Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice
Abstract
Several studies have shown that oxytocin (OXT) modulates social behavior. Similarly, monoamines such as dopamine (DA) play a role in regulating social behavior. Previous studies have demonstrated that the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) protein syntaxin 1A (STX1A) regulates the secretion of OXT and monoamines, and that STX1A gene knockout (STX1A KO) mice exhibit atypical social behavior, such as deficient social recognition, due to reduced OXT release. In this study, we analyzed the neural mechanism regulating social behavior by OXT and/or DA using STX1A KO mice as a model animal. We found that OXT directly induced DA release from cultured DA neurons through OXT and V1a receptors. In STX1A KO mice, the atypical social behavior was partially improved by OXT administration, which was inhibited by D1 receptor blockade. In addition, the atypical social behavior in STX1A KO mice was partially improved by facilitation of DAergic signaling with the DA reuptake inhibitor GBR12909. Moreover, the amelioration by GBR12909 was inhibited by OXTR blockade. These results suggest that the reciprocal interaction between the DAergic and OXTergic neuronal systems in the CNS may be important in regulating social behavior.
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This enhancement in the social response was subsequently followed by a reduction in DA release in the striatum.
“This enhancement in the social response was subsequently followed by a reduction in DA release in the striatum (Fujiwara et al., 2021).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Fujiwara et al., 2021
i.c.v. OXT administration elevated social novelty preference in HPC-1 syntaxin 1A (Stx1a) KO mice, another animal model exhibiting autism-like behaviour.
“Similarly, i.c.v. OXT administration elevated social novelty preference in HPC-1 syntaxin 1 A ( Stx1a ) KO mice, another animal model exhibiting autism-like behaviour.”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Fujiwara et al., 2021
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Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51 · see citing works
“This enhancement in the social response was subsequently followed by a reduction in DA release in the striatum (Fujiwara et al., 2021).”
Background
- Authors
- Fujiwara, T., Kofuji, T., & Akagawa, K.
- Affiliations
- Kyorin University (JP)
- Corresponding author
- Fujiwara, Tomonori
- ORCID
- Fujiwara, Tomonori
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 413
- Pages
- 113447
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W3181349097
- Cited by
- 6
- References
- 8
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Government of Japan Ministry of Education Culture Sports Science and Technology (16K01954, 16K07064)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, dopamine, syntaxin 1A, social behavior, oxytocin receptor, dopamine D1 receptor, GBR 12909, dopamine uptake inhibition, V1a receptor, SNARE proteins, neurotransmitter release, social recognition, knockout mice
- MeSH terms
- Animals, Behavioral Symptoms, Cells, Cultured, Central Nervous System, Chemotactic Factors, Disease Models, Animal, Dopamine, Oxytocin, Piperazines, Social Behavior, Receptors, Dopamine D1, Receptors, Oxytocin, Mice, Knockout, Dopamine Antagonists, Syntaxin 1, Mice, Dopaminergic Neurons
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