Enhanced wakefulness following lesions of a mesopontine locus essential for the induction of general anesthesia
Abstract
The induction of general anesthesia shares many features with the transition from wakefulness to non-rapid eye movement (NREM) sleep, suggesting that the two types of brain-state transition are orchestrated by a common neuronal mechanism. Previous studies revealed a brainstem locus, the mesopontine tegmental anesthesia area (MPTA), that is of singular importance for anesthetic induction. Microinjection of GABAergic anesthetics there induces rapid loss-of-consciousness and lesions render the animal relatively insensitive to anesthetics administered systemically. Here we show that MPTA lesions also alter the natural sleep-wake rhythm by increasing overall wake time at the expense of time asleep (NREM and REM sleep equally), with nearly all of the change occurring during the dark hours of the light-dark cycle. The effect was proportional to the extent of the lesion and was not seen after lesions just outside of the MPTA, or following sham lesions. Thus, MPTA neurons appear to play a role in natural bistable brain-state switching (sleep-wake) as well as in loss and recovery of consciousness induced pharmacologically.
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In rats, damaging neurons in this region raises wakefulness while reducing NREM and REM sleep.
“Lesioning neurons in this region also increases wakefulness in rats at the expense of NREM and REM sleep [123].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [123]
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Self-citation
- Authors
- Lanir-Azaria, S., Meiri, G., Avigdor, T., Minert, A., & Devor, M.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Devor, Marshall
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 341
- Pages
- 198-211
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2777873895
- Cited by
- 20
- References
- 67
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israeli Ministry of Health
- the Seymour and Cecile Alpert Chair in Pain Research
- the Hebrew University Center for Research on Pain
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- general anesthesia induction, sleep-wake cycle, wakefulness, NREM sleep, REM sleep, brain state transitions, loss of consciousness, light-dark cycle, brainstem lesions
- MeSH terms
- Anesthesia, General, Animals, Electrodes, Implanted, Electroencephalography, Electromyography, Ibotenic Acid, Male, Motor Activity, Sleep, Tegmentum Mesencephali, Time Factors, Wakefulness, Rats, Wistar, Photoperiod, Muscle, Skeletal, Anesthetics, General
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