Epigenetic memory: The Lamarckian brain
Open accessAbstract
Recent data support the view that epigenetic processes play a role in memory consolidation and help to transmit acquired memories even across generations in a Lamarckian manner. Drugs that target the epigenetic machinery were found to enhance memory function in rodents and ameliorate disease phenotypes in models for brain diseases such as Alzheimer's disease, Chorea Huntington, Depression or Schizophrenia. In this review, I will give an overview on the current knowledge of epigenetic processes in memory function and brain disease with a focus on Morbus Alzheimer as the most common neurodegenerative disease. I will address the question whether an epigenetic therapy could indeed be a suitable therapeutic avenue to treat brain diseases and discuss the necessary steps that should help to take neuroepigenetic research to the next level.
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These epigenetic processes may have evolved in order to program the phenotype to effectively and rapidly adapt to new environmental demands.
“these epigenetic processes may have evolved in order to program the phenotype to effectively and rapidly adapt to new environmental demands (Fischer, 2014;Gapp et al., 2016;Yeshurun & Hannan, 2019).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Fischer, 2014
In “Writers, erasers, readers” (page not supplied), Fischer describes epigenetic mechanisms as turning genetic and environmental factors into long-term adaptive changes. “How much Lamarck is in our memories?” (page not supplied) gives an example of offspring better adapting to liver damage. The copy does not say these processes evolved for that purpose or establish rapid adaptation to new environmental demands. (LLM, conf=0.82)
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Self-citationThe role of microRNAs in learning and long-term memory
Grinkevich, L. N. (2020) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj20.687 · Cited by 12 · see citing works
Goli, P., Yazdi, M., Poursafa, P., & Kelishadi, R. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10081 · Cited by 10 · see citing works
Peter, M., Aschauer, D. F., Rose, R., Sinning, A., Groessl, F., Kargl, D., Kraitsy, K., Burkard, T. R., Luhmann, H. J., Haubensak, W. E., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244038 · Cited by 10 · see citing works
The molecular and cellular basis of memory engrams: Mechanisms of synaptic and systems consolidation
Kupke, J., & Oliveira, A. M. M. (2025) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2025.108057 · Cited by 9 · see citing works
Wille, A., Maurer, V., Piatti, P., Whittle, N., Rieder, D., Singewald, N., & Lusser, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00313 · Cited by 8 · see citing works
The Role of Dynamic Histone Modifications in Learning Behavior
Fischer, A. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_108 · Cited by 8 · see citing works
Self-citationA Transcriptome Analysis Identifies Potential Preventive and Therapeutic Approaches Towards COVID-19Preprint
Islam, R., & Fischer, A. (2020) · Preprints.org · doi:10.20944/preprints202004.0399.v1 · Cited by 8 · see citing works
Self-citationThe (not so) Controversial Role of DNA Methylation in Epigenetic Inheritance Across Generations
Irmler, M., Kaspar, D., de Angelis, M. H., & Beckers, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-35213-4_10 · Cited by 7 · see citing works
Zhang, F., Liu, L., Peng, J., Ding, G., Li, Y., Biswal, B. B., & Wang, P. (2024) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2024.11.015 · Cited by 4 · see citing works
New friends for Ago2 in neuronal plasticity
Sananbenesi, F., & Fischer, A. (2015) · The EMBO Journal · doi:10.15252/embj.201592466 · Cited by 3 · see citing works
Self-citationShea, T. B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.039 · Cited by 3 · see citing works
Calcium signaling then and now, via Stockholm
Bano, D., Jewell, S. A., & Nicotera, P. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.151 · Cited by 3 · see citing works
GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health
Craig, C. J., Boeringer, T., Pardo, M., Pozo, A. D., & Maudsley, S. R. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48020127 · Cited by 2 · see citing works
The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory
Flores, A. I., & Liester, M. B. (2024) · Cureus · doi:10.7759/cureus.73063 · Cited by 2 · see citing works
Lee, H., Kim, J.-H., Kim, J.-Y., An, M.-J., Shin, G.-S., Jo, A.-R., Park, Y., Kim, C.-H., Hwangbo, Y., Lee, K. H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-11065-z · Cited by 2 · see citing works
Perspectives of neurobiological research in schizophrenia
Falkai, P., Hasan, A., Rossner, M. J., & Schmitt, A. (2016) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2016.01.007 · Cited by 2 · see citing works
Potential Contribution of Retrotransposons to Learning and Memory
Glanzman, D. L. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_12 · Cited by 1 · see citing works
Ebrahimi, R., Fekri, M., Salarvandian, S., Arashlow, F. T., & Noori, S. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113155 · Cited by 1 · see citing works
Personalized Medicine and Epigenetic Drug Development
Lundstrom, K. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420135-4.00013-9 · Cited by 1 · see citing works
Lundstrom, K. H. (2015) · International Journal Of Nutrition · doi:10.14302/issn.2324-7339.ijn-14-603
Epigenetik – neue Erkenntnisse zum Verständnis neurodegenerativer Erkrankungen
Fischer, A., Schneider, A., & Wüllner, U. (2015) · Aktuelle Neurologie · doi:10.1055/s-0035-1552630 · Cited by 1 · see citing works
Self-citationHistone Deacetylases as Therapeutic Targets in Neurodegenerative Diseases
Sananbenesi, F., & Fischer, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00003-x · Cited by 1 · see citing works
Self-citationRemodeling the susceptibility to stress-induced depression
Sananbenesi, F., & Fischer, A. (2015) · Nature Medicine · doi:10.1038/nm.3970
Self-citationNeuroepigenomics and Human Disease
Greally, J. M., & Nestler, E. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00005-6
Commentary: Violent Aggression Predicted by Multiple Pre-Adult Adverse Experiences
Ehrenreich, H. (2018) · Journal of Pediatrics and Pediatric Medicine · doi:10.29245/2578-2940/2018/4.1134
SETD1B controls cognitive function via cell type specific regulation of neuronal identity genesPreprint
Michurina, A., Sakib, M. S., Kerimoglu, C., Krüger, D. M., Kaurani, L., Islam, R., Centeno, T. P., Cha, J., Xu, X., Zeisberg, E. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.07.240853
Self-citationA novel miR-99b-5p- Zbp1 pathway in microglia contributes to the pathogenesis of schizophreniaPreprint
Kaurani, L., Islam, R., Heilbronner, U., Krüger, D. M., Zhou, J., Methi, A., Strauß, J., Pradhan, R., Burkhardt, S., Peña, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.21.533602
Self-citationPersonalized medicine and epigenetic drug development
Lundstrom, K. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23802-4.00008-9
- Authors
- Fischer, A.
- Venue
- The EMBO Journal
- Published
- 2014-04-09
- Volume
- 33
- Issue
- 9
- Pages
- 945-967
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC4193930
- OpenAlex
- W2107234429
- Cited by
- 107
- References
- 299
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 5
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion, cc-by-nc-nd)
- GRO (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- epigenetic memory, memory consolidation, Lamarckian inheritance, epigenetic drugs, Alzheimer's disease, Huntington's disease, depression, schizophrenia, neuroepigenetics, epigenetic therapy, brain disorders
- MeSH terms
- Alzheimer Disease, Animals, Brain, Gene Expression Regulation, Histones, Humans, Memory, RNA, Untranslated, Epigenesis, Genetic
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