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Stress, pain, anxiety, and depression in endometriosis–Targeting glial activation and inflammation

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Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives

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Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence

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Ghrelin attenuates depressive-like behavior, heart failure, and neuroinflammation in postmyocardial infarction rat model

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Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway

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Evidence for lack of direct causality between pain and affective disturbances in a rat peripheral neuropathy model

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Brain regional pharmacokinetics of hydroxytyrosol and its molecular mechanism against depression assessed by multi-omics approaches

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Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis

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Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

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Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress

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Intranasal lipopolysaccharide administration prevents chronic stress-induced depression- and anxiety-like behaviors in mice

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The effect of chronic stress on behaviors, inflammation and lymphocyte subtypes in male and female rats

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HMGB1 in depression: An overview of microglial HMBG1 in the pathogenesis of depression

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Sleep deprivation alleviates depression-like behaviors in mice via inhibiting immune and inflammatory pathways and improving neuroplasticity

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Chronic stress induces depression-like behavior in rats through affecting brain mitochondrial function and inflammation

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Effects of S100B neutralization on the long-term cognitive impairment and neuroinflammatory response in an animal model of sepsis

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Neuropsychiatric symptoms and seizure related with serum cytokine in epilepsy patients

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Stress, Allostatic Load, and Neuroinflammation: Implications for Racial and Socioeconomic Health Disparities in Glaucoma

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Inhibition of Microglial GSK3β Activity Is Common to Different Kinds of Antidepressants: A Proposal for an In Vitro Screen to Detect Novel Antidepressant Principles

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Across Barriers: Blood–Brain and Gut Barrier Signaling in Psychiatric Disorders

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Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways

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Site-Specific Knockdown of Microglia in the Locus Coeruleus Regulates Hypervigilant Responses to Social Stress in Female Rats

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Endogenous ω-3 fatty acids in Fat-1 mice attenuated depression-like behaviors, spatial memory impairment and relevant changes induced by olfactory bulbectomy

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Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression

Zhu, H., Cheng, L., Yang, R.-W. O., Liu, J., Liu, J., Dai, D., Yang, N., Yang, N., & Li, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.926323 · Cited by 15

Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans

Kodali, M., Jankay, T., Shetty, A. K., & Reddy, D. S. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06319-5 · Cited by 15

Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance

Du, E., Fan, R., Rong, L.-L., Xie, Z., & Xu, C. (2020) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900425 · Cited by 14

Inhaled Litsea glaucescens K. (Lauraceae) leaves’ essential oil has anxiolytic and antidepressant-like activity in mice by BDNF pathway activation.

Díaz-Cantón, J. K., Torres-Ramos, M., Limón‐Morales, O., Santiago, M. L., Rivero-Segura, N. A., Tapia‐Mendoza, E., Guzmán‐Gutiérrez, S. L., & Reyes‐Chilpa, R. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117489 · Cited by 14

Comparison between sub-chronic and chronic sleep deprivation-induced behavioral and neuroimmunological abnormalities in mice: Focusing on glial cell phenotype polarization

Niazi, N. U. K., Huang, C.-Y., Yang, Z., Zhang, Y., & Song, C. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115067 · Cited by 17

Aggravating Effects of Psychological Stress on Ligature-Induced Periodontitis via the Involvement of Local Oxidative Damage and NF-κB Activation

Li, Q., Zhao, Y.-J., Deng, D., Yang, J., Chen, Y., Liu, J., & Zhang, M. (2022) · Mediators of Inflammation · doi:10.1155/2022/6447056 · Cited by 14

Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induces Depression-Like Behavior and Learning-Memory Impairment: A Possible Link with Decreased Hippocampal Neurogenesis and Astrocyte Activation

Šutulović, N., Vesković, M. N., Puškaš, N., Zubelić, A., Jerotić, D., Suvakov, S. R., Despotović, S. Z., Grubač, Ž., Mladenović, D. R., Μacut, D., et al. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/3199988 · Cited by 13

Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr.

Ding, X.-Y., Wen, J., Lin, W.-Y., Huang, G.-Y., Feng, Q., Duan, L., Zhang, S., Liu, Z., Zhang, R.-R., & Wang, Y. (2023) · Phytochemistry · doi:10.1016/j.phytochem.2023.113774 · Cited by 13

Treatment with Minocycline Suppresses Microglia Activation and Reverses Neural Stem Cells Loss after Simulated Microgravity

Lin, T., Du, J., Liu, L., Wu, Z., Kong, X., Liu, Y., & Cai, Y. (2020) · BioMed Research International · doi:10.1155/2020/7348745 · Cited by 13

Emotional Impairments and Neuroinflammation are Induced in Male Mice Invulnerable to Repeated Social Defeat Stress

Ito, N., Sasaki, K., Takemoto, H., Kobayashi, Y., Isoda, H., & Odaguchi, H. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.023 · Cited by 12

Pinocembrin ameliorates depressive-like behaviors by regulating P2X7/TRL4 receptors expression in mouse hippocampus

Li, J., Hu, T., Jiang, C., & Wang, W. (2022) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000677 · Cited by 12

The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction

Liu, B.-P., Zhang, C., Zhang, Y., Li, K.-W., & Song, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277945 · Cited by 13

Comparative Analysis of HPA-Axis Dysregulation and Dynamic Molecular Mechanisms in Acute Versus Chronic Social Defeat Stress

Yang, J., Jia, Y., Guo, T., Zhang, S., Huang, J., Lu, H., Li, L., Xu, J., Liu, G., & Xiao, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136063 · Cited by 11

Apocynin Prevents Cigarette Smoke-Induced Anxiety-Like Behavior and Preserves Microglial Profiles in Male Mice

Alateeq, R., Akhtar, A., Luca, S. N. D., Chan, S. M. H., & Vlahos, R. (2024) · Antioxidants · doi:10.3390/antiox13070855 · Cited by 11

RasGRF1 participates in the protective effect of tanshinone IIA on depressive like behaviors of a chronic unpredictable mild stress induced mouse model

Cheng, Y., An, Q., Wang, J., Wang, Y., Dong, J., & Yin, J. (2020) · Gene · doi:10.1016/j.gene.2020.144817 · Cited by 11

Gastrodiae Rhizoma Water Extract Ameliorates Hypothalamic–Pituitary–Adrenal Axis Hyperactivity and Inflammation Induced by Chronic Unpredictable Mild Stress in Rats

Wang, M., Dong, W., Wang, R., Xu, X., Wu, Y., Sun, G., & Sun, X. (2020) · BioMed Research International · doi:10.1155/2020/8374614 · Cited by 11

Effect of Regular Physical Exercise on Gut Microbiota and Depressive Behaviors in Rats

Sheng, L., Wang, Y., Jiang, A., Zhou, Y., & Hong, Z. (2021) · Journal of Food Quality · doi:10.1155/2021/1210089 · Cited by 10

Minocycline as a potential anxiolytic drug: systematic review and meta-analysis of evidence in murine models

Iglesias, L. P., Soares, N., Asth, L., Moreira, F. A., & de Aguiar, D. C. (2023) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000754 · Cited by 8

Cannabidiol/cannabidiolic acid-rich hemp (Cannabis sativa L.) extract attenuates cognitive impairments and glial activations in rats exposed to chronic stress

Kamsrijai, U., Charoensup, R., Jaidee, W., Hawiset, T., Thaweethee-Sukjai, B., & Praman, S. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119113 · Cited by 9

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice

Hu, Y., Niu, T.-T., Xu, J., Peng, L., Sun, Q., Huang, Y., Zhou, J., & Ding, Y. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20144-x · Cited by 10

Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice

Kunisawa, K., Shan, J., Lu, Q., Yang, Y., Kosuge, A., Kurahashi, H., Saito, K., Zou, L., Nabeshima, T., & Mouri, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03692-z · Cited by 9

Promising immunomodulators for management of substance and alcohol use disorders

Acuña, A. M., Park, C., Leyrer‐Jackson, J. M., & Olive, M. F. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2360653 · Cited by 10

Targeting Phactr4 to rescue chronic stress-induced depression-like behavior in rats via regulating neuroinflammation and neuroplasticity

Li, Y., Chen, X., Lan, T., Wang, W., Wang, C., Chang, M., Yu, Z., & Yu, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132854 · Cited by 8

Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis

Bassett, B., Subramaniyam, S., Yang, F., Varney, S., Pan, H., Carneiro, A. M. D., & Chung, C. Y. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.009 · Cited by 221

Chronic stress-induced depression-like behaviors through Th1-lymphocytes and microglia-mediated neuroinflammation in the mouse

Zhang, C., Liu, B., Li, X., Charlier, T. D., Kunikullaya, K. U., Steinbusch, H. W. M., & Song, C. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178710 · Cited by 4

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663

7. The role of microglia in stress-induced depression

Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Menachem-Zidon, O. B., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.027 · Cited by 3

Microglial Activation Mediates Chronic Mild Stress-Induced Depressive- and Anxiety-like Behavior in Adult Rats

Wang, Y.-L., Han, Q.-Q., Gong, W.-Q., Pan, D.-H., Wang, L.-Z., Hu, W., Yang, M., Li, B., Yu, J., & Liu, Q. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1054-3 · Cited by 438