The DOI matches its Crossref record; 179 of the 181 references it cites were found in a registry or an index.
Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors
Open accessAbstract
Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and participate in a variety of physiological functions. Recent advances have revealed roles of nAChRs in the regulation of synaptic transmission and synaptic plasticity, particularly in the hippocampus and midbrain dopamine centers. In general, activation of nAChRs causes membrane depolarization and directly and indirectly increases the intracellular calcium concentration. Thus, when nAChRs are expressed on presynaptic membranes their activation generally increases the probability of neurotransmitter release. When expressed on postsynaptic membranes, nAChR-initiated calcium signals and depolarization activate intracellular signaling mechanisms and gene transcription. Together, the presynaptic and postsynaptic effects of nAChRs generate and facilitate the induction of long-term changes in synaptic transmission. The direction of hippocampal nAChR-mediated synaptic plasticity - either potentiation or depression - depends on the timing of nAChR activation relative to coincident presynaptic and postsynaptic electrical activity, and also depends on the location of cholinergic stimulation within the local network. Therapeutic activation of nAChRs may prove efficacious in the treatment of neuropathologies where synaptic transmission is compromised, as in Alzheimer's or Parkinson's disease.
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“A sign switch of synaptic plasticity (necessary in the D network when the target remains real during the REM phase) was experimentally observed by the action of acetylcholine [36] and is also involved in the regulation of REM sleep [19].”
From How Adversarial REM Dreams May Facilitate Creativity, and Why We Become Aware of Them (2024) · cites this paper as [36]
In the citing paper
“An important role for both nAChRs and mAChRs has been defined in hippocampal synaptic plasticity (reviewed in (Giocomo and Hasselmo, 2007; McKay et al., 2007)) and these effects are mediated through intracellular signaling pathways downstream of mAChRs and nAChRs (reviewed in (Berg and Conroy, 2002; Cancela, 2001; Lanzafame et al., 2003; Rathouz et al., 1996)).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as McKay et al., 2007
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Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Bi, G.-Q., & Poo, M.-M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10464.1998 · Cited by 4,744
Ion Channels/Excitable Membranes
(2011) · Springer eBooks · doi:10.1007/springerreference_33998 · Cited by 4,066
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Excitatory actions of gaba during development: the nature of the nurture
Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., & Kaila, K. (1999) · Nature · doi:10.1038/16697 · Cited by 2,152
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Neuromodulation of neurons and synapses
Farzan Nadim, A., & Bucher, D. M. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.05.003 · Cited by 340
The Allen Brain Atlas: 5 years and beyond
Jones, A. R., Overly, C. C., & Sunkin, S. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2722 · Cited by 333
Le Foll, B., Piper, M. E., Fowler, C. D., Tonstad, S., Bierut, L., Lu, L., Jha, P., & Hall, W. D. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00346-w · Cited by 316
Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine
Dani, J. A. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.07.001 · Cited by 309
Self-citation
Metadata
- Authors
- McKay, B. E., Placzek, A. N., & Dani, J. A.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Dani, John A.
- ORCID
- Dani, John A.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 74
- Issue
- 8
- Pages
- 1120-1133
- ISSN
- 0006-2952 (ISSN-L)
- PMC
- PMC2047292
- OpenAlex
- W1964188222
- Cited by
- 181
- References
- 181
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 12 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 11
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke (T32NS043124, R37NS021229, R01NS021229)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, synaptic transmission, synaptic plasticity, hippocampus, midbrain dopamine, presynaptic neurotransmitter release, intracellular signaling, long-term potentiation, long-term depression, cholinergic modulation, Alzheimer's disease, Parkinson's disease
- MeSH terms
- Animals, Hippocampus, Humans, Synaptic Transmission, Neuronal Plasticity, Receptors, Nicotinic, Signal Transduction, Ventral Tegmental Area, Long-Term Potentiation
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