Psychological aspects of chronic musculoskeletal pain

Crofford, Leslie J.

doi:10.1016/j.berh.2015.04.027

Cited by 204Musculoskeletal pain and rehabilitationFibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their Treatments

Psychological aspects of chronic musculoskeletal pain

Open access

Crofford, Leslie J.·2015·Best Practice & Research Clinical Rheumatology

DOI 10.1016/j.berh.2015.04.027PMC PMC5061342

Open this paper in CoChat — free account

Abstract

Chronic musculoskeletal pain, by its very nature, is associated with negative emotions and psychological distress. There are individual differences in personality, coping skills, behavioral adaptation, and social support that dramatically alter the psychological outcomes of patients with chronic pain. Patients who have an aspect of central pain amplification associated with mechanical or inflammatory pain and patients with fibromyalgia (FM) are likely to exhibit higher levels of psychological distress and illness behaviors. This manuscript discusses several different constructs for the association between chronic pain, central pain amplification, and psychological distress. The first key question addresses mechanisms shared in common between chronic pain and mood disorders, including the individual factors that influence psychological comorbidity, and the second addresses how pain affects mood and vice versa. Finally, the utility of cognitive behavioral approaches in the management of chronic pain symptoms is discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.berh.2015.04.027

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Yellow flags represent a narrow set of cognitive and affective responses to pain.
“However, yellow flags represent a narrow set of cognitive and affective responses to pain (Crofford, 2015;Edwards et al., 2016).”
From Beyond yellow flags: The Big‐Five personality traits and psychologically informed musculoskeletal rehabilitation. (2023) · cites this paper as Crofford, 2015
The Cognitive and Emotional Aspects of Chronic Pain and Social and Psychological Factors sections discuss cognitive, affective, and behavioral responses to pain. However, our copy does not identify these responses as “yellow flags” or say that yellow flags represent a narrow set of them (searched: “yellow flags” and the claim’s wording). (LLM, conf=0.73)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders(DSM)
Leong, F. T. L. (2008) · Sage eBooks · doi:10.4135/9781412963978.n182 · Cited by 10,858 · see citing works
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Glass, R. M. (2009) · Oxford University Press eBooks · doi:10.1093/jama/9780195176339.022.529 · Cited by 2,155 · see citing works
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082 · see citing works
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076 · see citing works
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Diatchenko, L., Slade, G. D., Nackley, A. G., Bhalang, K., Sigurdsson, A., Belfer, I., Goldman, D., Xu, K., Shabalina, S. A., Shagin, D., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi013 · Cited by 1,280 · see citing works
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263 · see citing works
Functional Somatic Syndromes
BARSKY, A. J., & Borus, J. F. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-11-199906010-00016 · Cited by 964 · see citing works
The amplification of somatic symptoms.
BARSKY, A. J., Goodson, J. D., Lane, R. S., & Cleary, P. D. (1988) · Psychosomatic Medicine · doi:10.1097/00006842-198809000-00007 · Cited by 671 · see citing works
Reciprocal Relationship Between Pain and Depression: A 12-Month Longitudinal Analysis in Primary Care
Kroenke, K., Wu, J., Bair, M. J., Krebs, E. E., Damush, T. M., & Tu, W. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2011.03.003 · Cited by 573 · see citing works
Fibromyalgia prevalence, somatic symptom reporting, and the dimensionality of polysymptomatic distress: Results from a survey of the general population
Wolfe, F., Brähler, E., Hinz, A., & Häuser, W. (2013) · Arthritis Care & Research · doi:10.1002/acr.21931 · Cited by 443 · see citing works
Comorbidity of Fibromyalgia and Psychiatric Disorders
Arnold, L. M., Hudson, J. I., Keck, P. E., Auchenbach, M. B., Javaras, K. N., & Hess, E. V. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0807 · Cited by 382 · see citing works
The role of psychosocial factors in predicting the onset of chronic widespread pain: results from a prospective population-based study
Gupta, A., Silman, A. J., Ray, D. W., Morriss, R. K., Dickens, C. M., Macfarlane, G. J., Chiu, Y. H., Nicholl, B. I., & McBeth, J. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel363 · Cited by 361 · see citing works
Elevated insular glutamate in fibromyalgia is associated with experimental pain
Harris, R. E., Sundgren, P. C., Craig, A. D., Kirshenbaum, E., Sen, A., Napadow, V., & Clauw, D. J. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24849 · Cited by 328 · see citing works
Non-pharmacological interventions for somatoform disorders and medically unexplained physical symptoms (MUPS) in adults
van Dessel, N., den Boeft, M., van der Wouden, J. C., Kleinstäuber, M., Leone, S. S., Terluin, B., Numans, M. E., van der Horst, H. E., & van Marwijk, H. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011142.pub2 · Cited by 302 · see citing works
Pain and Depression: An Integrative Review of Neurobiological and Psychological Factors
Goesling, J., Clauw, D. J., & Hassett, A. L. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0421-0 · Cited by 285 · see citing works
Cognitive behavioural therapies for fibromyalgia
Bernardy, K., Klose, P., Busch, A. J., Choy, E. H., & Häuser, W. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009796.pub2 · Cited by 272 · see citing works
A systematic review and meta-analysis of mindfulness-based stress reduction for the fibromyalgia syndrome
Lauche, R., Cramer, H., Dobos, G., Langhorst, J., & Schmidt, S. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.10.010 · Cited by 268 · see citing works
Efficacy of cognitive-behavioral therapies in fibromyalgia syndrome - a systematic review and metaanalysis of randomized controlled trials
BERNARDY, K., FÜBER, N., KÖLLNER, V., & HÄUSER, W. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100104 · Cited by 266 · see citing works
The phenotypic and genetic signatures of common musculoskeletal pain conditions
Diatchenko, L., Fillingim, R. B., Smith, S. B., & Maixner, W. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.43 · Cited by 241 · see citing works
Noncancer pain conditions and risk of suicide
Ilgen, M. A., Kleinberg, F., Ignacio, R. V., Bohnert, A. S. B., Valenstein, M., McCarthy, J. F., Blow, F. C., & Katz, I. R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.908 · Cited by 238 · see citing works
Chronic pain and comorbid mental health conditions: independent associations of posttraumatic stress disorder and depression with pain, disability, and quality of life
Outcalt, S. D., Kroenke, K., Krebs, E. E., Chumbler, N. R., Wu, J., Yu, Z., & Bair, M. J. (2015) · Journal of Behavioral Medicine · doi:10.1007/s10865-015-9628-3 · Cited by 200 · see citing works
The T102C Polymorphism of the 5-HT2A-Receptor Gene in Fibromyalgia
Bondy, B., Spaeth, M., Offenbächer, M., Glatzeder, K., Stratz, T., Schwarz, M., de Jonge, S., Krüger, M., Engel, R. R., Färber, L., et al. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0262 · Cited by 192 · see citing works
Perceived physical and emotional trauma as precipitating events in fibromyalgia. Associations with health care seeking and disability status but not pain severity
Aaron, L. A., Bradley, L. A., Alarcón, G. S., Triana‐Alexander, M., ALEXANDER, R. W., Martin, M. Y., & Alberts, K. R. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400311 · Cited by 168 · see citing works
Cognitive–Behavioral Therapy for Insomnia in Knee Osteoarthritis: A Randomized, Double‐Blind, Active Placebo–Controlled Clinical Trial
Smith, M. T., Finan, P. H., Buenaver, L. F., Robinson, M., Haque, U. J., Quain, A. M., McInrue, E., Han, D., Leoutsakis, J., & Haythornthwaite, J. A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39048 · Cited by 159 · see citing works
A Neural Circuit Framework for Somatosensory Amplification in Somatoform Disorders
Perez, D. L., BARSKY, A. J., Vago, D. R., Baslet, G. C., & Silbersweig, D. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13070170 · Cited by 148 · see citing works
Non-pharmacological interventions for somatoform disorders and medically unexplained physical symptoms (MUPS) in adults
Van Dessel, N., Den Boeft, M., van der Wouden, J. C., Kleinstäuber, M., Leone, S. S., Terluin, B., Numans, M. E., van der Horst, H. E., & van Marwijk, H. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011142 · Cited by 148 · see citing works
Mindfulness and cognitive-behavioral interventions for chronic pain: Differential effects on daily pain reactivity and stress reactivity
Davis, M. C., Zautra, A. J., Wolf, L. D., Tennen, H., & Yeung, E. W. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0038200 · Cited by 146 · see citing works
Mindfulness meditation alleviates fibromyalgia symptoms in women: results of a randomized clinical trial
Cash, E., Salmon, P., Weissbecker, I., Rebholz, W. N., Bayley-Veloso, R., Zimmaro, L. A., Floyd, A., Dedert, E., & Sephton, S. E. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-014-9665-0 · Cited by 146 · see citing works
The contribution of psychosocial factors to the development of chronic pain: The key to better outcomes for patients?
Blyth, F., Macfarlane, G. J., & Nicholas, M. K. (2007) · Pain · doi:10.1016/j.pain.2007.03.009 · Cited by 140 · see citing works
The risk of suicide mortality in chronic pain patients
Hassett, A. L., Aquino, J. K., & Ilgen, M. A. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0436-1 · Cited by 140 · see citing works
Responder criteria for operant and cognitive-behavioral treatment of fibromyalgia syndrome.
Thieme, K., Turk, D., & Flor, H. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22778 · Cited by 124 · see citing works
Comparison of an Online Mindfulness-based Cognitive Therapy Intervention With Online Pain Management Psychoeducation: A Randomized Controlled Study
Dowd, H., Hogan, M. J., McGuire, B. E., Davis, M. C., Sarma, K. M., Fish, R. A., & Zautra, A. J. (2015) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000201 · Cited by 121 · see citing works
Mortality in fibromyalgia: A study of 8,186 patients over thirty‐five years
Wolfe, F., Hassett, A. L., Walitt, B. T., & Michaud, K. D. (2010) · Arthritis Care & Research · doi:10.1002/acr.20301 · Cited by 116 · see citing works
Mortality in a cohort of Danish patients with fibromyalgia: Increased frequency of suicide
Dreyer, L., Kendall, S. A., Danneskiold‐Samsøe, B., Bartels, E. M., & Bliddal, H. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27623 · Cited by 104 · see citing works
Premorbid psychosocial factors are associated with poor health-related quality of life in subjects with new onset of chronic widespread pain – Results from the EPIFUND study
Nicholl, B. I., Macfarlane, G. J., Davies, K. A., Morriss, R. K., Dickens, C. M., & McBeth, J. (2008) · Pain · doi:10.1016/j.pain.2008.10.022 · Cited by 96 · see citing works
Genetic variation in the beta2-adrenergic receptor but not catecholamine- O -methyltransferase predisposes to chronic pain: Results from the 1958 British Birth Cohort Study
Hocking, L. J., Smith, B. H., Jones, G. T., Reid, D. M., Strachan, D. P., & Macfarlane, G. J. (2010) · Pain · doi:10.1016/j.pain.2010.01.023 · Cited by 95 · see citing works
What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of `centralized' pain?
Napadow, V., & Harris, R. E. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0425-0 · Cited by 92 · see citing works
A chimeric antibody with the human ?1 constant region as a putative standard for assays to detect IgG ?2-glycoprotein I-dependent anticardiolipin and anti-?2-glycoprotein I antibodies
Ichikawa, K., Tsutsumi, A., Atsumi, T., Matsuura, E., Kobayashi, S., Hughes, G. R. V., Khamashta, M. A., & Koike, T. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199911)42:11 · Cited by 88 · see citing works
Individualized Guided Internet-delivered Cognitive-Behavior Therapy for Chronic Pain Patients With Comorbid Depression and Anxiety: A Randomized Controlled Trial
Buhrman, M., Syk, M., Burvall, O., Hartig, T., Gordh, T., & Andersson, G. (2015) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000176 · Cited by 83 · see citing works
Psychophysiological responses in patients with fibromyalgia syndrome
Thieme, K., Rose, U., Pinkpank, T., Spies, C., Turk, D. C., & Flor, H. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.07.004 · Cited by 82 · see citing works
The Association of Socioeconomic Status and Symptom Severity in Persons with Fibromyalgia
Fitzcharles, M., Rampakakis, E., Ste‐Marie, P. A., Sampalis, J. S., & Shir, Y. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.131515 · Cited by 70 · see citing works
Personality does not distinguish people with fibromyalgia but identifies subgroups of patients
Torres, X., Baillés, E., Valdes, M., Gutiérrez, F., Peri, J., Arias, A., Gómez, E., & Collado, A. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.07.014 · Cited by 66 · see citing works
The Relationship Among Psychological and Psychophysiological Characteristics of Fibromyalgia Patients
Thieme, K., Turk, D. C., Gracely, R. H., Maixner, W. D., & Flor, H. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.11.009 · Cited by 59 · see citing works
Association of HTR2A polymorphisms with chronic widespread pain and the extent of musculoskeletal pain: Results from two population-based cohorts
Nicholl, B. I., Holliday, K. L., Macfarlane, G. J., Thomson, W., Davies, K. A., O’Neill, T. W., Bártfai, G., Boonen, S., Casanueva, F. F., Finn, J. D., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30185 · Cited by 58 · see citing works
Psychiatric comorbidity in fibromyalgia
Bradley, L. A. (2005) · Current Pain and Headache Reports · doi:10.1007/s11916-005-0042-3 · Cited by 54 · see citing works
Predictors of Suicidal Ideation in Chronic Pain Patients
Racine, M., Choinière, M., & Nielson, W. R. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31829e9d4d · Cited by 45 · see citing works
Pressure Pain Sensitivity and Insular Combined Glutamate and Glutamine (Glx) Are Associated with Subsequent Clinical Response to Sham But Not Traditional Acupuncture in Patients Who Have Chronic Pain
Harte, S. E., Clauw, D. J., Napadow, V., & Harris, R. E. (2013) · Medical Acupuncture · doi:10.1089/acu.2013.0965 · Cited by 31 · see citing works
THE MANAGEMENT OF CHRONIC ARTHRITIS AND OTHER RHEUMATIC DISEASES AMONG SOLDIERS OF THE UNITED STATES ARMY
Hench, P. S., & Boland, E. W. (1946) · Annals of Internal Medicine · doi:10.7326/0003-4819-24-5-808 · Cited by 22 · see citing works
The Management of Chronic Arthritis and other Rheumatic Diseases among Soldiers of the United States Army
Hench, P. S., & Boland, E. W. (1946) · Annals of the Rheumatic Diseases · doi:10.1136/ard.5.4.106 · Cited by 16 · see citing works
Untitled work
Shigeyama (2000) · doi:10.1002/1529-0131(200011)43:11

Flagged first, then by citations

1 of the 52 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

[12]Offenbaecher M Bondy B de Jonge S Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region Arthritis Rheum 1999 42 2482 2488 10555044
[25]Hassett AL Cone JD Patella SJ The role of catastrophizing in the pain and depression of women with fibromyalgia syndrome Arthritis and rheumatism 2000 43 2493 2500 11083273

Sorted by citations

Chronic pain: an update on burden, best practices, and new advances
Cohen, S. P., Vase, L., & Hooten, W. M. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00393-7 · Cited by 2,614 · see citing works
Are Pain Beliefs, Cognitions, and Behaviors Influenced by Race, Ethnicity, and Culture in Patients with Chronic Musculoskeletal Pain: A Systematic Review
Meeus, M. (2018) · Pain Physician · doi:10.36076/ppj.2018.6.541 · Cited by 176 · see citing works
“Chronic pain has been considered as a biopsychosocial condition in which contextual, cognitive and emotional factors as well as biological factors significantly affect pain perception (8-11).”
Background
Pain-Related Fear, Pain Intensity and Function in Individuals With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis
Martinez-Calderon, J., Flores-Cortes, M., Morales-Asencio, J. M., & Luque-Suarez, A. (2019) · The Journal of Pain · doi:10.1016/j.jpain.2019.04.009 · Cited by 141 · see citing works
Do Nutritional Factors Interact with Chronic Musculoskeletal Pain? A Systematic Review
Elma, Ö., Yılmaz, S. T., Deliens, T., Coppieters, I., Clarys, P., Nijs, J., & Malfliet, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030702 · Cited by 131 · see citing works
Which Psychological Factors Are Involved in the Onset and/or Persistence of Musculoskeletal Pain? An Umbrella Review of Systematic Reviews and Meta-Analyses of Prospective Cohort Studies
Martinez-Calderon, J., Flores-Cortes, M., Morales-Asencio, J., & Luque-Suarez, A. (2020) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000838 · Cited by 75 · see citing works
Co-occurrence of Chronic Musculoskeletal Pain and Cardiovascular Diseases: A Systematic Review with Meta-analysis.
Oliveira, C. B., Maher, C., Franco, M. R., Kamper, S., Williams, C., Silva, F. G., & Pinto, R. (2020) · Pain medicine (Malden, Mass.) · doi:10.1093/pm/pnz217 · Cited by 78 · see citing works
Chronic Pain in Musculoskeletal Diseases: Do You Know Your Enemy?
Bonanni, R., Cariati, I., Tancredi, V., Iundusi, R., Gasbarra, E., & Tarantino, U. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092609 · Cited by 84 · see citing works
“Furthermore, the existence of a bidirectional relationship between depression and chronic pain has been reported, as pain is a strong predictor of depression severity and vice versa [41].”
Background
Violence from childhood to adulthood: The influence of child victimization and domestic violence on physical health in later life
Riedl, D., Beck, T., Exenberger, S., Daniels, J., Dejaco, D., Unterberger, I., & Lampe, A. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.019 · Cited by 69 · see citing works
Psychological Approaches for the Integrative Care of Chronic Low Back Pain: A Systematic Review and Metanalysis
Petrucci, G., Papalia, G. F., Russo, F., Vadalà, G., Piredda, M., Marinis, M. G. D., Papalia, R., & Denaro, V. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19010060 · Cited by 70 · see citing works
“Therefore, cognitive and emotional factors have a crucial impact on pain perception and, in line with the literature [46], it is fundamental to identify and take care of psychological factors, through a multidisciplinary approach in patients with chronic pain.”
Background
Relationship between self‐reported cognitive difficulties, objective neuropsychological test performance and psychological distress in chronic pain
Baker, K. S., Gibson, S. J., Georgiou‐Karistianis, N., & Giummarra, M. J. (2017) · European Journal of Pain · doi:10.1002/ejp.1151 · Cited by 69 · see citing works
“There is no question that psychological disturbances such as anxiety, depression and catastrophizing are highly prevalent in patients with chronic pain (McWilliams et al., 2003; Erickson, 2005; Crofford, 2015), regardless of whether these characteristics were present before or after pain became chronic.”
Background
Chronic widespread pain and increased mortality: biopsychosocial interconnections
Silva, J. D. D., Geenen, R., & Jacobs, J. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211893 · Cited by 24 · see citing works
Concurrent validation of a pressure pain threshold scale for individuals with myofascial pain syndrome and fibromyalgia
Cheatham, S. W., Kolber, M. J., Butcher-Mokha, M., & Hanney, W. J. (2017) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2017.1349592 · Cited by 61 · see citing works
Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model
Pinto, A. M., Luís, M., Geenen, R., Palavra, F., Lumley, M. A., Ablin, J. N., Amris, K., Branco, J., Buskila, D., Castelhano, J., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105235 · Cited by 68 · see citing works
Self-citation
Randomized-controlled trial assessing a digital care program versus conventional physiotherapy for chronic low back pain
Cui, D., Janela, D., Costa, F., Molinos, M., Areias, A. C., Moulder, R. G., Scheer, J. K., Bento, V., Cohen, S. P., Yanamadala, V., et al. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00870-3 · Cited by 60 · see citing works
Pain Status and Its Association with Physical Activity, Psychological Stress, and Telework among Japanese Workers with Pain during the COVID-19 Pandemic
Yoshimoto, T., Fujii, T., Oka, H., Kasahara, S., Kawamata, K., & Matsudaira, K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115595 · Cited by 54 · see citing works
“aspects have been recognized as an important factor in the chronicity of pain from the perspective of a biopsychosocial model [19].”
Background
Long-term Chikungunya sequelae and quality of life 2.5 years post-acute disease in a prospective cohort in Curaçao
Doran, C., Elsinga, J., Fokkema, A., Berenschot, K., Gerstenbluth, I. I., Duits, A. J., Lourents, N., Halabi, Y., Burgerhof, J. G. M., Bailey, A., et al. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010142 · Cited by 51 · see citing works
Stress, non-restorative sleep, and physical inactivity as risk factors for chronic pain in young adults: A cohort study
Lindell, M., & Grimby‐Ekman, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262601 · Cited by 53 · see citing works
“It is widely believed that psychosocial distress, earlier traumas or abuse, depression or sleep problems matter in the development of chronic pain [9, 10], and that perceived stress may have an important role.”
Background
Cognitive complaints in women with fibromyalgia: Are they due to depression or to objective cognitive dysfunction?
Gelonch, O., Garolera, M., Valls, J., Rosselló, L., & Pifarré, J. (2017) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2017.1301391 · Cited by 50 · see citing works
“In clinical practice, subjective cognitive complaints reported by fibromyalgia patients are frequently attributed to depressive symptoms, which are very frequent in this population (Comeche, Pardo, Rodríguez, Díaz, & Vallejo, 2012; Crofford, 2015; Walitt, Nahin, Katz, Bergman, & Wolfe, 2015).”
Background
Chronic pain and frequent use of emergency department: A systematic review
Dépelteau, A., Racine-Hemmings, F., Lagueux, É., & Hudon, C. (2019) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2019.158492 · Cited by 46 · see citing works
Optimizing Cognitive Function in Persons With Chronic Pain
Baker, K. S., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000423 · Cited by 44 · see citing works
Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study
Protheroe, J., Saunders, B., Bartlam, B., Dunn, K. M., Cooper, V., Campbell, P., Hill, J. C., Tooth, S., Mallen, C. D., Hay, E. M., et al. (2019) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-019-2587-z · Cited by 40 · see citing works
Quality of Life and Mental Distress in Patients with Chronic Low Back Pain: A Cross-Sectional Study
Hnatešen, D., Pavić, R., Radoš, I., Dimitrijević, I., Budrovac, D., Čebohin, M., & Gusar, I. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710657 · Cited by 41 · see citing works
“Crofford, in his research, cites a downward physical and emotional spiral called “physical and mental deconditioning” because patients with chronic back pain have a reduced ability to engage in various activities such as work, recreational activities, and interactions with family members and friends [65].”
Background
Self‐efficacy as a prognostic factor and treatment moderator in chronic musculoskeletal pain patients attending pain management programmes: A systematic review
Hayward, R., & Stynes, S. M. (2020) · Musculoskeletal Care · doi:10.1002/msc.1533 · Cited by 36 · see citing works
Couriers’ safety and health risks before and during the COVID-19 pandemic
Egozi, L., Reiss-Hevlin, N., Dallasheh, R., & Pardo, A. (2021) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-021-01795-8 · Cited by 35 · see citing works
“This finding is backed up by many studies that have established a relationship between stress and pain; although the nature of the relationship is not yet fully understood—i.e., whether stress causes pain, pain causes stress, or they share a common factor such as genetics (Crofford 2015).”
I call it stinkin’ thinkin’’: A qualitative analysis of metacognition in people with chronic low back pain and elevated catastrophizing
Schütze, R., Rees, C., Slater, H., Smith, A., & O'Sullivan, P. (2017) · British Journal of Health Psychology · doi:10.1111/bjhp.12240 · Cited by 30 · see citing works
“Chronic pain – defined as pain that persists beyond 3–6 months (Merskey & Bogduk, 1994) – is strongly associated with poor self-rated health, lower quality of life, and psychopathology (Crofford, 2015).”
Background
Development of a clinical risk score for pain and function following total knee arthroplasty: results from the TRIO study
Shim, J., McLernon, D. J., Hamilton, D. F., Simpson, H., Beasley, M., & Macfarlane, G. J. (2018) · Rheumatology Advances in Practice · doi:10.1093/rap/rky021 · Cited by 30 · see citing works
Suffering in silence: a qualitative study of older adults’ experiences of living with long-term musculoskeletal pain at home
Gillsjö, C., Nässén, K., & Berglund, M. (2020) · European Journal of Ageing · doi:10.1007/s10433-020-00566-7 · Cited by 30 · see citing works
“2011; Crofford 2015; Hoyos et al.”
Background
Proposal for Improvement of the Hospital Anxiety and Depression Scale for the Assessment of Emotional Distress in Patients With Chronic Musculoskeletal Pain: A Bifactor and Item Response Theory Analysis
Giusti, E. M., Jonkman, A., Manzoni, G. M., Castelnuovo, G., Terwee, C. B., Roorda, L. D., & Chiarotto, A. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.08.003 · Cited by 27 · see citing works
The effect of depressive symptoms on cognition in patients with fibromyalgia
Gelonch, O., Garolera, M., Valls, J., Castellà, G., Varela, O., Rosselló, L., & Pifarré, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200057 · Cited by 26 · see citing works
Demonstration of the relationship between MSD and online learning during the COVID-19 pandemic
Karingada, K. T. B., & Sony, M. (2021) · Journal of Applied Research in Higher Education · doi:10.1108/jarhe-08-2020-0269 · Cited by 26 · see citing works
Emotional Distress Correlates Among Patients With Chronic Nonspecific Low Back Pain: A Hierarchical Linear Regression Analysis
Du, S., Hu, Y., Bai, Y., Hu, L., Dong, J., Jin, S., & Zhang, H. (2019) · Pain Practice · doi:10.1111/papr.12772 · Cited by 24 · see citing works
“Including CLBP, chronic musculoskeletal pain, by its very nature, is related to emotional distress and negative psychological variables.(11) The Lancet has recently emphasized that emotional distress is one of the factors that potentially increases the risk for persistent disabling CLBP.”
BackgroundInfluential
Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia
Alves, C. F. D. S., Caumo, W., Silvestri, J. M., Zortéa, M., dos Santos, V. S., Cardoso, D. F., Regner, A., de Souza, A. H., & Simon, D. (2020) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-020-00141-9 · Cited by 26 · see citing works
Development of culturally sensitive Pain Neuroscience Education for first-generation Turkish patients with chronic pain: A modified Delphi study
Orhan, C., Cagnie, B. J., Favoreel, A., Looveren, E. V., Akel, U., Mukhtar, N. B., Meulemeester, K. D., Pas, R., Lenoir, D., & Meeus, M. (2018) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2018.10.007 · Cited by 22 · see citing works
Fibromyalgia and central sensitization in chronic inflammatory joint diseases
Dougados, M., & Perrot, S. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2017.03.001 · Cited by 24 · see citing works
Navigating diagnostic uncertainty in musculoskeletal practice: The perspectives and experiences of new graduate physiotherapists
Almond, A., Zou, Y., & Forbes, R. (2021) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2021.102354 · Cited by 22 · see citing works
Mental Disorders, Musculoskeletal Disorders and Income-Driven Patterns: Evidence from the Global Burden of Disease Study 2017
Tyrovolas, S., Moneta, V., Giné-Vázquez, I., Koyanagi, A., Abduljabbar, A. S., & Haro, J. M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072189 · Cited by 22 · see citing works
Objective wearable measures and subjective questionnaires for predicting response to neurostimulation in people with chronic pain
Heros, R. D., Patterson, D., Huygen, F. J. P. M., Skaribas, I. M., Schultz, D., Wilson, D. K., Fishman, M. A., Falowski, S. M., Moore, G., Kallewaard, J. W., et al. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00115-4 · Cited by 21 · see citing works
“2021; Crofford 2015).”
Psychological well-being and distress: Their associations with temporomandibular disorder symptoms and interrelationships
Yap, A. U., Marpaung, C. D., & Rahmadini, E. D. (2021) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2021.02.012 · Cited by 21 · see citing works
Incidence rates of suicidal behaviors and treated depression in patients with and without psoriatic arthritis using the Clinical Practice Research Datalink
Hagberg, K. W., Li, L., Peng, M., Shah, K., Paris, M. M., & Jick, S. S. (2016) · Modern Rheumatology · doi:10.3109/14397595.2015.1136726 · Cited by 21 · see citing works
Prognostic Factors for Quality of Life After Interdisciplinary Pain Rehabilitation in Patients with Chronic Pain—A Systematic Review
Liechti, S., Tseli, E., Taeymans, J., & Grooten, W. J. A. (2022) · Pain Medicine · doi:10.1093/pm/pnac098 · Cited by 20 · see citing works
“Our results support the current evidence that psychological factors are strongly related to chronic pain [52].”
Result
The Intersection of Sarcopenia and Musculoskeletal Pain: Addressing Interconnected Challenges in Aging Care
Grosman, Y., & Kalichman, L. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22040547 · Cited by 23 · see citing works
Frequency of and Various Factors Associated with Stress, Anxiety, and Depression among Low Back Pain Patients
Azfar, S. M., Murad, M. A., Azim, S. R., & Baig, M. (2019) · Cureus · doi:10.7759/cureus.5701 · Cited by 19 · see citing works
Effects of Monopolar Dielectric Radiofrequency Signals on the Symptoms of Fibromyalgia: A Single-Blind Randomized Controlled Trial
Ibáñez‐Vera, A. J., García-Romero, J., Alvero‐Cruz, J. R., & Lomas‐Vega, R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072465 · Cited by 19 · see citing works
“This important placebo effect may be linked to the highly complex biopsychosocial impact that fibromyalgia patients experience [37], which increases the difficulty of obtaining accurate data because of their expectation of finding a cure for their symptoms.”
Background
Effects of electromyographic biofeedback interventions for shoulder pain and function: Systematic review and meta-analysis
Kamonseki, D. H., Calixtre, L. B., Barreto, R. P. G., & Camargo, P. R. (2021) · Clinical Rehabilitation · doi:10.1177/0269215521990950 · Cited by 19 · see citing works
Central sensitization inventory is associated with psychological functioning but not with psychophysical assessment of pain amplification
Salbego, R. S., Conti, P. C. R., Soares, F. F. C., Ferreira, D. M. A. O., Herreira‐Ferreira, M., Netto, B. A. D. L., Costa, Y. M., & Bonjardim, L. R. (2024) · European Journal of Pain · doi:10.1002/ejp.4713 · Cited by 18 · see citing works
“Although psychophysical phenomena and emotional vulnerability may be closely linked (Crofford, 2015; Fillingim et al., 2013; McBeth et al., 2001; Slade et al., 2007; Sullivan et al., 2001), based on the results of this and other studies (Adams et al., 2023; Proença et al., 2021), the CSI…”
Effects of intranasal oxytocin on pain perception among human subjects: A systematic literature review and meta-analysis
Lopes, S., & Osório, F. D. L. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105282 · Cited by 19 · see citing works
The association between pain characteristics, pain catastrophizing and health care use – Baseline results from the SWEPAIN cohort
Jöud, A., Björk, J., Gerdle, B. U. C., Grimby‐Ekman, A., & Larsson, B. K. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.04.071 · Cited by 17 · see citing works
Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities
Tarabeih, N., Kalinkovich, A., Shalata, A., Cherny, S. S., & Livshits, G. (2022) · Journal of Pain Research · doi:10.2147/jpr.s349251 · Cited by 17 · see citing works
“a 50% prevalence of chronic pain (including LBP) has been observed in patients whose primary diagnosis is depression.(66) It also has been found that the rate of major depression is increased in a linear fashion with chronic”
Background
Applying AI to Safely and Effectively Scale Care to Address Chronic MSK Conditions
Areias, A. C., Janela, D., Moulder, R. G., Jr., Molinos, M., Bento, V., Moreira, C., Yanamadala, V., Correia, F. D., & Costa, F. M. T. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154366 · Cited by 16 · see citing works
“Finally, future research should consider an evaluation of workflow time savings and qualitative analysis of the providers’ perceptions of the tool for further workflow sustainability and increased workforce wellbeing.”
Method
Psychosocial impacts of Mendelian eye conditions: A systematic literature review
D'Amanda, C. S., Nolen, R., Huryn, L. A., & Turriff, A. E. (2020) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.02.002 · Cited by 16 · see citing works
Environmental enrichment prevents chronic stress‐induced brain‐gut axis dysfunction through a GR‐mediated mechanism in the central nucleus of the amygdala
Orock, A. M., Louwies, T., Yuan, T., & Meerveld, B. G. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13826 · Cited by 16 · see citing works
“002), but failed to reveal an effect of housing condition (F(1,5) = 0.”
Background
Beyond yellow flags: The Big‐Five personality traits and psychologically informed musculoskeletal rehabilitation.
Williams, M. K., Waite, L., Van Wyngaarden, J. J., Meyer, A. R., & Koppenhaver, S. L. (2023) · Musculoskeletal Care · doi:10.1002/msc.1797 · Cited by 15 · see citing works
Role of Nutrition in the Management of Patients with Chronic Musculoskeletal Pain
Cuomo, A., & Parascandolo, I. (2024) · Journal of Pain Research · doi:10.2147/jpr.s456202 · Cited by 15 · see citing works
The Role of Positive Psychological Factors in the Association between Pain Intensity and Pain Interference in Individuals with Chronic Musculoskeletal Pain: A Cross-Sectional Study
Martínez-Calderón, J., Flores-Cortés, M., Clavero-Cano, S., Morales‐Asencio, J. M., Jensen, M. P., Rondón-Ramos, A., Díaz-Cerrillo, J. L., Ariza-Hurtado, G. R., & Luque-Suárez, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103252 · Cited by 15 · see citing works
“Chronic musculoskeletal pain is known to be associated with a substantial burden in terms of greater lack of work productivity [3], medication overuse [4], healthcare expenditures [5], loneliness [6], mental health decline [7], suicidal behaviors [8], and premature mortality [7].”
Background
Chronic musculoskeletal pain in Japan (the final report of the 3-year longitudinal study): Association with a future decline in activities of daily living
Sugai, K., Tsuji, O., Matsumoto, M., Nishiwaki, Y., & Nakamura, M. (2017) · Journal of orthopaedic surgery · doi:10.1177/2309499017727945 · Cited by 15 · see citing works
“A complex network of factors underlies chronic musculoskeletal pain, including joint degeneration, neural pathways,(8,17) muscle weakness,(16) and psychosocial factors.(8,17,18) Accordingly, the mechanisms underlying a decline in ADL is also likely to be multifactorial.”
Background
Musculoskeletal Pain is Associated With New-Onset Psychological Distress in Survivors of the Great East Japan Earthquake
Yabe, Y., Hagiwara, Y., Sekiguchi, T., Sugawara, Y., Tsuchiya, M., Koide, M., Itaya, N., Yoshida, S., Sogi, Y., Yano, T., et al. (2018) · Disaster Medicine and Public Health Preparedness · doi:10.1017/dmp.2018.57 · Cited by 15 · see citing works
“Although the mechanisms are not well understood, the regions of the brain controlling pain perception have connectivity with the regions modulating emotional states, and chronic pain alters these regions.(40) Among types of pain, musculoskeletal pain has the highest association with psychological distress.”
Background
Obstructive Sleep Apnea and Serotoninergic Signalling Pathway: Pathomechanism and Therapeutic Potential
Witkowska, A., Jaromirska, J., Gabryelska, A., & Sochal, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179427 · Cited by 14 · see citing works
“Anxiety disorder is a complex, heterogeneous disease entity comprising separation disorder, neurons in respiratory, such as OSA, or musculoskeletal diseases are at a heightened risk of experiencing anxiety [104].”
Background
Symptoms patients receiving manual therapy experienced and perceived as adverse: a secondary analysis of a survey of patients’ perceptions of what constitutes an adverse response
Funabashi, M., & Carlesso, L. C. (2020) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2020.1761139 · Cited by 14 · see citing works
Relationships between chronic pain and mood symptoms among veterans with bipolar disorder
Travaglini, L. E., Kuykendall, L., Bennett, M. E., Abel, E. A., & Lucksted, A. A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.08.069 · Cited by 14 · see citing works
Emotion regulation strategies mediate the associations of positive and negative affect to upper extremity physical function
Talaei‐Khoei, M., Nemati-Rezvani, H., Fischerauer, S., Ring, D., Chen, N. C., & Vranceanu, A. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.03.005 · Cited by 14 · see citing works
Phenome-wide screening of the putative causal determinants of depression using genetic data
Aman, A. M., García‐Marín, L. M., Thorp, J. G., Campos, A. I., Cuéllar-Partida, G., Martin, N. G., & Rentería, M. E. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac081 · Cited by 13 · see citing works
Pain catastrophising, body mass index and depressive symptoms are associated with pain severity in tertiary referral orthopaedic foot/ankle patients
Holt, M., Swalwell, C., Silveira, G. H., Tippett, V. C., Walsh, T. P., & Platt, S. R. (2022) · Journal of Foot and Ankle Research · doi:10.1186/s13047-022-00536-5 · Cited by 13 · see citing works
“6% and proportionately lower response rate in younger patients, the cohort studied is comparable to those from previous studies of foot and ankle clinic waitlists in the public sector which constitutes a very large proportion of the total pool of patients seeking care [10, 11, 58].”
Result
Musculoskeletal pain and risk factors in office workers versus teleworkers: A systematic review
de Alencar, M. D. C. B., da Silva, N. R., & Serranheira, F. (2024) · Work · doi:10.1177/10519815241289675 · Cited by 12 · see citing works
“Patients with chronic musculoskeletal pain of any etiology may experience excessive emotional, cognitive and behavior responses to chronic pain, 74 which can in ﬂ uence the mental health risk and also WRMSD.”
A Biopsychosocial Model-Based Clinical Approach in Myofascial Pain Syndrome: A Narrative Review
Koukoulithras, I., Plexousakis, M., Kolokotsios, S., Stamouli, A., & Mavrogiannopoulou, C. (2021) · Cureus · doi:10.7759/cureus.14737 · Cited by 12 · see citing works
“In particular chronic musculoskeletal pain, by its very nature, is associated with psychological distress and negative emotions [18].”
Background
Impacts of Digital Care Programs for Musculoskeletal Conditions on Depression and Work Productivity: Longitudinal Cohort Study
Costa, F. M. T. A., Janela, D., Molinos, M., Moulder, R. G., Jr., Bento, V., Laíns, J., Scheer, J. K., Yanamadala, V., Cohen, S. P., & Correia, F. D. (2022) · Journal of Medical Internet Research · doi:10.2196/38942 · Cited by 12 · see citing works
“Comorbidity between MSK pain and depression is very common [2] due to shared pathophysiological mechanisms, which establishes a strong and complex bidirectional relationship [3,4].”
Coping and Beliefs as Predictors of Functioning and Psychological Adjustment in Fibromyalgia Subgroups
Fidel, L. R., García‐Palacios, A., Herrero, R., Molinari, G., & Suso‐Ribera, C. (2022) · Pain Research and Management · doi:10.1155/2022/1066192 · Cited by 13 · see citing works
Efficacy of percutaneous needle electrolysis versus dry needling in musculoskeletal pain: A systematic review and meta-analysis
Fakontis, C., Iakovidis, P., Lytras, D., Kasimis, K., Koutras, G., Ntinou, S. R., Kottaras, A., Chatziprodromidou, I. P., Chatzikonstantinou, P., & Apostolou, T. S. (2023) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-220408 · Cited by 10 · see citing works
“In addition, musculoskeletal pain has also been blamed for economic, social, and psychological impacts [4–6].”
Kann eine Online-Intervention für Depressionen emotionale Probleme und Schmerzen lindern? Eine randomisiert-kontrollierte Studie
Miegel, F. S., Gehlenborg, J., Bücker, L., Lion, D., & Moritz, S. (2019) · Verhaltenstherapie · doi:10.1159/000501736 · Cited by 10 · see citing works
“Sind Schmerzpatienten emotional belastet, verstärkt dies häufig ihr Schmerzempfinden [Crofford, 2015] und sagt ein schlechteres Ansprechen auf die Behandlung chronischer Schmerzen und Depressionen vorher [Sherman et al., 2000; Roditi und Robinson, 2011; Poleshuck et al., 2009].”
Background
Can psychological factors be associated with the severity of pain and disability in patients with fibromyalgia? A cross-sectional study
do Nascimento, B., Franco, K. F. M., Franco, Y. R. D. S., & Cabral, C. M. N. (2020) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2020.1765439 · Cited by 10 · see citing works
“If psychological factors are closely associated with the intensity of pain and disability in these patients, these factors should be considered in the treatments (Crofford, 2015; Fitzcharles et al., 2014).”
BackgroundInfluential
Chronic Pain, Mood Disorders and Substance Use: Outcomes of Interdisciplinary Care in a Residential Psychiatric Hospital
Buono, F. D., Savage, S. R., Cerrito, B., O'CONNELL, J. C., Garakani, A., Ackerman, S., & Cutter, C. J. (2020) · Journal of Pain Research · doi:10.2147/jpr.s250568 · Cited by 10 · see citing works
Predicting the outcome of plantar heel pain in adults: a systematic review of prognostic factors
Gülle, H., Morrissey, D., Tan, X. L., Cotchett, M., Miller, S., Jeffrey, A. B., & Prior, T. D. (2023) · Journal of Foot and Ankle Research · doi:10.1186/s13047-023-00626-y · Cited by 10 · see citing works
Higher self-perceived stress reactivity is associated with increased chronic pain risk
Boring, B. L., Richter, A., & Mathur, V. A. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001068 · Cited by 9 · see citing works
“mindfulness-based and cognitive behavioral therapy is recognized as a beneficial target for those with chronic pain, leading to a range of improved pain experiences.(6,10,12,23,51) However, the utility of SPSR as a predictive risk factor for chronic pain”
Background
Core patient-reported outcome measures for chronic pain patients treated with spinal cord stimulation or dorsal root ganglia stimulation
Huygen, F. J. P. M., Hagedorn, J. M., Falowski, S. M., Schultz, D. M., Vesper, J., Heros, R. D., Patterson, D. G., Dehghan, S., Ross, E., Kyani, A., et al. (2023) · Health and Quality of Life Outcomes · doi:10.1186/s12955-023-02158-2 · Cited by 9 · see citing works
“In addition to unpleasant sensory experiences, many subjects often suffer emotional and psychological distress due to the interference of pain with activities of daily life and with sleep [3, 4].”
Background
ConheceDOR: the development of a board game for modern pain education for patients with musculoskeletal pain
Bittencourt, J. V., Meziat‐Filho, N., Nogueira, L. A. C., & dos Reis, F. J. J. (2019) · Brazilian Journal Of Pain · doi:10.5935/2595-0118.20190030 · Cited by 9 · see citing works
Prevalence of musculoskeletal disorders in firefighters and its association with insomnia
Abbasi, M., Jalilolghadr, S., Soltanabadi, M., & Yazdi, Z. (2020) · Policy and Practice in Health and Safety · doi:10.1080/14773996.2019.1708613 · Cited by 9 · see citing works
“Musculoskeletal disorders and chronic pain caused by it are one the most common causes of occupational injuries in most countries with a prevalence of about 35% (Ahmadi, Abolsamadi, Roshanaei, & Jaliliyan, 2012; Crofford, 2015).”
Background
All-Cause Opioid Prescriptions Dispensed: The Outsized Role of Adults With Arthritis
Murphy, L. B., Cisternas, M. G., Theis, K. A., Brady, T. J., Bohm, M. K., Guglielmo, D., Hootman, J. M., Barbour, K. E., Boring, M. A., & Helmick, C. G. (2020) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2020.03.028 · Cited by 9 · see citing works
Introversion, Extraversion, and Worsening of Chronic Pain Impact during Social Isolation: A Mediation Analysis
Flowers, K. M., Colebaugh, C. A., Hruschak, V., Azizoddin, D. R., Meints, S. M., Jamison, R. N., Wilson, J. M., Edwards, R. R., & Schreiber, K. L. (2022) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-022-09901-9 · Cited by 9 · see citing works
“The biopsychosocial model provides a theoretical foundation for how biological, psychological, and social factors interact to influence the experience of pain (Fillingim, 2017), including certain personality traits which may contribute to variance in the pain experience (Conrad et al., 2013; Crofford, 2015; Gustin et…”
BackgroundInfluential
Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats
Álvarez, P., Green, P. G., & Levine, J. D. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.01.009 · Cited by 9 · see citing works
Job stress and chronic and widespread musculoskeletal pain: a cross-sectional analysis from the Brazilian Longitudinal Study of Adult Health Musculoskeletal
Ruela, G. D. A., Barreto, S. M., Griep, R. H., Benseñor, I. M., Telles, R. W., & Camelo, L. D. V. (2022) · Pain · doi:10.1097/j.pain.0000000000002602 · Cited by 10 · see citing works
Hatha yoga is more effective in improving kinesiophobia and subjective well-being when combined with self-compassion meditation in people with CLBP: a randomized control trial
Giorgio, A. D., Angilletta, S., Matteo, B. M., Bonavolontá, V., Bragazzi, N. L., & Kuvačić, G. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1272919 · Cited by 8 · see citing works
Effect of telemedicine-supported structured exercise program in patients with chronic low back pain: a randomized controlled trial
Yuan, F., Zhu, C., Liu, H., Bao, T., Wang, C., Wang, Z., Wang, X., Zhang, R., Zhang, Y., Zhang, S., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326218 · Cited by 11 · see citing works
“However, mental health status is influenced by more complex factors [38,39], such as work and family factors, which may explain the lack of significant differences in mental health outcomes between the two groups.”
Importance of Non-pharmacological Approaches for Treating Irritable Bowel Syndrome: Mechanisms and Clinical Relevance
Orock, A. M., Yuan, T., & Meerveld, B. G. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2020.609292 · Cited by 10 · see citing works
“CBT has been shown to decrease chronic pain and increase quality of life for patients suffering from fibromyalgia and musculoskeletal pain (57, 105, 106).”
Background
Rubus occidentalis alleviates hyperalgesia induced by repeated intramuscular injection of acidic saline in rats
Choi, G. J., Kang, H., Kim, W., Baek, C. W., Jung, Y. H., Woo, Y. C., & Kwon, J. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1192-z · Cited by 8 · see citing works
“Additionally, chronic pain can cause compounding effects by contributing to considerable psychological problems such as depression and anxiety [29].”
Background
Predictors of musculoskeletal symptoms in radiology technologists in Austria, Europe
Augner, C., & Kaiser, G. (2019) · Work · doi:10.3233/wor-193047 · Cited by 8 · see citing works
Exercise Intervention for Chronic Pain Management, Muscle Strengthening, and Functional Score in Obese Patients with Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis.
Tamin, T. Z., Murdana, N., Pitoyo, Y., & Safitri, E. D. (2018) · Acta medica Indonesiana · Cited by 8 · see citing works
Chronic pain: the role of biological and psychosocial factors
Generaal, E. (2016) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 8 · see citing works
Understanding the relationship between sleep, psychological and musculoskeletal health from a neuroimmune perspective
Klyne, D. M., Hall, M., Smith, S. S., Barbe, M. F., Egorova, N., Serafimovska, A., Hodges, P. W., & Suraev, A. S. (2026) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2026.103509 · Cited by 8 · see citing works
Insomnia-related Memory Impairment in Individuals With Very Complex Chronic Pain
Bothelius, K., Hysing, E., Filén, T., Lundeborg, L., & Gordh, T. (2019) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000196 · Cited by 7 · see citing works
Musculoskeletal pain latent classes and biopsychosocial characteristics among emerging adults
Gallagher, K. M., Howie, E. K., & Carney, M. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-06412-y · Cited by 6 · see citing works
“Because pain induces various emotional responses, these factors influence how individuals perceive pain [19].”
Background
Systematic Review of the Psychopathological Symptomatology and Neuropsychological Disorders of Chronic Primary Musculoskeletal Pain
Arévalo‐Martínez, A., Barbosa‐Torres, C., Manso, J. M. M., Cordero, P. C., Sánchez, M. E. G.-B., & Díaz‐Muñoz, C. L. (2024) · Healthcare · doi:10.3390/healthcare12151465 · Cited by 6 · see citing works
“In The most a ﬀ ected areas are related to nociception, the most important being the somatosensory cortex, the insular cortex, the anterior cingulate cortex, and the prefrontal cortices [3,6,7].”
Background
Stress during the COVID-19 Pandemic Moderates Pain Perception and Momentary Oxytocin Levels
Schneider, E., Hopf, D., Eckstein, M., Scheele, D., Aguilar‐Raab, C., Herpertz, S. C., Grinevich, V., & Ditzen, B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062333 · Cited by 6 · see citing works
“Initial research has demonstrated that stress per se modulates pain perception and vice versa, that is, the association between stress and pain seems to be bidirectional [11,12].”
Questionnaires assessing knowledge and beliefs about musculoskeletal conditions are potentially suitable for use, but further research is needed: a systematic review
Corrêa, L. A., Mathieson, S., Hancock, M. J., Verhagen, A. P., Nogueira, L. A. C., Young, A., Pate, J. W., & French, S. D. (2024) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2024.111398 · Cited by 6 · see citing works
Dexmedetomidine for chronic pain patients with anxiety and depression: a propensity score matching cohort study
Ren, Y., Huang, P., & Jin, X. (2025) · BMC Anesthesiology · doi:10.1186/s12871-025-03087-x · Cited by 6 · see citing works
“The bidirectional relationship between pain and psychological disorders creates a vicious cycle where each condition exacerbates the other, complicating treatment [27].”
Patient’s perceptions of physical examination in the setting of chronic pain
Hashim, M. M., Edgeworth, D. M., Saunders, J. A., & Harmon, D. C. (2020) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-020-02250-2 · Cited by 6 · see citing works
Magnitude of depression and associated risk factors among patients with musculoskeletal disorder treated in physiotherapy outpatient department in Amhara region comprehensive specialized hospital in Ethiopia: a prospective cross-sectional study
Yalew, E. S., Zemed, A., Guadie, Y. G., Abich, Y., Kassa, T., & Gashaw, M. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04658-3 · Cited by 6 · see citing works
“However, the burden of depression increases among people with chronic conditions and associated comorbidity; Without a doubt, the link between musculoskeletal pain and depression compromises a person’s health and drastically lowers their quality of life [7].”
Background
Coexistence of Chronic Pain and Depression: A Short Review with a Focus on the Antidepressant Effect of Tramadol and Buprenorphine
Szkutnik-Fiedler, D., & Grześkowiak, E. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000327 · Cited by 6 · see citing works
Estimation of the impact of migraine on self-rated health: A cross-sectional study in Slovenia
Popit, M., Zaletel‐Kragelj, L., Eržen, I., Zaletel, L. Z., & Zaletel, M. (2020) · Slovenian Journal of Public Health · doi:10.2478/sjph-2021-0007 · Cited by 6 · see citing works
Presenteeism Caused by Health Conditions and Its Economic Impacts Among Japanese Workers in the Post-COVID-19 Era
Yoshimoto, T., Matsudaira, K., Oka, H., Kasahara, S., Kokaze, A., & Inoue, S. (2025) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000003319 · Cited by 5 · see citing works
“22,23 Our study indicated that musculoskeletal pain was the leading cause of presenteeism, which is consistent with the findings of previous studies.”
Patients With Depression and/or Anxiety Having Arthroscopic Rotator Cuff Repair Show Decreased Number of Prescriptions and Number of Psychotherapy Sessions in the Year After Surgery
Abed, V., Lemaster, N. G., Hawk, G. S., Thompson, K. L., Conley, C., Mair, S. D., & Jacobs, C. A. (2023) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2023.05.032 · Cited by 5 · see citing works
The Role of Pain Catastrophizing and Anxiety Levels on Quality of Life in Fibromyalgia Compared with Healthy Women
Grinberg, K., Meshalhov, D., Adadi, D., & Biton, T. (2019) · Internal Medicine Open Access · doi:10.35248/2165-8048.19.9.313 · Cited by 5 · see citing works

Central nervous system mechanisms of pain in fibromyalgia and other musculoskeletal disorders: behavioral and psychologic treatment approaches
Bradley, L. A., & McKendree-Smith, N. L. (2002) · Current Opinion in Rheumatology · doi:10.1097/00002281-200201000-00009 · Cited by 59 · see citing works
Revisiting chronic musculoskeletal pain as a biopsychosocial disorder
Kirkik, D., & Sarıkaya, V. A. (2026) · World Journal of Clinical Cases · doi:10.12998/wjcc.122856
Systematic Review of the Psychopathological Symptomatology and Neuropsychological Disorders of Chronic Primary Musculoskeletal Pain
Arévalo‐Martínez, A., Barbosa‐Torres, C., Manso, J. M. M., Cordero, P. C., Sánchez, M. E. G.-B., & Díaz‐Muñoz, C. L. (2024) · Healthcare · doi:10.3390/healthcare12151465 · Cited by 6 · see citing works
The Relations among Pain, Emotional and Cognitive-behavioral Factors in Chronic Musculoskeletal Pain Patients
Lim, K.-B., Kim, J.-Y., Lee, H., Kim, D.-Y., & Kim, J.-M. (2008) · Annals of Rehabilitation Medicine · Cited by 6 · see citing works
Psychological and behavioural therapies in fibromyalgia and related syndromes.
Williams, D. A. (2003) · Best Practice & Research Clinical Rheumatology · doi:10.1016/s1521-6942(03)00034-2 · Cited by 118 · see citing works

Authors: Crofford, L. J.
Affiliations: Vanderbilt University (US)
Corresponding author: Crofford, Leslie J.
ORCID: Crofford, Leslie J.
Venue: Best Practice & Research Clinical Rheumatology
Publisher: Elsevier BV
Published: 2015-02
Volume: 29
Issue: 1
Pages: 147-155
ISSN: 1521-6942 (ISSN-L)
DOI: 10.1016/j.berh.2015.04.027
PMC: PMC5061342
OpenAlex: W1578893856
Cited by: 204
References: 52
Citations by year: 2026: 16 · 2025: 19 · 2024: 23 · 2023: 31 · 2022: 24 · 2021: 19 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 12 · 2016: 7
FWCI: 1.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Best Practice & Research Clinical Rheumatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381)
Topics: Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: chronic musculoskeletal pain, psychological distress, fibromyalgia, mood disorders, psychological comorbidity, coping, social support, behavioral adaptation, cognitive behavioral therapy
MeSH terms: Humans, Chronic Pain, Musculoskeletal Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Psychological aspects of chronic musculoskeletal pain

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks