Antibiotics and mental health: the good, the bad and the ugly
Open accessAbstract
Antibiotics are recognised as, on occasion, producing psychiatric side effects, most notably depression and anxiety. Apart from antimicrobial activity, antibiotics have multiple off-target effects. The brain-gut-microbiota axis has multiple sites for off-target activity, which may produce either positive or negative antibiotic effects. Here we review how antibiotics impact mental health by acting through the brain-gut-microbiota axis. Microbes in the gut influence brain function by acting through the vagus nerve or by altering the production of short-chain fatty acids or the amino acid tryptophan, the building block of serotonin. Not all antimicrobial actions of antibiotics have a negative impact. The first antidepressant discovered was actually an antibiotic: isoniazid is an antibacterial drug developed for treating tuberculosis. Minocycline, which enters the brain and mediates its effects through microglia, shows antidepressant activity. Some antibiotics bring about a significant decrease in gut microbial diversity, and this is viewed as a risk factor for depression. Other risk factors induced by antibiotics include altered gut barrier function, activation of the hypothalamic-pituitary-adrenal axis, reducing levels of brain-derived neurotrophic factor or oxytocin and alteration of vagal tone. Although most patients taking antibiotics do not suffer from an iatrogenic psychiatric disorder, some do. As clinicians, we need to keep this in mind. The development of new antibiotics is primarily focused on antibiotic resistance, but efforts should be made to reduce off-target brain-gut-microbiota effects resulting in mental health problems.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The microbiota-gut-brain axis has multiple sites for off-target activity, which may lead to positive or negative neurocognitive effects downstream.
“Certainly, the MGB axis has multiple sites for off-target activity, which may lead to positive or negative neurocognitive effects downstream, emphasizing the importance of antibiotic stewardship (404–407).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [405]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Self-citationMetagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Self-citationParada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050 · see citing works
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works
Self-citationBercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Self-citationPrinciples and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
Moving pictures of the human microbiome
Caporaso, J. G., Lauber, C. L., Costello, E. K., Berg-Lyons, D., Gonzalez, A., Stombaugh, J., Knights, D., Gajer, P., Ravel, J., Fierer, N., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-r50 · Cited by 1,138 · see citing works
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952 · see citing works
Self-citationGut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945 · see citing works
Chen, Y., Xu, J., & Chen, Y. (2021) · Nutrients · doi:10.3390/nu13062099 · Cited by 917 · see citing works
Vagotomy and subsequent risk of <scp>P</scp> arkinson's disease
Svensson, E., Horváth‐Puhó, E., Thomsen, R. W., Djurhuus, J. C., Pedersen, L., Borghammer, P., & Sørensen, H. T. (2015) · Annals of Neurology · doi:10.1002/ana.24448 · Cited by 806 · see citing works
Impact of antibiotics on the human microbiome and consequences for host health
Patangia, D. V., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2022) · MicrobiologyOpen · doi:10.1002/mbo3.1260 · Cited by 806 · see citing works
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works
Self-citationPerturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 760 · see citing works
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 742 · see citing works
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases
Lin, L., & Zhang, J. (2017) · BMC Immunology · doi:10.1186/s12865-016-0187-3 · Cited by 731 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology
Dinan, T. G., & Cryan, J. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.007 · Cited by 577 · see citing works
Self-citationTryptophan metabolism and gut-brain homeostasis
Roth, W., Zadeh, K., Vekariya, R., Ge, Y., & Mohamadzadeh, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062973 · Cited by 519 · see citing works
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513 · see citing works
Microbiota and the social brain
Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462 · see citing works
Self-citationKöhler‐Forsberg, O., N. Lydholm, C., Hjorthøj, C., Nordentoft, M., Mors, O., & Benros, M. E. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13016 · Cited by 432 · see citing works
Knights, D., Ward, T. L., McKinlay, C. E., Miller, H., Gonzalez, A., McDonald, D., & Knight, R. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.013 · Cited by 396 · see citing works
The effect of antibiotics on the composition of the intestinal microbiota—a systematic review
Zimmermann, P., & Curtis, N. (2019) · Journal of Infection · doi:10.1016/j.jinf.2019.10.008 · Cited by 383 · see citing works
Brain–gut–microbiota axis — mood, metabolism and behaviour
Dinan, T. G., & Cryan, J. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.200 · Cited by 361 · see citing works
Self-citationMicrobiota regulate social behaviour via stress response neurons in the brain
Wu, W., Adame, M. D., Liou, C.-W., Barlow, J. T., Lai, T.-T., Sharon, G., Schretter, C. E., Needham, B. D., Wang, M., Tang, W., et al. (2021) · Nature · doi:10.1038/s41586-021-03669-y · Cited by 344 · see citing works
Probiotics and the microbiota-gut-brain axis: Focus on psychiatry
Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F., & Dinan, T. G. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00313-5 · Cited by 337 · see citing works
Self-citationPlasma oxytocin levels and anxiety in patients with major depression
Scantamburlo, G., Hansenne, M., Fuchs, S., Pitchot, W., Maréchal, P., Péqueux, C., Ansseau, M., & Legros, J. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.01.009 · Cited by 325 · see citing works
Romijn, A. R., Rucklidge, J. J., Kuijer, R. G., & Frampton, C. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416686694 · Cited by 323 · see citing works
Cytokines: abnormalities in major depression and implications for pharmacological treatment
O’Brien, S. M., Scott, L. V., & Dinan, T. G. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.609 · Cited by 321 · see citing works
Self-citationSherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 297 · see citing works
Self-citationChakrabarti, A., Geurts, L., Hoyles, L., Iozzo, P., Kraneveld, A. D., Fata, G. L., Miani, M., Patterson, E., Pot, B., Shortt, C., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04060-w · Cited by 252 · see citing works
Association of Infant Antibiotic Exposure With Childhood Health Outcomes
Aversa, Z., Atkinson, E. J., Schafer, M. J., Theiler, R. N., Rocca, W. A., Blaser, M. J., & LeBrasseur, N. K. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.019 · Cited by 235 · see citing works
Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis: A Nested Case-Control Study
Lurie, I., Yang, Y.-X., Haynes, K., Mamtani, R., & Boursi, B. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m09961 · Cited by 231 · see citing works
Anthony, W., Wang, B., Sukhum, K. V., D’Souza, A. W., Hink, T., Cass, C., Seiler, S. M., Reske, K. A., Coon, C., Dubberke, E. R., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110649 · Cited by 231 · see citing works
Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 225 · see citing works
Feng, Y., Huang, Y., Wang, Y., Wang, P., Song, H., & Wang, F. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218384 · Cited by 225 · see citing works
Miyaoka, T., Wake, R., Furuya, M., Liaury, K., Ieda, M., Kawakami, K., Tsuchie, K., Taki, M., Ishihara, K., Araki, T., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.002 · Cited by 212 · see citing works
A gut (microbiome) feeling about the brain
Sherwin, E., Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000244 · Cited by 206 · see citing works
Self-citationAntimicrobial susceptibility of bifidobacteria
Moubareck, C. A., Gavini, F., Vaugien, L., Butel, M. J., & Doucet‐Populaire, F. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh495 · Cited by 199 · see citing works
Roager, H. M., Licht, T. R., Poulsen, S. K., Larsen, T. M., & Bahl, M. I. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.03549-13 · Cited by 194 · see citing works
Zhang, C., Zhang, Y.-P., Li, Y.-Y., Liu, B.-P., Wang, H.-Y., Li, K.-W., Zhao, S., & Song, C. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.001 · Cited by 172 · see citing works
Wang, S., Ishima, T., Zhang, J., Qu, Y., Chang, L., Pu, Y., Fujita, Y., Tan, Y., Wang, X., & Hashimoto, K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01916-z · Cited by 172 · see citing works
Patterson, E., Ryan, P. M., Wiley, N., Carafa, I., Sherwin, E., Moloney, G., Franciosi, E., Mandal, R., Wishart, D. S., Tuohy, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51781-x · Cited by 168 · see citing works
Self-citationHusain, M. I., Chaudhry, I. B., Khoso, A. B., Husain, M. O., Hodsoll, J., Ansari, M. A., Naqvi, H. A., Minhas, F. A., Carvalho, A. F., Meyer, J. H., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30138-3 · Cited by 167 · see citing works
Microbiome therapeutics: exploring the present scenario and challenges
Yadav, M., & Chauhan, N. S. (2021) · Gastroenterology report · doi:10.1093/gastro/goab046 · Cited by 157 · see citing works
A review of antibiotics, depression, and the gut microbiome
Hao, W., Li, X., Zhang, P.-W., & Chen, J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112691 · Cited by 144 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Molteni, R., Calabrese, F., Bedogni, F., Tongiorgi, E., Fumagalli, F., Racagni, G., & Andrea Riva, M. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005766 · Cited by 132 · see citing works
Romick‐Rosendale, L. E., Haslam, D. B., Lane, A., Denson, L. A., Lake, K. E., Wilkey, A., Watanabe, M., Bauer, S. J., Litts, B., Luebbering, N., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.07.030 · Cited by 132 · see citing works
Xie, R., Jiang, P., Li, L., Jiang, J. H., Yu, B., Rao, J., Liu, H., Wei, W., & Qiao, Y. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.12.013 · Cited by 126 · see citing works
More than a gut feeling: the microbiota regulates neurodevelopment and behavior
Cryan, J. F., & Dinan, T. G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.224 · Cited by 124 · see citing works
Self-citationBistoletti, M., Caputi, V., Baranzini, N., Marchesi, N., Filpa, V., Marsilio, I., Cerantola, S., Terova, G., Baj, A., Grimaldi, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212856 · Cited by 108 · see citing works
Interactions Between the Immune and Neuroendocrine Systems
Rivest, S. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81004-7 · Cited by 106 · see citing works
Minocycline in neurodegenerative and psychiatric diseases: An update
Romero‐Miguel, D., Lamanna‐Rama, N., Casquero‐Veiga, M., Gómez‐Rangel, V., Desco, M., & Soto‐Montenegro, M. L. (2020) · European Journal of Neurology · doi:10.1111/ene.14642 · Cited by 95 · see citing works
Gut-brain axis: Focus on gut metabolites short-chain fatty acids
Guo, C., Huo, Y., Li, Y., Han, Y., & Zhou, D. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i6.1754 · Cited by 95 · see citing works
Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook
Mahri, S. A., Malik, S. S., Ibrahim, M. A., Haji, E. M., Dairi, G., & Mohammad, S. (2022) · Cells · doi:10.3390/cells11040750 · Cited by 94 · see citing works
Maski, K. P., Trotti, L. M., Kotagal, S., Auger, R. R., Swick, T. J., Rowley, J. A., Hashmi, S. D., & Watson, N. F. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9326 · Cited by 92 · see citing works
Høverstad, T., Carlstedt‐Duke, B., Lingaas, E., et al. (1986) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528609003109 · Cited by 91 · see citing works
Resistant starches and gut microbiota
Wen, J.-J., Li, M., Hu, J., Tan, H., & Nie, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132895 · Cited by 86 · see citing works
Chen, M.-H., Cheng, C.-M., Gueorguieva, R., Lin, W.-C., Li, C.-T., Hong, C.-J., Tu, P.-C., Bai, Y.-M., Tsai, S.-J., Krystal, J. H., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0480-y · Cited by 84 · see citing works
Oxytocin receptor expression patterns in the human brain across development
Rokicki, J., Kaufmann, T., de Lange, A. G., van der Meer, D., Bahrami, S., Sartorius, A. M., Haukvik, U. K., Steen, N. E., Schwarz, E., Stein, D. J., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01305-5 · Cited by 74 · see citing works
Neuropsychiatric Effects of Antimicrobial Agents
Zareifopoulos, N., & Panayiotakopoulos, G. D. (2017) · Clinical Drug Investigation · doi:10.1007/s40261-017-0498-z · Cited by 73 · see citing works
Kaur, K., Fayad, R., Saxena, A., Frizzell, N., Chanda, A., Das, S., Chatterjee, S., Hegde, S., Baliga, M., Ponemone, V., et al. (2016) · The Journal of Community and Supportive Oncology · doi:10.12788/jcso.0167 · Cited by 63 · see citing works
Zhao, Z., Wang, B., Mu, L., Wang, H., Luo, J., Yang, Y., Yang, H., Li, M., Zhou, L., & Tao, C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00258 · Cited by 57 · see citing works
Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period
Lach, G., Fülling, C., Bastiaanssen, T. F. S., Fouhy, F., Donovan, A. N. O., Ventura‐Silva, A. P., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01073-0 · Cited by 55 · see citing works
Self-citationImpact of intestinal disorders on central and peripheral nervous system diseases
El-Hakim, Y., Bake, S., Mani, K. K., & Sohrabji, F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105627 · Cited by 54 · see citing works
Gut microbiota: a missing link in psychiatry
Dinan, T. G., & Cryan, J. F. (2020) · World Psychiatry · doi:10.1002/wps.20726 · Cited by 53 · see citing works
Self-citationAasmets, O., Krigul, K. L., Lüll, K., Metspalu, A., & Org, E. (2022) · Nature Communications · doi:10.1038/s41467-022-28464-9 · Cited by 53 · see citing works
Christensen, L. H., Sørensen, C. V., Wøhlk, F. U., Kjølbæk, L., Astrup, A. V., Sanz, Y., Hjorth, M. F., & Benítez‐Páez, A. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1847627 · Cited by 52 · see citing works
Precision Medicine for Idiopathic Hypersomnia
Arnulf, I., Leu‐Semenescu, S., & Dodet, P. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.05.007 · Cited by 50 · see citing works
Chakraborty, R., Lam, V., Kommineni, S., Stromich, J. J., Hayward, M., Kristich, C. J., & Salzman, N. H. (2018) · Infection and Immunity · doi:10.1128/iai.00674-18 · Cited by 49 · see citing works
Inslicht, S. S., Niles, A. N., Metzler, T. J., Lipshitz, S. L., Otte, C., Milad, M. R., Orr, S. P., Marmar, C. R., & Neylan, T. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01222-z · Cited by 44 · see citing works
Moody microbiome: Challenges and chances
Kuo, P.-H., & Chung, Y.-C. E. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.09.004 · Cited by 40 · see citing works
d-Cycloserine ameliorates social alterations that result from prenatal exposure to valproic acid
Wellmann, K. A., Varlinskaya, E. I., & Mooney, S. M. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.08.001 · Cited by 39 · see citing works
Kennedy, P. J., Allen, A. P., O’Neill, A., Quigley, E. M. M., Cryan, J. F., Dinan, T. G., & Clarke, G. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3767-z · Cited by 39 · see citing works
Self-citationProduction of psychoactive metabolites by gut bacteria
Wiley, N. C., Cryan, J. F., Dinan, T. G., Ross, R. P., & Stanton, C. (2021) · Modern trends in psychiatry · doi:10.1159/000510419 · Cited by 37 · see citing works
Self-citationFrom isoniazid to psychobiotics: the gut microbiome as a new antidepressant target
Butler, M., Sandhu, K., Cryan, J. F., & Dinan, T. G. (2019) · British Journal of Hospital Medicine · doi:10.12968/hmed.2019.80.3.139 · Cited by 33 · see citing works
Self-citationCole, J., Selby, B., Ismail, Z., & McGirr, A. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.04.002 · Cited by 32 · see citing works
Zazula, R., Husain, M. I., Mohebbi, M., Walker, A. J., Chaudhry, I. B., Khoso, A. B., Ashton, M. M., Agustini, B., Husain, N., Deakin, J., et al. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420965697 · Cited by 31 · see citing works
Grassi, D., Marraudino, M., García‐Segura, L. M., & Panzica, G. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100974 · Cited by 30 · see citing works
Pierro, F. D. (2021) · Microorganisms · doi:10.3390/microorganisms9112341 · Cited by 29 · see citing works
Huang, M., Liu, K., Wei, Z., Feng, Z., Chen, J., Yang, J., Zhong, Q., Wan, G., & Kong, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721884 · Cited by 28 · see citing works
Utilization of Host and Microbiome Features in Determination of Biological Aging
Ratiner, K., Abdeen, S. K., Goldenberg, K., & Elinav, E. (2022) · Microorganisms · doi:10.3390/microorganisms10030668 · Cited by 27 · see citing works
Infections, antibiotic treatment and the Microbiome in relation to schizophrenia
Klein‐Petersen, A. W., Köhler‐Forsberg, O., & Benros, M. E. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.033 · Cited by 26 · see citing works
Liu, X., Zhang, J., Sang, Y., Liu, K., Zhu, Y., Yang, L., Wang, S., Sheng, J., Wang, Q., Zhang, D., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12560-2 · Cited by 26 · see citing works
Fu, Z., Jia, Q., Zhang, H., et al. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.462680 · Cited by 25 · see citing works
Histone deacetylase inhibitor sodium butyrate attenuates gentamicin-induced hearing loss in vivo
Wang, J., Wang, Y., Chen, X., et al. (2014) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2014.11.003 · Cited by 24 · see citing works
Lin, C., Chen, Y.-M., & Lane, H. (2019) · Current Drug Targets · doi:10.2174/1389450120666191011163539 · Cited by 23 · see citing works
Host genetics, the microbiome & behaviour—a ‘Holobiont’ perspective
Nagpal, J. K., & Cryan, J. F. (2021) · Cell Research · doi:10.1038/s41422-021-00512-x · Cited by 23 · see citing works
Fan, S., Li, L., Xian, X., Liu, L., Gao, J., & Li, W. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107480 · Cited by 22 · see citing works
Neurobiology of peripartum mental illness
Pawluski, J. L., Swain, J. E., & Lonstein, J. S. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00005-8 · Cited by 22 · see citing works
Dissection of depression heterogeneity using proteomic clusters
van Haeringen, M., Milaneschi, Y., Lamers, F., Penninx, B. W. J. H., & Jansen, R. (2022) · Psychological Medicine · doi:10.1017/s0033291721004888 · Cited by 22 · see citing works
Evaluation of antibiotic-induced behavioral changes in mice
Kwon, H., Mohammed, A. E., Eltom, K. H., Albrahim, J. S., & Alburae, N. A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113015 · Cited by 21 · see citing works
Wu, S. V., & Hui, H. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00009 · Cited by 20 · see citing works
van Andel, M., van Schoor, N. M., Korten, N. C. M., Heijboer, A. C., & Drent, M. L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.069 · Cited by 20 · see citing works
Oluwagbemigun, K., Schnermann, M. E., Schmid, M. C., Cryan, J. F., & Nöthlings, U. (2022) · Gut Pathogens · doi:10.1186/s13099-022-00487-z · Cited by 19 · see citing works
Minocycline Pretreatment Prevents Blood–Brain Barrier Disruption in Septic Rats
Yang, G., Cao, Y., Wang, P., Mei, L., Chen, J., & Lü, W. (2022) · Journal of Surgical Research · doi:10.1016/j.jss.2022.01.021 · Cited by 18 · see citing works
Psychotropic Drugs and the Microbiome
Cussotto, S., Clarke, G. A., Dinan, T. G., et al. (2021) · Modern trends in psychiatry · doi:10.1159/000510423 · Cited by 15 · see citing works
Self-citationWigton, R. L., Tracy, D. K., Verneuil, T., Johns, M., White, T. P., Michalopoulou, P. G., Averbeck, B. B., & Shergill, S. S. (2021) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2021.100221 · Cited by 14 · see citing works
Multiple facets of serotonergic modulation
Beyeler, A., Ju, A., Chagraoui, A., Cuvelle, L., Teixeira, M., Giovanni, G. D., & Deurwaerdère, P. D. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.02.002 · Cited by 13 · see citing works
Dangoor, I., Stanić, D., Reshef, L., Pešić, V., & Gophna, U. (2021) · Microorganisms · doi:10.3390/microorganisms9091938 · Cited by 11 · see citing works
Penicillin als Stimulans des hypophys�r-Adrenalen Systems
Beiglb�ck, W., & Clotten, R. (1952) · Journal of Molecular Medicine · doi:10.1007/bf01484983 · Cited by 9 · see citing works
Sun, Q., Wang, Z., Liu, X., et al. (2021) · PubMed · doi:10.7499/j.issn.1008-8830.2107103 · Cited by 5 · see citing works
Theiss, P., & Slavin, K. V. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.001 · Cited by 5 · see citing works
Oxytocin Neurons Are Essential in the Social Transmission of Maternal Behavior
Fang, X., Wang, Y., & Huang, Z. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.847396 · Cited by 3 · see citing works
Metagenomic Analyses of Bifidobacterial Communities
Milani, C. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1274-3_15 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [75]Beiglbock W, Clotten R. Penicillin as stimulant of the pituitary–adrenal system. Klin Wochenschr. 1952; 30(5‐6): 126– 8. 14939684
Cited by
Sorted by citations
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Wei, J., Liu, C., Qin, D., Ren, F., Duan, J., Chen, T., & Wu, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102544 · Cited by 15 · see citing works
- Authors
- Dinan, K., & Dinan, T.
- Affiliations
- Trinity College Dublin (IE)
- University College Cork (IE)
- Corresponding author
- Dinan, Timothy
- ORCID
- Dinan, Timothy
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2022-07-12
- Volume
- 292
- Issue
- 6
- Pages
- 858-869
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- PMC
- PMC9796968
- OpenAlex
- W4285040840
- Cited by
- 69
- References
- 114
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 22 · 2023: 13 · 2022: 8
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Internal Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by)
- Funders
- Science Foundation Ireland (SFI/12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- antibiotics, mental health, brain-gut-microbiota axis, depression, anxiety, psychiatric adverse effects, vagus nerve, short-chain fatty acids, tryptophan, serotonin, isoniazid, minocycline, microglia, gut microbiota diversity, intestinal barrier, hypothalamic-pituitary-adrenal axis, brain-derived neurotrophic factor, oxytocin, vagal tone
- MeSH terms
- Anti-Bacterial Agents, Antidepressive Agents, Brain, Humans, Hypothalamo-Hypophyseal System, Mental Health, Pituitary-Adrenal System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
