Cited by 46Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsCancer Immunotherapy and Biomarkers

Photosynthetic Microorganisms Coupled Photodynamic Therapy for Enhanced Antitumor Immune Effect

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Wang, Haoran, Liu, Honghui, Guo, Yunfei, Zai, Wenjing, Li, Xianghui, Xiong, Wei, Zhao, Xiaozhi, Yao, Yingfang +3 more·2022·Bioactive Materials

Abstract

The ideal photodynamic therapy (PDT) should effectively remove the primary tumor, and produce a stronger immune memory effect to inhibit the tumor recurrence and tumor metastasis. However, limited by the hypoxic and immunosuppressive microenvironment, the PDT efficiency is apparently low. Here, Chlorella (Chl.) is exploited to enhance local effect by producing oxygen to reverse hypoxia, and release adjuvants to reverse immunosuppressive microenvironment to enhance abscopal effect afterwards. Results from different animal models indicated that Chl. could enhance local effect and PDT related immune response. Ultimately, Chl. coupled PDT elicited anti-tumor effects toward established primary tumors (inhibition rate: 90%) and abscopal tumors (75%), controlled the challenged tumors (100%) and alleviated metastatic tumors (90%). This Chl. coupled PDT strategy can also produce a stronger anti-tumor immune memory effect. Overall, this Chl. coupled PDT strategy generates enhanced local tumor killing, boosts PDT-induced immune responses and promotes anti-tumor immune memory effect, which may be a great progress for realizing systemic effect of PDT.

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Crossref · 10.1016/j.bioactmat.2021.10.028

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  • Treatment with Chlorella sp. produced a stronger antitumor immune memory effect and elicited antitumor effects toward established primary tumors (inhibition rate 90%), abscopal tumors (75%), controlled challenged tumors (100%), and alleviated metastatic tumors (90%).

    “The treatment with Chlorella sp. produced a stronger antitumor immune memory effect and elicited antitumor effects toward established primary tumors (inhibition rate: 90%) and abscopal tumors (75%), controlled the challenged tumors (100%), and alleviated metastatic tumors (90%).”

    From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [130]

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  • Chlorella sp. used as an O2 producer to reverse hypoxia and release adjuvants reversed the immunosuppressive microenvironment and enhanced the abscopal effect.

    “The microalga was used as an O2 producer to reverse hypoxia and release adjuvants to reverse the immunosuppressive microenvironment, enhancing the abscopal effect afterwards.”

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Authors
Wang, H., Liu, H., Guo, Y., Zai, W., Li, X., Xiong, W., Zhao, X., Yao, Y., Hu, Y., Zou, Z., & Wu, J.
Affiliations
  • Nanjing University of Chinese Medicine (CN)
  • State Key Laboratory of Pharmaceutical Biotechnology (CN)
  • Collaborative Innovation Center of Advanced Microstructures (CN)
  • Nanjing Drum Tower Hospital (CN)
Corresponding author
Wu, Jinhui
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2022-06
Volume
12
Pages
97-106
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
OpenAlex
W3208451036
Cited by
46
References
49
Citations by year
2026: 6 · 2025: 6 · 2024: 11 · 2023: 17 · 2022: 6
FWCI
5.52
Type
journal article
Language
en
Open access
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81872811, 32171372, 31872755, 2017YFA0205400)
  • Fundamental Research Funds for the Central Universities (02141438473)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
photodynamic therapy, Chlorella, photosynthetic microorganisms, tumor hypoxia, oxygen production, immunosuppressive tumor microenvironment, abscopal effect, metastasis, systemic antitumor immunity

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