Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice
Abstract
Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.
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The oxytocin and vasopressin systems are involved in recognising individuals as familiar.
“The OT and AVP systems are also involved in more subtle aspects of social cognition, including recognising individuals as familiar (8,9).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [9]
V1aR and V1bR are expressed in the brain and are the most well-known mediators of VP effects on social behavior.
“V1aR and V1bR are both expressed in the brain and are the most well-known mediators of the effects of VP in the brain on social behavior.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Bielsky et al., 2004
V1aR has been implicated in pair bonding, maternal care, aggression, social recognition, and social play.
“V1aR has been implicated in pair bonding, maternal care, aggression, social recognition, and social play”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Bielsky et al., 2004
Oxytocin can bind to AVPR1A receptors, which have been linked to social functioning.
“Finally, oxytocin can also bind to AVPR1A receptors25, which have also been linked to social functioning26.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [26]
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- Authors
- Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J.
- Affiliations
- Emory University (US)
- National Institutes of Health (US)
- Corresponding author
- Bielsky, Isadora F
- ORCID
- Young, Larry J
- Venue
- Neuropsychopharmacology
- Published
- 2003-11-26
- Volume
- 29
- Issue
- 3
- Pages
- 483-493
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2084931825
- Cited by
- 531
- References
- 52
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 26 · 2021: 24 · 2020: 15 · 2019: 20 · 2018: 19 · 2017: 26 · 2016: 21 · 2015: 21 · 2014: 35 · 2013: 30 · 2012: 25
- FWCI
- 32.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9876754)
- National Institutes of Health (NIH-R01, IBN-9876754, RR‐00165)
- National Institute of Mental Health (K02MH064692, R01 MH56897, K02 MH64692, R01MH056897)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, vasopressin V1a receptor, knockout mice, social recognition, anxiety-like behavior, oxytocin, social behavior, emotionality, autism spectrum disorder, anxiety disorders, stereotypy, olfactory learning and memory
- MeSH terms
- Animals, Anxiety, Female, Genotype, Male, Mice, Inbred C57BL, Social Behavior, Receptors, Vasopressin, Mice, Knockout, Maze Learning, Recognition, Psychology, Mice
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