ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Open accessAbstract
Improved treatment for major depressive disorder (MDD) remains elusive because of the limited understanding of its underlying biological mechanisms. It is likely that stress-induced maladaptive transcriptional regulation in limbic neural circuits contributes to the development of MDD, possibly through epigenetic factors that regulate chromatin structure. We establish that persistent upregulation of the ACF (ATP-utilizing chromatin assembly and remodeling factor) ATP-dependent chromatin-remodeling complex, occurring in the nucleus accumbens of stress-susceptible mice and depressed humans, is necessary for stress-induced depressive-like behaviors. We found that altered ACF binding after chronic stress was correlated with altered nucleosome positioning, particularly around the transcription start sites of affected genes. These alterations in ACF binding and nucleosome positioning were associated with repressed expression of genes implicated in susceptibility to stress. Together, our findings identify the ACF chromatin-remodeling complex as a critical component in the development of susceptibility to depression and in regulating stress-related behaviors.
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ACF overexpression regulates nucleosome architecture at transcriptional start sites, inhibiting the expression of a subset of genes, and increases susceptibility to stress-induced depression in mice and humans.
“This study also showed that ACF overexpression regulates nucleosome architecture at transcriptional start sites, inhibiting the expression of a subset of genes, and increases susceptibility to stress-induced depression in mice and humans.378”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [378]
The Results sections on ACF binding and target genes link altered nucleosome architecture near transcriptional start sites to repression of a subset of genes. The behavioral experiments show that ACF overexpression increases stress susceptibility in mice. The human evidence is an association between elevated BAZ1A in postmortem tissue and depression, not a demonstration that overexpression increases susceptibility in humans; page numbers were not provided. (LLM, conf=0.89)
Experimental — accuracy not yet measuredMice with ACF overexpression in NAc exhibit depression-like behaviors after social defeat stress.
“Mice with ACF overexpression in NAc exhibit depression-like behaviors after social defeat stress.378”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [378]
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The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
ChromHMM: automating chromatin-state discovery and characterization
Ernst, J., & Kellis, M. (2012) · Nature Methods · doi:10.1038/nmeth.1906 · Cited by 2,489 · see citing works
The biology of chromatin remodeling complexes.
Clapier, C. R., & Cairns, B. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062706.153223 · Cited by 2,384 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationTHE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · see citing works
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
Landt, S. G., Marinov, G. K., Kundaje, A., Kheradpour, P., Pauli, F., Batzoglou, S., Bernstein, B. E., Bickel, P., Brown, J. B., Cayting, P., et al. (2012) · Genome Research · doi:10.1101/gr.136184.111 · Cited by 2,033 · see citing works
Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
Shogren‐Knaak, M. A., Ishii, H., Sun, J.-M., Pazin, M. J., Davie, J., & Peterson, C. L. (2006) · Science · doi:10.1126/science.1124000 · Cited by 1,876 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationStress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Self-citationRapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Self-citationShen, L., Shao, N., Liu, X., & Nestler, E. J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-284 · Cited by 852 · see citing works
Self-citationEssential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665 · see citing works
Self-citationMechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes
Narlikar, G. J., Sundaramoorthy, R., & Owen‐Hughes, T. (2013) · Cell · doi:10.1016/j.cell.2013.07.011 · Cited by 659 · see citing works
Antidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Self-citationFrom neural development to cognition: unexpected roles for chromatin
Ronan, J. L., Wu, W., & Crabtree, G. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3413 · Cited by 544 · see citing works
Chromatin remodelling at promoters suppresses antisense transcription
Whitehouse, I., Rando, O. J., Delrow, J., & Tsukiyama, T. (2007) · Nature · doi:10.1038/nature06391 · Cited by 456 · see citing works
Charney, D. S., & Manji, H. K. (2004) · Science s STKE · doi:10.1126/stke.2252004re5 · Cited by 426 · see citing works
DANPOS: Dynamic analysis of nucleosome position and occupancy by sequencingPreprint
Chen, K.-F., Xi, Y., Pan, X.-W., Li, Z.-Y., Kaestner, K., Tyler, J. K., Dent, S., He, X.-W., & Li, W. (2013) · Genome Research · doi:10.1101/gr.142067.112 · Cited by 415 · see citing works
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works
Self-citationDeuring, R., Fanti, L., Armstrong, J. A., Sarte, M., Papoulas, O., Prestel, M., Daubresse, G., Verardo, M., Moseley, S. L., Berloco, M. F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80430-x · Cited by 385 · see citing works
What controls nucleosome positions?
Segal, E., & Widom, J. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.06.002 · Cited by 381 · see citing works
Genome-wide Nucleosome Specificity and Directionality of Chromatin Remodelers
Yen, K., Vinayachandran, V., Batta, K., Koerber, R. T., & Pugh, B. F. (2012) · Cell · doi:10.1016/j.cell.2012.04.036 · Cited by 327 · see citing works
Regulation of hippocampal H3 histone methylation by acute and chronic stress
Hunter, R. G., McCarthy, K. J., Milne, T. A., Pfaff, D. W., & McEwen, B. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911143106 · Cited by 290 · see citing works
A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works
Self-citationCiernia, A. V., Matheos, D. P., Barrett, R. M., Kramár, E. A., Azzawi, S., Chen, Y., Magnan, C. N., Zeller, M. D., Sylvain, A. S., Häettig, J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3359 · Cited by 234 · see citing works
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210 · see citing works
Self-citationEpigenetic Influence of Stress and the Social Environment
Gudsnuk, K. M., & Champagne, F. A. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.279 · Cited by 185 · see citing works
Altered gene expression of histone deacetylases in mood disorder patients
Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.015 · Cited by 185 · see citing works
Fyodorov, D. V., Blower, M. D., Karpen, G. H., & Kadonaga, J. T. (2004) · Genes & Development · doi:10.1101/gad.1139604 · Cited by 177 · see citing works
Acf1, the largest subunit of CHRAC, regulates ISWI‐induced nucleosome remodelling
Eberharter, A., Ferrari, S., Längst, G., Straub, T., Imhof, A., Varga‐Weisz, P., Wilm, M. S., & Becker, P. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3781 · Cited by 147 · see citing works
Self-citationGorwood, P. (2004) · European psychiatry · doi:10.1016/j.eurpsy.2003.10.002 · Cited by 131 · see citing works
Altered sirtuin deacetylase gene expression in patients with a mood disorder
Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, F., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.016 · Cited by 131 · see citing works
Jiang, Y., Jakovcevski, M., Bharadwaj, R., Connor, C., Schroeder, F. A., Lin, C. L., Straubhaar, J., Martin, G., & Akbarian, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1314-10.2010 · Cited by 118 · see citing works
Balancing histone methylation activities in psychiatric disorders
Peter, C. J., & Akbarian, S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.003 · Cited by 110 · see citing works
Hollis, F., Duclot, F., Gunjan, A., & Kabbaj, M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.005 · Cited by 107 · see citing works
Major depression and the environment: a psychiatric genetic perspective
Kendler, K. (1998) · Pharmacopsychiatry · doi:10.1055/s-2007-979287 · Cited by 85 · see citing works
Yadon, A., VanDemark, D., Basom, R., Delrow, J., Whitehouse, I., & Tsukiyama, T. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00602-10 · Cited by 84 · see citing works
Environmental regulation of the neural epigenome
Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82 · see citing works
Sala, A., Toto, M., Pinello, L., Gabriele, A., Benedetto, V. D., Ingrassia, A. M. R., Bosco, G. L., Gesù, V. D., Giancarlo, R., & Corona, D. F. V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.98 · Cited by 58 · see citing works
The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets
Liu, Y. I., Chang, M. V., Li, H. E., Barolo, S., Chang, J. L., Blauwkamp, T. A., & Cadigan, K. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.011 · Cited by 44 · see citing works
Anna-Monika-Prize paper. Major depression and the environment : a psychiatric perspective
Kendler, K. S. (1998) · Medical Entomology and Zoology · Cited by 29 · see citing works
Ewing, A. K., Attner, M. A., & Chakravarti, D. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0095 · Cited by 26 · see citing works
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Treatment resistant depression: A multi-scale, systems biology approach
Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 443 · see citing works
Self-citationEpigenetic basis of mental illness
Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works
Self-citationBiological embedding of experience: a primer on epigenetics
Aristizabal, M. J., Anreiter, I., Halldorsdottir, T., Odgers, C. L., McDade, T. W., Goldenberg, A., Mostafavi, S., Kobor, M. S., Binder, E. B., Sokolowski, M. B., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820838116 · Cited by 268 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“378 The inactivation of ATPase subunit of the SWI/SNF complexes, Brahma Related Gene 1, reduces the expression of stress-and cocaine-induced immediate early genes, increases heterochromatin levels, and generally reduces chromatin accessibility in striatal medium spiny neurons.”
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Han, M., & Nestler, E. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0527-x · Cited by 178 · see citing works
Self-citationEpigenetic programming by stress and glucocorticoids along the human lifespan
Zannas, A. S., & Chrousos, G. P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.35 · Cited by 158 · see citing works
Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression
Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Wang, J., Tan, C., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Lorsch, Z. S., Hamilton, P. J., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.023 · Cited by 156 · see citing works
Self-citationEpigenetic Modifications of Major Depressive Disorder
Saavedra, K., Molina-Márquez, A., Saavedra, N., Zambrano, T., & Salazar, L. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081279 · Cited by 124 · see citing works
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Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.122 · Cited by 116 · see citing works
Self-citationExpansion of the ISWI chromatin remodeler family with new active complexes
Oppikofer, M., Bai, T., Gan, Y., Haley, B., Liu, P., Sandoval, W. N., Ciferri, C., & Cochran, A. G. (2017) · EMBO Reports · doi:10.15252/embr.201744011 · Cited by 109 · see citing works
Liu, Y., Li, M., Fan, M., Song, Y., Yu, H., Zhi, X., Xiao, K., Lai, S., Zhang, J., Jin, X., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.025 · Cited by 106 · see citing works
Chandra, R., Engeln, M., Schiefer, C., Patton, M. H., Martin, J. A., Werner, C. T., Riggs, L. M., Francis, T. C., McGlincy, M., Evans, B., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.037 · Cited by 105 · see citing works
Self-citationUnraveling the epigenetic landscape of depression: focus on early life stress
Torres‐Berrío, A., Issler, O., Parise, E. M., & Nestler, E. J. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/enestler · Cited by 102 · see citing works
Self-citationDendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100 · see citing works
Epigenetic Regulation of the Social Brain
Bludau, A., Royer, M., Meister, G., Neumann, I. D., & Menon, R. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.04.001 · Cited by 91 · see citing works
Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction?
Nestler, E. J. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002426 · Cited by 90 · see citing works
Self-citationProgress in Epigenetics of Depression
Peña, C. J., & Nestler, E. J. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2017.12.011 · Cited by 84 · see citing works
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Self-citationGoodwin, L. R., & Picketts, D. J. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.10.008 · Cited by 74 · see citing works
Immuno-psychiatry: an agenda for clinical practice and innovative research
Leboyer, M., Berk, M., Yolken, R. H., Tamouza, R., Kupfer, D. J., & Groc, L. (2016) · BMC Medicine · doi:10.1186/s12916-016-0712-5 · Cited by 73 · see citing works
Multiomic profiling of the acute stress response in the mouse hippocampus
von Ziegler, L., Floriou‐Servou, A., Waag, R., Gupta, R. R. D., Sturman, O., Gapp, K., Maat, C. A., Kockmann, T., Lin, H.-Y., Duss, S. N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29367-5 · Cited by 66 · see citing works
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Lepack, A. E., Bagot, R. C., Peña, C. J., Loh, Y.-H. E., Farrelly, L. A., Lu, Y., Powell, S. K., Lorsch, Z. S., Issler, O., Cates, H. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608270113 · Cited by 63 · see citing works
Self-citationTet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors
Feng, J., Pena, C. J., Purushothaman, I., Engmann, O., Walker, D., Brown, A. N., Issler, O., Doyle, M., Harrigan, E., Mouzon, E., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.6 · Cited by 58 · see citing works
Self-citationThe long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression
Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Xia, S.-H., Zinsmaier, A. K., Tan, C., Li, W., Browne, C. J., Walker, D. M., Salery, M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn9494 · Cited by 53 · see citing works
Self-citationThe Acute Stress Response in the Multiomic Era
Floriou-Servou, A., von Ziegler, L., Waag, R., Schläppi, C., Germain, P.-L., & Bohacek, J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.031 · Cited by 51 · see citing works
Sengupta, T., Ange, J. S., Kaletsky, R. L., Moore, R. S., Seto, R. J., Marogi, J. G., Myhrvold, C., Gitai, Z., & Murphy, C. T. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011178 · Cited by 48 · see citing works
Vassilev, P., Pantoja-Urbán, A. H., Giroux, M., Nouel, D., Hernández, G., Orsini, T., & Flores, C. (2021) · eNeuro · doi:10.1523/eneuro.0045-21.2021 · Cited by 45 · see citing works
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Self-citationSun, H., Martin, J. A., Werner, C. T., Wang, Z.-J., Damez-Werno, D. M., Scobie, K. N., Shao, N., Dias, C., Rabkin, J., Koo, J. W., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3254-15.2016 · Cited by 40 · see citing works
Self-citationHervé, M., Bergon, A., Guisquet, A. L., Leman, S., Consoloni, J.-L., Fernandez, N., Lefebvre, M., El‐Hage, W., Belzeaux-R, R., Belzung, C., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00248 · Cited by 40 · see citing works
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Zaghlool, A., Halvardson, J., Zhao, J., Etemadikhah, M., Kalushkova, A., Końska, K., Jernberg‐Wiklund, H., Thuresson, A., & Feuk, L. (2016) · Human Mutation · doi:10.1002/humu.23034 · Cited by 37 · see citing works
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Bastle, R. M., & Maze, I. S. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.07.004 · Cited by 28 · see citing works
Self-citationWenderski, W., & Maze, I. (2016) · Bioessays · doi:10.1002/bies.201500171 · Cited by 26 · see citing works
Self-citationHamilton, P. J., Lim, C. J., Nestler, E. J., & Heller, E. A. (2018) · Methods in Molecular Biology · doi:10.1007/978-1-4939-7774-1_5 · Cited by 28 · see citing works
Self-citationDoherty, T. S., & Roth, T. L. (2016) · Development and Psychopathology · doi:10.1017/s095457941600081x · Cited by 26 · see citing works
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Farrelly, L. A., & Maze, I. S. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.07.001 · Cited by 25 · see citing works
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Kim, H.-D., Wei, J., Call, T., Quintus, N. T., Summers, A. J., Carotenuto, S., Johnson, R., Ma, X., Xu, C., Park, J. G., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01217-8 · Cited by 24 · see citing works
Morel, G., Chiavellini, P., Canatelli-Mallat, M., Lehmann, M., & Goya, R. G. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320966 · Cited by 23 · see citing works
Silveira, P. P., & Meaney, M. J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106008 · Cited by 24 · see citing works
Testing Depression in Mice: a Chronic Social Defeat Stress Model
Kim, H.-D., Call, T., Carotenuto, S., Johnson, R., & Ferguson, D. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2203 · Cited by 23 · see citing works
Epigenetic mechanisms in depression: Implications for pathogenesis and treatment
Chen, H.-S., Wang, F., & Chen, J. (2024) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2024.102854 · Cited by 23 · see citing works
Chawla, A., Nagy, C., & Turecki, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147612 · Cited by 20 · see citing works
Self-citationTargeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy
Zhang, Y., Gao, J., Li, N., Xu, P., Qu, S., Cheng, J., Wang, M., Li, X., Song, Y., Xiao, F., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.005 · Cited by 18 · see citing works
Identification of Neurensin-2 as a novel modulator of emotional behavior
Umschweif, G., Medrihan, L., Guillén-Samander, A., Wang, W., Sagi, Y., & Greengard, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01058-5 · Cited by 18 · see citing works
Zayed, A., Baranowski, C., Compagnion, A.-C., Vernochet, C., Karaki, S., Cuttoli, R. D.-D., Saint-Jour, E., Bhattacharya, S., Marti, F., Vanhoutte, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29380-8 · Cited by 17 · see citing works
Dysregulation of select ATP-dependent chromatin remodeling factors in high trait anxiety
Wille, A., Amort, T., Singewald, N., Sartori, S. B., & Lusser, A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.036 · Cited by 17 · see citing works
Epigenetic mechanisms, trauma, and psychopathology: targeting chromatin remodeling complexes
Bielawski, T., Misiak, B., Moustafa, A. A., & Frydecka, D. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0055 · Cited by 17 · see citing works
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Petersen, C. L., Chen, J., Salas, L. A., & Christensen, B. C. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00972-9 · Cited by 15 · see citing works
The Emerging Role of ATP-Dependent Chromatin Remodeling in Memory and Substance Use Disorders
López, A. J., Hecking, J. K., & White, A. O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186816 · Cited by 16 · see citing works
The epigenome under pressure: On regulatory adaptation to chronic stress in the brain
Arzate‐Mejía, R. G., Carullo, N. V. N., & Mansuy, I. M. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102832 · Cited by 15 · see citing works
Transcriptional signatures of fentanyl use in the mouse ventral tegmental area
Fox, M. E., Montemarano, A., Ostman, A. E., Basu, M., Herb, B. R., Ament, S. A., & Fox, L. D. (2024) · Addiction Biology · doi:10.1111/adb.13403 · Cited by 14 · see citing works
Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine
Sun, H., Damez-Werno, D. M., Scobie, K. N., Shao, N., Dias, C., Rabkin, J., Wright, K. N., Mouzon, E., Kabbaj, M., Neve, R. L., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.007 · Cited by 13 · see citing works
Self-citationUmschweif, G., Medrihan, L., McCabe, K. A., Sagi, Y., & Greengard, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01059-4 · Cited by 13 · see citing works
Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
Han, M., Russo, S. J., & Nestler, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00012-3 · Cited by 13 · see citing works
Self-citationChromatin remodeling: a complex affair
Gioacchini, N., & Peterson, C. L. (2017) · EMBO Reports · doi:10.15252/embr.201744852 · Cited by 12 · see citing works
Athira, K. V., Wahul, A. B., Soren, K., Das, T., Dey, S. K., Samudrala, P. K., Kumar, A., Lahkar, M., & Chakravarty, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105083 · Cited by 11 · see citing works
Cook, I. A., Congdon, E. L., Krantz, D. E., Hunter, A. M., Coppola, G., Hamilton, S. P., & Leuchter, A. F. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00870 · Cited by 10 · see citing works
Nucleosome positioning sequence patterns as packing or regulatory
Pranckevičienė, E., Hosid, S., Liang, N., & Ioshikhes, I. P. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007365 · Cited by 10 · see citing works
Early-life stress alters chromatin modifications in VTA to prime stress sensitivityPreprint
Geiger, L. T., Rodier, J.-A., Barrett, M. R., Thompson, J. M., Fang, L. Z., Farrelly, L. A., Chen, A. S., Tang, M., Bennett, S. N., Garcia, B. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.14.584631 · Cited by 11 · see citing works
Self-citationYim, Y. S., Han, W., Seo, J., Kim, C. H., & Kim, D. G. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.172 · Cited by 6 · see citing works
Epigenetic signatures of chronic social stress in stress-susceptible animals
O’Toole, N., Zhang, T.-Y., Wen, X., Diorio, J., Silveira, P. P., Labonté, B., Nestler, E. J., & Meaney, M. J. (2019) · doi:10.1101/690826 · Cited by 4 · see citing works
Self-citationPharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Lu, Y., Shang, R., Zhong, X., Shi, J., Zhang, G., Zhao, W., & Teng, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1616322 · Cited by 6 · see citing works
Ponzi, E., Gentile, M., Agolini, E., Matera, E., Palumbi, R., Buonadonna, A. L., Peschechera, A., Gabellone, A., Antonucci, M. F., & Margari, L. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1289 · Cited by 5 · see citing works
Epigenetics and the Impact of Early-Life Stress Across Generations
van Steenwyk, G., & Mansuy, I. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813156-5.00029-7 · Cited by 4 · see citing works
Réus, G. Z., Abelaira, H. M., Coutellier, L. D., Manosso, L. M., & Pavlovic, Z. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-87480-3_3 · Cited by 4 · see citing works
Lee, H., Park, J., & Kim, S. (2023) · Metabolites · doi:10.3390/metabo13030453 · Cited by 3 · see citing works
Molecular characterization of the resilient brain
Issler, O., Lorsch, Z. S., & Nestler, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00015-x · Cited by 3 · see citing works
Self-citationMolecular roadmap of the healthy stress response in the mouse hippocampusPreprint
von Ziegler, L., Floriou‐Servou, A., Waag, R., Gupta, R. R. D., Sturman, O., Gapp, K., Maat, C. A., Kockmann, T., Lin, H.-Y., Duss, S. N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.26.436970 · Cited by 3 · see citing works
Early-life stress alters H3K4me1 in VTA to prime stress sensitivity
Kim, H. J. J., Geiger, L. T., Rodier, J.-A., Fang, L. Z., Barrett, M. R., Thompson, J. M., Farrelly, L. A., Hage, T. A., Lin, R., Chen, A. S., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.07.018 · Cited by 2 · see citing works
Self-citationGenome-wide methylation patterns associated with chronic stress
O’Toole, N., Zhang, T., Fitzgerald, E., Wen, X., Diorio, J. C., Silveira, P. P., Labonté, B., Nestler, E. J., & Meaney, M. J. (2026) · Epigenomics · doi:10.1080/17501911.2026.2613012 · Cited by 1 · see citing works
Self-citationClimate Change-Induced Stress and Neural Plasticity: Genetic and Epigenetic Mechanisms of Adaptation
Uddin, T., Zohora, F. T., Khanam, T., Akter, M., Himika, L. I., Aziz, A. T., Tabassum, F., Tushy, S. M. K., Aktar, S., Misha, M. M., et al. (2026) · OBM Genetics · doi:10.21926/obm.genet.2602337 · Cited by 1 · see citing works
Altered Postnatal Chromatin Development in the Nucleus Accumbens Primes Enduring Stress Sensitivity
Rashford, R. L., Fang, L. Z., DeBerardine, M., Kim, H. J. J., Hirschfield, L. W., Cervi, E., Barrett, M. R., Thompson, J. M., Creed, M. C., & Peña, C. J. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2217-25.2026 · Cited by 4 · see citing works
Epigenetics and drug addiction: translational aspects
Feng, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00017-4 · Cited by 1 · see citing works
Epigenetics and Brain Plasticity: Back to Function
Morelli, G., Valle, F. D., & Orlando, V. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-24930-3_11 · Cited by 1 · see citing works
Epigenetic regulation of stress
Alamoudi, M. K., Alibrahim, N., Alsaleh, A. A., & Raza, M. L. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.007 · Cited by 1 · see citing works
Remodeling the susceptibility to stress-induced depression
Sananbenesi, F., & Fischer, A. (2015) · Nature Medicine · doi:10.1038/nm.3970
The epigenetics of brain aging and psychiatric disorders
Gong, H., & Xu, X. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00008-3
Hervé, M., Bergon, A., Guisquet, A. M. L., Leman, S., Consoloni, J.-L., Fernandez, N., Lefebvre, M. N., El‐Hage, W., Belzeaux-R, R., Belzung, C., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(17)31124-0
Galaxy Dnpatterntools for Computational Analysis of Nucleosome Positioning Sequence Patterns
Pranckevičienė, E., Hosid, S., Maziukas, I., & Ioshikhes, I. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094869
Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulansPreprint
Nanni, A. V., Martinez, N., Graze, R. M., Morse, A. M., Newman, J. R. B., Jain, V., Vlaho, S., Signor, S. A., Nuzhdin, S. V., Renne, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.13.523946
Qian, R., Gao, H., Qiu, B., Li, Z., Gu, B., Ye, T., Wu, D., & Zhao, Z. (2024) · medRxiv · doi:10.1101/2024.11.20.24317665 · Cited by 1 · see citing works
Additional file 2 of Altered immune phenotype and DNA methylation in panic disorder
Petersen, C. L., Chen, J.-Q., Salas, L. A., & Christensen, B. C. (2020) · Figshare · doi:10.6084/m9.figshare.13257575
The role of chromatin remodelers in dopaminoceptive neurons
Zayed, A. (2019) · theses.fr (ABES) · doi:10.70675/f1d09c9dz29c5z44e4zae26z358715db672e
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_14
Gao, F.-F., Xu, Y.-F., Zhang, J., Qu, S.-M., Xiao, F., Cheng, J.-Q., Yuan, Z.-Q., Wang, G., Yu, M.-J., & Aa, J. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01834-5
Lin, C., Zhang, S., Li, Q., Qi, Z., & Liu, W. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.07.053
Li, J., Guan, X., Zhang, R., & Zhang, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08772-0
Epigenetic mechanisms in brain aging and their role in cognitive decline and mental health disorders
Chinn, C., & Wood, M. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00023-2
- Authors
- Sun, H., Damez-Werno, D. M., Scobie, K. N., Shao, N.-Y., Dias, C., Rabkin, J., Koo, J. W., Korb, E., Bagot, R. C., Ahn, F. H., Cahill, M. E., Labonté, B., Mouzon, E., Heller, E. A., Cates, H., Golden, S. A., Gleason, K., Russo, S. J., Andrews, S., Neve, R., Kennedy, P. J., Maze, I., Dietz, D. M., Allis, C. D., Turecki, G., Varga-Weisz, P., Tamminga, C., Shen, L., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Rockefeller University (US)
- The University of Texas Southwestern Medical Center (US)
- Babraham Institute (GB)
- Massachusetts Institute of Technology (US)
- University of California, Los Angeles (US)
- University at Buffalo, State University of New York (US)
- McGill University (CA)
- Corresponding author
- Nestler, Eric J
- ORCID
- Sun, HaoSheng
- Damez-Werno, Diane M
- Shao, Ning-Yi
- Dias, Caroline
- Koo, Ja Wook
- Korb, Erica
- Bagot, Rosemary C
- Cahill, Michael E
- Mouzon, Ezekiell
- Heller, Elizabeth A
- Cates, Hannah
- Golden, Sam A
- Russo, Scott J
- Andrews, Simon
- Neve, Rachael
- Kennedy, Pamela J
- Maze, Ian
- Dietz, David M
- Allis, C David
- Turecki, Gustavo
- Tamminga, Carol
- Shen, Li
- Nestler, Eric J
- Venue
- Nature Medicine
- Published
- 2015-09-21
- Volume
- 21
- Issue
- 10
- Pages
- 1146-1153
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC4598281
- OpenAlex
- W2199825548
- Cited by
- 91
- References
- 47
- Citations by year
- 2026: 9 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 14 · 2016: 12 · 2015: 2
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Open Access at Essex (University of Essex) (submittedVersion)
- Funders
- University of Texas Southwestern Medical Center
- Biotechnology and Biological Sciences Research Council (BBS/E/B/0000H125, BBS/E/B/000C0404, BB/F020236/1)
- National Institute of Mental Health (P50MH096890, R01 MH-51399, R01MH051399)
- National Institute on Drug Abuse (R01DA037257)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- chromatin remodeling, major depressive disorder, stress-induced depression, nucleus accumbens, chronic stress, nucleosome positioning, transcriptional regulation, epigenetics, depression vulnerability, transcription start sites
- MeSH terms
- Bromodomain Containing Proteins, Animals, Chromosomal Proteins, Non-Histone, Depression, Humans, Male, Mice, Inbred C57BL, Stress, Psychological, Transcription Factors, Chromatin Assembly and Disassembly, Mice
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