Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1
Open accessAbstract
N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. Genetic polymorphisms of NAT2 modify drug efficacy and toxicity and susceptibility to diseases such as cancer and type 2 diabetes. Expression of NAT2 has been documented in the liver and gastrointestinal tract but not in other tissues. Deacetylation of cytosolic proteins by sirtuins is a post-translational modification important in regulatory networks of diverse cellular processes. The aim of the present study was to investigate NAT2 expression in peripheral blood mononuclear cells (PBMC) and the effects of NAT2 genotype and Sirtuin 1 (SIRT1). Both NAT2 and SIRT1 proteins were expressed on PBMC. Their expression was more prevalent on CD3+ compared to CD19+ and CD56+ cell populations. N-acetylation capacity of PBMC exhibited a NAT2 gene-dose response toward the N-acetylation of isoniazid. Subjects with rapid NAT2 genotype showed an apparent V max of 42.1 ± 2.4; intermediate NAT2 genotypes an apparent V max of 22.6 ± 2.2; and slow acetylator NAT2 genotypes an apparent V max of 19.9 ± 1.7 nM acetyl-isoniazid/24 h/million cells. The N-acetylation capacity of NAT2 in the presence of SIRT1 enhancer was significantly decreased (p < 0.001), conversely, the transient silencing of SIRT1 resulted in an increase of N-acetylation capacity (p < 0.001). These findings are the first report of NAT2 genotype-dependent expression on PBMC and post-translational modification by SIRT1. These findings constitute a substantial advance in our understanding of human N-acetyltransferase expression and a new much less invasive method for measurement of human NAT2 expression and phenotype.
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NAT2 is regulated by SIRT1, which has a gene-dose response on isoniazid N-acetylation in peripheral blood mononuclear cells.
“NAT2 is regulated by sirtuin deacetylase 1 (SIRT1), which has been shown to have a gene-dose response on isoniazid N-acetylation in peripheral blood mononuclear cells.48”
From N-Acetyltransferase (NAT) 1 and NAT2 Enzyme Activities Drive Interindividual Variability in Sulfamethoxazole N-Acetylation (2025) · cites this paper as [48]
The Abstract and Discussion report that SIRT1 modulates NAT2 activity in peripheral blood mononuclear cells. However, the reported gene-dose response in isoniazid N-acetylation is associated with NAT2 genotype, not SIRT1; the Discussion separately describes a dose-dependent effect of a SIRT1 activator. Page numbers were not provided in our copy. (LLM, conf=0.90)
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- Authors
- Salazar-González, R. A., Turiján-Espinoza, E., Hein, D. W., Milán-Segovia, R. C., Uresti-Rivera, E. E., & Portales-Pérez, D. P.
- Affiliations
- Autonomous University of San Luis Potosí (MX)
- University of Louisville (US)
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 156
- Pages
- 340-347
- ISSN
- 0006-2952 (ISSN-L)
- PMC
- PMC6350916
- OpenAlex
- W2888631579
- Cited by
- 20
- References
- 65
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P50AA024337)
- National Institute of General Medical Sciences (P20GM113226)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- N-acetyltransferase 2, SIRT1, peripheral blood mononuclear cells, NAT2 genotype, post-translational modification, drug-metabolizing enzymes, CD3+ T cells, CD19+ B cells, CD56+ NK cells
- MeSH terms
- Adult, Arylamine N-Acetyltransferase, Female, Gene Expression Regulation, Genotype, Humans, Isoniazid, Leukocytes, Mononuclear, Male, RNA, Messenger, Young Adult, Sirtuin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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