Cited by 133Dermatology and Skin DiseasesToxic Organic Pollutants ImpactSkin and Cellular Biology Research

Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Furue, Masutaka, Tsuji, Gaku, Mitoma, Chikage, Nakahara, Takeshi, Chiba, Takahito, Morino-Koga, Saori, Uchi, Hiroshi·2015·Journal of Dermatological Science

Abstract

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

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Crossref · 10.1016/j.jdermsci.2015.07.011

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Authors
Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H.
Affiliations
Kyushu University (JP)
Venue
Journal of Dermatological Science
Publisher
Elsevier BV
Published
2015-11
Volume
80
Issue
2
Pages
83-88
ISSN
0923-1811 (ISSN-L)
OpenAlex
W2196195787
Cited by
132
References
50
Citations by year
2026: 7 · 2025: 3 · 2024: 12 · 2023: 17 · 2022: 20 · 2021: 17 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 5
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dermatological Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords
aryl hydrocarbon receptor, filaggrin, skin barrier proteins, skin barrier, gene expression regulation, oxidative stress, antioxidant signaling, NF-E2-related factor 2, dioxins, tryptophan photoproducts, coal tar, flavonoids, transcriptional activation
MeSH terms
Polychlorinated Dibenzodioxins, Filaggrin Proteins, Animals, Coal Tar, Environmental Pollutants, Gene Expression Regulation, Humans, Intermediate Filament Proteins, Malassezia, Permeability, Skin, Transcription, Genetic, Ultraviolet Rays, Receptors, Aryl Hydrocarbon, Oxidative Stress, NF-E2-Related Factor 2, Hypoxia-Inducible Factor 1, alpha Subunit, Phytochemicals

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