Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction
Open accessAbstract
Dioxins exert a variety of adverse effects on organisms, including teratogenesis, immunosuppression, tumor promotion, and estrogenic action. Studies using aryl hydrocarbon receptor (AhR)-deficient mice suggest that the majority of these toxic effects are mediated by the AhR. In spite of the adverse effects mediated by this receptor, the AhR gene is conserved among a number of animal species, ranging from invertebrates to vertebrates. This high degree of conservation strongly suggests that AhR possesses an important physiologic function, and a critical function is also supported by the reduced fertility observed with AhR-null female mice. We demonstrate that AhR plays a crucial role in female reproduction by regulating the expression of ovarian P450 aromatase (Cyp19), a key enzyme in estrogen synthesis. As revealed by in vitro reporter gene assay and in vivo chromatin immunoprecipitation assay, AhR cooperates with an orphan nuclear receptor, Ad4BP/SF-1, to activate Cyp19 gene transcription in ovarian granulosa cells. Administration to female mice of an AhR ligand, DMBA (9,10-dimethyl-1,2-benzanthracene), induced ovarian Cyp19 gene expression, irrespective of the intrinsic phase of the estrus cycle. In addition to elucidating a physiological function for AhR, our studies also suggest a possible mechanism for the toxic effects of exogenous AhR ligands as endocrine disruptors.
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Female AhrLacZ mice are sub-fertile due to impaired follicular development and ovulation.
“This mouse has also been used to examine fertility endpoints such that females were reported to be sub-fertile due to impaired follicular development and ovulation (Baba et al., 2005).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Baba et al., 2005
The Results report reduced litter sizes in AhR−/− females and evidence of impaired final follicular maturation and ovulation; the Discussion links these ovarian defects to reduced fertility. The paper identifies the mice as AhR knockouts, but our copy does not identify them as AhrLacZ mice or establish that the two designations refer to the same model. (LLM, conf=0.84)
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- Authors
- Baba, T., Mimura, J., Nakamura, N., Harada, N., Yamamoto, M., Morohashi, K.-I., & Fujii-Kuriyama, Y.
- Affiliations
- National Institute for Basic Biology (JP)
- University of Tsukuba (JP)
- Fujita Health University (JP)
- TARA Center, University of Tsukuba, 1-1-1 Tennoudai
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2005-11
- Volume
- 25
- Issue
- 22
- Pages
- 10040-10051
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC1280268
- OpenAlex
- W2142798058
- Cited by
- 256
- References
- 62
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 16 · 2019: 11 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 20 · 2012: 15
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- aryl hydrocarbon receptor, dioxins, female reproduction, aromatase, estrogen synthesis, granulosa cells, Ad4BP/SF-1, nuclear receptor transcriptional regulation, endocrine disruptors, 7,12-dimethylbenz(a)anthracene, fertility
- MeSH terms
- Animals, Aromatase, Estradiol, Estrogens, Female, Gene Expression Regulation, Genotype, Granulosa Cells, Humans, Immunohistochemistry, Ligands, Luciferases, Male, Models, Genetic, Ovary, Ovulation, Phenotype, Promoter Regions, Genetic, Reproduction, Steroids, Transcription Factors, Transcription, Genetic, Transfection, 9,10-Dimethyl-1,2-benzanthracene, Up-Regulation, Polymerase Chain Reaction, Genes, Reporter, DNA Primers, Receptors, Cytoplasmic and Nuclear, Receptors, Aryl Hydrocarbon, Homeodomain Proteins, Chromatin Immunoprecipitation, Immunoprecipitation, Mice, Steroidogenic Factor 1
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