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Cited by 14

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts

Fujitani, Masashi, Honda, Akiko, Hata, Katsuhiko, Yamagishi, Satoru, Tohyama, Masaya, Yamashita, Toshihide·2005·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2004.11.151
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Abstract

The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells, is implicated in the control of neuronal morphology. Here, we report that neurotrophin dependent cytoskeletal changes, characteristic of the phenotype of Rac1, in the hippocampal neurons or PC12 cells are inhibited by the disruption of lipid raft integrity. Activation of Rac1 induced by NGF is impaired in cholesterol-depleted PC12 cells. Pretreatment with gammaGTP shifted significant amount of Rac1, presumably in a GTP-bound form, from non-raft to raft fractions. Proper recruitment of activated Rac1 to lipid rafts, structures that represent specialized signaling organelles, is of fundamental importance in determining neurotrophins' bioactivity.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bbrc.2004.11.151

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

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Verification

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Claims other papers make about this one

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Citations

Cites

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Metadata

Authors
Fujitani, M., Honda, A., Hata, K., Yamagishi, S., Tohyama, M., & Yamashita, T.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2005-02
Volume
327
Issue
1
Pages
150-154
ISSN
0006-291X
DOI
10.1016/j.bbrc.2004.11.151
Cited by
14
References
26
Language
en
Licence

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.