Astroglia induce neurogenesis from adult neural stem cells
Abstract
During an investigation of the mechanisms through which the local environment controls the fate specification of adult neural stem cells, we discovered that adult astrocytes from hippocampus are capable of regulating neurogenesis by instructing the stem cells to adopt a neuronal fate. This role in fate specification was unexpected because, during development, neurons are generated before most of the astrocytes. Our findings, together with recent reports that astrocytes regulate synapse formation and synaptic transmission, reinforce the emerging view that astrocytes have an active regulatory role--rather than merely supportive roles traditionally assigned to them--in the mature central nervous system.
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Radial glial cells, stem cell precursors, and astrocytes all express GFAP and are found in the dentate gyrus.
“Radial glial cells, stem cell precursors, and astrocytes - all reported to express GFAP (reviewed in ref.26) - are found in the dentate gyrus2,27,28.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [27]
Astrocytes within the adult hippocampus influence stem cell proliferation, their commitment to a neuronal phenotype, and their survival.
“Astrocytes within the adult hippocampus influence stem cell proliferation, their commitment to a neuronal phenotype, and their survival (Song et al., 2002), raising the possibility that there are distinct properties of astrocytes in the hippocampus that promote adult neurogenesis (Figure 2A).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Song et al., 2002
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- Authors
- Song, H., Stevens, C. F., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Stevens, Charles F.
- Gage, Fred H.
- Venue
- Nature
- Published
- 2002-05
- Volume
- 417
- Issue
- 6884
- Pages
- 39-44
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2117523148
- Cited by
- 1,452
- References
- 44
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 22 · 2023: 20 · 2022: 41 · 2021: 32 · 2020: 41 · 2019: 38 · 2018: 39 · 2017: 56 · 2016: 47 · 2015: 61 · 2014: 58 · 2013: 74 · 2012: 83
- FWCI
- 23.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, adult neural stem cells, neurogenesis, neuronal fate specification, hippocampus, astrocyte-neuron interaction, stem cell fate regulation
- MeSH terms
- Aging, Animals, Animals, Newborn, Astrocytes, Bromodeoxyuridine, Cell Differentiation, Cell Division, Cell Survival, Cells, Cultured, Fibroblasts, Hippocampus, Laminin, Neurons, Oligodendroglia, Organ Specificity, Rats, Inbred F344, Spinal Cord, Stem Cells, Culture Media, Serum-Free, Coculture Techniques, Cell Lineage, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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