GPCR Oligomerization: Contribution to Receptor Biogenesis
Abstract
G protein-coupled receptor (GPCR) export to the plasma membrane is considered to follow the default secretory pathway. Several observations indicate that trafficking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from the ER to the trans-golgi network. The assembly of several GPCRs into a quaternary structure is started in the ER, before cell surface delivery, and helps in the correct expression of the GPCRs. This review will mainly focus on the role of GPCR oligomerization in receptor biogenesis.
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Oligomerization of GPCRs results in the diversification of receptor signaling.
“Oligomerization of GPCRs results in the diversification of receptor signaling [84].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [84]
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- Authors
- Van Craenenbroeck, K.
- Venue
- Subcellular Biochemistry
- Publisher
- Springer Netherlands
- Published
- 2012
- Volume
- 63
- Pages
- 43-65
- ISSN
- 0306-0225 (ISSN-L)
- OpenAlex
- W2098226790
- Cited by
- 18
- References
- 71
- Citations by year
- 2022: 2 · 2020: 2 · 2019: 5 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 4.92
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- G protein-coupled receptors, receptor oligomerization, receptor biogenesis, ER chaperones, protein folding, ER-Golgi trafficking, trans-Golgi network, plasma membrane delivery
- MeSH terms
- Animals, Cell Membrane, Endoplasmic Reticulum, Humans, Receptors, G-Protein-Coupled, Protein Multimerization
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