Melatonin and cortisol profiles in the absence of light perception
Abstract
As light plays an important role in the synchronisation of the internal biological clock to the environmental day/night schedule, we compared the 24-h profiles of biological circadian markers in blind and normal sighted individuals. Salivary melatonin and cortisol concentrations were collected every two hours in eleven blind subjects, reporting no conscious light perception, and eleven age- and sex-matched normal sighted controls. Timing of melatonin onset and associated cortisol quiescence period confirm an increased incidence of abnormal circadian patterns in blindness. Additionally, blind subjects showed a greater overall melatonin concentration throughout the 24-h period. Cortisol profiles, including concentration and morning cortisol peaks, on the other hand, did not differ between blind and sighted individuals. These findings support previous reports of an increase in abnormal circadian rhythms and the absence of the entrainment properties of light in blindness.
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Individuals who are blind tend to have increased abnormalities in circadian rhythm compared with those who have sight.
“In fact, individuals who are blind tend to have increased abnormalities in circadian rhythm compared with those who have sight [95].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [95]
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- Authors
- Aubin, S., Kupers, R., Ptito, M., & Jennum, P.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Kupers, R.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 317
- Pages
- 515-521
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2524352664
- Cited by
- 23
- References
- 59
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2019: 3 · 2018: 3 · 2017: 4
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- NovoNordisk Research Foundation (NNF13OC0007531)
- Harland Sanders Chair in Visual Science
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- blindness, melatonin, cortisol, circadian rhythm, light perception, circadian entrainment, melatonin onset, salivary biomarkers, circadian rhythm disruption
- MeSH terms
- Adult, Blindness, Circadian Rhythm, Female, Humans, Hydrocortisone, Light, Male, Melatonin, Middle Aged, Perception, Saliva, Statistics, Nonparametric, Area Under Curve
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