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Cited by 68Toxic Organic Pollutants ImpactPharmacogenetics and Drug MetabolismPeroxisome Proliferator-Activated Receptors

AhR protein trafficking and function in the skin

Ikuta, Togo, Namiki, Takeshi, Fujii-Kuriyama, Yoshiaki, Kawajiri, Kaname·2009·Biochemical Pharmacology
DOI 10.1016/j.bcp.2008.10.003
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Abstract

Because aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, its nuclear translocation in response to ligands may be directly linked to transcriptional activation of target genes. We have investigated the biological significance of AhR from the perspective of its subcellular localization and revealed that AhR possesses a functional nuclear localization signal (NLS) as well as a nuclear export signal (NES) which controls the distribution of AhR between the cytoplasm and nucleus. The intracellular localization of AhR is regulated by phosphorylation of amino acid residues in the vicinity of the NLS and NES. In cell culture systems, cell density affects not only its intracellular distribution of AhR, but also its transactivation activity of the target genes such as transcriptional repressor Slug, which is important for the induction of epithelial-mesenchymal transitions. These effects of AhR observed in cultured cells are proposed to be reflected on the in vivo response such as morphogenesis and tumor formation. This review summarizes recent work on the control mechanism of AhR localization and progress in understanding the physiological role of AhR in the skin. We propose that AhR is involved in normal skin formation during fetal development as well as in pathological states such as epidermal wound healing and skin carcinogenesis.

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  • The ligand/AHR complex binds to specific DNA recognition sites and upregulates transcription of responsive genes, such as CYP1A1, leading to robust generation of reactive oxygen species.

    “The ligand/AHR complex then binds to specific DNA recognition sites, namely, xenobiotic-responsive elements or dioxin-responsive elements, and upregulates the transcription of a series of responsive genes, such as CYP1A1 leading to a robust generation of reactive oxygen species [16,24].”

    From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [24]

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Authors
Ikuta, T., Namiki, T., Fujii-Kuriyama, Y., & Kawajiri, K.
Affiliations
  • Research Institute for Clinical Oncology, Saitama Cancer Center (JP)
  • Tokyo Medical and Dental University (JP)
  • Japan Science and Technology Agency (JP)
Corresponding author
Ikuta, Togo
ORCID
Venue
Biochemical Pharmacology
Publisher
Elsevier BV
Published
2009-02
Volume
77
Issue
4
Pages
588-596
ISSN
0006-2952 (ISSN-L)
DOI
10.1016/j.bcp.2008.10.003
OpenAlex
W2033158431
Cited by
68
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 5 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 9
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biochemical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
aryl hydrocarbon receptor, subcellular localization, nuclear localization signal, nuclear export signal, phosphorylation, epithelial-mesenchymal transition, skin development, epidermal wound healing, skin carcinogenesis, ligand-activated transcription factors
MeSH terms
Polychlorinated Dibenzodioxins, Animals, Cell Count, Humans, Skin, Skin Neoplasms, Skin Physiological Phenomena, Wound Healing, Receptors, Aryl Hydrocarbon, Protein Transport

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