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Cited by 11

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells

Jin, Hanyong, Won, Miae, Shin, Eunkyoung, Kim, Hong-Man, Lee, Kangseok, Bae, Jeehyeon·2017·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2016.11.127
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Abstract

Pituitary gonadotropins are key hormones that orchestrate the growth and development of ovarian follicles. However, limited information is available on intra-ovarian factors that mediate the actions of gonadotropins. In this study, we identified that the early growth response 2 gene (EGR2) is a gonadotropin-inducible gene in granulosa cells of rats and humans. Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. Overexpression of EGR2 promoted survival of KGN human granulosa-derived cells in which IER3 acts as a mediator; knockdown of EGR2 induced death in KGN cells. Additionally, EGR2 was found to regulate the expression of myeloid cell leukemia 1 (MCL-1), which belongs to the BCL-2 family of proteins regulating cell survival. Thus, this study identified a novel signaling axis, comprised of gonadotropins-EGR2-IER3, which is important for the survival of granulosa cells during folliculogenesis.

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Metadata

Authors
Jin, H., Won, M., Shin, E., Kim, H.-M., Lee, K., & Bae, J.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2017-01
Volume
482
Issue
4
Pages
877-882
ISSN
0006-291X
DOI
10.1016/j.bbrc.2016.11.127
Cited by
11
References
42
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Research Foundation of Korea
  • Ministry of Science, ICT, and Future Planning (NRF-2015R1A5A1008958, NRF-2015R1A2A1A15054332)

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CoChat. (2026). Citation check: EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells. https://app.cochat.ai/papers/10.1016/j.bbrc.2016.11.127
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Jin, H., Won, M., Shin, E., Kim, H.-M., Lee, K., & Bae, J. (2017). EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2016.11.127

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.