expression of various genes has been detected in patients suffering from persistent high anxiety as well as in high anxiety rodent models, the molecular mechanisms responsible for altered transcription regulation have been poorly addressed. Transcription regulation intimately involves the contribution of chromatin modifying processes, such as histone modification and ATP-dependent chromatin remodeling, yet their role in pathological anxiety is not known. Here, we investigated for the first time if altered levels of several ATP-dependent chromatin remodeling factors (ChRFs) and histone deacetylases (HDACs) may be linked to high trait anxiety in mice. While we found protein levels of the ChRFs SNF2H, ATRX, CHD1, CHD3 and CHD5 and of HDACs 1-3 and 6 to be similar in most of the tested brain areas of mice with high (HAB) versus normal (NAB) anxiety-related behavior, we observed distinctly altered regulation of SNF2H in the amygdala, and of CHD3 and CHD5 in the ventral hippocampus. In particular, CHD3 and CHD5 exhibited altered expression of protein but not of mRNA in HAB mice. Since both proteins are components of NuRD-like complexes, these results may indicate an impaired equilibrium between different NuRD-like complexes in the ventral hippocampus. Overall, our data provide novel evidence for localized differences of specific ATP-dependent chromatin remodeling factors in mice with high trait anxiety that may ultimately contribute to altered transcriptional programs resulting in the manifestation of pathological anxiety.
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Altered levels of selective ATP-dependent chromatin remodeling factors are reported in mice with high anxiety-related behavior, including SNF2H in the amygdala and CHD3 and CHD5 in the ventral hippocampus.
“Other studies reported altered levels of selective ATP-dependent chromatin remodeling factors in mice with high anxiety-related behavior, including SNF2H in the amygdala and CHD3 and CHD5 in the ventral hippocampus.380”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [380]
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- Authors
- Wille, A., Amort, T., Singewald, N., Sartori, S. B., & Lusser, A.
- Affiliations
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Corresponding author
- Sartori, Simone B.
- Lusser, Alexandra
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 311
- Pages
- 141-146
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2398634881
- Cited by
- 17
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2020: 1 · 2019: 3 · 2017: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Behavioural Brain Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund (F4408-B19, F4410)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- trait anxiety, ATP-dependent chromatin remodeling, histone deacetylase, SNF2H, CHD3, CHD5, ATRX, CHD1, amygdala, ventral hippocampus, transcriptional regulation, anxiety-like behavior
- MeSH terms
- Adenosine Triphosphatases, Adenosine Triphosphate, Amygdala, Animals, Anxiety, Chromosomal Proteins, Non-Histone, DNA Helicases, Hippocampus, Male, Personality, RNA, Messenger, Species Specificity, Cadherins, Chromatin Assembly and Disassembly, Mice
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