Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
Abstract
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
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Various herbal and antioxidant phytochemicals activate AHR.
“Various herbal and antioxidant phytochemicals have been shown to activate AHR [16,17,19].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
AHR is an essential transcription factor for human epidermal barrier proteins including FLG and LOR.
“In addition to CYP1A1 induction, AHR is an essential transcription factor for human epidermal barrier proteins including FLG and LOR [17,28,29].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
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Indirubin-pregnane X receptor-JNK axis accelerates skin wound healing
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Self-citationThe Impact of Air Pollution on Atopic Dermatitis
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Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne
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Cosmeceuticals: A Newly Expanding Industry in South Africa
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Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis
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Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
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Adult atopic dermatitis: new and emerging therapies
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Innate lymphoid cells: a new key player in atopic dermatitis
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Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes
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Self-citationUrinary lipid profile of atopic dermatitis in murine model and human patients
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From Nucleus to Organs: Insights of Aryl Hydrocarbon Receptor Molecular Mechanisms
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Xenobiotic Receptors and Their Mates in Atopic Dermatitis
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Systems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma
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T helper type 2 signatures in atopic dermatitis
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Self-citationLead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders
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Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation
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Luftverschmutzung und atopisches Ekzem
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Biologic and Small Molecule Therapy in Atopic Dermatitis
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Revival of AHR Agonist for the Treatment of Atopic Dermatitis: Tapinarof
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Atopic Dermatitis Biomarkers and the Movement Toward Personalized Treatment
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The Antioxidant PAPLAL Protects against Allergic Contact Dermatitis in Experimental Models
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- Authors
- Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H.
- Affiliations
- Kyushu University (JP)
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 80
- Issue
- 2
- Pages
- 83-88
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2196195787
- Cited by
- 132
- References
- 50
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 12 · 2023: 17 · 2022: 20 · 2021: 17 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- aryl hydrocarbon receptor, filaggrin, skin barrier proteins, skin barrier, gene expression regulation, oxidative stress, antioxidant signaling, NF-E2-related factor 2, dioxins, tryptophan photoproducts, coal tar, flavonoids, transcriptional activation
- MeSH terms
- Polychlorinated Dibenzodioxins, Filaggrin Proteins, Animals, Coal Tar, Environmental Pollutants, Gene Expression Regulation, Humans, Intermediate Filament Proteins, Malassezia, Permeability, Skin, Transcription, Genetic, Ultraviolet Rays, Receptors, Aryl Hydrocarbon, Oxidative Stress, NF-E2-Related Factor 2, Hypoxia-Inducible Factor 1, alpha Subunit, Phytochemicals
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