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STAM–AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH

Kim, Man Su, Kim, Jeom-A, Song, Hyun Kyu, Jeon, Hyesung·2006·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2006.10.068
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Abstract

Signal transducing adaptor molecule (STAM) complexed with hepatocyte growth factor regulated tyrosine kinase substrate (Hrs) works on sorting of cargo proteins in multivesicular body (MVB) pathway. Associated molecule with SH3 domain of STAM (AMSH), a zinc-containing ubiquitin isopeptidase, is thought to play a role in regulation of ubiquitin-mediated degradation by binding to STAM. We have found that AMSH requires the conformation of Px(V/I)(D/N)RxxKP sequence to bind SH3 domain of STAM with approximately 7 microM affinity, and that the isolated C-terminal domain of AMSH contains the isopeptidase activity. Deubiquitination by AMSH was assisted when ubiquitins were bound to STAM which can bind to AMSH simultaneously. With the specificity toward K63-linked ubiquitins, this facilitated ubiquitin processing activity of AMSH may imply a distinct regulatory mechanism for sorting and degradation through STAM binding.

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Research works printed but not linked: 25

  1. Gruenberg, 1995, Membrane transport in the endocytic pathway, Curr. Opin. Cell Biol., 7, 552, 10.1016/0955-0674(95)80013-1 · DOI
  2. Gruenberg, 2001, The endocytic pathway: a mosaic of domains, Nat. Rev. Mol. Cell Biol., 2, 721, 10.1038/35096054 · DOI
  3. Dunn, 2001, Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis, J. Biol. Chem., 276, 25974, 10.1074/jbc.M104113200 · DOI
  4. Dupre, 2001, Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase, Mol. Cell Biol., 21, 4482, 10.1128/MCB.21.14.4482-4494.2001 · DOI
  5. Komada, 1995, Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain, Mol. Cell Biol., 15, 6213, 10.1128/MCB.15.11.6213 · DOI · Paper page
  6. Takeshita, 1996, Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM, Biochem. Biophys. Res. Commun., 225, 1035, 10.1006/bbrc.1996.1290 · DOI
  7. Komada, 2005, The Hrs/STAM complex in the downregulation of receptor tyrosine kinases, J. Biochem. (Tokyo), 137, 1, 10.1093/jb/mvi001 · DOI
  8. Raiborg, 2002, Hrs and endocytic sorting of ubiquitinated membrane proteins, Cell Struct. Funct., 27, 403, 10.1247/csf.27.403 · DOI
  9. Urbe, 2003, The UIM domain of Hrs couples receptor sorting to vesicle formation, J. Cell Sci., 116, 4169, 10.1242/jcs.00723 · DOI · Paper page
  10. Mizuno, 2003, STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif, Mol. Biol. Cell, 14, 3675, 10.1091/mbc.e02-12-0823 · DOI
  11. Tanaka, 1999, Possible involvement of a novel STAM-associated molecule “AMSH” in intracellular signal transduction mediated by cytokines, J. Biol. Chem., 274, 19129, 10.1074/jbc.274.27.19129 · DOI
  12. Kato, 2000, A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP, J. Biol. Chem., 275, 37481, 10.1074/jbc.M007251200 · DOI · Paper page
  13. McCullough, 2004, AMSH is an endosome-associated ubiquitin isopeptidase, J. Cell Biol., 166, 487, 10.1083/jcb.200401141 · DOI
  14. Mizuno, 2005, Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes, Mol. Biol. Cell, 16, 5163, 10.1091/mbc.e05-06-0560 · DOI · Paper page
  15. Pawson, 1993, SH2 and SH3 domains, Curr. Biol., 3, 434, 10.1016/0960-9822(93)90350-W · DOI
  16. Mayer, 1995, SH3 domains. Minding your p’s and q’s, Curr. Biol., 5, 364, 10.1016/S0960-9822(95)00073-X · DOI
  17. Gorina, 1996, Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2, Science, 274, 1001, 10.1126/science.274.5289.1001 · DOI
  18. Mongiovi, 1999, A novel peptide-SH3 interaction, EMBO J., 18, 5300, 10.1093/emboj/18.19.5300 · DOI
  19. Chan, 2003, SAP couples Fyn to SLAM immune receptors, Nat. Cell Biol., 5, 155, 10.1038/ncb920 · DOI
  20. Kaneko, 2003, Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain, J. Biol. Chem., 278, 48162, 10.1074/jbc.M306677200 · DOI · Paper page
  21. Amerik, 2004, Mechanism and function of deubiquitinating enzymes, Biochim. Biophys. Acta, 1695, 189, 10.1016/j.bbamcr.2004.10.003 · DOI
  22. Row, 2006, The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation, J. Biol. Chem., 281, 12618, 10.1074/jbc.M512615200 · DOI · Paper page
  23. Hicke, 2003, Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins, Annu. Rev. Cell Dev. Biol., 19, 141, 10.1146/annurev.cellbio.19.110701.154617 · DOI
  24. Reggiori, 2001, Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting, EMBO J., 20, 5176, 10.1093/emboj/20.18.5176 · DOI · Paper page
  25. McCullough, 2006, Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery, Curr. Biol., 16, 160, 10.1016/j.cub.2005.11.073 · DOI

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Metadata

Authors
Kim, M. S., Kim, J.-A., Song, H. K., & Jeon, H.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2006-12
Volume
351
Issue
3
Pages
612-618
ISSN
0006-291X
DOI
10.1016/j.bbrc.2006.10.068
Cited by
28
References
0
Language
en
Licence
Funders
Ministry of Science and Technology

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