Sirtuins: The ‘ magnificent seven ’, function, metabolism and longevity

Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 2× · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works

Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775 · see citing works

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

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Extrachromosomal rDNA circles—a cause of aging in yeast

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daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,348 · see citing works

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.057 · Cited by 1,162 · see citing works

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060 · see citing works

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057 · see citing works

Cloning and Characterization of the cDNA Encoding a Novel Human pre-B-Cell Colony-enhancing Factor

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Calorie restriction, SIRT1 and metabolism: understanding longevity

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Revollo, J. R., Grimm, A. A., & Imai, S.-I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408388200 · Cited by 1,010 · see citing works

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205670200 · Cited by 1,002 · see citing works

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

Hwangbo, D., Gersham, B., Tu, M., Palmer, M., & Tatar, M. (2004) · Nature · doi:10.1038/nature02549 · Cited by 954 · see citing works

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917 · see citing works

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891 · see citing works

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

Hallows, W. C., Lee, S., & Denu, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604392103 · Cited by 792 · see citing works

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.Preprint

Braunstein, M., Rose, A. B., Holmes, S. G., Allis, C. D., & Broach, J. R. (1993) · Genes & Development · doi:10.1101/gad.7.4.592 · Cited by 792 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A. (2003) · Nature · doi:10.1038/nature01578 · Cited by 736 · see citing works

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040031 · Cited by 715 · see citing works

SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

Shi, T., Wang, F., Stieren, E., & Tong, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414670200 · Cited by 712 · see citing works

Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

Rine, J., & Herskowitz, I. (1987) · Genetics · doi:10.1093/genetics/116.1.9 · Cited by 711 · see citing works

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

Chen, H.-W., Lin, R. J., Xie, W., Wilpitz, D. C., & Evans, R. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80054-9 · Cited by 635 · see citing works

Calorie restriction extends yeast life span by lowering the level of NADH

Lin, S.-J., Ford, E., Haigis, M., Liszt, G., & Guarente, L. (2004) · Genes &amp; Development · doi:10.1101/gad.1164804 · Cited by 632 · see citing works

Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bernal‐Mizrachi, E., Ford, E. L., CRAS-MÉNEUR, C. M. H., Permutt, M. A., & Imai, S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.07.001 · Cited by 630 · see citing works

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., & Guarente, L. (2006) · Genes &amp; Development · doi:10.1101/gad.1399706 · Cited by 629 · see citing works

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626 · see citing works

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase

Schwer, B., North, B. J., Frye, R. A., Ott, M., & Verdin, E. M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205057 · Cited by 599 · see citing works

Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577 · see citing works

SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

Onyango, P. O., Celic, I., McCaffery, J. M., Boeke, J. D., & Feinberg, A. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222538099 · Cited by 573 · see citing works

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1- O- acetyl-ADP-ribose

Tanner, K. G., Landry, J. W., Sternglanz, R., & Denu, J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250422697 · Cited by 557 · see citing works

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

Kitamura, Y., Kitamura, T., Kruse, J.-P., Raum, J. C., Stein, R. W., Gu, W. J., & Accili, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.08.004 · Cited by 552 · see citing works

Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase

Liszt, G., Ford, E., Kurtev, M., & Guarente, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413296200 · Cited by 548 · see citing works

Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae

Bakker, B. M., Overkamp, K. M., van Maris, A. J. A., Kötter, P., Luttik, M. A. H., van Dijken, J. P., & Pronk, J. T. (2001) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2001.tb00570.x · Cited by 540 · see citing works

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

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Role for Human SIRT2 NAD-Dependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle

Dryden, S. C., Nahhas, F. A., Nowak, J. E., Goustin, A. S., & Tainsky, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3173-3185.2003 · Cited by 500 · see citing works

Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

Lin, S.-J., & Guarente, L. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00006-1 · Cited by 477 · see citing works

PPARγ AND G LUCOSE H OMEOSTASIS

Picard, F., & Auwerx, J. H. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102808 · Cited by 412 · see citing works

C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span

Berdichevsky, A., Viswanathan, M., Horvitz, H. R., & Guarente, L. (2006) · Cell · doi:10.1016/j.cell.2006.04.036 · Cited by 393 · see citing works

SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast

Fabrizio, P., Liou, L.-L., Moy, V. N., Diaspro, A., Valentine, J. S., Gralla, E. B., & Longo, V. D. (2003) · Genetics · doi:10.1093/genetics/163.1.35 · Cited by 335 · see citing works

Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation

裕夫, 神., Tanny, J. C., Rudner, A. D., Gerber, S. A., Danaie, S., Gygi, S. P., & Moazed, D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4167-4180.2002 · Cited by 303 · see citing works

Transcriptional repression: the long and the short of itPreprint

Courey, A. J., & Jia, S. (2001) · Genes & Development · doi:10.1101/gad.939601 · Cited by 300 · see citing works

Epigenetic silencing of RNA polymerase I transcription

Grummt, I., & Pikaard, C. S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1171 · Cited by 298 · see citing works

Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels

Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Cohen, H. Y., Lin, S., Manchester, J. K., Gordon, J. I., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111773200 · Cited by 295 · see citing works

Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., et al. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00209-2 · Cited by 282 · see citing works

Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

Rogina, B., Helfand, S. L., & Frankel, S. A. (2002) · Science · doi:10.1126/science.1078986 · Cited by 276 · see citing works

Sirtuin 2, a Mammalian Homolog of Yeast Silent Information Regulator-2 Longevity Regulator, Is an Oligodendroglial Protein That Decelerates Cell Differentiation through Deacetylating α-Tubulin

Li, W., Zhang, B., Tang, J., Cao, Q., Wu, Y., Wu, C. A., Guo, J., Ling, E., & Liang, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4181-06.2007 · Cited by 265 · see citing works

Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

Hiratsuka, M., Inoue, T., Toda, T., Kimura, N., Shirayoshi, Y., Kamitani, H., Watanabe, T., Ohama, E., Tahimic, C. G. T., Kurimasa, A., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.029 · Cited by 261 · see citing works

Assembly of the SIR Complex and Its Regulation by O-Acetyl-ADP-Ribose, a Product of NAD-Dependent Histone Deacetylation

Liou, G., Tanny, J. C., Kruger, R. G., Walz, T., & Moazed, D. (2005) · Cell · doi:10.1016/j.cell.2005.03.035 · Cited by 260 · see citing works

SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

Inoue, T., Hiratsuka, M., Osaki, M., Yamada, H. Y., Kishimoto, I., Yamaguchi, S., Nakano, S., Katoh, M., Ito, H., & Oshimura, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209857 · Cited by 258 · see citing works

HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction

Lamming, D. W., Latorre‐Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., Lin, S.-J., & Sinclair, D. A. (2005) · Science · doi:10.1126/science.1113611 · Cited by 228 · see citing works

Acetylation of TAFI68, a subunit of TIF‐IB/SL1, activates RNA polymerase I transcription

Muth, V., Nadaud, S., Grummt, I., & Voit, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1353 · Cited by 201 · see citing works

Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)

Qin, W., Chachich, M. E., Lane, M. A., Roth, G., Bryant, M., de Cabo, R., Ottinger, M. A., Mattison, J. A., Ingram, D., Gandy, S., et al. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10411 · Cited by 183 · see citing works

Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans

Burnell, A. M., Houthoofd, K., O’Hanlon, K. A., & Vanfleteren, J. R. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.006 · Cited by 159 · see citing works

Sir2: An NAD-dependent Histone Deacetylase That Connects Chromatin Silencing, Metabolism, and AgingPreprint

Imai, S., Johnson, F. B., Marciniak, R. A., McVey, M., Park, P. U., & Guarente, L. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.297 · Cited by 152 · see citing works

High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction

Kaeberlein, M. R., Andalis, A. A., Fink, G. R., & Guarente, L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.8056-8066.2002 · Cited by 144 · see citing works

The Ras and Sch9 pathways regulate stress resistance and longevity

Longo, V. D. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00113-x · Cited by 121 · see citing works

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO

Wang, Y., Oh, S. W., Deplancke, B., Luo, J., Walhout, A. J. M., & Tissenbaum, H. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.005 · Cited by 120 · see citing works

Telomeric and rDNA Silencing in Saccharomyces cerevisiae Are Dependent on a Nuclear NAD+ Salvage Pathway

Sandmeier, J. J., Celic, I., Boeke, J. D., & Smith, J. S. (2002) · Genetics · doi:10.1093/genetics/160.3.877 · Cited by 120 · see citing works

Mechanism of Transcriptional Silencing in Yeast

Chen, L., & Widom, J. (2005) · Cell · doi:10.1016/j.cell.2004.11.030 · Cited by 112 · see citing works

Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13

Bellizzi, D., Dato, S., Cavalcante, P., Covello, G., Cianni, F. D., Passarino, G., Rose, G., & BENEDICTIS, G. D. (2006) · Genomics · doi:10.1016/j.ygeno.2006.09.004 · Cited by 87 · see citing works

Sir2 : An NAD-dependent histone deacetylase that connects chromatin silencing metabolism, and aging. Cold Spring Harbor Symp

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Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy

Sempowski, G. D., Rhein, M. E., Scearce, R. M., & Haynes, B. F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200211)32:11 · Cited by 38 · see citing works

The mammalian circadian timing system: organization and coordination of central and peripheral clocks

Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

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Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

Lim, J.-H., Lee, Y.-M., Chun, Y.-S., Chen, J., Kim, J.-E., & Park, J.-W. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.023 · Cited by 758 · see citing works

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD ⁺ Precursor Vitamins in Human Nutrition

Bogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707 · see citing works

Cellular and molecular biology of aging endothelial cells

Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works

Metabolism and Circadian Rhythms—Implications for Obesity

Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Protective effects and mechanisms of sirtuins in the nervous system

Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.001 · Cited by 211 · see citing works

Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1α

Kang, C., Chung, E., Diffee, G., & Ji, L. L. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.004 · Cited by 174 · see citing works

Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis

Gurd, B. J. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-070 · Cited by 171 · see citing works

NAD⁺metabolism and oxidative stress: the golden nucleotide on a crown of thorns

Massudi, H., Grant, R., Guillemin, G. J., & Braidy, N. (2012) · Redox Report · doi:10.1179/1351000212y.0000000001 · Cited by 158 · see citing works

Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals

Belenky, P., Christensen, K. C., Gazzaniga, F., Pletnev, A. A., & Brenner, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807976200 · Cited by 95 · see citing works

Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

Tauriainen, E., Luostarinen, M., Martonen, E., Finckenberg, P., Kovalainen, M., Huotari, A., Herzig, K.-H., Lecklin, A., & Mervaala, E. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/525094 · Cited by 81 · see citing works

Role of PGC-1α in sarcopenia: Etiology and potential intervention—A mini-review

Ji, L. L., & Kang, C. (2015) · Gerontology · doi:10.1159/000365947 · Cited by 77 · see citing works

Protective Effect of Garlic on Cellular Senescence in UVB-Exposed HaCaT Human Keratinocytes

Kim, H. (2016) · Nutrients · doi:10.3390/nu8080464 · Cited by 67 · see citing works

Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?

Körner, S., Böselt, S., Thau, N., Rath, K. J., Dengler, R., & Petri, S. (2013) · Neurodegenerative Diseases · doi:10.1159/000338048 · Cited by 64 · see citing works

Ethanol intoxication increases hepatic N-lysyl protein acetylation

Picklo, M. J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.039 · Cited by 60 · see citing works

Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

Ziętara, P., Dziewięcka, M., & Augustyniak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010728 · Cited by 40 · see citing works

Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1

Salazar-González, R. A., Turiján-Espinoza, E., Hein, D. W., Milán-Segovia, R. C., Uresti-Rivera, E. E., & Portales-Pérez, D. P. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.034 · Cited by 20 · see citing works

Effect of Nutritional Stress on the Expression of Sirtuin Gene Family

Zhang, X., Ameer, F. S., Crane, J., et al. (2020) · Innovation in Aging · doi:10.1093/geroni/igaa057.407

Abstract 4986: Association of sirtuins and diet in cancer development: Studying the roles of SIRT2/3

Ahmed, M. A. H., O'Callaghan, C., & Vassilopulos, A. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4986

Sirtuins as Potential Drug Targets for Metabolic Diseases

Tong, Q. (2011) · doi:10.1002/9780470910016.ch15

Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function

Zhang, G., Deng, Y.-J., Xie, Q.-Q., Ren, E., Ma, Z., He, X., Gao, Y., & Kang, X. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.016 · Cited by 157 · see citing works

Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function

Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00187 · Cited by 289 · see citing works