GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3
Open accessAbstract
While the pro-neurogenic actions of antidepressants in the adult hippocampal dentate gyrus (DG) are thought to be one of the mechanisms through which antidepressants exert their therapeutic actions, antidepressants do not increase proliferation of neural precursor cells derived from the adult DG. Because previous studies showed that antidepressants increase the expression and secretion of glial cell line-derived neurotrophic factor (GDNF) in C6 glioma cells derived from rat astrocytes and GDNF increases neurogenesis in adult DG in vivo, we investigated the effects of GDNF on the proliferation, differentiation and apoptosis of cultured neural precursor cells derived from the adult DG. Data showed that GDNF facilitated the differentiation of neural precursor cells into astrocytes but had no effect on their proliferation or apoptosis. Moreover, GDNF increased the phosphorylation of STAT3, and both a specific inhibitor of STAT3 and lentiviral shRNA for STAT3 decreased their differentiation into astrocytes. Taken together, our findings suggest that GDNF facilitates astrogliogenesis from neural precursor cells in adult DG through activating STAT3 and that this action might indirectly affect neurogenesis.
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GDNF induces differentiation of DG-derived neural precursors into astrocytes in vitro.
“Moreover, GDNF induced differentiation of DG-derived neural precursors into astrocytes in vitro (Boku et al. 2013).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Boku et al. 2013
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Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
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- Authors
- Boku, S., Nakagawa, S., Takamura, N., Kato, A., Takebayashi, M., Hisaoka-Nakashima, K., Omiya, Y., Inoue, T., & Kusumi, I.
- Affiliations
- Hokkaido University (JP)
- Sumitomo Dainippon Pharma (Japan) (JP)
- National Hospital Organization (JP)
- Corresponding author
- Boku, Shuken
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 434
- Issue
- 4
- Pages
- 779-784
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2049832142
- Cited by
- 31
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 3
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glial cell line-derived neurotrophic factor, dentate gyrus, neural progenitor cells, astrocyte differentiation, astrogliogenesis, STAT3, antidepressants, adult hippocampal neurogenesis, cell proliferation, apoptosis, STAT3 phosphorylation
- MeSH terms
- Age Factors, Animals, Astrocytes, Cell Differentiation, Glial Fibrillary Acidic Protein, Immunohistochemistry, Male, Phosphorylation, Blotting, Western, Rats, Sprague-Dawley, Apoptosis, Dentate Gyrus, RNA Interference, Cell Proliferation, STAT3 Transcription Factor, Glial Cell Line-Derived Neurotrophic Factor, Rats, Neural Stem Cells
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