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Cited by 239

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation

Row, Paula E., Prior, Ian A., McCullough, John, Clague, Michael J., Urbé, Sylvie·2006·Journal of Biological Chemistry
DOI 10.1074/jbc.m512615200
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Crossref · 10.1074/jbc.m512615200

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  • USP8 does not exhibit intrinsic linkage selectivity when Ub chains are not attached to parkin; it cleaves K6-, K11-, K48-, and K63-linked free di-Ub.

    “USP8 did not appear to exhibit intrinsic linkage selectivity when the Ub chains were not attached to parkin, as it could efficiently cleave K6-, K11-, K48-, and K63-linked free di-Ub”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Row et al, 2006

    The Results report that UBPY (USP8) shows little discrimination between K48- and K63-linked chains, and the Figure 1 caption describes cleavage of tetraubiquitin chains. The paper does not establish cleavage of K6- or K11-linked chains or free di-Ub, and it does not compare chains attached to parkin with unattached chains. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • USP8 is a deubiquitinating enzyme not previously implicated in mitochondrial quality control.

    “USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy.”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Row et al, 2006

    The Abstract identifies UBPY as USP8 and a ubiquitin-specific processing protease, and the Discussion calls it a DUB enzyme. The paper discusses endosomal functions, but these passages do not establish the broader claim that USP8 had not previously been implicated in mitochondrial quality control. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Two reports described endosomal enlargement when UBPy was knocked down by RNA interference.

    “While this work was in progress, two reports also described endosomal enlargement when UBPy was knocked down by RNA interference (7,48)”

    From Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo (2007) · cites this paper as [48]

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Citations

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Metadata

Authors
Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbé, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2006-05
Volume
281
Issue
18
Pages
12618-12624
ISSN
0021-9258
DOI
10.1074/jbc.m512615200
Cited by
239
References
1
Language
en
Licence

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