Antioxidant soybean tar G lyteer rescues T‐helper‐mediated downregulation of filaggrin expression via aryl hydrocarbon receptor
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Soybean tar G lyteer (G ly) has been widely used for the treatment of various inflammatory skin diseases in J apan since 1924 as an alternative to coal tar remedy. Recently, coal tar has been shown to induce barrier repair in atopic dermatitis via aryl hydrocarbon receptor (A h R). In this study, we demonstrated that G ly activated A h R by inducing its cytoplasmic to nuclear translocation in keratinocytes. The A h R ligation by G ly was biologically active, with significant and dose‐dependent upregulation of CYP 1 A 1 expression, which is a specific marker for A h R activation. Gly upregulated the expression of filaggrin in an A h R‐dependent manner because its enhancing effect was completely abrogated in A h R‐knockdown keratinocytes. T‐helper (T h)2 cytokines inhibited the expression of filaggrin; however, G ly completely restored the T h2‐mediated inhibition of filaggrin expression. Furthermore, G ly coordinately upregulated a series of epidermal differentiation complex genes, including involucrin, loricrin and hornerin. In addition, G ly exhibited potent antioxidant activity through the activation of nuclear factor‐erythroid 2‐related factor‐2 (N rf2) and downstream antioxidant enzymes such as NAD(P)H:quinone oxidoreductase 1 (N qo1), which actually inhibited the generation of reactive oxygen species in keratinocytes treated with tumor necrosis factor‐α or benzo[α]pyrene. In conclusion, antioxidant G ly rescues the downregulated expression of filaggrin (and plausibly other barrier proteins) in a T h2‐skewed milieu via A h R activation, which may partly explain its empirical anti‐inflammatory therapeutic effects.
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Both coal tar and soybean tar actively enhance the expression of FLG and LOR via AHR.
“As both remedies actively enhance the expression of FLG and LOR via aryl hydrocarbon receptor (AHR) [13,14], the AHR-mediated upregulation of barrier proteins has attracted increasing attention in skin barrier and inflammation research [15,16,17].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [14]
The Introduction reports that coal tar activates AhR and upregulates filaggrin and loricrin. The Results show that soybean tar Glyteer activates AhR, upregulates both genes, and requires AhR for its effect on filaggrin; they do not establish that its loricrin upregulation requires AhR. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSome ligands for AHR, such as coal tar and soybean tar, actively upregulate FLG and LOR expression.
“Some ligands for AHR, such as coal tar and soybean tar, actively upregulate FLG and LOR expression [13,14].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [14]
Some antioxidant phytochemicals such as soybean tar and Opuntia ficus-indica extract activate NRF2 via the AHR pathway.
“Some antioxidant phytochemicals such as soybean tar and Opuntia ficus-indica extract activate NRF2 via AHR pathway [14,19,21].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [14]
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- Authors
- Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Uchi, H., Takahara, M., Tsuji, G., Kido‐Nakahara, M., Nakahara, T., & Furue, M.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Furue, Masutaka
- Venue
- The Journal of Dermatology
- Publisher
- Wiley
- Published
- 2014-12-06
- Volume
- 42
- Issue
- 2
- Pages
- 171-180
- ISSN
- 0385-2407 (ISSN-L)
- 1346-8138
- PMC
- PMC4340044
- OpenAlex
- W2060661512
- Cited by
- 81
- References
- 36
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 1 · 2015: 1
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Dermatology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- aryl hydrocarbon receptor, filaggrin, Th2 cytokines, keratinocytes, epidermal differentiation complex, involucrin, loricrin, hornerin, Nrf2, NQO1, antioxidant activity, reactive oxygen species, benzo[a]pyrene, TNF-α, CYP1A1, skin barrier repair, atopic dermatitis
- MeSH terms
- Filaggrin Proteins, Antioxidants, Benzo(a)pyrene, Calcium-Binding Proteins, Cell Line, Humans, Intermediate Filament Proteins, Membrane Proteins, Protein Precursors, Tars, Tumor Necrosis Factor-alpha, Signal Transduction, Down-Regulation, Keratinocytes, Gene Expression, Cytokines, NAD(P)H Dehydrogenase (Quinone), Reactive Oxygen Species, Receptors, Aryl Hydrocarbon, Th2 Cells, Cytochrome P-450 CYP1A1, Protein Transport, NF-E2-Related Factor 2
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