Neuroendocrine and metabolic effects of adipocyte-derived hormones
Abstract
Obesity is characterized by an increase in adipose tissue mass. Contrary to the previous view of adipose tissue as simply an inert tissue devoted to energy storage, studies over the past decade have shown that adipose tissue is actively involved in regulating physiological processes and participates in disease. Adipose tissue secretes factors that exert local and systemic effects. Leptin, pro-inflammatory cytokines, resistin and proteins involved in haemodynamic regulation and coagulation are increased in obesity while adiponectin is reduced. The production of active corticosteroids is also increased in obesity. There is now growing evidence that adipocyte secretory factors regulate energy homoeostasis, as well as cardiovascular and immune systems. Some adipocyte hormones, most notably leptin, act in the brain to influence the neuroendocrine axis and energy balance, whereas adiponectin and resistin exert opposing effects on glucose and lipids. Understanding the actions of adipocyte hormones will provide novel insights into the pathophysiology and treatment of obesity.
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Reduction in leptin promotes a switch between the fasted state and the fed state by promoting food intake and reducing energy expenditure.
“This reduction in leptin promotes a switch between the “fasted state” and the “fed state” by promoting food intake and reducing energy expenditure 54.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [54]
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- Authors
- Jackson, M. B., & Ahima, R. S.
- Affiliations
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- ORCID
- Ahima, Rexford S.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2006-01-17
- Volume
- 110
- Issue
- 2
- Pages
- 143-152
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W1985982057
- Cited by
- 68
- References
- 107
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-DK49210, R01-DK62348, P01DK049210, R01DK062348, T32DK063688, T32-DK63688)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipose tissue, obesity, leptin, adiponectin, resistin, inflammatory cytokines, corticosteroids, energy homeostasis, neuroendocrine axis, glucose metabolism, lipid metabolism, cardiovascular effects, immune regulation
- MeSH terms
- Homeostasis, Hormones, Humans, Inflammation, Insulin Resistance, Neurosecretory Systems, Obesity, Adipocytes
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