Altered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD)
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Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) carry the bulk of excitatory synaptic transmission. Their modulation plays key roles in synaptic plasticity, which underlies hippocampal learning and memory. A dysfunctional glutamatergic system may negatively affect learning abilities and underlie symptoms of attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to investigate whether the expression and function of AMPARs were altered in ADHD. We recorded AMPAR mediated synaptic transmission at hippocampal excitatory synapses and quantified immunogold labelling density of AMPAR subunits GluA1 and GluA2/3 in a rat model for ADHD; the spontaneously hypertensive rat (SHR). Electrophysiological recordings showed significantly reduced AMPAR mediated synaptic transmission at the CA3-to-CA1 pyramidal cell synapses in stratum radiatum and stratum oriens in SHRs compared to control rats. Electronmicroscopic immunogold quantifications did not show any statistically significant changes in labelling densities of the GluA1 subunit of the AMPAR on dendritic spines in stratum radiatum or in stratum oriens. However, there was a significant increase of the GluA2/3 subunit intracellularly in stratum oriens in SHR compared to control, interpreted as a compensatory effect. The proportion of synapses lacking AMPAR subunit labelling was the same in the two genotypes. In addition, electronmicroscopic examination of tissue morphology showed th…
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Glutamate signalling is the most common excitatory synapse NT and deficiencies in this signalling have been associated with ADHD symptoms, although it is unknown whether ADHD is associated with differences in glutamate levels.
“Glutamate signalling is the most common excitatory synapse NT [93] and deficiencies in this signalling has been associated with ADHD symptoms [94], although it is unknown whether ADHD is associated with differences in glutamate levels [95–97].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [94]
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Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730 · see citing works
Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder
Sagvolden, T., Aase, H., Zeiner, P., & Berger, D. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00170-8 · Cited by 345 · see citing works
Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses
Scassellati, C., Bonvicini, C., Faraone, S. V., & Gennarelli, M. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.015 · Cited by 235 · see citing works
Johansen, E. B., Aase, H., Meyer, A., & Sagvolden, T. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00434-x · Cited by 195 · see citing works
Scott, D. B., Blanpied, T. A., & Ehlers, M. D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00250-8 · Cited by 186 · see citing works
Di Filippo, M., Picconi, B., Tantucci, M., Ghiglieri, V., Bagetta, V., Sgobio, C., Tozzi, A., Parnetti, L., & Calabresi, P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.025 · Cited by 158 · see citing works
Aase, H., & Sagvolden, T. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01468.x · Cited by 92 · see citing works
Johansen, E. B., Killeen, P. R., & Sagvolden, T. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-60 · Cited by 56 · see citing works
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Quintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00392-2 · Cited by 70 · see citing works
- Authors
- Medin, T., Jensen, V., Skare, Ø., Storm-Mathisen, J., Hvalby, Ø., & Bergersen, L. H.
- Affiliations
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
- University of Copenhagen (DK)
- Corresponding author
- Medin, Tirill
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 360
- Pages
- 209-215
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2904137850
- Cited by
- 20
- References
- 8
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Molecular Life Science, University of Oslo, and the Research Council of Norway
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- AMPA receptors, attention deficit hyperactivity disorder, spontaneously hypertensive rats, hippocampus, GluA1 subunit, synaptic transmission, dendritic spines, CA3-CA1 synapses, glutamatergic system, synaptic plasticity, learning deficits
- MeSH terms
- Animals, Animals, Newborn, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Electric Stimulation, Hippocampus, Immunohistochemistry, Male, Microscopy, Electron, Rats, Inbred SHR, Rats, Inbred WKY, Synaptic Membranes, Pyramidal Cells, Receptors, AMPA, Excitatory Postsynaptic Potentials, Dendritic Spines, Rats, In Vitro Techniques
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