Cited by 500Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

The role of hepatokines in metabolism

Stefan, Norbert, Häring, Hans-Ulrich·2013·Nature Reviews Endocrinology

Abstract

The liver is known to be involved in the natural history of the ongoing epidemics of type 2 diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased glucose production and dysregulated lipoprotein metabolism, conditions that are often found in patients with nonalcoholic fatty liver disease. Additionally, several proteins that are exclusively or predominantly secreted from the liver are now known to directly affect glucose and lipid metabolism. In analogy to the functional proteins released from adipose tissue and skeletal muscle-adipokines and myokines-these liver-derived proteins are known as hepatokines. The first hepatokine that has been proven to have a major pathogenetic role in metabolic diseases is α2-HS-glycoprotein (fetuin-A). Production of this glycoprotein is increased in steatotic and inflamed liver, but not in expanded and dysregulated adipose tissue. Thus, research into this molecule and other hepatokines is expected to aid in differentiating between the contribution of liver and those of skeletal muscle and adipose tissue, to the pathogenesis of type 2 diabetes mellitus and cardiovascular disease.

Integrity signals

Registry

Crossref · 10.1038/nrendo.2012.258

Cites

120 of 120 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NAFLD is the most common chronic liver disease worldwide and a risk factor for type 2 diabetes, obesity, and cardiovascular disease.

    “NAFLD is the most common chronic liver disease worldwide and a risk factor for type 2 diabetes, obesity, and cardiovascular disease (CVD) [8,12,22].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Stefan, N., & Häring, H.-U.
Affiliations
Universitätsklinikum Tübingen (DE)
Corresponding author
Stefan, Norbert
Venue
Nature Reviews Endocrinology
Published
2013-01-22
Volume
9
Issue
3
Pages
144-152
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W2060371641
Cited by
500
References
120
Citations by year
2026: 25 · 2025: 28 · 2024: 24 · 2023: 28 · 2022: 36 · 2021: 48 · 2020: 36 · 2019: 40 · 2018: 43 · 2017: 55 · 2016: 53 · 2015: 39 · 2014: 36 · 2013: 9
FWCI
5.41
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
hepatokines, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, fetuin-A, glucose metabolism, lipid metabolism, lipoprotein metabolism, adipokines, myokines, drug development, disease screening
MeSH terms
Adipose Tissue, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Fatty Liver, Female, Glucose, Humans, Liver, Male, Muscle Proteins, Muscle, Skeletal, Lipid Metabolism, Adipokines, alpha-2-HS-Glycoprotein, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review