Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat
Open accessAbstract
Depression is a heterogeneous disorder and has been regarded as an inflammatory disease. The aerial parts of the Convolvulus pluricaulis are used in Indian traditional medicines for the management of nervous disorders. However, the influence of methanolic extract of aerial parts of Convolvulus pluricaulis (CPE) on a chronic animal model of depression has not been investigated yet, and associated biochemical changes are still unclear. Therefore, this study investigates the effects of CPE on a chronic rat model of depression and explores its underlying mechanism of action on neuroinflammation and brain monoamines. The antidepressant-like effect of CPE (25, 50, and 100 mg/kg, p.o.) was depicted using the sucrose preference test and the forced swimming test (FST) while CUMS-induced alteration in the locomotor index was measured using the open field test (OFT) and actophotometer. A consecutive one-week treatment of CPE (50, and 100 mg/kg) or fluoxetine (10 mg/kg, p.o.) treatment significantly increased sucrose preference index, reduced immobility time in the FST, and increased the number of squares crossed, the number of rearing in the OFT and locomotion in the actophotometer in the CUMS-exposed rats. Moreover, elevated levels of pro-inflammatory cytokines IL-1β, IL-6, TNF-α and liver biomarkers ALT, AST were also significantly reversed by CPE (50, and 100 mg/kg) or fluoxetine administration in the CUMS-exposed rats. Furthermore, a one-week treatment of CPE (50 and 100 mg/kg) or fluoxetine also remarkably restored the serotonin and noradrenaline levels in the hippocampus as well as in the prefrontal cortex of the CUMS-exposed rats. However, CPE (25 mg/kg) exerted insignificant protection against CUMS-induced depressive-like behavior and associated neuroinflammation. Therefore, this study demonstrates that CPE exerted antidepressant-like effect which could be mediated by anti-inflammatory potential, restoring liver biomarkers or monoaminergic responses in the stressed rats.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Convolvulus pluricaulis extract (50, 100 mg/kg) or fluoxetine decreases increased levels of IL-1, IL-6, TNF-, ALT, and AST in CUMS-exposed rats.
“CPE (50 and 100 mg/kg) or fluoxetine administration significantly decreased the increased levels of pro-inflammatory cytokines IL-1, IL-6, TNF-, and liver biomarkers ALT and AST in the CUMS-exposed rats.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [141]
Convolvulus pluricaulis extract has antidepressant-like impact on stressed rats, restoring liver biomarkers or monoaminergic responses, possibly mediated via anti-inflammatory potential.
“As a result, this study showed that CPE had an antidepressant-like impact on stressed rats, restoring liver biomarkers or monoaminergic responses, which might be mediated via anti-inflammatory potential [141].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [141]
In CUMS-exposed rats, fluoxetine or Convolvulus pluricaulis extract (50, 100 mg/kg) over one week increases sucrose preference index, decreases immobility time in FST, and increases squares crossed and locomotion.
“The study uncovers the effects of CP extract (CPE) on a chronic rat model of depression, and the findings revealed that in the (chronic unpredictable mild stress) CUMS-exposed rats, fluoxetine (10 mg/kg, p.o.) or CPE (50, and 100 mg/kg) treatments given back-to-back over one week markedly increased sucrose preference index, decreased immobility time in the FST, and increased the number of squares”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [141]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423 · see citing works
Trease and Evans' Pharmacognosy
Evans, W. C. (1978) · Andalas University Repository (Andalas University) · Cited by 1,231 · see citing works
Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.001 · Cited by 1,129 · see citing works
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.168 · Cited by 620 · see citing works
Reward and Punishment Processing in Depression
Eshel, N., & Roiser, J. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.027 · Cited by 575 · see citing works
Targeting glutamate signalling in depression: progress and prospects
Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.16 · Cited by 482 · see citing works
Trease and Evans' Pharmacognosy
Barnes, J. (1999) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.1999.tb01062.x · Cited by 474 · see citing works
Köhler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., de Andrade, N. Q., Morris, G., Fernandes, B. S., Brunoni, A. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0632-1 · Cited by 449 · see citing works
Effects of Cytokines on Cerebral Neurotransmission: Comparison with the Effects of Stress
Dunn, A. J., Wang, J., & Ando, T. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_8 · Cited by 316 · see citing works
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
Gerhard, D. M., Wohleb, E. S., & Duman, R. S. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.016 · Cited by 287 · see citing works
Barbour, M., Plevin, R., & Jiang, H.-R. (2016) · Scientific Reports · doi:10.1038/srep38999 · Cited by 206 · see citing works
Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress
Liu, Y., Shen, J.-D., Xu, L., Li, H., Li, Y., & Yi, L. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.02.007 · Cited by 184 · see citing works
Zhang, C., Zhang, Y.-P., Li, Y.-Y., Liu, B.-P., Wang, H.-Y., Li, K.-W., Zhao, S., & Song, C. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.001 · Cited by 172 · see citing works
Capra, J. C., Cunha, M. P., Machado, D. G., Zomkowski, A. D. E., Mendes, B. G., Santos, A. R. S., Pizzolatti, M. G., & Rodrigues, A. L. S. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.06.043 · Cited by 164 · see citing works
Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
Bihaqi, S. W., Sharma, M., Singh, A., & Tiwari, M. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.05.038 · Cited by 159 · see citing works
Cytokines as biomarkers in depressive disorder: current standing and prospects
Lichtblau, N., Schmidt, F. M., Schumann, R., Kirkby, K. C., & Himmerich, H. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.813442 · Cited by 155 · see citing works
Immune changes and neurotransmitters: Possible interactions in depression?
Sperner‐Unterweger, B., Kohl, C. A., & Fuchs, D. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.006 · Cited by 134 · see citing works
Cai, L., Li, R., Tang, W., Meng, G., Hu, X., & Wu, T. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.009 · Cited by 133 · see citing works
Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism?
Park, C., Brietzke, E. M., Rosenblat, J. D., Musial, N., Zuckerman, H., Ragguett, R., Pan, Z., Rong, C., Fus, D., & McIntyre, R. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.006 · Cited by 128 · see citing works
CHALLENGES OF TREATMENT-RESISTANT DEPRESSION
Pandarakalam, J. P. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.273 · Cited by 127 · see citing works
An update on Ayurvedic herb Convolvulus pluricaulis Choisy
Agarwa, P., Sharma, B., Fatima, A., & Jain, S. (2014) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(14)60240-9 · Cited by 112 · see citing works
Bihaqi, S. W., Singh, A., & Tiwari, M. (2012) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.100383 · Cited by 108 · see citing works
Involvement of α-MSH in the social isolation induced anxiety- and depression-like behaviors in rat
Kokare, D. M., Dandekar, M. P., Singru, P. S., Gupta, G. L., & Subhedar, N. K. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.006 · Cited by 107 · see citing works
Self-citationKim, H. J., Jang, S. I., Kim, Y., et al. (2004) · Fitoterapia · doi:10.1016/j.fitote.2003.12.021 · Cited by 105 · see citing works
Machado, D. G., Cunha, M. P., Neis, V. B., Balen, G. O., Colla, A. R. D. S., Grando, J., Brocardo, P. S., Bettio, L. E. B., Capra, J. C., & Rodrigues, A. L. S. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.08.024 · Cited by 94 · see citing works
Song, Y., Sun, R., Ji, Z., Li, X., Fu, Q., & Ma, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.05.038 · Cited by 91 · see citing works
Xue, J., Li, H., Deng, X., Ma, Z., Fu, Q., & Ma, S. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.04.014 · Cited by 88 · see citing works
Xu, P., Wang, K. Z., Lü, C., Dong, L., Zhai, J. L., Liao, Y. H., Aibai, S., Yang, Y., & Liu, X. M. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.09.023 · Cited by 77 · see citing works
Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression
Jia, H., Li, Q., Zhou, C., Yu, M., Yang, Y., Zhang, H., Ding, G., Shang, H., & Zou, Z. (2016) · Scientific Reports · doi:10.1038/srep23441 · Cited by 76 · see citing works
Qin, T., Fang, F., Song, M., Li, R., Ma, Z., & Ma, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.039 · Cited by 75 · see citing works
Liu, X., & Liu, C. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.04.019 · Cited by 75 · see citing works
MacMaster, F. P., CARREY, N. J., Langevin, L. M., Jaworska, N., & Crawford, S. G. (2013) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9264-x · Cited by 71 · see citing works
Dey, A., & Hankey Giblin, P. A. (2018) · Pharmaceuticals · doi:10.3390/ph11030064 · Cited by 65 · see citing works
Fan, C., Song, Q., Wang, P., Li, Y., Yang, M., Liu, B., & Yu, S. Y. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.028 · Cited by 65 · see citing works
Ge, J., Gao, W.-C., Cheng, W., Lu, W., Tang, J., Peng, L., Li, N., & Chen, F. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.05.007 · Cited by 64 · see citing works
Erburu, M. M., Muñoz-Cobo, I., Diaz-Perdigón, T., Mellini, P., Suzuki, T., Puerta, E., & Tordera, R. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.033 · Cited by 64 · see citing works
Zhu, X.-L., Chen, J., Han, F., Pan, C., Zhuang, T.-T., Cai, Y., & Lu, Y.-P. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4915-7 · Cited by 63 · see citing works
Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation
Dong, S., Zhang, Q., Zhu, J., Chen, M., Li, C., Liu, Q., Geng, D., & Yi, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.040 · Cited by 62 · see citing works
Effect of Convolvulus pluricaulis Chois on gastric ulceration and secretion in rats.
Sairam, K., Rao, C. V., & Goel, R. K. (2001) · PubMed · Cited by 60 · see citing works
A current update on phytochemistry, pharmacology and herb–drug interactions of Hypericum perforatum
Velingkar, V. S., Gupta, G. L., & Hegde, N. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-017-9503-7 · Cited by 58 · see citing works
Self-citationJia, K., Zheng, Y.-J., Zhang, Y., Liu, J.-H., Jiao, R., Pan, Y., & Kong, L. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.08.004 · Cited by 58 · see citing works
Anupama, K. P., Olakkaran, S., Antony, A., Kumbar, S. T., & Gurushankara, H. P. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.002 · Cited by 58 · see citing works
Anxiolytic activity of<i>Evolvulus alsinoides</i>and<i>Convulvulus pluricaulis</i>in rodents
Nahata, A., Patil, U. K., & Dixit, V. K. (2009) · Pharmaceutical Biology · doi:10.1080/13880200902822596 · Cited by 57 · see citing works
Kokare, D. M., Singru, P. S., Dandekar, M. P., Chopde, C. T., & Subhedar, N. K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.064 · Cited by 55 · see citing works
Risk assessment and serotonin: Animal models and human psychopathologies
Blanchard, D. C., & Meyza, K. Z. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.008 · Cited by 55 · see citing works
Rachitha, P., Krupashree, K., Jayashree, G. V., Kandikattu, H. K., Amruta, N., Gopalan, N., Rao, M. K., & Khanum, F. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.11.002 · Cited by 53 · see citing works
Jia, K., Pan, S., Ding, H., Liu, J.-H., Zheng, Y.-J., Wang, S., Pan, Y., & Kong, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.171 · Cited by 52 · see citing works
Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions
Gerhard, D. M., & Duman, R. S. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0139-8 · Cited by 52 · see citing works
Zu, X., Zhang, M., Li, W., Xie, H., Zhang, L., Yang, N., Liu, X., & Zhang, W. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2360-3 · Cited by 50 · see citing works
Martínez, P., Lien, L., Zemore, S. E., Bramness, J. G., & Neupane, S. P. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.02.011 · Cited by 50 · see citing works
Study of Convolvulus pluricaulis for Antioxidant and Anticonvulsant Activity
Verma, S., Sinha, R., Kumar, P., Amin, F., Jain, J., & Tanwar, S. (2012) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152412800229161 · Cited by 49 · see citing works
Li, Z., Yan, Z., Lan, F., Dong, Y.-Q., & Xiong, Y. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.085 · Cited by 48 · see citing works
Dhingra, D., & Valecha, R. (2007) · PubMed · Cited by 47 · see citing works
Thomas, J. M., Khanam, R., & Vohora, D. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.991837 · Cited by 47 · see citing works
Jia, H., Yu, M., Ma, L.-Y., Zhang, H., & Zou, Z. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.08.003 · Cited by 47 · see citing works
Wang, G., Wang, Y., Zheng, J., & Zhang, L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.05.035 · Cited by 47 · see citing works
Sharma, K., Bhatnagar, M., & Kulkarni, S. K. (2010) · PubMed · Cited by 46 · see citing works
Routine application of Raman spectroscopy in the quality control of hospital compounded ganciclovir
Amin, A., Bourget, P., Vidal, F., & Ader, F. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.08.028 · Cited by 45 · see citing works
Kumar, A., Prakash, A. K., & Pahwa, D. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.03.010 · Cited by 43 · see citing works
Malik, J., Karan, M., & Vasisht, K. (2016) · Natural Product Research · doi:10.1080/14786419.2015.1025398 · Cited by 41 · see citing works
Sethiya, N. K., & Mishra, S. H. (2010) · Australian journal of medical herbalism · Cited by 38 · see citing works
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., & Yang, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5517 · Cited by 37 · see citing works
Tricyclic Antidepressants and Monoamine Oxidase Inhibitors: Are They Too Old for a New Look?
Chockalingam, R., Gott, B. M., & Conway, C. R. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_133 · Cited by 37 · see citing works
Malik, J., Choudhary, S., & Kumar, P. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.984856 · Cited by 35 · see citing works
Wu, S., Guo, Y., Jiang, S., Wei, L., Liu, Z., Wang, X., & Su, Y. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2552-5 · Cited by 34 · see citing works
Yang, C., Bosker, F. J., Li, J., & Schoevers, R. A. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1845-1 · Cited by 34 · see citing works
Kaur, M., Prakash, A. K., & Kalia, A. N. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000022 · Cited by 31 · see citing works
Morphology supporting function: attenuation correction for SPECT/CT, PET/CT, and PET/MR imaging.
Lee, T. C., Alessio, A. M., Miyaoka, R. M., et al. (2016) · PubMed · Cited by 30 · see citing works
Siddiqui, N. A., Ahmad, N., Musthaq, N., Chattopadhyaya, I., Kumria, R., & Gupta, S. (2011) · The Open Neurology Journal · doi:10.2174/1874205x01408010011 · Cited by 29 · see citing works
Zhang, Y., Fan, K., Liu, Y., Liu, G., Yang, X., & Ma, J. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2320-y · Cited by 26 · see citing works
Jiang, H., Zheng, G., Lv, J., Chen, H., Lin, J.-J., Li, Y., Fan, G., & Ding, X. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/9634750 · Cited by 25 · see citing works
Current Rapid-Onset Antidepressants and Related Animal Models
Yan, K., Chen, Y., Wu, J. R., et al. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180727115222 · Cited by 25 · see citing works
Yawalkar, R., Changotra, H., & Gupta, G. L. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.04.011 · Cited by 23 · see citing works
Self-citationGarg, G., Patil, A., Singh, J., Kaushik, N., Praksah, A., Pal, A., & Chakrabarti, A. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13004 · Cited by 23 · see citing works
Effect of shankhpushpi on alcohol addiction in mice
Banerjee, S., Heba, M., & Faraz, S. (2017) · Pharmacognosy Magazine · doi:10.4103/0973-1296.203976 · Cited by 20 · see citing works
Pharmacologic implications of inflammatory comorbidity in bipolar disorder
Rosenblat, J. D., Gregory, J. M., & McIntyre, R. S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.06.007 · Cited by 19 · see citing works
Amin, H., Sharma, R., Vyas, M. K., et al. (2014) · International Journal of Green Pharmacy · doi:10.22377/ijgp.v8i4.413 · Cited by 16 · see citing works
Amin, H., Dhiman, K. S., Sharma, R., et al. (2014) · International Journal of Green Pharmacy · doi:10.4103/0973-8258.142666 · Cited by 16 · see citing works
Nootropic (medhya) effect of Bhāvita Śaṇkhapuṣpī tablets: A clinical appraisal
Amin, H., Sharma, R., Vyas, H., Vyas, M. K., Prajapati, P., & Dwivedi, R. (2014) · Ancient Science of Life · doi:10.4103/0257-7941.153476 · Cited by 14 · see citing works
Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity
Seth, A., Dhar, A., Maurya, S., Mishra, A., Singh, G., & Singh, M. (2016) · Ancient Science of Life · doi:10.4103/0257-7941.195410 · Cited by 13 · see citing works
Zhang, W., Wang, K., Li, Y., Li, Y.-R., & Lu, R.-Z. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.235060 · Cited by 13 · see citing works
Abdul Rahim, E., Mohd-Zain, Z., Hussaini, J., et al. (2017) · Malaysian Journal of Microbiology · doi:10.21161/mjm.96416 · Cited by 3 · see citing works
Zhang, Y., Fan, K., Liu, Y., et al. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2564-1 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Panossian, A. G., Efferth, T., Shikov, A. N., Pozharitskaya, O. N., Kuchta, K., Mukherjee, P. K., Banerjee, S., Heinrich, M., Wu, W., Guo, D., et al. (2021) · Medicinal Research Reviews · doi:10.1002/med.21743 · Cited by 347 · see citing works
Cordaro, M., Cuzzocrea, S., & Crupi, R. (2020) · Antioxidants · doi:10.3390/antiox9030216 · Cited by 98 · see citing works
Sharma, R., Singla, R. K., Banerjee, S., Sinha, B., Shen, B., & Sharma, R. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104795 · Cited by 81 · see citing works
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
- Authors
- Gupta, G. L., & Fernandes, J.
- Affiliations
- Narsee Monjee Institute of Management Studies (IN)
- Corresponding author
- Gupta, Girdhari Lal
- ORCID
- Gupta, Girdhari Lal
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 109
- Pages
- 1698-1708
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2901719908
- Cited by
- 55
- References
- 88
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 13 · 2021: 10 · 2020: 9 · 2019: 1
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- Convolvulus pluricaulis, antidepressant effects, neuroinflammation, chronic unpredictable mild stress, depression, methanol extract, inflammatory cytokines, liver biomarkers, monoamines, serotonin, norepinephrine, hippocampus, prefrontal cortex, fluoxetine, traditional medicine
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antidepressive Agents, Chronic Disease, Depression, Dose-Response Relationship, Drug, Male, Plant Extracts, Stress, Psychological, Rats, Wistar, Neuroprotective Agents, Inflammation Mediators, Convolvulus, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
