Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine
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Nicotinic acetylcholine receptors (nAChRs) belong to the "Cys-loop" superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors. There are 16 homologous mammalian nAChR subunits encoded by a multigene family. These subunits combine to form many different nAChR subtypes with various expression patterns, diverse functional properties, and differing pharmacological characteristics. Because cholinergic innervation is pervasive and nAChR expression is extremely broad, practically every area of the brain is impinged upon by nicotinic mechanisms. This review briefly examines the structural and functional properties of the receptor/channel complex itself. The review also summarizes activation and desensitization of nAChRs by the low nicotine concentrations obtained from tobacco. Knowledge of the three-dimensional structure and the structural characteristics of channel gating has reached an advanced stage. Likewise, the basic functional properties of the channel also are reasonably well understood. It is these receptor/channel properties that underlie the participation of nAChRs in nearly every anatomical region of the mammalian brain.
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Nicotine acts through nicotinic cholinergic receptors, which are pentameric ligand-gated ion channels widely distributed throughout the brain.
“Nicotine mediates its effects via nicotinic cholinergic receptors (nAChRs), pentameric ligand-gated ion channels that are widely distributed throughout the brain (Dani, 2015; Zoli et al., 2015).”
From Unique, long-term effects of nicotine on adolescent brain. (2020) · cites this paper as Dani, 2015
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Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724 · see citing works
Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution
Unwin, N. C. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.031 · Cited by 1,661 · see citing works
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471 · see citing works
Self-citationNicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
Self-citationNicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070 · see citing works
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947 · see citing works
Self-citationEmerging structure of the Nicotinic Acetylcholine receptors
Karlin, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn731 · Cited by 921 · see citing works
Celie, P. H. N., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., & Sixma, T. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00115-1 · Cited by 781 · see citing works
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720 · see citing works
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Taly, A., Corringer, P., Guédin, D., Lestage, P. J., & Changeux, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2927 · Cited by 706 · see citing works
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
Hilf, R. J. C., & Dutzler, R. (2008) · Nature · doi:10.1038/nature06717 · Cited by 665 · see citing works
Molecular and cellular aspects of nicotine abuse
Dani, J. A., & Heinemann, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80112-9 · Cited by 605 · see citing works
Self-citationMutations in the channel domain alter desensitization of a neuronal nicotinic receptor
Revah, F., Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M., & Changeux, J. (1991) · Nature · doi:10.1038/353846a0 · Cited by 524 · see citing works
Recent advances in Cys-loop receptor structure and function
Sine, S. M., & Engel, A. G. (2006) · Nature · doi:10.1038/nature04708 · Cited by 521 · see citing works
Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
Vernino, S. A., Amador, M., Luetje, C. W., Patrick, J., & Dani, J. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90114-s · Cited by 468 · see citing works
Self-citationDesensitization of neuronal nicotinic receptors
Quick, M. W., & Lester, R. A. J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10109 · Cited by 456 · see citing works
Cellular and synaptic mechanisms of nicotine addiction
Mansvelder, H. D., & McGehee, D. S. (2002) · Journal of Neurobiology · doi:10.1002/neu.10148 · Cited by 438 · see citing works
Galzi, J., Devillers‐Thiéry, A., Hussy, N., Bertrand, S., Changeux, J., & Bertrand, D. (1992) · Nature · doi:10.1038/359500a0 · Cited by 417 · see citing works
Overview of nicotinic receptors and their roles in the central nervous system
Dani, J. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01011-8 · Cited by 414 · see citing works
Self-citationBertrand, D., Galzi, J., Devillers‐Thiéry, A., Bertrand, S., & Changeux, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6971 · Cited by 390 · see citing works
Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors
Brody, A. L., Mandelkern, M. A., London, E. D., Olmstead, R. E., Farahi, J., Scheibal, D., Jou, J., Allen, V., Tiongson, E., Chefer, S. I., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.907 · Cited by 367 · see citing works
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
Self-citationWooltorton, J. R. A., Pidoplichko, V. I., Broide, R. S., & Dani, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03176.2003 · Cited by 363 · see citing works
Self-citationDesensitization of nicotinic ACh receptors: shaping cholinergic signaling
GINIATULLIN, R., NISTRI, A., & YAKEL, J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.04.009 · Cited by 357 · see citing works
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332 · see citing works
Ca2+ permeability of nicotinic acetylcholine receptors
Fucile, S. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.08.006 · Cited by 320 · see citing works
Diversity of native nicotinic receptor subtypes in mammalian brain
Zoli, M., Pistillo, F., & Gotti, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.003 · Cited by 277 · see citing works
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
Lee, W. Y., & Sine, S. M. (2005) · Nature · doi:10.1038/nature04156 · Cited by 273 · see citing works
alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability
Castro, N. G., & Albuquerque, E. X. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80213-4 · Cited by 273 · see citing works
Galzi, J., Revah, F., Black, D. M., Goeldner, M. P., HIRTH, C. G., & Changeux, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86964-2 · Cited by 248 · see citing works
Unwin, P. N. T., Miyazawa, A., Li, J., & Fujiyoshi, Y. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00381-9 · Cited by 246 · see citing works
Tzartos, S. J., Kokla, A., Walgrave, S. L., & Conti-Tronconi, B. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.2899 · Cited by 215 · see citing works
Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing
Unwin, N. C., & Fujiyoshi, Y. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.07.010 · Cited by 209 · see citing works
Potentiation of nicotinic receptor response by external calcium in rat central neurons
Mulle, C., Léna, C., & Changeux, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90208-u · Cited by 197 · see citing works
Pidoplichko, V. I., Noguchi, J., Areola, O. O., Liang, Y., Peterson, J., Zhang, T., & Dani, J. A. (2004) · Learning & Memory · doi:10.1101/lm.70004 · Cited by 196 · see citing works
Self-citationMerging old and new perspectives on nicotinic acetylcholine receptors
Papke, R. L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.029 · Cited by 183 · see citing works
Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors
McKay, B. E., Placzek, A. N., & Dani, J. A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.001 · Cited by 181 · see citing works
Self-citationIon-channel entrances influence permeation. Net charge, size, shape, and binding considerations
Dani, J. A. (1986) · Biophysical Journal · doi:10.1016/s0006-3495(86)83688-8 · Cited by 177 · see citing works
Self-citationDecker, E. R., & Dani, J. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-10-03413.1990 · Cited by 175 · see citing works
Self-citationDopamine Signaling Differences in the Nucleus Accumbens and Dorsal Striatum Exploited by Nicotine
Zhang, T., Zhang, L., Liang, Y., Siapas, A. G., Zhou, F.-M., & Dani, J. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0261-09.2009 · Cited by 165 · see citing works
Self-citationVernino, S. A., Rogers, M., Radcliffe, K. A., & Dani, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05514.1994 · Cited by 163 · see citing works
Self-citationThe nicotinic receptor ligand binding domain
Sine, S. M. (2002) · Journal of Neurobiology · doi:10.1002/neu.10139 · Cited by 161 · see citing works
Unwin, N. (2013) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583513000061 · Cited by 153 · see citing works
(1999) · doi:10.1016/s0376-8716(99)00025-3 · Cited by 146 · see citing works
Liu, L., Zhao-Shea, R., McIntosh, J. M., Gardner, P. D., & Tapper, A. R. (2012) · Molecular Pharmacology · doi:10.1124/mol.111.076661 · Cited by 121 · see citing works
Zhao-Shea, R., Liu, L., Soll, L. G., Improgo, M. R., Meyers, E. E., McIntosh, J. M., Grady, S. R., Marks, M. J., Gardner, P. D., & Tapper, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.240 · Cited by 113 · see citing works
Popot, J., DEMEL, R. A., Sobel, A., Deenen, L. L. M. V., & Changeux, J. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12209.x · Cited by 108 · see citing works
Dani, J. A., Radcliffe, K. A., & Pidoplichko, V. I. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00003-0 · Cited by 103 · see citing works
Self-citationDani, J. A., & Eisenman, G. (1987) · The Journal of General Physiology · doi:10.1085/jgp.89.6.959 · Cited by 101 · see citing works
Self-citationLuo, J., Taylor, P., Losen, M. H., Baets, M. H. D., Shelton, G. D., & Lindstrom, J. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2833-09.2009 · Cited by 90 · see citing works
Nicotinic Receptors in Addiction Pathways
Leslie, F. M., Mojica, C., & Reynaga, D. D. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083659 · Cited by 87 · see citing works
Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel
Dani, J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-03-00884.1989 · Cited by 86 · see citing works
Self-citationAmador, M., & Dani, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04525.1995 · Cited by 81 · see citing works
Self-citationStratification of the channel domain in neurotransmitter receptors
Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Bertrand, S., & Changeux, J. (1993) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(93)90141-c · Cited by 81 · see citing works
Haghighi, A. P., & Cooper, E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00529.2000 · Cited by 75 · see citing works
Kracun, S., Harkness, P. C., Gibb, A. J., & Millar, N. S. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707676 · Cited by 70 · see citing works
Structure and function of glutamate and nicotinic acetylcholine receptors
Dani, J. A., & Mayer, M. L. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80043-3 · Cited by 63 · see citing works
Self-citationHistorical and current perspective on tobacco use and nicotine addiction
Dani, J. A., & Balfour, D. J. K. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.05.001 · Cited by 60 · see citing works
Self-citationTracking the Molecular Evolution of Calcium Permeability in a Nicotinic Acetylcholine Receptor
Lipovsek, M., Fierro, A., Pérez, E. G., Boffi, J. C., Millar, N. S., Fuchs, P. A., Katz, E., & Elgoyhen, A. B. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu258 · Cited by 49 · see citing works
Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones
Fayuk, D. A., & Yakel, J. L. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089789 · Cited by 48 · see citing works
The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
Williams, D. K., Stokes, C. A., Horenstein, N. A., & Papke, R. L. (2011) · The Journal of General Physiology · doi:10.1085/jgp.201010587 · Cited by 48 · see citing works
Structure of Neuronal Nicotinic Receptors
Fasoli, F., & Gotti, C. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13665-3_1 · Cited by 45 · see citing works
Lewis, A. S., & Picciotto, M. R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3126-5 · Cited by 38 · see citing works
Pollock, V. V., Pastoor, T., Katnik, C., Cuevas, J., & Wecker, L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.032 · Cited by 31 · see citing works
Dendritic Spikes and Their Influence on Extracellular Calcium Signaling
Wiest, M., Eagleman, D. M., King, R., & Montague, P. R. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1329 · Cited by 28 · see citing works
Agonist activation of a nicotinic acetylcholine receptor
Auerbach, A. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.004 · Cited by 27 · see citing works
Function of nicotinic acetylcholine receptors.
Steinbach, J. H., & Sine, S. M. (1987) · PubMed · Cited by 7 · see citing works
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- Dani JA Kosten TR Benowitz NL 2014 The pharmacology of nicotine and tobacco Ries RK Fiellin DA Miller SC Saitz R The ASAM principles of addiction medicine 5 201 216 Philadelphia, PA Wolters Kluwer chapter 12
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Current advances in research in treatment and recovery: Nicotine addiction
Prochaska, J. J., & Benowitz, N. L. (2019) · Science Advances · doi:10.1126/sciadv.aay9763 · Cited by 219 · see citing works
Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction
Wittenberg, R. E., Wolfman, S. L., Biasi, M. D., & Dani, J. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108256 · Cited by 200 · see citing works
Self-citationRuan, S., Zhou, Y., Jiang, X., & Gao, H. (2021) · Advanced Science · doi:10.1002/advs.202004025 · Cited by 195 · see citing works
Gąsiorowska, A., Wydrych, M., Drapich, P., Zadrożny, M., Steczkowska, M., Niewiadomski, W., & Niewiadomska, G. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654931 · Cited by 192 · see citing works
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Aroniadou‐Anderjaska, V., Figueiredo, T. H., Furtado, M. D. A., Pidoplichko, V. I., & Braga, M. F. M. (2023) · Toxics · doi:10.3390/toxics11100866 · Cited by 182 · see citing works
Unique, long-term effects of nicotine on adolescent brain.
Leslie, F. M. (2020) · Pharmacology, Biochemistry, and Behavior · doi:10.1016/j.pbb.2020.173010 · Cited by 178 · see citing works
“…its effects via nicotinic cholinergic receptors (nAChRs), pentameric ligand-gated ion channels that are widely distributed throughout the brain (Dani, 2015; Zoli et al., 2015). nAChRs consist of pentameric arrays of homomeric (α7–α10) or heteromeric of α (α2–α7) and β (β2–β4) subunits, giving…”
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Nicotine and the nicotinic cholinergic system in COVID‐19
Tizabi, Y., Getachew, B., Copeland, R., & Aschner, M. (2020) · FEBS Journal · doi:10.1111/febs.15521 · Cited by 64 · see citing works
Alexandris, N., Lagoumintzis, G., Chasapis, C. T., Leonidas, D. D., Papadopoulos, G. E., Tzartos, S. J., Tsatsakis, A. M., Eliopoulos, E., Poulas, K. A., & Farsalinos, K. E. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.12.013 · Cited by 63 · see citing works
Cunha, J. E., Barbosa, G. M., Castro, P. A. T. D. S., Luiz, B. L. F., Silva, A. C. A., Russo, T. L., Vasilceac, F. A., Cunha, T. M., Cunha, F. Q., & Salvini, T. F. (2019) · Scientific Reports · doi:10.1038/s41598-019-42546-7 · Cited by 62 · see citing works
Molecular mechanisms for nicotine intoxication
Alkam, T., & Nabeshima, T. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.02.006 · Cited by 62 · see citing works
Molecular insights into the benefits of nicotine on memory and cognition (Review)
Alhowail, A. H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12037 · Cited by 61 · see citing works
Tobacco and Nervous System Development and Function—New Findings 2015–2020
Hajdusianek, W., Żórawik, A., Waliszewska‐Prosół, M., Poręba, R., & Gać, P. (2021) · Brain Sciences · doi:10.3390/brainsci11060797 · Cited by 61 · see citing works
Schwartz, A., & Bellissimo, N. (2021) · Appetite · doi:10.1016/j.appet.2021.105260 · Cited by 59 · see citing works
Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
Mamaligas, A. A., Cai, Y., & Ford, C. (2016) · Scientific Reports · doi:10.1038/srep37834 · Cited by 56 · see citing works
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
Naumenko, V. S., & Ponimaskin, E. G. (2018) · Neural Plasticity · doi:10.1155/2018/5701348 · Cited by 55 · see citing works
Yang, Y. H., Eguchi, A., Wan, X., Chang, L., Wang, X., Qu, Y., Mori, C., & Hashimoto, K. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110652 · Cited by 53 · see citing works
Immunopathogenesis of COVID-19 and early immunomodulators
Lee, K., Rhim, J. W., & Kang, J.-H. (2020) · Korean Journal of Pediatrics · doi:10.3345/cep.2020.00759 · Cited by 49 · see citing works
Lee, C.-H., & Hung, S.-Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010031 · Cited by 50 · see citing works
Rueda‐Ruzafa, L., Cedillo, J. L., & Hone, A. J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031189 · Cited by 50 · see citing works
Opposite effects of smoking and nicotine intake on cognition
de Almeida, N. L. P., Rodrigues, S. J., Gonçalves, L. M., Silverstein, S. M., Sousa, I. C., Gomes, G. H., Butler, P. D., Fernandes, T. P., & dos Santos, N. A. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113357 · Cited by 47 · see citing works
Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone, RIC-3
Mizrachi, T., Vaknin‐Dembinsky, A., Brenner, T., & Treinin, M. (2021) · Molecules · doi:10.3390/molecules26206139 · Cited by 46 · see citing works
Novel Pharmacotherapies in Parkinson’s Disease
Tizabi, Y., Getachew, B., & Aschner, M. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00375-5 · Cited by 43 · see citing works
Cartereau, A., Martin, C., & Thany, S. H. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14018 · Cited by 43 · see citing works
Potential Therapeutic Application for Nicotinic Receptor Drugs in Movement Disorders
Quik, M., Boyd, J. T., Bordia, T., & Perez, X. A. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty063 · Cited by 38 · see citing works
Getachew, B., Csoka, A. B., Aschner, M., & Tizabi, Y. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.12.003 · Cited by 38 · see citing works
Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease
Iarkov, A., Mendoza, C., & Echeverrı́a, V. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.665820 · Cited by 34 · see citing works
Lessons from lonely flies: Molecular and neuronal mechanisms underlying social isolation
Yadav, R. S. P., Ansari, F., Bera, N., Kent, C. F., & Agrawal, P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105504 · Cited by 34 · see citing works
A cholinergic circuit that relieves pain despite opioid tolerance
Sullere, S., Kunczt, A., & McGehee, D. S. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.017 · Cited by 30 · see citing works
Siregar, P., Hsieh, Y.-C., Audira, G., Suryanto, M. E., Macabeo, A. P. G., Vasquez, R. D., & Hsiao, C. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124111 · Cited by 30 · see citing works
Acetylcholine nicotinic receptor subtypes in chromaffin cells
Criado, M. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2050-7 · Cited by 30 · see citing works
Nicotinic Receptor Subunits Atlas in the Adult Human Lung
Diabasana, Z., Perotin, J., Belgacemi, R., Ancel, J., Mulette, P., Delépine, G., Gosset, P., Maskos, U., Polette, M., Deslée, G., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207446 · Cited by 30 · see citing works
Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
Singh, S., Agrawal, N., & Goyal, A. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230627123426 · Cited by 29 · see citing works
Takata, K., Kimura, H., Yanagisawa, D., Harada, K., Nishimura, K., Kitamura, Y., Shimohama, S., & Tooyama, I. (2022) · Molecules · doi:10.3390/molecules27092780 · Cited by 29 · see citing works
You, H., Liu, C., Du, X., & McManus, D. P. (2017) · Molecules · doi:10.3390/molecules22091550 · Cited by 28 · see citing works
Jin, W., Wu, Y., Chen, N., Wang, Q., Wang, Y., Li, Y., Li, S., Han, X., Yang, E., Tong, F., et al. (2021) · Theranostics · doi:10.7150/thno.58947 · Cited by 28 · see citing works
Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease
Soares, É. N., Costa, A. C. D. S., Ferrolho, G. D. J., Ureshino, R. P., Getachew, B., Costa, S. L., da Silva, V. D. A., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13060474 · Cited by 27 · see citing works
Nicotine and Cardiovascular Health: When Poison is Addictive – a WHF Policy Brief
Dorotheo, E. U., Arora, M., Banerjee, A., Bianco, E., Cheah, N. P., Dalmau, R., Eissenberg, T., Hasegawa, K., Naidoo, P., Nazir, N. T., et al. (2024) · Global Heart · doi:10.5334/gh.1292 · Cited by 28 · see citing works
Luo, J., Remy, A., & Zhang, Y. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00579 · Cited by 27 · see citing works
Ranjit, S., Patters, B. J., Gerth, K. A., Haque, S., Choudhary, S., & Kumar, S. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1501473 · Cited by 27 · see citing works
Tobacco Use Decreases Visual Sensitivity in Schizophrenia
Fernandes, T. M. P., de Andrade, M. J. O., Santana, J. B., Nogueira, R. M. T. B. L., & dos Santos, N. A. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00288 · Cited by 27 · see citing works
Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives
Wedn, A. M., El‐Bassossy, H. M., Eid, A. H., & El‐Mas, M. M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114703 · Cited by 27 · see citing works
Carcinogenicity of nicotine and signal pathways in cancer progression: a review
Rao, Z., Xu, Y., He, Z., Wang, J., Ji, H., Zhang, Z., Zhou, J., Zhou, T., & Wang, H. (2023) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01668-1 · Cited by 26 · see citing works
Lin, M., Chen, Y., Yang, H.-B., Lin, C., & Hung, S. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00803-7 · Cited by 26 · see citing works
Cooper, S. Y., & Henderson, B. J. (2020) · Molecules · doi:10.3390/molecules25184223 · Cited by 28 · see citing works
Hirano, T., Miyata, Y., Kubo, S., Ohno, S., Onaru, K., Maeda, M., KITAUCHI, S., NISHI, M., Tabuchi, Y., Ikenaka, Y., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.02.010 · Cited by 26 · see citing works
Embryonic Nicotine Exposure Disrupts Adult Social Behavior and Craniofacial Development in Zebrafish
Borrego‐Soto, G., & Eberhart, J. K. (2022) · Toxics · doi:10.3390/toxics10100612 · Cited by 26 · see citing works
Guzmán‐Mejía, F., López‐Rubalcava, C., & González‐Espinosa, C. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9760-7 · Cited by 25 · see citing works
Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells
Harmych, S. J., Kumar, J. P., Bouni, M. E., & Chadee, D. N. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112167 · Cited by 25 · see citing works
Singh, N., Wanjari, A., & Sinha, A. H. (2023) · Cureus · doi:10.7759/cureus.49162 · Cited by 24 · see citing works
Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease
Carbone, E., Borges, R., Eiden, L. E., Garcı́a, A. G., & Hernández‐Cruz, A. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00098.x · Cited by 23 · see citing works
Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies
Odegaard, K. E., Chand, S., Wheeler, S. P., Tiwari, S., Flores, A., Hernandez, J. B., Savine, M., Gowen, A. M., Pendyala, G., & Yelamanchili, S. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186765 · Cited by 27 · see citing works
Conserved Nicotine-Activated Neuroprotective Pathways Involve Mitochondrial Stress
Nourse, J. B., Harshefi, G., Marom, A. D., Karmi, A., Ben-Ami, H. C., Caldwell, K. A., Caldwell, G. A., & Treinin, M. (2020) · iScience · doi:10.1016/j.isci.2021.102140 · Cited by 23 · see citing works
Lee, A. M., Mansuri, M. S., Wilson, R. S., Lam, T. T., Nairn, A. C., & Picciotto, M. R. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.657064 · Cited by 23 · see citing works
Xu, Y., Cao, K., Guo, B., Xiang, J., Dong, Y., Qi, X., Yu, W., Xiao, Y. C., & Guan, Z. (2020) · Aging · doi:10.18632/aging.103435 · Cited by 22 · see citing works
Chang, L., Liang, H., Kandel, S. R., & He, J. J. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09963-2 · Cited by 22 · see citing works
Nour, M. A., Hajiasgharzadeh, K., Kheradmand, F., Asadzadeh, Z., Bolandi, N., & Baradaran, B. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119557 · Cited by 22 · see citing works
Lee, S., & Kim, J. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.3.320 · Cited by 21 · see citing works
Nguyen, T. M., Ngoc, D. T. M., Choi, J., & Lee, C. H. (2023) · Cells · doi:10.3390/cells12151996 · Cited by 20 · see citing works
Nicotinic receptors in airway disease
Borkar, N. A., Thompson, M. A., Bartman, C. M., Khalfaoui, L., Sine, S. M., Sathish, V., Prakash, Y. S., & Pabelick, C. M. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00268.2023 · Cited by 19 · see citing works
Magnussen, J. H. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70061 · Cited by 21 · see citing works
Rosenthal, J., Yin, J., Lei, J., Sathyamurthy, A., Short, J., Long, C., Spillman, E., Sheng, C., & Yuan, Q. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004685118 · Cited by 19 · see citing works
Delgado‐Vélez, M., Quesada, O., Villalobos‐Santos, J. C., Maldonado‐Hernández, R., Asmar-Rovira, G. A., Stevens, R. C., & Lasalde‐Dominicci, J. A. (2021) · Molecules · doi:10.3390/molecules26195753 · Cited by 19 · see citing works
Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors
Hone, A. J., & McIntosh, J. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.981760 · Cited by 19 · see citing works
Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell
d’Incamps, B. L., Zorbaz, T., Dingová, D., Krejci, É., & Ascher, P. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0070-18.2018 · Cited by 19 · see citing works
Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function
Lallai, V., Grimes, N. P., Fowler, J. P., Sequeira, P. A., Cartagena, P. M., Limón, A., Coutts, M., Monuki, E. S., Bunney, W. E., Demuro, A., et al. (2019) · eNeuro · doi:10.1523/eneuro.0051-19.2019 · Cited by 19 · see citing works
Nicotinic Receptor Intervention in Parkinson's Disease: Future Directions.
Tizabi, Y., & Getachew, B. (2017) · PubMed · Cited by 19 · see citing works
Mild‐to‐severe poisoning due to Conium maculatum as toxic herb: A case series
Boskabadi, S. J., Askari, Z., Zakariaei, Z., Fakhar, M., & Tabaripour, R. (2021) · Clinical Case Reports · doi:10.1002/ccr3.4509 · Cited by 17 · see citing works
Chellian, R., & Pandy, V. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.137 · Cited by 18 · see citing works
Perrier, S., Moreau, E., Deshayes, C., Adouzi, M. E., Goven, D., Chandre, F., & Lapied, B. (2021) · Communications Biology · doi:10.1038/s42003-021-02192-0 · Cited by 18 · see citing works
Cano, M., Reynaga, D. D., Belluzzi, J. D., Loughlin, S. E., & Leslie, F. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108308 · Cited by 17 · see citing works
Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090724 · Cited by 20 · see citing works
Nicotine Ingestion Reduces Heart Rate Variability in Young Healthy Adults
Guo, Q., Wang, J., Liu, H., Wu, D., & Liao, S. (2022) · BioMed Research International · doi:10.1155/2022/4286621 · Cited by 17 · see citing works
Ding, R., Ren, X., Sun, Q., Sun, Z., & Duan, J. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.08.012 · Cited by 17 · see citing works
Xu, Y., Wang, J., He, Z., Rao, Z., Zhang, Z., Zhou, T., Zhou, T., & Wang, H. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115980 · Cited by 16 · see citing works
- Authors
- Dani, J. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Dani, John A.
- ORCID
- Dani, John A.
- Venue
- International Review of Neurobiology
- Publisher
- Elsevier
- Published
- 2015
- Volume
- 124
- Pages
- 3-19
- ISSN
- 0074-7742 (ISSN-L)
- PMC
- PMC4795468
- OpenAlex
- W2427261560
- Cited by
- 309
- References
- 69
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 41 · 2023: 38 · 2022: 27 · 2021: 46 · 2020: 41 · 2019: 28 · 2018: 22 · 2017: 10 · 2016: 4
- FWCI
- 19.11
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA09411, R01DA009411, R01DA036572)
- National Institute of Neurological Disorders and Stroke (NS 21229, R37NS021229, R01NS021229)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, Cys-loop ligand-gated ion channels, receptor structure, channel gating, receptor desensitization, nAChR subtypes
- MeSH terms
- Animals, Humans, Models, Molecular, Nicotine, Receptors, Nicotinic, Ion Channel Gating, Protein Subunits
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