The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
Abstract
Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments for diabetic chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in chronic wounds is the primary difference between diabetic chronic wounds and normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) for chronic wound healing of diabetic rats through integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species to modulate the oxidative stress microenvironment in diabetic chronic wounds, which leads to a natural transition from the inflammation phase to the proliferation phase. Impressively, the efficacy of one-time-applied MOF/Gel was comparable to that of the human epidermal growth factor Gel, a widely used clinical drug for various wound treatments. Such an effective, safe, and convenient MOF/Gel system can meet complex clinical demands.
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Cites
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Genetics of diabetes mellitus and diabetes complications
Cole, J. B., & Florez, J. C. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0278-5 · Cited by 1,797
Metal–Organic Frameworks for Biomedical Applications
Yang, J., & Yang, Y. (2020) · Small · doi:10.1002/smll.201906846 · Cited by 998
The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing
Deng, L., Du, C., Song, P., Chen, T., Rui, S., Armstrong, D. G., & Deng, W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8852759 · Cited by 763
Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives
Wang, Y., Yang, Y., Shi, Y., Song, H., & Yu, C. (2020) · Advanced Materials · doi:10.1002/adma.201904106 · Cited by 700
Singh, N., Savanur, M. A., Srivastava, S., D'Silva, P., & Mugesh, G. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201708573 · Cited by 657
Zinc in Wound Healing Modulation
Lin, P.-H., Sermersheim, M., Li, H., Lee, P. H. U., Steinberg, S. M., & Ma, J. (2017) · Nutrients · doi:10.3390/nu10010016 · Cited by 643
ROS scavenging Mn3O4nanozymes for in vivo anti-inflammation
Yao, J., Cheng, Y., Zhou, M., Zhao, S., Lin, S., Wang, X., Wu, J., Li, S., & Wei, H. (2018) · Chemical Science · doi:10.1039/c7sc05476a · Cited by 635
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Cited by
Hu, S., Yang, Z., Zhai, Q., Li, D., Zhu, X., He, Q., Li, L., Cannon, R. D., Wang, H., Tang, H., et al. (2023) · Small · doi:10.1002/smll.202207437 · Cited by 87
Dai, S., Jiang, L., Liu, L., Su, Z., Yao, L., Yang, P., & Huang, N. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae119 · Cited by 43
Self-citation
Metadata
- Authors
- Chao, D., Dong, Q., Yu, Z., Qi, D., Li, M., Xu, L., Liu, L., Fang, Y., & Dong, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-12-13
- Volume
- 144
- Issue
- 51
- Pages
- 23438-23447
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W4311275416
- Cited by
- 317
- References
- 60
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chao, D., Dong, Q., Yu, Z., Qi, D., Li, M., Xu, L., Liu, L., Fang, Y., & Dong, S. (2022). Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.2c09663
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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