Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors

Scott, Derek B.; Blanpied, Thomas A.; Ehlers, Michael D.

doi:10.1016/s0028-3908(03)00250-8

Cited by 186Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingCellular transport and secretion

Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors

Scott, Derek B., Blanpied, Thomas A., Ehlers, Michael D.·2003·Neuropharmacology

DOI 10.1016/s0028-3908(03)00250-8

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Abstract

Endoplasmic reticulum (ER) retention mediated by the RXR (Arg-X-Arg) motif is an important quality control mechanism used by G-protein coupled receptors and ion channels, including N-methyl-D-aspartate (NMDA) receptors, to ensure the proper assembly and trafficking of multimeric complexes. During assembly, RXR motifs are masked by intersubunit interactions thereby allowing ER release. Here, we find that PKA and PKC phosphorylation sites flanking the RXR motif of the NMDA receptor NR1 subunit suppress ER retention and regulate receptor forward trafficking. These sites are differentially phosphorylated during the trafficking of NR1 subunits in vivo, and phosphorylation at these sites occurs in early secretory compartments. In addition, residues near the RXR motif not involved in phosphorylation are also required for ER retention. These results indicate that ER retention of NMDA receptors is tightly regulated, and suggest that coordinated phosphorylation by PKA and PKC mediates release of receptors from the ER for subsequent traffic to synapses. Phosphorylation-induced ER export of RXR-containing channels and receptors may serve as a novel quality control mechanism for creating a readily releasable pool of receptors sensitive to the activation of intracellular signaling pathways.

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Zerangue, N., Schwappach, B., Jan, Y. N., & Jan, L. Y. (1999) · Neuron · doi:10.1016/s0896-6273(00)80708-4 · Cited by 1,025 · see citing works
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Turrigiano, G. G., & Nelson, S. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00091-x · Cited by 687 · see citing works
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Margeta, M., Jan, Y. N., & Jan, L. Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00012-x · Cited by 680 · see citing works
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Quinlan, E., Philpot, B. D., Huganir, R., & Bear, M. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 614 · see citing works
Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells
Hirschberg, K., Miller, C. M., Ellenberg, J., Presley, J. F., Siggia, E. D., Phair, R. D., & Lippincott‐Schwartz, J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1485 · Cited by 610 · see citing works
Long-Term Depression in Hippocampus
Bear, M. F., & Abraham, W. C. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002253 · Cited by 601 · see citing works
Molecular determinants of NMDA receptor internalization
Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., & Wenthold, R. J. (2001) · Nature Neuroscience · doi:10.1038/90498 · Cited by 550 · see citing works
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Klauck, T. M., Faux, M. C., Labudda, K., Langeberg, L. K., Jaken, S., & Scott, J. D. (1996) · Science · doi:10.1126/science.271.5255.1589 · Cited by 550 · see citing works
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515 · see citing works
SIGNAL-MEDIATED SORTING OF MEMBRANE PROTEINS BETWEEN THE ENDOPLASMIC RETICULUM AND THE GOLGI APPARATUS
Teasdale, R. D., & Jackson, M. R. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.27 · Cited by 500 · see citing works
Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies
Tingley, W. G., Ehlers, M., Kameyama, K., Doherty, C., Ptak, J., Riley, C. T., & Huganir, R. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.8.5157 · Cited by 496 · see citing works
Self-citation
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Westphal, R. S., Tavalin, S. J., Lin, J., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., Sheng, M., & Scott, J. D. (1999) · Science · doi:10.1126/science.285.5424.93 · Cited by 492 · see citing works
A Di-Acidic Signal Required for Selective Export from the Endoplasmic Reticulum
Nishimura, N., & Balch, W. E. (1997) · Science · doi:10.1126/science.277.5325.556 · Cited by 488 · see citing works
Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467 · see citing works
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Lan, J.-Y., Skeberdis, V. A., Jover, T., Grooms, S. Y., Lin, Y., Araneda, R. C., Zheng, X., Bennett, M. V. L., & Zukin, R. S. (2001) · Nature Neuroscience · doi:10.1038/86028 · Cited by 421 · see citing works
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418 · see citing works
Self-citation
LTP mechanisms: from silence to four-lane traffic.
Malinow, R., Mainen, Z., & Hayashi, Y. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00099-4 · Cited by 397 · see citing works
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
Dunah, A. W., & Standaert, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05546.2001 · Cited by 374 · see citing works
Trafficking of NMDA Receptors
Wenthold, R. J., Prybylowski, K., Standley, S., Sans, N., & Petralia, R. S. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135803 · Cited by 363 · see citing works
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1
Grosshans, D. R., Clayton, D. A., Coultrap, S. J., & Browning, M. D. (2001) · Nature Neuroscience · doi:10.1038/nn779 · Cited by 354 · see citing works
PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants
Standley, S., Roche, K. W., McCallum, J. D., Sans, N., & Wenthold, R. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00161-6 · Cited by 346 · see citing works
A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (Mr32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor
Snyder, G. L., Fienberg, A. A., Huganir, R. L., & Greengard, P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10297.1998 · Cited by 327 · see citing works
Receptor trafficking and the plasticity of excitatory synapses
Barry, M. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00329-x · Cited by 307 · see citing works
Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts
Goodnight, J., Mischak, H., Kölch, W., & Mushinski, J. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.9991 · Cited by 300 · see citing works
NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity
Carroll, R. C., & Zukin, R. S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02272-5 · Cited by 298 · see citing works
NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity
Ali, D. W., & Salter, M. W. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00216-6 · Cited by 296 · see citing works
Yotiao, a Novel Protein of Neuromuscular Junction and Brain That Interacts with Specific Splice Variants of NMDA Receptor Subunit NR1
Lin, J., Wyszynski, M. W., Madhavan, R., Sealock, R. W., Kim, J. U., & Sheng, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02017.1998 · Cited by 296 · see citing works
Regulated Subcellular Distribution of the NR1 Subunit of the NMDA Receptor
Ehlers, M., Tingley, W. G., & Huganir, R. L. (1995) · Science · doi:10.1126/science.7569904 · Cited by 293 · see citing works
Self-citation
Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
Pérez‐Otaño, I., Schulteis, C. T., Contractor, A., Lipton, S. A., Trimmer, J. S., Sucher, N. J., & Heinemann, S. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01228.2001 · Cited by 286 · see citing works
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
Flores‐Hernández, J., Cepeda, C., Hernández, E., Calvert, C. R., Jokel, E. S., Fienberg, A. A., Greengard, P., & Levine, M. S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00361.2002 · Cited by 270 · see citing works
Alterations in Subunit Expression, Composition, and Phosphorylation of Striatal N-Methyl-d-Aspartate Glutamate Receptors in a Rat 6-Hydroxydopamine Model of Parkinson’s Disease
Dunah, A. W., Wang, Y., Yasuda, R. P., Kameyama, K., Huganir, R. L., Wolfe, B. B., & Standaert, D. G. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23206-5 · Cited by 262 · see citing works
Turnover Analysis of Glutamate Receptors Identifies a Rapidly Degraded Pool of the N-Methyl-d-aspartate Receptor Subunit, NR1, in Cultured Cerebellar Granule Cells
Huh, K.-H., & Wenthold, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.151 · Cited by 239 · see citing works
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Ma, D., Zerangue, N., Raab‐Graham, K. F., Fried, S. R., Jan, Y. N., & Jan, L. Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00614-1 · Cited by 214 · see citing works
Alternative Splicing of the C-Terminal Domain Regulates Cell Surface Expression of the NMDA Receptor NR1 Subunit
Okabe, S., Miwa, A., & Okado, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07781.1999 · Cited by 186 · see citing works
Efficient Export of the Vesicular Stomatitis Virus G Protein from the Endoplasmic Reticulum Requires a Signal in the Cytoplasmic Tail That Includes Both Tyrosine-based and Di-acidic Motifs
Sevier, C. S., Weisz, O. A., Davis, M., & Machamer, C. E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.1.13 · Cited by 180 · see citing works
Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells
Zerangue, N., Malan, M. J., Fried, S. R., Dazin, P. F., Jan, Y. N., Jan, L. Y., & Schwappach, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051630198 · Cited by 175 · see citing works
Coordinated Movement of RACK1 with Activated βIIPKC
Dorit Ron, A., Jiang, Z., Yao, L., Vagts, A. J., Diamond, I., & Gordon, A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27039 · Cited by 170 · see citing works
Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin
Gomez, L. L., Alam, S., Smith, K. E., Horne, E., & Dell'Acqua, M. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07027.2002 · Cited by 170 · see citing works
NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum
Huang, L. J.-S., Wang, L., Ma, Y., Durick, K., Perkins, G. A., Deerinck, T. J., Ellisman, M. H., & Taylor, S. S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.951 · Cited by 166 · see citing works
Assembly intracellular targeting and cell surface expression of the human N-methyl-D-aspartate receptor subunits NR1a and NR2A in transfected cells.
McIlhinney, R. A. J., Bourdellès, B. L., Molnár, E., Tricaud, N., Streit, P., & Whiting, P. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00121-x · Cited by 160 · see citing works
Relationship between Availability of NMDA Receptor Subunits and Their Expression at the Synapse
Prybylowski, K., Fu, Z., Losi, G., Hawkins, L. M., Luo, J., Chang, K., Wenthold, R. J., & Vicini, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08902.2002 · Cited by 154 · see citing works
Differential Surface Expression and Phosphorylation of the N-Methyl-D-aspartate Receptor Subunits NR1 and NR2 in Cultured Hippocampal Neurons
Hall, R. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4135 · Cited by 143 · see citing works
cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors
Crump, F. T., Dillman, K. S., & Craig, A. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05079.2001 · Cited by 138 · see citing works
Trafficking of L-type Calcium Channels Mediated by the Postsynaptic Scaffolding Protein AKAP79
Altier, C., Dubel, S. J., Barr�re, C., Jarvis, S. E., Stotz, S. C., Spaetgens, R. L., Scott, J. D., Cornet, V., WAARD, M. M. D., Zamponi, G. W., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202476200 · Cited by 128 · see citing works
Kinase Signaling Initiates Coat Complex II (COPII) Recruitment and Export from the Mammalian Endoplasmic Reticulum
Aridor, M., & Balch, W. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000449200 · Cited by 117 · see citing works
An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits
Xia, H., Hornby, Z. D., & Malenka, R. C. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00103-4 · Cited by 115 · see citing works
Chapter 4 Using Temperature-Sensitive Mutants of VSV to Study Membrane Protein Biogenesis
Bergmann, J. E. (1989) · Methods in cell biology · doi:10.1016/s0091-679x(08)61168-1 · Cited by 113 · see citing works
Targeting of PKA, PKC and protein phosphatases to cellular microdomains
Sim, A. T. R., & Scott, J. D. (1999) · Cell Calcium · doi:10.1054/ceca.1999.0072 · Cited by 96 · see citing works
Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex
Beaver, C. J., Ji, Q., Fischer, Q. S., & Daw, N. W. (2001) · Nature Neuroscience · doi:10.1038/83985 · Cited by 85 · see citing works
Mechanisms of CFTR regulation by syntaxin 1A and PKA
Chang, S. Y., Di, A., Naren, A. P., Palfrey, H. C., Kirk, K. L., & Nelson, D. J. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.783 · Cited by 62 · see citing works
Protein Kinase C (PKC)-induced Phosphorylation of ROMK1 Is Essential for the Surface Expression of ROMK1 Channels
Lin, D., Sterling, H., Lerea, K. M., Giebisch, G., & Wang, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203702200 · Cited by 60 · see citing works
Synergism of protein kinase A, protein kinase C, and myosin light-chain kinase in the secretory cascade of the pancreatic beta-cell.
Yu, W., Niwa, T., Fukasawa, T., Hidaka, H., Senda, T., Sasaki, Y., & Niki, I. (2000) · Diabetes · doi:10.2337/diabetes.49.6.945 · Cited by 59 · see citing works
AKAP350 at the Golgi Apparatus
Shanks, R. A., Steadman, B. T., Schmidt, P. H., & Goldenring, J. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203307200 · Cited by 43 · see citing works
Regulation of Phospholipase D and Secretion in Mast Cells by Protein Kinase A and Other Protein Kinases
Choi, W. S., Chahdi, A., Kim, Y. M., Fraundorfer, P. F., & Beaven, M. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04336.x · Cited by 30 · see citing works
Trafficking of Na,K-ATPase Fused to Enhanced Green Fluorescent Protein Is Mediated by Protein Kinase A or C
Kristensen, B. W., Birkelund, S., & Jørgensen, P. L. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-002-1043-3 · Cited by 22 · see citing works
The Export of Major Histocompatibility Complex Class I Molecules from the Endoplasmic Reticulum of Rat Brown Adipose Cells Is Acutely Stimulated by Insulin
Malide, D. A., Yewdell, J. W., Bennink, J. R., & Cushman, S. W. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.101 · Cited by 22 · see citing works

Flagged first, then by citations

1 of the 62 references couldn’t be matched to a known paper.

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Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,645 · see citing works
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Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568 · see citing works
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Structure, function, and allosteric modulation of NMDA receptors
Hansen, K. B., Yi, F., Perszyk, R. E., Furukawa, H., Wollmuth, L. P., Gibb, A. J., & Traynelis, S. F. (2018) · The Journal of General Physiology · doi:10.1085/jgp.201812032 · Cited by 574 · see citing works
Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516 · see citing works
“NMDAR phosphorylation by PKA, in turn, can affect the receptor’s release from the endoplasmic reticulum onto the surface [316].”
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FAN, M., & Raymond, L. A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.11.003 · Cited by 410 · see citing works
Regulation of NMDA receptors by phosphorylation
Chen, B.-S., & Roche, K. W. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.018 · Cited by 386 · see citing works
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Beck, R., Ravet, M., Wieland, F., & Cassel, D. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.032 · Cited by 305 · see citing works
The NMDA receptor as a target for cognitive enhancement
Collingridge, G. L., Volianskis, A., Bannister, N. J., France, G., Hanna, L., Mercier, M., Tidball, P., Fang, G., Irvine, M. W., Costa, B. M., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.051 · Cited by 239 · see citing works
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Snyder, M. A., & Gao, W. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00031 · Cited by 237 · see citing works
Hide and run. Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins
Michelsen, K., Yuan, H., & Schwappach, B. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400480 · Cited by 235 · see citing works
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Self-citation
Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC‐dependent site, serine‐896, in spinal cord dorsal horn neurons
Brenner, G. J., Ji, R., Shaffer, S., & Woolf, C. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03506.x · Cited by 132 · see citing works
Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post‐synaptic densities following transient global ischemia in the rat brain
Besshoh, S., Bawa, D., Teves, L. M., Wallace, M. C., & Gurd, J. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03009.x · Cited by 128 · see citing works
Dopamine Receptor Modulation of Hypoxic—Ischemic Neuronal Injury in Striatum of Newborn Piglets
Yang, Z.-J., Torbey, M., Li, X., Bernardy, J., Golden, W. C., Martin, L. J., & Koehler, R. C. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600440 · Cited by 127 · see citing works
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
Scott, D. B., Michailidis, I. E., Mu, Y., Logothetis, D. E., & Ehlers, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0780-04.2004 · Cited by 123 · see citing works
Self-citation
SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking
Lau, C. G., Takayasu, Y., Rodenas-Ruano, A., Paternain, A. V., Lerma, J., Bennett, M. V. L., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4933-08.2010 · Cited by 120 · see citing works
Assembly, organization, and function of the COPII coat
Hughes, H., & Stephens, D. J. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0363-x · Cited by 121 · see citing works
Phosphorylation of Ser1166 on GluN2B by PKA Is Critical to Synaptic NMDA Receptor Function and Ca2+Signaling in Spines
Murphy, J. A., Stein, I. S., Lau, C. G., Peixoto, R. T., Aman, T. K., Kaneko, N., Aromolaran, K. A., Saulnier, J. L., Popescu, G., Sabatini, B. L., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4538-13.2014 · Cited by 115 · see citing works
Chronic Lithium Chloride Administration Attenuates Brain NMDA Receptor-Initiated Signaling via Arachidonic Acid in Unanesthetized Rats
Basselin, M., Chang, L., Bell, J. M., & Rapoport, S. I. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300920 · Cited by 114 · see citing works
Learning from NMDA Receptor Trafficking: Clues to the Development and Maturation of Glutamatergic Synapses
Pérez‐Otaño, I., & Ehlers, M. (2004) · Neurosignals · doi:10.1159/000077524 · Cited by 112 · see citing works
Self-citation
Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness
McCullumsmith, R. E., Hammond, J. H., Shan, D., & Meador‐Woodruff, J. H. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.239 · Cited by 110 · see citing works
Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain
Rondón, L. J., Privat, A. M., Daulhac, L., Davin, N., Mazur, A., Fialip, J., Eschalier, A., & Courteix, C. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.197004 · Cited by 107 · see citing works
PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport
Palmer, K. J., Konkel, J. E., & Stephens, D. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.02496 · Cited by 99 · see citing works
Involvement of a Dysfunctional Dopamine-D1/N-Methyl-d-aspartate-NR1 and Ca2+/Calmodulin-Dependent Protein Kinase II Pathway in the Impairment of Latent Learning in a Model of Schizophrenia Induced by Phencyclidine
Mouri, A., Noda, Y., Noda, A., Nakamura, T., Tokura, T., Yura, Y., Nitta, A., Furukawa, H., & Nabeshima, T. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.032961 · Cited by 96 · see citing works
Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cells
Hallaq, H., Yang, Z., VISWANATHAN, P., Fukuda, K., SHEN, W., WANG, D., Wells, K. S., ZHOU, J., YI, J., & Murray, K. J. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.007 · Cited by 95 · see citing works
Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat
Tang, B., Ji, Y., & Traub, R. J. (2008) · Pain · doi:10.1016/j.pain.2007.10.017 · Cited by 93 · see citing works
Functions of intrinsic disorder in transmembrane proteins
Kjærgaard, M., & Kragelund, B. B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2562-5 · Cited by 90 · see citing works
Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat
Coultrap, S. J., Nixon, K. M., Alvestad, R. M., Valenzuela, C. F., & Browning, M. D. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.005 · Cited by 86 · see citing works
N ‐ethylmaleimide‐sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation
Katano, T., Furue, H., Okuda‐Ashitaka, E., Tagaya, M., Watanabe, M., Yoshimura, M., & Ito, S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06293.x · Cited by 85 · see citing works
Role of Electrostatic Interaction in Receptor–Receptor Heteromerization
Woods, A. S., Ciruela, F., Fuxé, K., Agnati, L. F., Lluís, C., Franco, R., & Ferré, S. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:125 · Cited by 82 · see citing works
Different Roles of C-terminal Cassettes in the Trafficking of Full-length NR1 Subunits to the Cell Surface*
Horak, M., & Wenthold, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807050200 · Cited by 83 · see citing works
Ethanol Alters Trafficking and Functional N-Methyl-D-aspartate Receptor NR2 Subunit Ratio via H-Ras
Suvarna, N. U., Borgland, S. L., Wang, J., Phamluong, K., Auberson, Y. P., Bonci, A., & Dorit Ron, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504120200 · Cited by 79 · see citing works
Effects of Chronic Electroacupuncture on Depression‐ and Anxiety‐Like Behaviors in Rats with Chronic Neuropathic Pain
Li, Q., Yue, N., Liu, S., Wang, Z., Mi, W., Jiang, J., Wu, G.-C., Yu, J. M., & Wang, Y.-Q. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/158987 · Cited by 79 · see citing works
14-3-3 proteins: regulation of endoplasmic reticulum localization and surface expression of membrane proteins
Shikano, S., Coblitz, B., Wu, M., & Li, M. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.05.006 · Cited by 79 · see citing works
Membrane Proteins as 14-3-3 Clients in Functional Regulation and Intracellular Transport
Smith, A. J., Daut, J., & Schwappach, B. (2011) · Physiology · doi:10.1152/physiol.00042.2010 · Cited by 75 · see citing works
Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus
Jouvenceau, A., Hédou, G., Potier, B., Kollen, M., Dutar, P., & Mansuy, I. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04938.x · Cited by 74 · see citing works
Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates
Tillo, S., Xiong, W.-H., Takahashi, M., Miao, S., Andrade, A. L., Fortin, D. A., Yang, G., Qin, M., Smoody, B. F., Stork, P. A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.070 · Cited by 69 · see citing works
Estructura y función de las subunidades del receptor a glutamato tipo NMDA
Flores-Soto, M. E., Chaparro-Huerta, V., Escoto-Delgadillo, M., Vázquez-Valls, E., González-Castañeda, R. E., & Beas‐Zárate, C. (2012) · Neurología · doi:10.1016/j.nrl.2011.10.014 · Cited by 66 · see citing works
Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn
Yang, X. Z., Yang, H., Xie, Q., Liu, X.-H., & Hu, X. (2009) · Pain · doi:10.1016/j.pain.2009.04.005 · Cited by 64 · see citing works
Structure and function of NMDA-type glutamate receptor subunits
Flores-Soto, M. E., Chaparro-Huerta, V., Escoto-Delgadillo, M., Vázquez-Valls, E., González-Castañeda, R. E., & Beas‐Zárate, C. (2012) · Neurología (English Edition) · doi:10.1016/j.nrleng.2011.10.003 · Cited by 63 · see citing works
Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons
Yang, Z.-J., Carter, E. L., Torbey, M., Martin, L. J., & Koehler, R. C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.019 · Cited by 62 · see citing works
A Phosphorylation-dependent Export Structure in ROMK (Kir 1.1) Channel Overrides an Endoplasmic Reticulum Localization Signal
Yoo, D. S., Fang, L., Mason, A., Kim, B. Y., & Welling, P. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504836200 · Cited by 59 · see citing works
NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain
Liu, Y., Li, Y., Fang, Z., Liao, H.-L., Zhang, Y., Lin, J., Liu, F., & Shen, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.999509 · Cited by 60 · see citing works
The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs
Górska, A. M., & Eugenín, E. A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00261 · Cited by 56 · see citing works
Dopamine D1receptor‐mediated enhancement of NMDA receptor trafficking requires rapid PKC‐dependent synaptic insertion in the prefrontal neurons
Li, Y., Liu, G., Hu, J., Gao, W., & Huang, Y. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06720.x · Cited by 55 · see citing works
Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: Involvement of ERK1/2 signaling
Sarantis, K., Matsokis, N. A., & Angelatou, F. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.056 · Cited by 55 · see citing works
Spinal Cord NR1 Serine Phosphorylation and NR2B Subunit Suppression following Peripheral Inflammation
Caudle, R. M., Perez, F. M., Valle-Pinero, A. Y. D., & Iadarola, M. J. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-25 · Cited by 54 · see citing works
Activity-Dependent Anchoring of Importin α at the Synapse Involves Regulated Binding to the Cytoplasmic Tail of the NR1-1a Subunit of the NMDA Receptor
Jeffrey, R., Ch’ng, T. H., O’Dell, T. J., & Martin, K. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3314-09.2009 · Cited by 53 · see citing works
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K + channel (ROMK)
O'Connell, A. D., Leng, Q., Dong, K., MacGregor, G. G., Giebisch, G., & Hébert, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504332102 · Cited by 53 · see citing works
How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington’s Disease? A Comprehensive Review
Lontay, B., Kiss, A., Virág, L., & Tar, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124282 · Cited by 52 · see citing works
Calcium Sensing Receptor Mutations Implicated in Pancreatitis and Idiopathic Epilepsy Syndrome Disrupt an Arginine-rich Retention Motif
Stepanchick, A. N., McKenna, J., McGovern, O. L., Huang, Y. S., & Breitwieser, G. E. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000320560 · Cited by 51 · see citing works
RETRACTED: Repeated electro-acupuncture attenuates chronic visceral hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat irritable bowel syndrome model
Tian, S.-L., Wang, X., & Ding, G. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.06.027 · Cited by 51 · see citing works
Retracted
The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease
Warnet, X. L., Bakke Krog, H., Sevillano‐Quispe, O. G., Poulsen, H., & Kjaergaard, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14842 · Cited by 50 · see citing works
Scaffolding protein Homer1a protects against NMDA-induced neuronal injury
Wang, Y., Rao, W., Zhang, C., Zhang, C., Liu, M.-D., Han, F., Yao, L.-B., Han, H., Luo, P., Su, N., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.216 · Cited by 49 · see citing works
Differential Regulation of Kainate Receptor Trafficking by Phosphorylation of Distinct Sites on GluR6
Nasu‐Nishimura, Y., Jaffe, H., Isaac, J. T. R., & Roche, K. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081141 · Cited by 50 · see citing works
Influences of dopamine and glutamate in the medial preoptic area on male sexual behavior
Will, R. G., Hull, E. M., & Dominguez, J. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.02.005 · Cited by 50 · see citing works
Silencing of the Tandem Pore Domain Halothane-inhibited K+ Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane
Chatelain, F. C., Bichet, D., Feliciangeli, S. F., Larroque, M. M., Braud, V. M., Douguet, D., & Lesage, F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.503318 · Cited by 49 · see citing works
Magnesium enhances opioid-induced analgesia – What we have learnt in the past decades?
Bujalska‐Zadrożny, M., Tatarkiewicz, J., Kulik, K., Filip, M., & Naruszewicz, M. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.11.020 · Cited by 49 · see citing works
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus
Niimura, M., Moussa, R. A.-G., Bissoon, N., Ikeda-Douglas, C. J., Milgram, N. W., & Gurd, J. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.02977.x · Cited by 49 · see citing works
NMDA Receptor Phosphorylation at a Site Affected in Schizophrenia Controls Synaptic and Behavioral Plasticity
Li, B., Devidze, N., Barengolts, D., Prostak, N., Sphicas, E., Apicella, A. J., Malinow, R., & Emamian, E. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2109-09.2009 · Cited by 48 · see citing works
The Human Immunodeficiency Virus Coat Protein gp120 Promotes Forward Trafficking and Surface Clustering of NMDA Receptors in Membrane Microdomains
Xu, H., Bae, M. H., Tovar‐y‐Romo, L. B., Patel, N. P., Bandaru, V. V. R., Pomerantz, D. J., Steiner, J. P., & Haughey, N. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4072-11.2011 · Cited by 48 · see citing works
siRNA-Mediated Knockdown of the NR1 Subunit Gene of the NMDA Receptor Attenuates Formalin-Induced Pain Behaviors in Adult Rats
Garraway, S. M., Xu, Q., & Inturrisi, C. E. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.09.013 · Cited by 47 · see citing works
Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus
Sarantis, K., Antoniou, K., Matsokis, N. A., & Angelatou, F. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.018 · Cited by 46 · see citing works
S-acylation regulates Kv1.5 channel surface expression
Zhang, L., Foster, K., Li, Q., & Martens, J. R. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00480.2006 · Cited by 46 · see citing works
Phosphorylation Regulates Removal of Synaptic N-Methyl-d-Aspartate Receptors after Withdrawal from Chronic Ethanol Exposure
Clapp, P., Gibson, E. S., Dell’Acqua, M. L., & Hoffman, P. L. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.158741 · Cited by 45 · see citing works
Phosphorylation-dependent C-terminal Binding of 14-3-3 Proteins Promotes Cell Surface Expression of HIV Co-receptor GPR15
Okamoto, Y., & Shikano, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199695 · Cited by 43 · see citing works
Mechanisms of HIV-tat-Induced Phosphorylation of N-Methyl-d-Aspartate Receptor Subunit 2A in Human Primary Neurons
King, J. E., Eugenin, E. A., Hazleton, J. E., Morgello, S., & Berman, J. W. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090642 · Cited by 43 · see citing works
Prostaglandin E2Promotes Nav1.8 Trafficking via Its Intracellular RRR Motif Through the Protein Kinase A Pathway
Liu, C., Li, Q., Su, Y., & Bao, L. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.01027.x · Cited by 42 · see citing works
mGluR5 Upregulation Increases Excitability of Hypothalamic Presympathetic Neurons through NMDA Receptor Trafficking in Spontaneously Hypertensive Rats
Li, D., Zhu, L.-H., Pachuau, J., Lee, H., & Pan, H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4295-13.2014 · Cited by 42 · see citing works
MLC1 trafficking and membrane expression in astrocytes: Role of caveolin-1 and phosphorylation
Lanciotti, A., Brignone, M. S., Camerini, S., Serafini, B., Macchia, G., Raggi, C., Molinari, P., Crescenzi, M., Musumeci, M., Sargiacomo, M., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.008 · Cited by 41 · see citing works
Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy
Marchetti, C., Tafi, E., Middei, S., Rubinacci, M. A., Restivo, L., Ammassari‐Teule, M., & Marie, H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.017 · Cited by 41 · see citing works
Trafficking and Targeting of NMDA Receptors
Petralia, R. S., Wenthold, R. J., & Al‐Hallaq, R. A. (2008) · Frontiers in neuroscience · doi:10.1201/9781420044157.ch8 · Cited by 41 · see citing works
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain
Choi, S., Moon, J.-Y., Roh, D., Yoon, S. Y., Kwon, S. G., Choi, H., Kang, S.-Y., Han, H., Beitz, A. J., & Lee, J. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.12.002 · Cited by 40 · see citing works
Golgi structural stability and biogenesis depend on associated PKA activity
Bejarano, E., Cabrera, M., Vega, L., Hidalgo, J., & Velasco, A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03146 · Cited by 40 · see citing works
Targeting N-Methyl-d-Aspartate Receptors in Neurodegenerative Diseases
Carles, A., Freyssin, A., Perin-Dureau, F., Rubinstenn, G., & Maurice, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073733 · Cited by 42 · see citing works
GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn
Cao, J., Yang, X. Z., Liu, Y., Suo, Z., Shi, L., Zheng, C., Yang, H., Li, S., & Hu, X. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.034 · Cited by 39 · see citing works
MLC1 protein: a likely link between leukodystrophies and brain channelopathies
Brignone, M. S., Lanciotti, A., Camerini, S., Nuccio, C. D., Petrucci, T. C., Visentin, S., & Ambrosini, E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00106 · Cited by 39 · see citing works
CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice
Vingtdeux, V., Chang, E. H., Frattini, S. A., Zhao, H., Chandakkar, P., Adrien, L. R., Strohl, J. J., Gibson, E. L., Ohmoto, M., Matsumoto, I., et al. (2016) · Scientific Reports · doi:10.1038/srep24250 · Cited by 36 · see citing works
The role of cyclin-dependent kinase 5 in neuropathic pain
Gómez, K., Vallecillo, T., Moutal, A., Perez‐Miller, S., Delgado‐Lezama, R., Felix, R., & Khanna, R. (2020) · Pain · doi:10.1097/j.pain.0000000000002027 · Cited by 38 · see citing works
Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia–ischemia in newborn piglet striatum
Yang, Z.-J., Ni, X., Carter, E. L., Kibler, K. K., Martin, L. J., & Koehler, R. C. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.018 · Cited by 37 · see citing works
Dendritic trafficking for neuronal growth and plasticity
Ehlers, M. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130081 · Cited by 36 · see citing works
Self-citation
The RCC1 Domain of Protein Associated with Myc (PAM) Interacts with and Regulates KCC2
Garbarini, N., & Delpire, E. J. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000149781 · Cited by 36 · see citing works
Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease
Tsang, S. W. Y., Pomakian, J., Marshall, G. A., Vinters, H. V., Cummings, J. L., Chen, C., Wong, P. T. ‐., & Lai, M. K. P. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.001 · Cited by 35 · see citing works
Running to Stand Still: Ionotropic Receptor Dynamics at Central and Peripheral Synapses
Bruneau, E., & Akaaboune, M. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:137 · Cited by 34 · see citing works
Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity
Yang, J., Hertz, E., Zhang, X., Leinartaité, L., Lundius, E. G., Li, J., & Svenningsson, P. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.11.023 · Cited by 33 · see citing works
Immobilization of titanium dioxide/ions on magnetic microspheres for enhanced recognition and extraction of mono- and multi-phosphopeptides
Wang, J., Wang, Z., Sun, N., & Deng, C. (2019) · Microchimica Acta · doi:10.1007/s00604-019-3346-4 · Cited by 33 · see citing works
Adenosine A 2A Receptor Contributes to Ischemic Brain Damage in Newborn Piglet
Yang, Z.-J., Wang, B., Kwansa, H. E., Heitmiller, K., Hong, G., Carter, E. L., Jamrogowicz, J. L., Larson, A. C., Martin, L. J., & Koehler, R. C. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.117 · Cited by 32 · see citing works
Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid
Severino, P. C., Muller, G. D. A. S., Vandresen-Filho, S., & Tasca, C. I. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.05.014 · Cited by 32 · see citing works

An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418 · see citing works
Self-citation
An Endoplasmic Reticulum Retention Signal Located in the Extracellular Amino-terminal Domain of the NR2A Subunit of N-Methyl-d-aspartate Receptors
Qiu, S., Zhang, X., Cao, J.-Y., Yang, W., Yan, Y.-G., Shan, L., Zheng, J., & Luo, J.-H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004960 · Cited by 55 · see citing works
Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors
Fang, X.-Q., Qiao, H., Groveman, B. R., Feng, S., Pflueger, M., Xin, W.-K., Ali, M. K., Lin, S.-X., Xu, J., Duclot, F., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0167-1 · Cited by 10 · see citing works
SAP97 blocks the RXR ER retention signal of NMDA receptor subunit GluN1-3 through its SH3 domain
Hong, X., Avetisyan, M., Ronilo, M., & Standley, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.11.030 · Cited by 7 · see citing works
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K + channel (ROMK)
O'Connell, A. D., Leng, Q., Dong, K., MacGregor, G. G., Giebisch, G., & Hébert, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504332102 · Cited by 53 · see citing works

Authors: Scott, D. B., Blanpied, T. A., & Ehlers, M. D.
Affiliations: Duke Medical Center (US)
Duke University (US)
Corresponding author: Ehlers, Michael D.
ORCID: Blanpied, Thomas A.
Ehlers, Michael D.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2003-11
Volume: 45
Issue: 6
Pages: 755-767
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/s0028-3908(03)00250-8
OpenAlex: W2052488789
Cited by: 186
References: 62
Citations by year: 2025: 2 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 6
FWCI: 4.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (F31 AA13220, F31AA013220)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: NMDA receptor, NR1 subunit, endoplasmic reticulum retention, protein kinase A, protein kinase C, phosphorylation, receptor trafficking, ER export, quality control, G protein-coupled receptors, ion channels
MeSH terms: Amino Acid Sequence, Animals, Arginine, Cell Membrane, Chlorocebus aethiops, Endoplasmic Reticulum, Humans, Molecular Sequence Data, Neurons, Phosphorylation, Protein Kinase C, Receptors, N-Methyl-D-Aspartate, Cyclic AMP-Dependent Protein Kinases, COS Cells, Amino Acid Motifs, Rats

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Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors

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