Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions

Direct observation of individual endogenous protein complexes in situ by proximity ligation

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Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

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Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

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Adenosine A2A and Dopamine D2 Heteromeric Receptor Complexes and Their Function

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D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties

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Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum

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Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine

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BTB Protein KLHL12 Targets the Dopamine D4 Receptor for Ubiquitination by a Cul3-based E3 Ligase

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Triplet Puzzle: Homologies of Receptor Heteromers

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Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domains

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The M5 muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization

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Bioinformatics and mathematical modelling in the study of receptor–receptor interactions and receptor oligomerization

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Dopamine receptors – IUPHAR R eview 13

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Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

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Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease

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Dopamine in Health and Disease: Much More Than a Neurotransmitter

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Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences

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Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

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Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

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G Protein–Coupled Receptor Heterodimerization in the Brain

Borroto‐Escuela, D. O., Romero‐Fernandez, W., Garriga, P., Ciruela, F., Narváez, M., Tarakanov, A. O., Palkovits, M., Agnati, L. F., & Fuxé, K. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-391862-8.00015-6 · Cited by 116 · see citing works

Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field

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Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain

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Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes

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Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease

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Multivariate Analysis of Dopaminergic Gene Variants as Risk Factors of Heroin Dependence

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Dopamine, cognitive function, and gamma oscillations: role of D4 receptors

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On the existence and function of galanin receptor heteromers in the central nervous system

Fuxé, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Tarakanov, A. O., Calvo, F., Garriga, P., Tena, M., Narváez, M., Millón, C., Parrado, C., et al. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00127 · Cited by 69 · see citing works

DRD4 Genotype Predicts Longevity in Mouse and Human

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Moonlighting characteristics of G protein‐coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration

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Disruption of a2ar-d2r heteroreceptor complexes after A2AR transmembrane 5 peptide administration enhances cocaine self-administration in rats

Borroto-Escuela, D. O., Wydra, K., Li, X., Rodriguez, D., Carlsson, J., Jastrzębska, J., Filip, M., & Fuxe, K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0887-1 · Cited by 58 · see citing works

The Effects of Statins on Neurotransmission and Their Neuroprotective Role in Neurological and Psychiatric Disorders

Kosowski, M., Smolarczyk, J., Hachuła, M., Maligłówka, M., Basiak, M., Machnik, G., Pudło, R., & Okopień, B. (2021) · Molecules · doi:10.3390/molecules26102838 · Cited by 58 · see citing works

Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission

Bonaventura, J., Quiroz, C., Cai, N., Rubinstein, M., Tanda, G., & Ferré, S. (2017) · Science Advances · doi:10.1126/sciadv.1601631 · Cited by 58 · see citing works

Return of D4Dopamine Receptor Antagonists in Drug Discovery

Lindsley, C. W., & Hopkins, C. R. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00151 · Cited by 57 · see citing works

From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research

Pagliaroli, L., Vető, B., Arányi, T., & Barta, C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00277 · Cited by 48 · see citing works

Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants

Ferré, S., Belcher, A. M., Bonaventura, J., Quiroz, C., Sánchez‐Soto, M., Casadó-Anguera, V., Cai, N.-S., Moreno, E., Boateng, C. A., Keck, T. M., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1014678 · Cited by 45 · see citing works

In Situ Proximity Ligation Assay to Study and Understand the Distribution and Balance of GPCR Homo- and Heteroreceptor Complexes in the Brain

Borroto‐Escuela, D. O., Hagman, B., Woolfenden, M., Pinton, L., Jimenez‐Beristain, A., Oflijan, J., Narváez, M., Palma, M. D., Feltmann, K., Sartini, S., et al. (2016) · Neuromethods · doi:10.1007/978-1-4939-3064-7_9 · Cited by 45 · see citing works

Shear stress induces Gαq/11 activation independently of G protein-coupled receptor activation in endothelial cells

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Dopamine D2 heteroreceptor complexes and their receptor–receptor interactions in ventral striatum

Fuxé, K., Borroto‐Escuela, D. O., Tarakanov, A. O., Romero‐Fernandez, W., Ferraro, L., Tanganelli, S., Pérez‐Alea, M., Palma, M. D., & Agnati, L. F. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00005-2 · Cited by 43 · see citing works

G-protein-coupled receptor type A heteromers as an emerging therapeutic target

Guidolin, D., Agnati, L. F., Marcoli, M., Borroto‐Escuela, D. O., & Fuxé, K. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.981155 · Cited by 43 · see citing works

Developmental Differences in Early Adolescent Aggression: A Gene × Environment × Intervention Analysis

Schlomer, G. L., Cleveland, H. H., Vandenbergh, D. J., Feinberg, M. E., Neiderhiser, J. M., Greenberg, M. T., Spoth, R. L., & Redmond, C. R. (2014) · Journal of Youth and Adolescence · doi:10.1007/s10964-014-0198-4 · Cited by 40 · see citing works

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS

Borroto‐Escuela, D. O., & Fuxé, K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00230 · Cited by 39 · see citing works

Receptor-receptor interactions in heteroreceptor complexes: a new principle in biology. Focus on their role in learning and memory

Fuxé, K., Borroto-Escuela, D. O., Ciruela, F., Guidolin, D., & Agnati, L. F. (2014) · Neuroscience Discovery · doi:10.7243/2052-6946-2-6 · Cited by 38 · see citing works

Understanding GPCR dimerization

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Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone

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Genetics of child aggression, a systematic review

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Diversity and bias through dopamine D2R heteroreceptor complexes

Borroto‐Escuela, D. O., & Fuxé, K. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.10.004 · Cited by 33 · see citing works

Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers

Botta, J. A., Bibič, L., Killoran, P. M., McCormick, P. J., & Howell, L. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009160 · Cited by 33 · see citing works

The magnificent seven: A quantitative review of dopamine receptor d4 and its association with child behavior

Pappa, I., Mileva‐Seitz, V. R., Bakermans‐Kranenburg, M. J., Tiemeier, H. W., & van IJzendoorn, M. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.009 · Cited by 31 · see citing works

Biophysical Detection of Diversity and Bias in GPCR Function

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Neural correlates of inhibitory control and functional genetic variation in the dopamine D4 receptor gene

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Heteromerization of dopaminergic receptors in the brain: Pharmacological implications

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On the Role of the Balance of GPCR Homo/ Heteroreceptor Complexes in the Brain

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Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation

Gago, B., Suárez‐Boomgaard, D., Fuxé, K., Brené, S., Reina‐Sánchez, M. D., Rodríguez‐Pérez, L., Agnati, L. F., de la Calle, A., & Rivera, A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.046 · Cited by 27 · see citing works

Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson’s Disease and Schizophrenia

de la Mora, M. P., Hernández-Mondragón, J. C., Crespo‐Ramírez, M., Rejón-Orantes, J. D. C., Borroto‐Escuela, D. O., & Fuxé, K. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.026 · Cited by 27 · see citing works

In situ detection of estrogen receptor dimers in breast carcinoma cells in archival materials using proximity ligation assay (PLA)

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New dimensions of connectomics and network plasticity in the central nervous system

Guidolin, D., Marcoli, M., Maura, G., & Agnati, L. F. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0051 · Cited by 26 · see citing works

<i>NCAM1‐TTC12‐ANKK1‐DRD2</i> gene cluster and the clinical and genetic heterogeneity of adults with ADHD

Mota, N. R., Rovaris, D. L., Kappel, D. B., Picon, F. A., Vitola, E. S., Salgado, C. A. I., Karam, R. G., Rohde, L. A., Grevet, E. H., & Bau, C. H. D. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32317 · Cited by 25 · see citing works

Functional characterization of G-protein-coupled receptors: A bioinformatics approach

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Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression

Aguinaga, D., Medrano, M., Vega‐Quiroga, I., Gysling, K., Canela, E. I., Navarro, G., & Franco, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00017 · Cited by 24 · see citing works

Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family

Romero‐Fernandez, W., Borroto‐Escuela, D. O., Tarakanov, A. O., Mudò, G., Narváez, M., Pérez‐Alea, M., Agnati, L. F., Ciruela, F., Belluardo, N., & Fuxé, K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.085 · Cited by 22 · see citing works

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

Vasudevan, L., Borroto‐Escuela, D. O., Huysentruyt, J., Fuxé, K., Saini, D. K., & Stove, C. P. (2019) · Biomolecules · doi:10.3390/biom9080368 · Cited by 22 · see citing works

Recent findings leading to the discovery of selective dopamine D4 receptor ligands for the treatment of widespread diseases

Giorgioni, G., Bello, F. D., Pavletić, P., Quaglia, W., Botticelli, L., Cifani, C., Bonaventura, E. M. D., Bonaventura, M. V. M. D., & Piergentili, A. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113141 · Cited by 20 · see citing works

Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction

Stolf, A. R., Cupertino, R. B., Müller, D., Sanvicente‐Vieira, B., Roman, T., Vitola, E. S., Grevet, E. H., DIEMEN, L. V., Kessler, F. H. P., Grassi‐Oliveira, R., et al. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1946-5 · Cited by 19 · see citing works

Investigation of Receptor Heteromers Using NanoBRET Ligand Binding

Johnstone, E. K. M., See, H. B., Abhayawardana, R. S., Song, A., Rosengren, K. J., Hill, S. J., & Pfleger, K. D. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031082 · Cited by 19 · see citing works

Paroxetine and Low-dose Risperidone Induce Serotonin 5-HT1A and Dopamine D2 Receptor Heteromerization in the Mouse Prefrontal Cortex

Kolasa, M., Solich, J., Faron‐Górecka, A., Żurawek, D., Pabian, P., Łukasiewicz, S., Kuśmider, M., Szafran‐Pilch, K., Szlachta, M., & Dziedzicka‐Wasylewska, M. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.004 · Cited by 19 · see citing works

GPCR Oligomerization: Contribution to Receptor Biogenesis

Van Craenenbroeck, K. (2012) · Subcellular Biochemistry · doi:10.1007/978-94-007-4765-4_3 · Cited by 18 · see citing works

Class A and C GPCR Dimers in Neurodegenerative Diseases

Moreira, I. S., Caniceiro, A. B., Bueschbell, B., & Schiedel, A. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220327221830 · Cited by 18 · see citing works

Association between DRD2/DRD4 interaction and conduct disorder: A potential developmental pathway to alcohol dependence

Mota, N. R., Bau, C. H. D., Banaschewski, T., Buitelaar, J. K., Ebstein, R. P., Franke, B., Gill, M., Kuntsi, J., Manor, I., Miranda, A., et al. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32179 · Cited by 18 · see citing works

On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation

Borroto‐Escuela, D. O., Romero‐Fernandez, W., Rivera, A., Craenenbroeck, K. V., Tarakanov, A. O., Agnati, L. F., & Fuxé, K. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/563716 · Cited by 17 · see citing works

Modafinil improves performance in the multiple T-Maze and modifies GluR1, GluR2, D2 and NR1 receptor complex levels in the C57BL/6J mouse

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Revisiting the Functional Role of Dopamine D4 Receptor Gene Polymorphisms: Heteromerization-Dependent Gain of Function of the D4.7 Receptor Variant

Sánchez‐Soto, M., Yano, H., Cai, N.-S., Casadó-Anguera, V., Moreno, E., Casadó, V., & Ferré, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1413-1 · Cited by 17 · see citing works

The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson’s Disease

Romero‐Fernandez, W., Taura, J. J., Crans, R. A. J., López‐Cano, M., Fores‐Pons, R., Narváez, M., Carlsson, J., Ciruela, F., Fuxé, K., & Borroto‐Escuela, D. O. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02946-9 · Cited by 15 · see citing works

Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing

Palma, M. D., Sartini, S., Lattanzi, D., Cuppini, R., Pita-Rodríguez, M., Diaz-Carmenate, Y., Narváez, M., Fuxé, K., Borroto‐Escuela, D. O., & Ambrogini, P. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111289 · Cited by 15 · see citing works

Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

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On the G Protein-Coupled Receptor Neuromodulation of the Claustrum

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BindingDB Entry 50000653: Return of D

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