The MAPK signalling pathways and colorectal cancer

Fang, Jing Yuan; Richardson, Bruce C

doi:10.1016/s1470-2045(05)70168-6

Cited by 1,185Melanoma and MAPK PathwaysColorectal Cancer Treatments and StudiesProtein Kinase Regulation and GTPase Signaling

The MAPK signalling pathways and colorectal cancer

Fang, Jing Yuan, Richardson, Bruce C·2005·The Lancet Oncology

DOI 10.1016/s1470-2045(05)70168-6

Open this paper in CoChat — free account

Abstract

There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases (JNK or SAPK); and MAPK14. The ERK MAPK pathway is one of the most important for cell proliferation. The MAPK pathways are located downstream of many growth-factor receptors, including that for epidermal growth factor. Overexpression and activation of this receptor are commonly detected in colorectal cancer, and several lines of evidence indicate that overexpression and activation of ERK MAPK play an important part in progression of this cancer. ERK MAPK could be a molecular target for treatment of the disorder. This review focuses on the ERK MAPK signal-transduction pathway, the consequences of its dysregulation in colorectal cancer, and its potential as an approach to cancer treatment. Future challenges for the assessment of these targeted agents in the clinic are also presented.

Integrity signals

Registry

Crossref · 10.1016/s1470-2045(05)70168-6

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Targeting JAK/STAT and PI3K, which affect the MAPK pathway, has been explored in the treatment of colon cancer.
“Additionally, targeting the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and phosphatidylinositol-3 kinase (PI3K), which affect the MAPK pathway, has been explored in the treatment of colon cancer [64].”
From RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches (2025) · cites this paper as [64]

1 retracted

Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Tai, Y., Podar, K., Catley, L. P., Tseng, Y., Akiyama, M., Shringarpure, R., Burger, R., Hideshima, T., Chauhan, D., Mitsiades, N., et al. (2003) · PubMed · Cited by 189 · see citing works
Retracted
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674 · see citing works
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448 · see citing works
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016 · see citing works
Prevalence of ras gene mutations in human colorectal cancers
Bos, J. L., Fearon, E. R., Hamilton, S. R., Vries, M. V., BOOM, J. H. V., van der Eb, A. J., & Vogelstein, B. (1987) · Nature · doi:10.1038/327293a0 · Cited by 1,860 · see citing works
Signal Transduction through MAP Kinase Cascades
Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,746 · see citing works
MAP Kinases in the Immune Response
Dong, C., Davis, R. J., & Flavell, R. A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.091301.131133 · Cited by 1,660 · see citing works
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538 · see citing works
RAF/RAS oncogenes and mismatch-repair status
Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002) · Nature · doi:10.1038/418934a · Cited by 1,224 · see citing works
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,213 · see citing works
Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway
Lavoie, J. N., L’Allemain, G., Brunet, A., Müller, R., & Pouysségur, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20608 · Cited by 1,210 · see citing works
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
Forrester, K., Almoguera, C., Han, K., Grizzle, W. E., & Perucho, M. (1987) · Nature · doi:10.1038/327298a0 · Cited by 1,061 · see citing works
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
Sebolt, J. S., Dudley, D. T., Herrera, R., Becelaere, K. V., Wiland, A. M., Gowan, R. C., Tecle, H., Barrett, S. D., Bridges, A. J., Przybranowski, S. A., et al. (1999) · Nature Medicine · doi:10.1038/10533 · Cited by 972 · see citing works
The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product
Crews, C. M., Alessandrini, A., & Erikson, R. L. (1992) · Science · doi:10.1126/science.1411546 · Cited by 930 · see citing works
Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
Pai, R., Soreghan, B. A., Szabó, I., Pavelka, M., Baatar, D., & Tarnawski, A. S. (2002) · Nature Medicine · doi:10.1038/nm0302-289 · Cited by 836 · see citing works
Kirsten ras mutations in patients with colorectal cancer: The multicenter “RASCAL” study
Andreyev, H. J. N., Norman, A. R., Clarke, P. A., Cunningham, D., & Oates, J. R. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.9.675 · Cited by 748 · see citing works
c‐Jun regulates cell cycle progression and apoptosis by distinct mechanisms
Wisdom, R., Johnson, R. S., & Moore, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.188 · Cited by 687 · see citing works
Ternary complex factors: growth factor regulated transcriptional activators
Treisman, R. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90097-3 · Cited by 676 · see citing works
Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation
Khokhlatchev, A. V., Canagarajah, B. J., Wilsbacher, J. L., Robinson, M. J., Atkinson, M. A., Goldsmith, E. J., & Cobb, M. H. (1998) · Cell · doi:10.1016/s0092-8674(00)81189-7 · Cited by 675 · see citing works
Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice
Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., & Pouysségur, J. (1999) · Science · doi:10.1126/science.286.5443.1374 · Cited by 654 · see citing works
Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer
Rinehart, J., Adjei, A. A., LoRusso, P. M., Waterhouse, D., Hecht, J. R., Natale, R. B., Hamid, O., Varterasian, M., Asbury, P., Kaldjian, E. P., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.01.185 · Cited by 645 · see citing works
Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1
Woods, D. B., Parry, D., Cherwinski, H. M., Bosch, E., Lees, E. M., & McMahon, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5598 · Cited by 639 · see citing works
The Sevenfold Way of PKC Regulation
Liu, W. S., & Heckman, C. A. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00012-6 · Cited by 487 · see citing works
Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers
Bardelli, A., Parsons, D. W., Silliman, N., Ptak, J., Szabo, S., Saha, S., Markowitz, S. D., Willson, J. K. V., Parmigiani, G., Kinzler, K. W., et al. (2003) · Science · doi:10.1126/science.1082596 · Cited by 485 · see citing works
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
Hommes, D. W., Peppelenbosch, M. P., & van Deventer, S. J. H. (2002) · Gut · doi:10.1136/gut.52.1.144 · Cited by 474 · see citing works
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
Caltagirone, S., Rossi, C., Poggi, A., Ranelletti, F. O., Natali, P. G., Brunetti, M., Aiello, F. B., & Piantelli, M. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20000815)87:4 · Cited by 441 · see citing works
BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, But Not in Hereditary Nonpolyposis Colorectal Cancer
Deng, G., Bell, I., Crawley, S., Gum, J. R., Terdiman, J. P., Allen, B. A., Truta, B., Sleisenger, M. H., & Kim, Y. S. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1118-3 · Cited by 408 · see citing works
The role of mitogen-activated protein (MAP) kinase in breast cancer
Santen, R. J., Song, R. X.-D., McPherson, R., Kumar, R., Adam, L., Jeng, M., & Yue, W. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00189-3 · Cited by 403 · see citing works
A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
Smalley, K. S. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.10978 · Cited by 325 · see citing works
Development of anticancer drugs targeting the MAP kinase pathway
Sebolt–Leopold, J. S. (2000) · Oncogene · doi:10.1038/sj.onc.1204083 · Cited by 321 · see citing works
Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation
Schwenger, P., Bellosta, P., Vietor, I., Basilico, C., Skolnik, E. Y., & Vilček, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2869 · Cited by 273 · see citing works
Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.
Yen, A., Roberson, M. S., Varvayanis, S. S., & Lee, A. T. (1998) · PubMed · Cited by 256 · see citing works
Phase III Double-Blind Placebo-Controlled Study of Farnesyl Transferase Inhibitor R115777 in Patients With Refractory Advanced Colorectal Cancer
Rao, S., Cunningham, D., de Gramont, A., Scheithauer, W., Šmakal, M., Humblet, Y., Kourteva, G., Iveson, T. J., André, T., Dostalova, J., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.10.037 · Cited by 244 · see citing works
Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.
Troppmair, J., Bruder, J. T., Munoz, H., Lloyd, P. A., Kyriakis, J. M., Banerjee, P., Avruch, J., & Rapp, U. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37478-1 · Cited by 240 · see citing works
The Genetics of Colorectal Cancer
Calvert, P. M., & Frucht, H. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-7-200210010-00012 · Cited by 231 · see citing works
The Stress-activated Protein Kinases p38α and JNK1 Stabilize p21Cip1 by Phosphorylation
Kim, G.-Y., Mercer, S. E., Ewton, D. Z., Yan, Z., Jin, K., & Friedman, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201299200 · Cited by 231 · see citing works
CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family
Maroney, A. C., Finn, J. P., Connors, T. J., Durkin, J. T., Angeles, T. S., Gessner, G. W., Xu, Z., Meyer, S. L., Savage, M. J., Greene, L. A., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011601200 · Cited by 206 · see citing works
Mechanism of 17-β-Estradiol-induced Erk1/2 Activation in Breast Cancer Cells
Keshamouni, V. G., Mattingly, R. R., & Reddy, K. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202351200 · Cited by 174 · see citing works
Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1
Kerkhoff, E., & Rapp, U. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2576 · Cited by 165 · see citing works
Ursodeoxycholic Acid (UDCA) Can Inhibit Deoxycholic Acid (DCA)-induced Apoptosis via Modulation of EGFR/Raf-1/ERK Signaling in Human Colon Cancer Cells
Im, E., & Martinez, J. D. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.483 · Cited by 153 · see citing works
Farnesyl transferase inhibitors: a novel targeted therapy for cancer
Johnston, S. R. D. (2001) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00191-1 · Cited by 142 · see citing works
Up-regulation of Cyclooxygenase-2 and Apoptosis Resistance by p38 MAPK in Hypericin-mediated Photodynamic Therapy of Human Cancer Cells
Hendrickx, N., Volanti, C., Moens, U. L., Seternes, O. M., de Witte, P. A. M., Vandenheede, J. R., Piette, J. G., & Agostinis, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307591200 · Cited by 141 · see citing works
Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells
Vial, E., & Marshall, C. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00812 · Cited by 138 · see citing works
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.
Remacle-Bonnet, M. M., Garrouste, F. L., Heller, S., André, F., Marvaldi, J. L., & Pommier, G. J. (2000) · PubMed · Cited by 138 · see citing works
Protein Kinase C (PKC) βII Induces Cell Invasion through a Ras/Mek-, PKCι/Rac 1-dependent Signaling Pathway
Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A., & Fields, A. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400774200 · Cited by 136 · see citing works
Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.
Soh, J. W., Mao, Y. K., Kim, M., et al. (2000) · PubMed · Cited by 134 · see citing works
Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway
Sato, S., Fujita, N., & Tsuruo, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402055200 · Cited by 108 · see citing works
Cyclic AMP Promotes cAMP-responsive Element-binding Protein-dependent Induction of Cellular Inhibitor of Apoptosis Protein-2 and Suppresses Apoptosis of Colon Cancer Cells through ERK1/2 and p38 MAPK
Nishihara, H., Hwang, M., Kizaka‐Kondoh, S., Eckmann, L., & Insel, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313346200 · Cited by 105 · see citing works
Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κB
Wang, Q., Wang, X., & Evers, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306541200 · Cited by 104 · see citing works
15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor γ via the MAPK Signaling Pathway
Hsi, L. C., Wilson, L. C., Nixon, J. B., & Eling, T. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100280200 · Cited by 100 · see citing works
Regulation of the Activity of p38 Mitogen-Activated Protein Kinase by Akt in Cancer and Adenoviral Protein E1A-Mediated Sensitization to Apoptosis
Liao, Y., & Hung, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.19.6836-6848.2003 · Cited by 97 · see citing works
Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK
Zhu, H., Zhang, L., Wu, S., Teraishi, F., Davis, J. J., Jacob, D., & Fang, B. (2004) · Oncogene · doi:10.1038/sj.onc.1207645 · Cited by 88 · see citing works
Alterations of MAPK Activities Associated with Intestinal Cell Differentiation
Ding, Q., Wang, Q., & Evers, B. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4969 · Cited by 83 · see citing works
Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1
Soh, J., Mao, Y., Liu, L., Thompson, W. J., Pamukcu, R., & Weinstein, I. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100079200 · Cited by 82 · see citing works
Diallyl Disulfide Induces ERK Phosphorylation and Alters Gene Expression Profiles in Human Colon Tumor Cells
Knowles, L. M., & Milner, J. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2901 · Cited by 82 · see citing works
Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR–β1 integrin complex in colon cancer cells
Ahmed, N., Oliva, K., Wang, Y., Quinn, M. A., & Rice, G. E. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601098 · Cited by 80 · see citing works
Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-κB-dependent pathway
Wang, X., Wang, Q., Hu, W., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207312 · Cited by 79 · see citing works
Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation
Taupin, D. R., & Podolsky, D. K. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70010-7 · Cited by 79 · see citing works
Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells
Ukegawa, J.-I., Takeuchi, Y., Kusayanagi, S., et al. (2003) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-003-0433-y · Cited by 73 · see citing works
Suppression of polyamine catabolism by activated Ki‐ras in human colon cancer cells
Ignatenko, N. A., Babbar, N., Mehta, D. J., Casero, R. A., & Gerner, E. W. (2004) · Molecular Carcinogenesis · doi:10.1002/mc.10166 · Cited by 72 · see citing works
Ras/Raf signalling and emerging pharmacotherapeutic targets
Kölch, W. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.6.709 · Cited by 62 · see citing works
Cell-type-specific activation of c-Jun N-terminal kinase by salicylates
Schwenger, P., Alpert, D. R., Skolnik, E. Y., & ek, J. V. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199904)179:1 · Cited by 55 · see citing works
Therapeutics targeting signal transduction for patients with colorectal carcinoma
Bono, J. S. D., & Rowinsky, E. K. (2002) · British Medical Bulletin · doi:10.1093/bmb/64.1.227 · Cited by 52 · see citing works
MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival
Finlay, D., Healy, V., Furlong, F. M., et al. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400652 · Cited by 51 · see citing works
Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer
Watanabe, M., Ishiwata, T., Nishigai, K., Moriyama, Y., & Asano, G. (2000) · Pathology International · doi:10.1046/j.1440-1827.2000.01054.x · Cited by 50 · see citing works
Analysis of Signaling Protein Kinases in Human Colon or Colorectal Carcinomas
Licato, L. L., & Brenner, D. A. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018894227169 · Cited by 49 · see citing works
Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases
McMillan, L., Butcher, S. K., Pongracz, J. E., & Lord, J. M. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600793 · Cited by 49 · see citing works
Activation of c‐Jun‐N‐terminal‐kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers
Grösch, S., Tegeder, I., Schilling, K., Maier, T. J., Niederberger, E., & Geißlinger, G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0919fje · Cited by 48 · see citing works
Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells
Chen, D.-B., & Davis, J. S. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00379-9 · Cited by 43 · see citing works
Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors
Lynch, C. C., Crawford, H. C., Matrisian, L. M., et al. (2004) · International Journal of Oncology · doi:10.3892/ijo.24.6.1565 · Cited by 42 · see citing works
Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3′-kinase activation: potential role of insulin-stimulated H2O2
Mahadev, K. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.002 · Cited by 37 · see citing works
Involvement of both extracellular signal‐regulated kinase and c‐jun N‐terminal kinase pathways in the 12‐O‐tetradecanoylphorbol‐13‐acetate–induced upregulation of p21Cip1 in colon cancer cells
Lin, S., Liang, Y., Ho, Y., et al. (2002) · Molecular Carcinogenesis · doi:10.1002/mc.10070 · Cited by 36 · see citing works
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Rice, P. L., Washington, M. N., Schleman, S., et al. (2003) · PubMed · Cited by 35 · see citing works
Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
Okumura, K., Shirasawa, S., Nishioka, M., & Sasazuki, T. (1999) · PubMed · Cited by 34 · see citing works
Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer.
Cassano, A., Bagalá, C., Battelli, C., et al. (2002) · PubMed · Cited by 31 · see citing works
ERK1/2 phosphorylation: a biomarker analysis within a phase I study with the new Raf kinase inhibitor BAY43-9006
Hilger, R. A., Kredke, S., Hedley, D. W., et al. (2002) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp40567 · Cited by 17 · see citing works

Flagged first, then by citations

Sorted by citations

A novel signaling pathway impact analysis
Tarca, A. L., Draghici, S., Khatri, P., Hassan, S. S., Mittal, P., Kim, J.-S., Kim, C. J., Kusanovic, J. P., & Romero, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btn577 · Cited by 1,031 · see citing works
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
Joanito, I., Wirapati, P., Zhao, N., Nawaz, Z., Yeo, G., Lee, F., Eng, C. L. P., Macalinao, D. C., Kahraman, M., Srinivasan, H., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01100-4 · Cited by 434 · see citing works
Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?
Stefani, C., Miricescu, D., Stanescu-Spinu, I.-I., Nica, R. I., Greabu, M., Totan, A. R., & Jinga, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910260 · Cited by 402 · see citing works
Retaining cell–cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer
Kondo, J., Endo, H., Okuyama, H., Ishikawa, O., Iishi, H., Tsujii, M., Ohue, M., & Inoue, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015938108 · Cited by 322 · see citing works
Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials
Song, Y., Bi, Z., Liu, Y., Qin, F., Wei, Y., & Wei, X. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.05.006 · Cited by 212 · see citing works
Recurrent inactivating RASA2 mutations in melanoma
Arafeh, R., Qutob, N., Emmanuel, R., Keren-Paz, A., Madore, J., Elkahloun, A., Wilmott, J. S., Gartner, J. J., Di Pizio, A., Winograd-Katz, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3427 · Cited by 107 · see citing works
The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction
Nagasaka, K., Pim, D., Massimi, P., Thomas, M., Tomaić, V, Subbaiah, V. K., Kranjec, C., Nakagawa, S., Yano, T., Taketani, Y., et al. (2010) · Oncogene · doi:10.1038/onc.2010.265 · Cited by 75 · see citing works
Solution NMR Insights into Docking Interactions Involving Inactive ERK2
Piserchio, A., Warthaka, M., Devkota, A. K., Kaoud, T. S., Lee, S., Abramczyk, O., Ren, P., Dalby, K. N., & Ghose, R. (2011) · Biochemistry · doi:10.1021/bi2000559 · Cited by 41 · see citing works
Histone deacetylase 6 selective inhibitor ACY1215 inhibits cell proliferation and enhances the chemotherapeutic effect of 5-fluorouracil in HCT116 cells
Tan, Y., Zhang, S., Zhu, H., Chu, Y., Zhou, H., Liu, D., & Huo, J. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2018.11.48 · Cited by 35 · see citing works
TfR2 expression in human colon carcinomas
Calzolari, A., Deaglio, S., Maldi, E., Cassoni, P., Malavasi, F., & Testa, U. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.08.001 · Cited by 32 · see citing works
Quantifying ERK2–protein interactions by fluorescence anisotropy: PEA-15 inhibits ERK2 by blocking the binding of DEJL domains
Callaway, K., Rainey, M. A., & Dalby, K. N. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.11.002 · Cited by 26 · see citing works
Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro
Su, Y., Liu, Y., He, D., Hu, G., Wang, H., Ye, B., He, Y., Gao, X., & Liu, D. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108694 · Cited by 26 · see citing works
Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation
Zhang, X., Du, L., Zhang, J., Li, C., Zhang, J., & Lv, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.712232 · Cited by 17 · see citing works
Protozoan‐Derived Cytokine‐Transgenic Macrophages Reverse Hepatic Fibrosis
Chen, Y., Wang, J., Zhou, N., Fang, Q., Cai, H., Du, Z., An, R., Liu, D., Chen, X., Wang, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202308750 · Cited by 12 · see citing works
RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches
Sütcüoğlu, O., Yıldırım, H. Ç., Almuradova, E., Günenç, D., & Yalçın, Ş. (2025) · Medicina · doi:10.3390/medicina61071202 · Cited by 10 · see citing works
PPP1r18 promotes tumor progression in esophageal squamous cell carcinoma by regulating the calcineurin-mediated ERK pathway
Ren, C., Wu, L., Zhang, S., Qi, K., Zhang, Y., Xu, J., Ruan, Y., & Feng, M. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae028 · Cited by 5 · see citing works

Effects of radiofrequency fields on RAS and ERK kinases activity in live cells using the bioluminescence resonance energy transfer technique
Poque, E., Arnaud‐Cormos, D., Patrignoni, L., et al. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1730016 · Cited by 10 · see citing works
Phosphorylation of MAP kinases by MAP/ERK kinases involves multiple regions of MAP kinases.
Wilsbacher, J. L., Goldsmith, E. J., & Cobb, M. H. (1999) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)55580-6
Effect of Angiotensin III on ERK1/2 and p38 mitogen activated protein (MAP) kinases in Wistar rat VSMCs
Alanazi, A. Z., & Clark, M. A. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.782.4
Intracellular Signal Cascade in CD4+T-Lymphocyte Migration Stimulated by Interferon-γ-Inducible Protein-10
Kukhtina, N. B., Arefieva, T. I., & Krasnikova, T. L. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0165-5 · Cited by 7 · see citing works
The Role of MAP Kinases in Trauma and Ischemia–Reperfusion
Lai, E. W., Toledo-Pereyra, L. H., Walsh, J., et al. (2004) · Journal of Investigative Surgery · doi:10.1080/08941930490269646 · Cited by 11 · see citing works

Authors: Fang, J. Y., & Richardson, B. C.
Affiliations: Renji Hospital (CN)
University of Michigan (US)
Corresponding author: Fang, Jing Yuan
ORCID: Fang, Jing Yuan
Richardson, Bruce C
Venue: The Lancet Oncology
Publisher: Elsevier BV
Published: 2005-05
Volume: 6
Issue: 5
Pages: 322-327
ISSN: 1470-2045 (ISSN-L)
DOI: 10.1016/s1470-2045(05)70168-6
OpenAlex: W2154458783
Cited by: 1,185
References: 76
Citations by year: 2026: 61 · 2025: 131 · 2024: 126 · 2023: 116 · 2022: 116 · 2021: 94 · 2020: 50 · 2019: 42 · 2018: 46 · 2017: 39 · 2016: 40 · 2015: 49 · 2014: 31 · 2013: 37 · 2012: 35
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: MAPK signaling, colorectal cancer, ERK MAPK, JNK, MAPK14, epidermal growth factor receptor, cell proliferation, signal transduction, targeted cancer therapy, tumor progression
MeSH terms: Cell Cycle, Enzyme Activation, Humans, Colorectal Neoplasms, MAP Kinase Signaling System, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The MAPK signalling pathways and colorectal cancer

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks