Cited by 18Receptor Mechanisms and SignalingCellular transport and secretionEndoplasmic Reticulum Stress and Disease

GPCR Oligomerization: Contribution to Receptor Biogenesis

Van Craenenbroeck, Kathleen·2012·Subcellular Biochemistry

Abstract

G protein-coupled receptor (GPCR) export to the plasma membrane is considered to follow the default secretory pathway. Several observations indicate that trafficking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from the ER to the trans-golgi network. The assembly of several GPCRs into a quaternary structure is started in the ER, before cell surface delivery, and helps in the correct expression of the GPCRs. This review will mainly focus on the role of GPCR oligomerization in receptor biogenesis.

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Crossref · 10.1007/978-94-007-4765-4_3

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Authors
Van Craenenbroeck, K.
Venue
Subcellular Biochemistry
Published
2012
Volume
63
Pages
43-65
ISSN
0306-0225 (ISSN-L)
OpenAlex
W2098226790
Cited by
18
References
71
Citations by year
2022: 2 · 2020: 2 · 2019: 5 · 2015: 2 · 2014: 4 · 2013: 3
FWCI
4.92
Type
book chapter
Language
en
Open access
closed
Locations
  • Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Keywords
G protein-coupled receptors, receptor oligomerization, receptor biogenesis, ER chaperones, protein folding, ER-Golgi trafficking, trans-Golgi network, plasma membrane delivery
MeSH terms
Animals, Cell Membrane, Endoplasmic Reticulum, Humans, Receptors, G-Protein-Coupled, Protein Multimerization

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