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Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

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The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance

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Renal Amyloidosis

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Hepatokines and metabolism: Deciphering communication from the liver

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Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals

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LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

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Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice.

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Leukocyte chemotactic factor 2: A novel renal amyloid protein

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LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

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LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor

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Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of β-catenin in the liver

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Characterization and outcomes of renal leukocyte chemotactic factor 2-associated amyloidosis

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Amyloidosis: Insights from Proteomics

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A strategy of vascular‐targeted therapy for liver fibrosis

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Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver

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Leukocyte Chemotactic Factor 2 (LECT2)-Associated Renal Amyloidosis: A Case Series

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Increase in Hepatic NKT Cells in Leukocyte Cell-Derived Chemotaxin 2-Deficient Mice Contributes to Severe Concanavalin A-Induced Hepatitis

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Hepatokines and non-alcoholic fatty liver disease

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Leukocyte cell-derived chemotaxin 2 (LECT2)–associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States

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Difference in skin immune responses to infection with salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar L.) of families selected for resistance and susceptibility

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Leukocyte Cell–Derived Chemotaxin 2–Associated Amyloidosis

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A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression

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Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis

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A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans

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New insights into molecular pathways associated with flatfish ovarian development and atresia revealed by transcriptional analysis

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Suppressive role of leukocyte cell–derived chemotaxin 2 in mouse anti–type II collagen antibody–induced arthritis

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Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites

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Effects of Vitamin D2 (Ergocalciferol) and D3 (Cholecalciferol) on Atlantic Salmon (Salmo salar) Primary Macrophage Immune Response to Aeromonas salmonicida subsp. salmonicida Infection

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LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH

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Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

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LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells

Hwang, H.-J., Jung, T. W., Hong, H. C., Seo, J. A., Kim, S. G., Kim, N. H., Choi, K. M., Choi, D. S., Baik, S. H., & Yoo, H. J. (2015) · Metabolism · doi:10.1016/j.metabol.2015.06.001 · Cited by 60 · see citing works

MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

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Expression of a Neutrophil Chemotactic Protein LECT2 in Human Hepatocytes Revealed by Immunochemical Studies Using Polyclonal and Monoclonal Antibodies to a Recombinant LECT2

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Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver

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Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

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LECT2 promotes inflammation and insulin resistance in adipocytes via P38 pathways

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Molecular Cloning, Structural Characterization, and Chromosomal Mapping of the Human LECT2 Gene

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Immune modulatory properties of 6-gingerol and resveratrol in Atlantic salmon macrophages

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Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis

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Systemic expression of a newly recognized protein, LECT2, in the human body

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Kupffer cell programming by maternal obesity triggers fatty liver disease

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The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target

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LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells

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Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

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Deficiency of Mbd2 Attenuates Wnt Signaling

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Globular Hepatic Amyloid Is Highly Sensitive and Specific for LECT2 Amyloidosis

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Gene expression patterns associated with chicken jejunal development

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Leukocyte cell-derived chemotaxin-2: it's role in pathophysiology and future in clinical medicine

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Serum LECT2 level as a prognostic indicator in acute liver failure

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LECT2 improves the outcomes in ayu with Vibrio anguillarum infection via monocytes/macrophages

Chen, J., Chen, Q., Lu, X., & Li, C. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.10.012 · Cited by 43 · see citing works

Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice

Chikamoto, K., Misu, H., Takayama, H., Kikuchi, A., Ishii, K.-A., Lan, F., Takata, N., Tajima-Shirasaki, N., Takeshita, Y., Tsugane, H., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.117 · Cited by 37 · see citing works

Changes in hepatic gene expression related to innate immunity, growth and iron metabolism in GH-transgenic amago salmon (Oncorhynchus masou) by cDNA subtraction and microarray analysis, and serum lysozyme activity

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iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis

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Diagnostic amyloid proteomics: experience of the UK National Amyloidosis Centre

Canetti, D., Rendell, N. B., Gilbertson, J. A., Botcher, N. A., Nocerino, P., Blanco, A., Vagno, L. D., Rowczenio, D. M., Verona, G., Mangione, P. P., et al. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-1007 · Cited by 36 · see citing works

Osteoclasts Secrete the Chemotactic Cytokine Mim-1

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Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation

Miao, X., Alidadipour, A., Saed, V., Sayyadi, F., Jadidi, Y., Davoudi, M., Amraee, F., Jadidi, N., & Afrisham, R. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02335-9 · Cited by 34 · see citing works

Characterization of the LECT2 gene and its associations with resistance to the big belly disease in Asian seabass

Fu, G. H., Bai, Z. Y., Xia, J. H., Liu, X., Liu, F., Wan, Z. Y., & Yue, G. H. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.01.019 · Cited by 34 · see citing works

Sequencing of the first ayu (Plecoglossus altivelis) macrophage transcriptome and microarray development for investigation the effect of LECT2 on macrophages

Lu, X., Hang, X., Yin, L., He, Y.-Q., Chen, J., Shi, Y., & Li, C. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.11.047 · Cited by 33 · see citing works

Genomic resources for flatfish research and their applications

Cerdà, J., Douglas, S. E., & Reith, M. (2010) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2010.02695.x · Cited by 33 · see citing works

LECT2 Protects Nile Tilapia (Oreochromis niloticus) Against Streptococcus agalatiae Infection

Li, Q., Zhang, Z., Fan, W., Huang, Y., Niu, J., Luo, G., Liu, X., Huang, Y., & Jian, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.667781 · Cited by 33 · see citing works

The inhibitory effect of environmental ammonia on Danio rerio LPS induced acute phase response

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Role of Leukocyte Cell-Derived Chemotaxin 2 as a Biomarker in Hepatocellular Carcinoma

Okabe, H., Delgado, E. R., Lee, J. M., Yang, J., Kinoshita, H., Hayashi, H., Tsung, A., Behari, J., Beppu, T., Baba, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098817 · Cited by 33 · see citing works

Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation

Sato, Y., Watanabe, H., Kameyama, H., Kobayashi, T., Yamamoto, S., Takeishi, T., Hirano, K., Oya, H., Nakatsuka, H., Watanabe, T., et al. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.07.006 · Cited by 32 · see citing works

An interaction between a C-type lectin receptor and leukocyte cell-derived chemotaxin 2 of ayu, Plecoglossus altivelis

Chen, J., Lü, X., Yang, H., & Shi, Y. H. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.10.011 · Cited by 32 · see citing works

LECT2 amyloidosis

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Identification of hepatokines involved in pathology of type 2 diabetes and obesity

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