The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
The gut microbiome in psoriasis and psoriatic arthritis
Abstract
This review summarizes existing research on the gut microbiome composition and function in psoriasis and psoriatic arthritis, exploring potential roles in disease pathogenesis, progression, and management. A strong relationship between skin, joint, and gastrointestinal inflammation exists, as demonstrated by an increased prevalence of psoriasis, psoriatic arthritis, and inflammatory bowel disease co-occurring together; however, the link between them has not been fully elucidated. Studies analyzing the gut microbiome in psoriasis and psoriatic arthritis reveal a unique pattern of dysbiosis. With regard to the gut microbiome's role in psoriasis and psoriatic arthritis pathogenesis, we discuss several theories including intestinal permeability, altered immune homeostasis, and imbalance of short- and medium-chain fatty acid-producing bacteria. We also discuss how the gut microbiome affects patient risk of psoriatic arthritis and other serious comorbidities, and how fecal microbes could be used clinically as therapeutic targets or markers of disease.
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“the abundance of Actinobacteria in the gut of patients with psoriasis was less than that of healthy controls.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [101]
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Cites
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Cited by
Sorted by citations
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 513
“Clostridium citroniae, Collinsella aerofaciens, Dorea formicigenerans, Parabacteroides distasonis, Prevotella copri, and Ruminococcus gnavus.(149,151) Technological advancements have opened up new possibilities for the selection and manufacture of monoclonal antibodies that target specific diseases.”
BackgroundSkin Barrier Dysregulation in Psoriasis
Orsmond, A., Bereza-Malcolm, L., Lynch, T., MARCH, L. M., & Xue, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910841 · Cited by 250
Psoriasis and Gut Microbiome—Current State of Art
Polak, K., Bergler-Czop, B. S., Szczepanek, M., Wojciechowska, K., Frątczak, A., & Kiss, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094529 · Cited by 133
“This may result in the restoration of the correct bacterial microbiota composition [33,68,81,82].”
BackgroundExploring the Links between Obesity and Psoriasis: A Comprehensive Review
Barros, G., Durán, P., Vera, I., & Bermúdez, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147499 · Cited by 142
“These pathological changes in microbiota support the chronic inflammatory state hypothesis [29] based on lipoteichoic acid and lipopolysaccharides released into the bloodstream [39].”
BackgroundInfluential
Metadata
- Authors
- Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W.
- Affiliations
- University of California, San Francisco (US)
- University of California, Berkeley (US)
- Corresponding author
- Liao, Wilson
- ORCID
- Venue
- Best Practice & Research Clinical Rheumatology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 33
- Issue
- 6
- Pages
- 101494
- ISSN
- 1521-6942 (ISSN-L)
- OpenAlex
- W3023269883
- Cited by
- 127
- References
- 98
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 31 · 2023: 26 · 2022: 23 · 2021: 24 · 2020: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- gut microbiota, psoriasis, psoriatic arthritis, dysbiosis, intestinal permeability, immune homeostasis, short-chain fatty acids, medium-chain fatty acids, inflammatory bowel disease, comorbidities, pathogenesis, fecal microbiota transplantation, biomarkers, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Humans, Psoriasis, Arthritis, Psoriatic, Microbiota, Dysbiosis
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