The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Construction of heparin-based hydrogel incorporated with Cu5.4O ultrasmall nanozymes for wound healing and inflammation inhibition
Open accessAbstract
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing. The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel ‘weeding and uprooting’ treatment strategy for inflammatory conditions. In the present study, a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol (starPEG) and heparin for chemokine sequestration as well as Cu 5.4 O ultrasmall nanozymes for ROS scavenging (Cu 5.4 O@Hep-PEG) was developed. The material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8, decreasing the migratory activity of macrophages and neutrophils. Furthermore, it scavenges the ROS in wound fluids to mitigate oxidative stress, and the sustained release of Cu 5.4 O promotes angiogenesis. In acute wounds and impaired-healing wounds (diabetic wounds), Cu 5.4 O@Hep-PEG hydrogels outperform the standard-of-care product Promogram® in terms of inflammation reduction, increased epidermis regeneration, vascularization, and wound closure.
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Cites
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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
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Distinct fibroblast subsets drive inflammation and damage in arthritis
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Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
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Cited by
Smart wound dressings for wound healing
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Anti‐inflammatory hydrogel dressings and skin wound healing
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Self-citationMicroenvironment‐Based Diabetic Foot Ulcer Nanomedicine
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Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
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Metadata
- Authors
- Peng, Y., He, D., Ge, X., Lu, Y., Chai, Y., Zhang, Y., Mao, Z., Luo, G., Deng, J., & Zhang, Y.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 6
- Issue
- 10
- Pages
- 3109-3124
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W3148272723
- Cited by
- 211
- References
- 12
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Peng, Y., He, D., Ge, X., Lu, Y., Chai, Y., Zhang, Y., Mao, Z., Luo, G., Deng, J., & Zhang, Y. (2021). Construction of heparin-based hydrogel incorporated with Cu5.4O ultrasmall nanozymes for wound healing and inflammation inhibition. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2021.02.006
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