The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
Open accessAbstract
Sulforaphane (SFN) is a natural isothiocyanate that is present in cruciferous vegetables such as broccoli and cabbage. Previous studies have shown that SFN is effective in preventing carcinogenesis induced by carcinogens in rodents, which is related in part to its potent anti-inflammation properties. In the present study, we compared the anti-inflammatory effect of SFN on LPS-stimulated inflammation in primary peritoneal macrophages derived from Nrf2 (+/+) and Nrf2 mice. Pretreatment of SFN in Nrf2 (+/+) primary peritoneal macrophages potently inhibited LPS-stimulated mRNA expression, protein expression and production of TNFα, IL-1β, Cox-2 and iNOS. HO-1 expression, which is significantly augmented in LPS-stimulated Nrf2 (+/+) primary peritoneal macrophages by SFN. Interestingly, the anti-inflammatory effect was attenuated in Nrf2 (−/−) primary peritoneal macrophages. We concluded that SFN exerts its anti-inflammatory activity mainly via activation of Nrf2 in mouse peritoneal macrophages.
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Zhang, Y., Kensler, T. W., Cho, C. G., Posner, G. H., & Talalay, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3147 · Cited by 745
Liu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.002 · Cited by 697 · cited 2×
“Given the fact that SFN at high concentration displayed a moderate inhibition in LPS-stimulated Nrf2(−/−) peritoneal macrophages, it is possible that SFN might impact AP-1 activity, which is not related to Nrf2-ARE pathway.”
BackgroundInflammation as a Tumor Promoter in Cancer Induction
Philip, M., Rowley, D. A., & Schreiber, H. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.006 · Cited by 640
Nuclear Factor κB Is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms
Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., & Gerhäuser, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104794200 · Cited by 632
Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J., & Talalay, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051632198 · Cited by 590
Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis
Khor, T. O., Huang, M.-T., Kwon, K. H., Chan, J. Y., Reddy, B. S., & Kong, A.-N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3562 · Cited by 530
Self-citationKawanishi, S., Hiraku, Y., Pinlaor, S., & Ma, N. (2006) · Biological Chemistry · doi:10.1515/bc.2006.049 · Cited by 449
Anderson, M. T., Staal, F. J., Gitler, C., Herzenberg, L. A., & Herzenberg, L. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11527 · Cited by 401
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M., Kensler, T. W., & Biswal, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.102 · Cited by 357
Chung, F.-L. (2000) · Carcinogenesis · doi:10.1093/carcin/21.12.2287 · Cited by 350
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Nrf2 signaling pathway: pivotal roles in inflammation
Ahmed, S. M. U., Luo, L., Namani, A., Wang, X. J., & Tang, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.005 · Cited by 1,794
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
Wardyn, J. D., Ponsford, A. H., & Sanderson, C. M. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150014 · Cited by 1,200
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M. J., Barbas, C., Daiber, A., Ghezzi, P., León, R., López, M. G., Oliva, B., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014753 · Cited by 632
Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents
Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.001 · Cited by 358
Negi, G., Kumar, A., & Sharma, S. S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00821.x · Cited by 314
Metadata
- Authors
- Lin, W., Wu, R. T., Wu, T., Khor, T.-O., Wang, H., & Kong, A.-N.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 76
- Issue
- 8
- Pages
- 967-973
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2059944694
- Cited by
- 323
- References
- 21
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, W., Wu, R. T., Wu, T., Khor, T.-O., Wang, H., & Kong, A.-N. (2008). Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2008.07.036
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