The role of hepatokines in metabolism
Abstract
The liver is known to be involved in the natural history of the ongoing epidemics of type 2 diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased glucose production and dysregulated lipoprotein metabolism, conditions that are often found in patients with nonalcoholic fatty liver disease. Additionally, several proteins that are exclusively or predominantly secreted from the liver are now known to directly affect glucose and lipid metabolism. In analogy to the functional proteins released from adipose tissue and skeletal muscle-adipokines and myokines-these liver-derived proteins are known as hepatokines. The first hepatokine that has been proven to have a major pathogenetic role in metabolic diseases is α2-HS-glycoprotein (fetuin-A). Production of this glycoprotein is increased in steatotic and inflamed liver, but not in expanded and dysregulated adipose tissue. Thus, research into this molecule and other hepatokines is expected to aid in differentiating between the contribution of liver and those of skeletal muscle and adipose tissue, to the pathogenesis of type 2 diabetes mellitus and cardiovascular disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NAFLD is the most common chronic liver disease worldwide and a risk factor for type 2 diabetes, obesity, and cardiovascular disease.
“NAFLD is the most common chronic liver disease worldwide and a risk factor for type 2 diabetes, obesity, and cardiovascular disease (CVD) [8,12,22].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [12]
Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488 · see citing works
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416 · see citing works
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works
General and abdominal adiposity and risk of death in Europe
Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M. B., Overvad, K., van der Schouw, Y. T., Spencer, E., Moons, K. G. M., Tjønneland, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801891 · Cited by 2,155 · see citing works
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works
Human Fatty Liver Disease: Old Questions and New Insights
Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science · doi:10.1126/science.1204265 · Cited by 2,089 · see citing works
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
Targher, G., Day, C. P., & Bonora, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912063 · Cited by 1,907 · see citing works
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.001 · Cited by 1,773 · see citing works
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works
Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection
Starley, B. Q., Calcagno, C. J., & Harrison, S. A. (2010) · Hepatology · doi:10.1002/hep.23594 · Cited by 1,340 · see citing works
Lipid-induced insulin resistance: unravelling the mechanism
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189 · see citing works
Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H.-M., Gerhold, K., Mayers, J. R., Wiest, M., Watkins, S., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,142 · see citing works
ANDERSON, D. C. (1974) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1974.tb03298.x · Cited by 1,127 · see citing works
Identification and characterization of metabolically benign obesity in humans
Stefan, N. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1609 · Cited by 1,049 · see citing works
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972 · see citing works
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works
Type 2 diabetes across generations: from pathophysiology to prevention and management
Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923 · see citing works
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works
Cusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 912 · see citing works
The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease
Utzschneider, K. M., & Kahn, S. E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0587 · Cited by 858 · see citing works
Adiposity as Compared with Physical Activity in Predicting Mortality among Women
Hu, F. B., Willett, W. C., Li, T., Stampfer, M. J., Colditz, G. A., & Manson, J. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042135 · Cited by 798 · see citing works
Kotronen, A., & Yki‐Järvinen, H. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147538 · Cited by 793 · see citing works
Sex hormone-binding globulin and risk of type 2 diabetes in women and men
Ding, E. L., Song, Y., Manson, J. E., Hunter, D. J., Lee, C. C., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804381 · Cited by 726 · see citing works
Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works
Adiponectin: mechanistic insights and clinical implications
Turer, A. T., & Scherer, P. E. (2012) · Diabetologia · doi:10.1007/s00125-012-2598-x · Cited by 636 · see citing works
Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R., Buzzigoli, E., Sironi, A. M., Cersosimo, E., Ferrannini, E., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.068 · Cited by 629 · see citing works
A liver-derived secretory protein, selenoprotein P, causes insulin resistance
Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
Fu, S., Watkins, S. M., & Hotamışlıgil, G. S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.007 · Cited by 547 · see citing works
Causes and Metabolic Consequences of Fatty Liver
Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 527 · see citing works
Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Kröber, S. M., Machicao, F. E., Fritsche, A., & Häring, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1938 · Cited by 475 · see citing works
Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women
Li, T. Y., Rana, J. S., Manson, J. E., Willett, W. C., Stampfer, M. J., Colditz, G. A., Rexrode, K. M., & Hu, F. B. (2006) · Circulation · doi:10.1161/circulationaha.105.574087 · Cited by 472 · see citing works
The Role of Liver-Derived Insulin-Like Growth Factor-I
Ohlsson, C., Mohan, S., Sjögren, K., Tivesten, Å., Isgaard, J., Isaksson, O. G. P., Jansson, J., & Svensson, J. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0010 · Cited by 448 · see citing works
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works
Mechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance
Roden, M. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0190 · Cited by 404 · see citing works
Sutton-Tyrrell, K., Wildman, R. P., Matthews, K. A., Chae, C. U., Lasley, B. L., Brockwell, S. E., Pasternak, R. C., Lloyd‐Jones, D. M., Sowers, M. F., & Torréns, J. I. (2005) · Circulation · doi:10.1161/01.cir.0000157697.54255.ce · Cited by 401 · see citing works
Plasma fetuin-A levels and the risk of type 2 diabetes
Stefan, N., Fritsche, A., Weikert, C., Boeing, H., Joost, H.-G., Häring, H.-U., & Schulze, M. B. (2008) · Diabetes · doi:10.2337/db08-0538 · Cited by 379 · see citing works
Self-citationSpeliotes, E. K., Butler, J. L., Palmer, C. D., Voight, B. F., & Hirschhorn, J. N. (2010) · Hepatology · doi:10.1002/hep.23768 · Cited by 362 · see citing works
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works
Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human Disease
Jogie‐Brahim, S., Feldman, D., & Oh, Y. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0028 · Cited by 326 · see citing works
Auberger, P., Falquerho, L., Contreres, J. O., Pagès, G., Cam, G. L., Rossi, B., & Cam, A. L. (1989) · Cell · doi:10.1016/0092-8674(89)90098-6 · Cited by 321 · see citing works
Association Between Human Fetuin-A and the Metabolic Syndrome
Ix, J. H., Shlipak, M. G., Brandenburg, V. M., Ali, S., Ketteler, M., & Whooley, M. A. (2006) · Circulation · doi:10.1161/circulationaha.105.588723 · Cited by 316 · see citing works
Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.
Krssak, M., Brehm, A., Bernroider, E., Anderwald, C., Nowotny, P., Man, C. D., Cobelli, C., Cline, G. W., Shulman, G. I., Waldhäusl, W., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3048 · Cited by 313 · see citing works
Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke
Weikert, C., Stefan, N., Schulze, M. B., Pischon, T., Berger, K., Joost, H., Häring, H., Boeing, H., & Fritsche, A. (2008) · Circulation · doi:10.1161/circulationaha.108.814418 · Cited by 310 · see citing works
Kantartzis, K., Peter, A., Machicao, F. E., Machann, J., Wagner, S., Königsrainer, I., Königsrainer, A., Schick, F., Fritsche, A., Häring, H., et al. (2009) · Diabetes · doi:10.2337/db09-0279 · Cited by 299 · see citing works
Moses, A. C., Young, S. C., Morrow, L. A., O'Brien, M., & Clemmons, D. R. (1996) · Diabetes · doi:10.2337/diab.45.1.91 · Cited by 291 · see citing works
Kotronen, A., Johansson, L. E., Johansson, L., Roos, C., Westerbacka, J., Hamsten, A., Bergholm, R., Arkkila, P., Arola, J. T., Kiviluoto, T. A., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1285-z · Cited by 288 · see citing works
Denecke, B., Gräber, S., Schäfer, C., Heiss, A., Wöltje, M., & Jahnen‐Dechent, W. (2003) · Biochemical Journal · doi:10.1042/bj20030676 · Cited by 287 · see citing works
Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
Hennige, A. M., Staiger, H., Wicke, C., Machicao, F., Fritsche, A., Häring, H.-U., & Stefan, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001765 · Cited by 282 · see citing works
Kantartzis, K., Thamer, C., Peter, A., Machann, J., Schick, F., Schraml, C., Konigsrainer, A., Konigsrainer, I., Krober, S., Niess, A., et al. (2009) · Gut · doi:10.1136/gut.2008.151977 · Cited by 273 · see citing works
Fetuin-A and Incident Diabetes Mellitus in Older Persons
Ix, J. H. (2008) · JAMA · doi:10.1001/jama.300.2.182 · Cited by 267 · see citing works
Fatty liver index and mortality: The cremona study in the 15th year of follow-up
Calori, G., Lattuada, G., Ragogna, F., Garancini, M. P., Crosignani, P., Villa, M., Bosi, E., Ruotolo, G., Piemonti, L., & Perseghin, G. (2011) · Hepatology · doi:10.1002/hep.24356 · Cited by 253 · see citing works
Non-alcoholic Steatohepatitis and Cancer
Bugianesi, E. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.02.006 · Cited by 244 · see citing works
Srinivas, P. R., Wagner, A. S., Reddy, L. V. K., Deutsch, D. D., Leon, M. A., Goustin, A. S., & Grunberger, G. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.11.7906861 · Cited by 243 · see citing works
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene
Selva, D. M., Hogeveen, K. N., Innis, S. M., & Hammond, G. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32249 · Cited by 232 · see citing works
Angiopoietin-related growth factor antagonizes obesity and insulin resistance
Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., et al. (2005) · Nature Medicine · doi:10.1038/nm1214 · Cited by 219 · see citing works
The role of interleukin‐6 in insulin resistance, body fat distribution and energy balance
Hoene, M., & Weigert, C. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00410.x · Cited by 218 · see citing works
Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp522 · Cited by 217 · see citing works
Association of Serum Fetuin-A With Insulin Resistance in Type 2 Diabetic and Nondiabetic Subjects
Mori, K., Emoto, M., Yokoyama, H., Araki, T., Teramura, M., Koyama, H., Shoji, T., Inaba, M., & Nishizawà, Y. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1484 · Cited by 213 · see citing works
Reinehr, T., & Roth, C. L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1505 · Cited by 208 · see citing works
The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
Farese, R. V., Zechner, R., Newgard, C. B., & Walther, T. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.004 · Cited by 207 · see citing works
Hepatic glucose metabolism in humans—its role in health and disease
Roden, M., & Bernroider, E. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(03)00031-9 · Cited by 201 · see citing works
Sex hormone-binding globulin is synthesized in target cells
Kahn, S., Hryb, D. J., Nakhla, A. M., Romas, N. A., & Rosner, W. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750113 · Cited by 199 · see citing works
Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
Rosner, W., Hryb, D. J., Khan, M., Nakhla, A. M., & Romas, N. A. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00070-9 · Cited by 195 · see citing works
Sex hormone-binding globulin and type 2 diabetes mellitus
Le, T. N., Nestler, J. E., Strauss, J. F., & Wickham, E. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.09.005 · Cited by 191 · see citing works
Yang, S. J., Hwang, S. Y., Choi, H. Y., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0620 · Cited by 191 · see citing works
Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies
Haukeland, J. W., Dahl, T. B., Yndestad, A., Gladhaug, I. P., Løberg, E. M., Haaland, T., Konopski, Z., Wium, C., Aasheim, E. T., Johansen, O. E., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0864 · Cited by 186 · see citing works
Mathews, S. T. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00237-9 · Cited by 179 · see citing works
The Metabolically Benign and Malignant Fatty Liver
Stefan, N., & Häring, H. (2011) · Diabetes · doi:10.2337/db11-0231 · Cited by 172 · see citing works
Adiels, M., Olofsson, S., Taskinen, M., & Borén, J. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000226115.97436.c0 · Cited by 172 · see citing works
Dasgupta, S., Bhattacharya, S., Biswas, A., Majumdar, S. S., Mukhopadhyay, S., Ray, S., & Bhattacharya, S. (2010) · Biochemical Journal · doi:10.1042/bj20100330 · Cited by 168 · see citing works
Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
Peter, A., Kantartzis, K., Machann, J., Schick, F., Staiger, H., Machicao, F. E., Schleicher, E. D., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetes · doi:10.2337/db10-0179 · Cited by 156 · see citing works
Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women
Rajpathak, S. N., He, M., Sun, Q., Kaplan, R. C., Muzumdar, R. H., Rohan, T. E., Gunter, M. J., Pollak, M., Kim, M., Pessin, J. E., et al. (2012) · Diabetes · doi:10.2337/db11-1488 · Cited by 148 · see citing works
The impact of liver fat vs visceral fat in determining categories of prediabetes
Kantartzis, K., Machann, J., Schick, F., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetologia · doi:10.1007/s00125-010-1663-6 · Cited by 146 · see citing works
Vassilatou, E., Lafoyianni, S., Vryonidou, A., Ioannidis, D., Kosma, L. K., Katsoulis, K., Papavassiliou, E. D., & Tzavara, I. (2009) · Human Reproduction · doi:10.1093/humrep/dep380 · Cited by 142 · see citing works
Stefan, N., Thamer, C., Staiger, H., Machicao, F. E., Machann, J., Schick, F., Venter, C., Niess, A. M., Laakso, M., Fritsche, A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1785 · Cited by 141 · see citing works
The nucleotide and partial amino acid sequences of rat fetuin
Rauth, G., Poeschke, O., Fink, E., Eulitz, M., Tippmer, S., Kellerer, M., Häring, H.-U., Nawratil, P., Haasemann, M., Jahnen‐Dechent, W., et al. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16663.x · Cited by 134 · see citing works
Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin
Simó, R., Barbosa-Desongles, A., Lecube, A., Hernández, C., & Selva, D. M. (2011) · Diabetes · doi:10.2337/db11-0727 · Cited by 127 · see citing works
Boulware, S. D., Tamborlane, W. V., Rennert, N. J., Gesundheit, N., & Sherwin, R. S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117065 · Cited by 121 · see citing works
SECRETION OF TESTOSTERONE-ESTRADIOL-BINDING GLOBULIN BY A HUMAN HEPATOMA-DERIVED CELL LINE
Khan, M., Knowles, B. B., Aden, D. P., & ROSNE, R. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-2-448 · Cited by 116 · see citing works
Misu, H., Ishikura, K., Kurita, S., Takeshita, Y., Ota, T., Saito, Y., Takahashi, K., Kaneko, S., & Takamura, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034952 · Cited by 105 · see citing works
Arturi, F., Succurro, E., Procopio, C., Pedace, E., Mannino, G. C., Lugarà, M., Procopio, T., Andreozzi, F., Sciacqua, A., Hribal, M. L., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1227 · Cited by 103 · see citing works
Misu, H., Takamura, T., Matsuzawa, N., Shimizu, A., Ota, T., Sakurai, M., Ando, H., Arai, K., Yamashita, T., Honda, M., et al. (2007) · Diabetologia · doi:10.1007/s00125-006-0489-8 · Cited by 102 · see citing works
Ramnanan, C. J., Saraswathi, V., Smith, M. S., Donahue, E. P., Farmer, B., Farmer, T. D., Neal, D. W., Williams, P. E., Lautz, M., Mari, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45472 · Cited by 97 · see citing works
Goustin, A. S., & Abou‐Samra, A. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.11.003 · Cited by 97 · see citing works
Fisher, E., Stefan, N., Saar, K., Drogan, D., Schulze, M. B., Fritsche, A., Joost, H., Häring, H., Hübner, N., Boeing, H., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.870410 · Cited by 97 · see citing works
Doğru, T., Genç, H., Tapan, S., Aslan, F., Erçin, C. N., Örs, F., Kara, M., Sertoğlu, E., Karslıoğlu, Y., Bağcı, S., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04460.x · Cited by 90 · see citing works
Plasma Levels of Fetuin-A and Hepatic Enzymes and Risk of Type 2 Diabetes in Women in the U.S.
Sun, Q., Cornelis, M. C., Manson, J. E., & Hu, F. B. (2012) · Diabetes · doi:10.2337/db12-0372 · Cited by 87 · see citing works
Simó, R., Barbosa-Desongles, A., Hernández, C., & Selva, D. M. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1152 · Cited by 84 · see citing works
Serum fetuin-A is correlated with metabolic syndrome in middle-aged and elderly Chinese
Xu, Y., Xu, M., Bi, Y., Song, A., Huang, Y., Liu, Y., Wu, Y., Chen, Y., Wang, W., Li, X., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.01.020 · Cited by 76 · see citing works
Fetuin-A: the missing link in lipid-induced inflammation
Heinrichsdorff, J., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2869 · Cited by 76 · see citing works
Thamer, C., Machann, J., Stefan, N., Schäfer, S., Machicao, F. E., Staiger, H., Laakso, M., Böttcher, M., Claussen, C. D., Schick, F., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1209 · Cited by 76 · see citing works
Siddiq, A., Leprêtre, F., Herçberg, S., Froguel, P., & Gibson, F. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2477 · Cited by 75 · see citing works
Kacerovsky-Bielesz, G., Chmelik, M., Ling, C., Pokan, R., Szendroedi, J., Farukuoye, M., Kacerovsky, M., Schmid, A. I., Gruber, S., Wolzt, M., et al. (2009) · Diabetes · doi:10.2337/db08-1240 · Cited by 75 · see citing works
Serum Fetuin-A is an Independent Marker of Insulin Resistance in Japanese Men
Ishibashi, A., Ikeda, Y., Ohguro, T., Kumon, Y., Yamanaka, S., Takata, H., Inoue, M., Suehiro, T., & Terada, Y. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.3830 · Cited by 71 · see citing works
Association of Fetuin-A With Incident Diabetes Mellitus in Community-Living Older Adults
Ix, J. H., Biggs, M. L., Mukamal, K. J., Kizer, J. R., Zieman, S. J., Siscovick, D. S., Mozaffarian, D., Jensen, M. K., Nelson, L., Ruderman, N. B., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.072751 · Cited by 71 · see citing works
Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase
Mathews, S. T., Srinivas, P. R., Leon, M. A., & Grunberger, G. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00737-6 · Cited by 68 · see citing works
Kaess, B. M., Enserro, D. M., McManus, D. D., Xanthakis, V., Chen, M., SULLIVAN, L. M., Ingram, C., O'Donnell, C. J., Keaney, J. F., Vasan, R. S., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1458 · Cited by 67 · see citing works
Takata, H., Ikeda, Y., Suehiro, T., Ishibashi, A., Inoue, M., Kumon, Y., & Terada, Y. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.no950 · Cited by 66 · see citing works
Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes
Stefan, N., Schick, F., & Häring, H.-U. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0910143 · Cited by 66 · see citing works
Rittig, K., Thamer, C., Haupt, A., Machann, J., Peter, A., Balletshofer, B. M., Fritsche, A., Häring, H., & Stefan, N. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.018 · Cited by 63 · see citing works
Sex Hormone‐Binding Globulin Binding to Cell Membranes and Generation of a Second Messenger
Rosner, W., Hryb, D. J., Khan, M., Nakhla, A. M., & Romas, N. A. (1992) · Journal of Andrology · doi:10.1002/j.1939-4640.1992.tb01637.x · Cited by 61 · see citing works
The stress response of the liver to physical exercise
Hoene, M., & Weigert, C. (2026) · PubMed · doi:10.22029/eir.2010.1658 · Cited by 60 · see citing works
AHSG Tag Single Nucleotide Polymorphisms Associate With Type 2 Diabetes and Dyslipidemia
Andersen, G., Burgdorf, K. S., Sparsø, T., Borch‐Johnsen, K., Jørgensen, T., Hansen, T. F., & Pedersen, O. B. (2008) · Diabetes · doi:10.2337/db07-0558 · Cited by 51 · see citing works
Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis
Ebert, T., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., Stümvoll, M., & Faßhauer, M. (2009) · Metabolism · doi:10.1016/j.metabol.2008.11.016 · Cited by 51 · see citing works
Viewpoints on the Way to a Consensus Session
Perseghin, G. (2009) · Diabetes Care · doi:10.2337/dc09-s303 · Cited by 50 · see citing works
Hepatic Gene Networks in Morbidly Obese Patients With Nonalcoholic Fatty Liver Disease
Gawrieh, S., Baye, T. M., Carless, M. A., Wallace, J. R., KOMOROWSKI, R. A., Kleiner, D. E., Andris, D. A., Makladi, B., Cole, R., Charlton, M., et al. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0171-6 · Cited by 43 · see citing works
Irisin—behind the benefits of exercise
Cunha, A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.11 · Cited by 23 · see citing works
A Proposed New Paradigm for Insulin Resistance
Lautt, W. W. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/1540419031361417 · Cited by 10 · see citing works
Glypican-4: role in insulin signalling
Mitchell, F. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.133 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Byrne, C. D., & Targher, G. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.12.012 · Cited by 3,082 · see citing works
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works
Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications
Stefan, N., Häring, H.-U., Hu, F. B., & Schulze, M. B. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70062-7 · Cited by 857 · see citing works
Self-citationStefan, N., Häring, H., & Cusi, K. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30154-2 · Cited by 848 · see citing works
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772 · see citing works
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D’Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman‐Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 726 · see citing works
Recent insights into the pathogenesis of nonalcoholic fatty liver disease
Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573 · see citing works
Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood
Blüher, S., Schwarz, P. E. H., & Klusmann, J. (2018) · Metabolism · doi:10.1016/j.metabol.2018.12.001 · Cited by 574 · see citing works
Francque, S., van der Graaff, D., & Kwanten, W. J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.005 · Cited by 557 · see citing works
The impact of insulin resistance on the kidney and vasculature
Artunç, F., Schleicher, E. D., Weigert, C., Fritsche, A., Stefan, N., & Häring, H. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.145 · Cited by 474 · see citing works
Oni, E., Agatston, A. S., Blaha, M. J., Fialkow, J. A., Cury, R. C., Sposito, A. C., Erbel, R., Blankstein, R., Feldman, T., Al-Mallah, M. H., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.052 · Cited by 352 · see citing works
Muscle as a “Mediator” of Systemic Metabolism
Baskin, K. K., Winders, B. R., & Olson, E. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.021 · Cited by 333 · see citing works
Novel insights in SHBG regulation and clinical implications
Simó, R., Sáez-López, C., Barbosa-Desongles, A., Hernández, C., & Selva, D. M. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.05.001 · Cited by 335 · see citing works
Okamura, T., Hashimoto, Y., Hamaguchi, M., Obora, A., Kojima, T., & Fukui, M. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0076-3 · Cited by 325 · see citing works
TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation
Velloso, L. A., Folli, F. B., & Saad, M. J. A. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1100 · Cited by 314 · see citing works
Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
Randrianarisoa, E., Lehn-Stefan, A., Wang, X., Hoene, M., Peter, A., Heinzmann, S. S., Zhao, X., Königsrainer, I., Königsrainer, A., Balletshofer, B., et al. (2016) · Scientific Reports · doi:10.1038/srep26745 · Cited by 296 · see citing works
The role of hepatokines in NAFLD
Stefan, N., Schick, F., Birkenfeld, A. L., Häring, H., & White, M. F. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.01.006 · Cited by 282 · see citing works
Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism
Jegatheesan, P., & Bandt, J. P. D. (2017) · Nutrients · doi:10.3390/nu9030230 · Cited by 280 · see citing works
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282 · see citing works
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works
Self-citationHepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism
Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255 · see citing works
The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease
Ruiz-Núñez, B., Dijck-Brouwer, J., & Muskiet, F. A. J. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.12.007 · Cited by 246 · see citing works
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
Stefan, N., Schick, F., & Häring, H.-U. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1412427 · Cited by 235 · see citing works
Pathogenesis of nonalcoholic steatohepatitis
Liu, W., Baker, R. D., Bhatia, T., Zhu, L., & Baker, S. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2161-x · Cited by 225 · see citing works
Meex, R. C. R., Blaak, E. E., & van Loon, L. J. C. (2019) · Obesity Reviews · doi:10.1111/obr.12862 · Cited by 218 · see citing works
CKD and Nonalcoholic Fatty Liver Disease
Targher, G., Chonchol, M. B., & Byrne, C. D. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.05.019 · Cited by 213 · see citing works
Insulin action at a molecular level – 100 years of progress
White, M. F., & Kahn, C. R. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101304 · Cited by 214 · see citing works
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210 · see citing works
Phenotypes of prediabetes and stratification of cardiometabolic risk
Stefan, N., Fritsche, A., Schick, F., & Häring, H.-U. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)00082-6 · Cited by 208 · see citing works
Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus
Ortiz‐Martínez, M., González‐González, M., Martagón, A. J., Hlavinka, V., Willson, R. C., & Rito‐Palomares, M. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01453-4 · Cited by 225 · see citing works
Biomarkers of insulin sensitivity and insulin resistance: Past, present and future
Park, S. E., Park, C., & Sweeney, G. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1023429 · Cited by 206 · see citing works
Crosstalk between adipokines and myokines in fat browning
Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works
Weinstein, G., Zelber-Sagi, S., Preis, S. R., Beiser, A. S., DeCarli, C., Speliotes, E. K., Satizabal, C. L., Vasan, R. S., & Seshadri, S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3229 · Cited by 186 · see citing works
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works
The immunomodulating role of exercise in metabolic disease
Lancaster, G. I., & Febbraio, M. A. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.02.008 · Cited by 193 · see citing works
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
Zhao, Y., Zhao, M., Jiang, S., Wu, J., Liu, J., Yuan, X., Shen, D., Zhang, J., Zhou, N., He, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14450-6 · Cited by 172 · see citing works
Nobili, V., Alisi, A., Newton, K. P., & Schwimmer, J. B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.009 · Cited by 171 · see citing works
Obesity, adipokines and neuroinflammation
Aguilar‐Valles, A., Inoue, W., Rummel, C. D., & Luheshi, G. N. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.023 · Cited by 166 · see citing works
Metabolic interplay between white, beige, brown adipocytes and the liver
Scheja, L., & Heeren, J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.025 · Cited by 171 · see citing works
NAFLD, and cardiovascular and cardiac diseases: Factors influencing risk, prediction and treatment
Targher, G., Corey, K. E., & Byrne, C. D. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.101215 · Cited by 170 · see citing works
Narasimhan, A., Mayilvanan, C., & Karundevi, B. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0002 · Cited by 164 · see citing works
Fetuin-A: A novel link between obesity and related complications
Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161 · see citing works
On the Run for Hippocampal PlasticityPreprint
Cooper, C. P., Moon, H. Y., & van Praag, H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029736 · Cited by 160 · see citing works
Targher, G., Mantovani, A., Pichiri, I., Mingolla, L., Cavalieri, V., Mantovani, W., Pancheri, S., Trombetta, M., Zoppini, G., Chonchol, M., et al. (2014) · Diabetes Care · doi:10.2337/dc13-2704 · Cited by 157 · see citing works
Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality
Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A., & Isaacs, A. J. (2019) · Diabetologia · doi:10.1007/s00125-019-05024-3 · Cited by 153 · see citing works
Gerst, F., Wagner, R., Kaiser, G., Panse, M., Heni, M., Machann, J., Bongers, M. N., Sartorius, T., Sipos, B., Fend, F., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4385-1 · Cited by 151 · see citing works
Self-citationPeriostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα
Lü, Y., Liu, X., Jiao, Y., Xiong, X., Wang, E., Wang, X., Zhang, Z., Zhang, H., Pan, L., Guan, Y., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74438 · Cited by 130 · see citing works
Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.005 · Cited by 129 · see citing works
Badoud, F., Perreault, M., Zulyniak, M. A., & Mutch, D. M. (2014) · The FASEB Journal · doi:10.1096/fj.14-263913 · Cited by 127 · see citing works
Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
Kim, H.-M., Lee, D. S., An, T. H., Park, H., Kim, W. K., Bae, K., & Oh, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094495 · Cited by 130 · see citing works
Circulating follistatin is liver-derived and regulated by the glucagon-to-insulin ratio
Hansen, J. S., Rutti, S., Arous, C., Clemmesen, J. O., Secher, N. H., Drescher, A., Gonelle-Gispert, C., Halban, P. A., Pedersen, B. K., Weigert, C., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3668 · Cited by 125 · see citing works
Bourebaba, L., & Marycz, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122033 · Cited by 123 · see citing works
Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk
Sanches, J. M., Zhao, L. N., Salehi, A. A., Wollheim, C. B., & Kaldis, P. (2021) · FEBS Journal · doi:10.1111/febs.16306 · Cited by 125 · see citing works
Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis?
Mantovani, A., Gisondi, P., Lonardo, A., & Targher, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020217 · Cited by 119 · see citing works
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
Kücükoglu, Ö., Sowa, J., Mazzolini, G. D., Syn, W., & Canbay, A. E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.030 · Cited by 115 · see citing works
Stefan, N., Ramsauer, M., Jordan, P., Nowotny, B., Kantartzis, K., Machann, J., Hwang, J., Nowotny, P., KAHL, S., Harreiter, J., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70170-0 · Cited by 114 · see citing works
Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity
Anjani, K., Lhomme, M., Sokolovska, N., Poitou, C., Aron-Wisnewsky, J., Bouillot, J.-L., Lesnik, P., Bedossa, P., Kontush, A., Clement, K., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.002 · Cited by 106 · see citing works
Hepatokines: unlocking the multi-organ network in metabolic diseases
Iroz, A., Couty, J.-P., & Postic, C. (2015) · Diabetologia · doi:10.1007/s00125-015-3634-4 · Cited by 111 · see citing works
Barazzoni, R., Deutz, N. E. P., Biolo, G., Bischoff, S., Boirie, Y., Cederholm, T., Cuerda, C., Delzenne, N., Leon Sanz, M., Ljungqvist, O., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.010 · Cited by 112 · see citing works
Stefan, N., Häring, H., Hu, F., & Schulze, M. (2016) · The Lancet Diabetes and Endocrinology · doi:10.1016/s2213-8587(15)00474-x · Cited by 108 · see citing works
Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes
Cohen, G., Riahi, Y., Sunda, V., Deplano, S., Chatgilialoglu, C., Ferreri, C., Kaiser, N., & Sasson, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.163 · Cited by 109 · see citing works
Sefried, S., Häring, H., Weigert, C., & Eckstein, S. S. (2018) · Royal Society Open Biology · doi:10.1098/rsob.180147 · Cited by 97 · see citing works
Hansen, J. S., Pedersen, B. K., Xu, G., Lehmann, R., Weigert, C., & Plomgaard, P. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1681 · Cited by 106 · see citing works
Inactivating hepatic follistatin alleviates hyperglycemia
Tao, R., Wang, C., Stöhr, O., Qiu, W., Hu, Y., Miao, J., Dong, X. C., Leng, S., Stefater, M., Stylopoulos, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0048-0 · Cited by 104 · see citing works
The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes
Oliveira, A. G., Araújo, T. G., Carvalho, B. D. M., Rocha, G. Z., Santos, A., & Saad, M. J. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00503 · Cited by 103 · see citing works
Karampela, Ι., Christodoulatos, G. S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00360-2 · Cited by 103 · see citing works
Organ-organ communication: The liver's perspective
Wang, F., So, K., Xiao, J., & Wang, H. (2021) · Theranostics · doi:10.7150/thno.55795 · Cited by 107 · see citing works
Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi
Xiong, X., Wang, Q., Wang, S., Zhang, J., Liu, T., Guo, L., Yu, Y., & Lin, J. D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2018.12.004 · Cited by 100 · see citing works
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.009 · Cited by 97 · see citing works
Children With Metabolically Healthy Obesity: A Review
Vuković, R., Santos, T. J. D., Ybarra, M., & Atar, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00865 · Cited by 98 · see citing works
Wu, H.-T., Ou, H.-Y., Hung, H.-C., Su, Y.-C., Lu, F.-H., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2016) · Diabetologia · doi:10.1007/s00125-016-3991-7 · Cited by 96 · see citing works
Dobson, R., Burgess, M. I., Sprung, V. S., Irwin, A., Hamer, M., Jones, J., Daousi, C., Adams, V. L., Kemp, G. J., Shojaee‐Moradie, F., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.151 · Cited by 93 · see citing works
Hepatokines as a Link between Obesity and Cardiovascular Diseases
Yoo, H. J., & Choi, K. M. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.1.10 · Cited by 94 · see citing works
Metabolically Healthy and Unhealthy Normal Weight and Obesity
Stefan, N. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.301 · Cited by 94 · see citing works
Gong, X.-M., Li, Y., Luo, J., Wang, J., Wei, J. N., Wang, J.-Q., Xiao, T., Xie, C., Hong, J., Ning, G., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0065-4 · Cited by 93 · see citing works
Chen, Y.-S., Liu, H.-M., & Lee, T.-Y. (2019) · Cells · doi:10.3390/cells8030253 · Cited by 92 · see citing works
Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease
Itoh, N., Nakayama, Y., & Konishi, M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00030 · Cited by 93 · see citing works
GDF15 is a heart‐derived hormone that regulates body growth
Wang, T., Liu, J., McDonald, C., Lupino, K., Zhai, X., Wilkins, B. J., Hakonarson, H. H., & Pei, L. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707604 · Cited by 92 · see citing works
Videla, L. A., & Valenzuela, R. (2021) · BioFactors · doi:10.1002/biof.1797 · Cited by 91 · see citing works
Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition
Hu, H., Lee, S., Sousa‐Lima, I., Kim, S. S., Hwang, W. M., Dagon, Y., Yang, W.-M., Cho, S., Kang, M., Seo, J. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci63562 · Cited by 89 · see citing works
Guria, S., Hoory, A., Das, S., Chattopadhyay, D., & Mukherjee, S. (2023) · Bioscience Reports · doi:10.1042/bsr20220200 · Cited by 89 · see citing works
Soto-Alarcón, S. A., Valenzuela, R., Valenzuela, A., & Videla, L. A. (2017) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530317666171114120552 · Cited by 88 · see citing works
Hepatokines and non-alcoholic fatty liver disease
Lebensztejn, D. M., Flisiak-Jackiewicz, M., Białokoz-Kalinowska, I., Bobrus-Chociej, A., & Kowalska, I. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1252 · Cited by 90 · see citing works
“This is not a homogeneous disease entity; depending on the severity of the pathological process, it may present as an isolated hepatic steatosis (simple steatosis), nonalcoholic steatohepatitis (NASH), or may lead to liver cirrhosis and hepatocellular carcinoma (HCC) (Caldwell & Argo, 2010; Vernon…”
BackgroundConnelly, M. A., Wolak, J. E., & Dullaart, R. P. F. (2017) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0145 · Cited by 85 · see citing works
Peter, A., Kovářová, M., Staiger, H., Machann, J., Schick, F., Königsrainer, A., Königsrainer, I., Schleicher, E. D., Fritsche, A., Häring, H., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2017 · Cited by 82 · see citing works
Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity
Seo, J. A., Kang, M., Yang, W.-M., Hwang, W. M., Kim, S. S., Hong, S. H., Heo, J.-I., Vijyakumar, A., de Moura, L. P., Üner, A. G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15963-w · Cited by 82 · see citing works
Heo, J., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Choi, K. M., Baik, S. H., Choi, D. S., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12493 · Cited by 80 · see citing works
Stefan, N., Sun, Q., Fritsche, A., Machann, J., Schick, F., Gerst, F., Jeppesen, C., Joost, H., Hu, F. B., Boeing, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092238 · Cited by 80 · see citing works
Oh, S., Tsujimoto, T., Kim, B., Uchida, F., Suzuki, H., Iizumi, S., Isobe, T., Sakae, T., Tanaka, K., & Shoda, J. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100253 · Cited by 77 · see citing works
Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population
Reinehr, T., & Roth, C. L. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1110-5 · Cited by 76 · see citing works
Impact of Lipotoxicity on Tissue “Cross Talk” and Metabolic Regulation
Montgomery, M. K., Nardo, W. D., & Watt, M. J. (2019) · Physiology · doi:10.1152/physiol.00037.2018 · Cited by 78 · see citing works
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
Zhou, B., Luo, Y., Ji, N., Hu, C., & Lu, Y. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00627-4 · Cited by 75 · see citing works
Bourebaba, N., Ngo, T., Śmieszek, A., Bourebaba, L., & Marycz, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113261 · Cited by 75 · see citing works
Tascher, G., Burban, A., Camus, S., Plumel, M. I., Chanon, S., Guével, R. L., Shevchenko, V., DORSSELAER, A. V., Lefai, É., Guguen‐Guillouzo, C., et al. (2019) · Cells · doi:10.3390/cells8020192 · Cited by 74 · see citing works
Hwang, H.-J., Jung, T. W., Kim, B.-H., Hong, H. C., Seo, J. A., Kim, S. G., Kim, N. H., Choi, K. M., Choi, D. S., Baik, S. H., et al. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.098 · Cited by 72 · see citing works
Yoo, H. J., Hwang, S. Y., Choi, J.-H., Lee, H. J., Chung, H. S., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174717 · Cited by 72 · see citing works
The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
Wang, Q., Sharma, V. P., Shen, H., Xiao, Y., Zhu, Q., Xiong, X., Guo, L., Jiang, L., Ohta, K., Li, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0020-9 · Cited by 71 · see citing works
Implication of hepatokines in metabolic disorders and cardiovascular diseases
Jung, T. W., Yoo, H. J., & Choi, K. M. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.002 · Cited by 71 · see citing works
Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
Liu, J., Zhang, Y., Tian, Y., Huang, W. C., Tong, N., & Fu, X. (2022) · Theranostics · doi:10.7150/thno.65778 · Cited by 69 · see citing works
- Authors
- Stefan, N., & Häring, H.-U.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Corresponding author
- Stefan, Norbert
- Venue
- Nature Reviews Endocrinology
- Published
- 2013-01-22
- Volume
- 9
- Issue
- 3
- Pages
- 144-152
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2060371641
- Cited by
- 500
- References
- 120
- Citations by year
- 2026: 25 · 2025: 28 · 2024: 24 · 2023: 28 · 2022: 36 · 2021: 48 · 2020: 36 · 2019: 40 · 2018: 43 · 2017: 55 · 2016: 53 · 2015: 39 · 2014: 36 · 2013: 9
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- hepatokines, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, fetuin-A, glucose metabolism, lipid metabolism, lipoprotein metabolism, adipokines, myokines, drug development, disease screening
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Fatty Liver, Female, Glucose, Humans, Liver, Male, Muscle Proteins, Muscle, Skeletal, Lipid Metabolism, Adipokines, alpha-2-HS-Glycoprotein, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review