Up-regulation of the expression of leucine-rich α2-glycoprotein in hepatocytes by the mediators of acute-phase response
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Leucine-rich alpha(2)-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG is not known, increases in the serum level of LRG have been reported in various diseases. In this study, we found that LRG was induced by recombinant human IL-6 in human hepatoma HepG2 cells. The induction of LRG by IL-6 was up-regulated synergistically with either IL-1beta or TNFalpha in a pattern similar to those for type 1 acute-phase proteins. We also found that lipopolysaccharide (LPS) administered intraperitoneally to mice enhanced dose-dependently the expression of LRG mRNA in the liver as well as those for mouse major acute-phase proteins. These results strongly suggest that LRG was a secretory type 1 acute-phase protein whose expression was up-regulated by the mediator of acute-phase response.
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Cytochrome c can bind to leucine-rich α2 glycoprotein, a plasma protein elevated during inflammation.
“reports suggest that cytochrome c can bind to leucine-rich α2 glycoprotein, a plasma protein that is elevated during inflammation206,207.”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [206]
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- Authors
- Shirai, R., Hirano, F., Ohkura, N., Ikeda, K., & Inoue, S.
- Affiliations
- Osaka University of Pharmaceutical Sciences (JP)
- Teikyo University (JP)
- Corresponding author
- Inoue, Seiji
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 382
- Issue
- 4
- Pages
- 776-779
- ISSN
- 0006-291X (ISSN-L)
- PMC
- PMC7092932
- OpenAlex
- W2028863735
- Cited by
- 193
- References
- 31
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 17 · 2023: 18 · 2022: 17 · 2021: 20 · 2020: 26 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Keywords
- acute phase response, hepatocytes, interleukin-6, IL-1β, TNF-α, lipopolysaccharide, gene upregulation, liver, HepG2 cells
- MeSH terms
- Acute-Phase Reaction, Animals, Cell Line, Disease Models, Animal, Glycoproteins, Humans, Mice, Inbred ICR, Up-Regulation, Cytokines, Endotoxemia, Hepatocytes, Mice
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